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Volume 61, Issue 10
1 October 2012
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ISSN 0012-1797
EISSN 1939-327X
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Commentary

Does Endurance Training Protect From Lipotoxicity?
Michael Roden
View articletitled, Does Endurance Training Protect From Lipotoxicity?
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Diabetes September 2012, Vol.61, 2397-2399. doi:https://doi.org/10.2337/db12-0662
Protective Effect of Nrf2 and Catalase in Maternal Diabetes-Induced Perinatal Hypertension and Kidney Disease
Nosratola D. Vaziri
View articletitled, Protective Effect of Nrf2 and Catalase in Maternal Diabetes-Induced Perinatal Hypertension and Kidney Disease
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Diabetes September 2012, Vol.61, 2400-2402. doi:https://doi.org/10.2337/db12-0764
Cardiac Natriuretic Peptides: Contributors to Cardiac Cachexia or Possible Anti-obesity Agents or Both?
Lisa C. Costello-Boerrigter
View articletitled, Cardiac Natriuretic Peptides: Contributors to Cardiac Cachexia or Possible Anti-obesity Agents or Both?
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Diabetes September 2012, Vol.61, 2403-2404. doi:https://doi.org/10.2337/db12-0763

Technological Advances

In Vivo Imaging of Immuno-Spin Trapped Radicals With Molecular Magnetic Resonance Imaging in a Diabetic Mouse Model
Rheal A. Towner; Nataliya Smith; Debra Saunders; Michael Henderson; Kristen Downum; Florea Lupu; Robert Silasi-Mansat; Dario C. Ramirez; Sandra E. Gomez-Mejiba; Marcelo G. Bonini; Marilyn Ehrenshaft; Ronald P. Mason
View articletitled, In Vivo Imaging of Immuno-Spin Trapped Radicals With Molecular Magnetic Resonance Imaging in a Diabetic Mouse Model
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Diabetes September 2012, Vol.61, 2405-2413. doi:https://doi.org/10.2337/db11-1540

Metabolism

Myostatin Inhibition Prevents Diabetes and Hyperphagia in a Mouse Model of Lipodystrophy
Tingqing Guo; Nichole D. Bond; William Jou; Oksana Gavrilova; Jennifer Portas; Alexandra C. McPherron
View articletitled, Myostatin Inhibition Prevents Diabetes and Hyperphagia in a Mouse Model of Lipodystrophy
Supplementary data
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Diabetes September 2012, Vol.61, 2414-2423. doi:https://doi.org/10.2337/db11-0915
Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity
Latha Ramalingam; Eunjin Oh; Stephanie M. Yoder; Joseph T. Brozinick; Michael A. Kalwat; Alexander J. Groffen; Matthijs Verhage; Debbie C. Thurmond
View articletitled, Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity
Supplementary data
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Diabetes September 2012, Vol.61, 2424-2432. doi:https://doi.org/10.2337/db11-1525
A Cyclic Guanosine Monophosphate–Dependent Pathway Can Regulate Net Hepatic Glucose Uptake in Vivo
Zhibo An; Jason J. Winnick; Mary C. Moore; Ben Farmer; Marta Smith; Jose M. Irimia; Peter J. Roach; Alan D. Cherrington
View articletitled, A Cyclic Guanosine Monophosphate–Dependent Pathway Can Regulate Net Hepatic Glucose Uptake in Vivo
Supplementary data
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Diabetes September 2012, Vol.61, 2433-2441. doi:https://doi.org/10.2337/db11-1816
Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver
Tatsuya Ehara; Yasutomi Kamei; Mayumi Takahashi; Xunmei Yuan; Sayaka Kanai; Erina Tamura; Miyako Tanaka; Tomomi Yamazaki; Shinji Miura; Osamu Ezaki; Takayoshi Suganami; Masaki Okano; Yoshihiro Ogawa
View articletitled, Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver
Supplementary data
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Diabetes September 2012, Vol.61, 2442-2450. doi:https://doi.org/10.2337/db11-1834
Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1α With CREB-Binding Protein
Amandine Gautier-Stein; Maud Soty; Julien Chilloux; Carine Zitoun; Fabienne Rajas; Gilles Mithieux
View articletitled, Glucotoxicity Induces Glucose-6-Phosphatase Catalytic Unit Expression by Acting on the Interaction of HIF-1α With CREB-Binding Protein
Supplementary data
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Diabetes September 2012, Vol.61, 2451-2460. doi:https://doi.org/10.2337/db11-0986
S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid
Tingting Xia; Ying Cheng; Qian Zhang; Fei Xiao; Bin Liu; Shanghai Chen; Feifan Guo
View articletitled, S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid
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Diabetes September 2012, Vol.61, 2461-2471. doi:https://doi.org/10.2337/db11-1278
High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
Esther Phielix; Ruth Meex; D. Margriet Ouwens; Lauren Sparks; Joris Hoeks; Gert Schaart; Esther Moonen-Kornips; Matthijs K.C. Hesselink; Patrick Schrauwen
View articletitled, High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
Supplementary data
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Diabetes September 2012, Vol.61, 2472-2478. doi:https://doi.org/10.2337/db11-1832
Insulin Sensitivity and β-Cell Function in Adults Born Preterm and Their Children
Sarah Mathai; Wayne S. Cutfield; José G.B. Derraik; Stuart R. Dalziel; Jane E. Harding; Elizabeth Robinson; Janene Biggs; Craig Jefferies; Paul L. Hofman
View articletitled, Insulin Sensitivity and β-Cell Function in Adults Born Preterm and Their Children
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Diabetes September 2012, Vol.61, 2479-2483. doi:https://doi.org/10.2337/db11-1672

Signal Transduction

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner
Yong Deuk Kim; Yong-Hoon Kim; Surendar Tadi; Ji Hoon Yu; Yong-Hyeon Yim; Nam Ho Jeoung; Minho Shong; Lothar Hennighausen; Robert A. Harris; In-Kyu Lee; Chul-Ho Lee; Hueng-Sik Choi
View articletitled, Metformin Inhibits Growth Hormone–Mediated Hepatic <em>PDK4</em> Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner
Supplementary data
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Diabetes September 2012, Vol.61, 2484-2494. doi:https://doi.org/10.2337/db11-1665

Obesity Studies

Attenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice
Carrie E. McCurdy; Simon Schenk; Michael J. Holliday; Andrew Philp; Julie A. Houck; David Patsouris; Paul S. MacLean; Susan M. Majka; Dwight J. Klemm; Jacob E. Friedman
View articletitled, Attenuated <em>Pik3r1</em> Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice
Supplementary data
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Diabetes September 2012, Vol.61, 2495-2505. doi:https://doi.org/10.2337/db11-1433
Neuroadrenergic Dysfunction Along the Diabetes Continuum: A Comparative Study in Obese Metabolic Syndrome Subjects
Nora E. Straznicky; Mariee T. Grima; Carolina I. Sari; Nina Eikelis; Elisabeth A. Lambert; Paul J. Nestel; Murray D. Esler; John B. Dixon; Reena Chopra; Alan J. Tilbrook; Markus P. Schlaich; Gavin W. Lambert
View articletitled, Neuroadrenergic Dysfunction Along the Diabetes Continuum<span class="subtitle-colon">: </span><span class="subtitle">A Comparative Study in Obese Metabolic Syndrome Subjects</span>
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Diabetes September 2012, Vol.61, 2506-2516. doi:https://doi.org/10.2337/db12-0138

Islet Studies

Nutrient Excess Stimulates β-Cell Neogenesis in Zebrafish
Lisette A. Maddison; Wenbiao Chen
View articletitled, Nutrient Excess Stimulates β-Cell Neogenesis in Zebrafish
Supplementary data
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Diabetes September 2012, Vol.61, 2517-2524. doi:https://doi.org/10.2337/db11-1841

Immunology and Transplantation

Dysregulated Toll-Like Receptor–Induced Interleukin-1β and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes
Aimon K. Alkanani; Marian Rewers; Fran Dong; Kathleen Waugh; Peter A. Gottlieb; Danny Zipris
View articletitled, Dysregulated Toll-Like Receptor–Induced Interleukin-1β and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes
Supplementary data
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Diabetes September 2012, Vol.61, 2525-2533. doi:https://doi.org/10.2337/db12-0099
Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
Ênio J. Bassi; Pedro M.M. Moraes-Vieira; Carla S.R. Moreira-Sá; Danilo C. Almeida; Leonardo M. Vieira; Cláudia S. Cunha; Meire I. Hiyane; Alexandre S. Basso; Alvaro Pacheco-Silva; Niels O.S. Câmara
View articletitled, Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
Supplementary data
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Diabetes September 2012, Vol.61, 2534-2545. doi:https://doi.org/10.2337/db11-0844
HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes
Matthieu Scotto; Georgia Afonso; Thomas Østerbye; Etienne Larger; Sandrine Luce; Cécile Raverdy; Giulia Novelli; Graziella Bruno; Céline Gonfroy-Leymarie; Odile Launay; François A. Lemonnier; Søren Buus; Jean-Claude Carel; Christian Boitard; Roberto Mallone
View articletitled, HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes
Supplementary data
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Diabetes September 2012, Vol.61, 2546-2555. doi:https://doi.org/10.2337/DB12-0136
Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study
Ahmed J. Delli; Fariba Vaziri-Sani; Bengt Lindblad; Helena Elding-Larsson; Annelie Carlsson; Gun Forsander; Sten A. Ivarsson; Johnny Ludvigsson; Ingrid Kockum; Claude Marcus; Ulf Samuelsson; Eva Örtqvist; Leif Groop; George P. Bondinas; George K. Papadopoulos; Åke Lernmark; for the Better Diabetes Diagnosis Study Group
View articletitled, Zinc Transporter 8 Autoantibodies and Their Association With <em>SLC30A8</em> and <em>HLA-DQ</em> Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study
Supplementary data
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Diabetes September 2012, Vol.61, 2556-2564. doi:https://doi.org/10.2337/db11-1659

Pathophysiology

Catalase Prevents Maternal Diabetes–Induced Perinatal Programming via the Nrf2–HO-1 Defense System
Shiao-Ying Chang; Yun-Wen Chen; Xin-Ping Zhao; Isabelle Chenier; Stella Tran; Alexandre Sauvé; Julie R. Ingelfinger; Shao-Ling Zhang
View articletitled, Catalase Prevents Maternal Diabetes–Induced Perinatal Programming via the Nrf2–HO-1 Defense System
Supplementary data
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Diabetes September 2012, Vol.61, 2565-2574. doi:https://doi.org/10.2337/db12-0248
Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
Ming-Zhi Zhang; Bing Yao; Shilin Yang; Haichun Yang; Suwan Wang; Xiaofeng Fan; Huiyong Yin; Agnes B. Fogo; Gilbert W. Moeckel; Raymond C. Harris
View articletitled, Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
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Diabetes September 2012, Vol.61, 2575-2584. doi:https://doi.org/10.2337/db12-0046
GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K+ Channel
Andrew C. Calabria; Changhong Li; Paul R. Gallagher; Charles A. Stanley; Diva D. De León
View articletitled, GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K<sup>+</sup> Channel
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Diabetes September 2012, Vol.61, 2585-2591. doi:https://doi.org/10.2337/db12-0166
B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
Greisa Vila; Gabriele Grimm; Michael Resl; Birgit Heinisch; Elisa Einwallner; Harald Esterbauer; Benjamin Dieplinger; Thomas Mueller; Anton Luger; Martin Clodi
View articletitled, B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
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Diabetes September 2012, Vol.61, 2592-2596. doi:https://doi.org/10.2337/db11-1466

Complications

Heterogeneous Nuclear Ribonucleoprotein F Suppresses Angiotensinogen Gene Expression and Attenuates Hypertension and Kidney Injury in Diabetic Mice
Chao-Sheng Lo; Shiao-Ying Chang; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao Ling Zhang; John S.D. Chan
View articletitled, Heterogeneous Nuclear Ribonucleoprotein F Suppresses Angiotensinogen Gene Expression and Attenuates Hypertension and Kidney Injury in Diabetic Mice
Supplementary data
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Diabetes September 2012, Vol.61, 2597-2608. doi:https://doi.org/10.2337/db11-1349
Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment
Chien-Ping Liang; Seongah Han; Gang Li; Ira Tabas; Alan R. Tall
View articletitled, Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment
Supplementary data
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Diabetes September 2012, Vol.61, 2609-2620. doi:https://doi.org/10.2337/db11-1415

Pharmacology and Therapeutics

Ephrin-B2–Activated Peripheral Blood Mononuclear Cells From Diabetic Patients Restore Diabetes-Induced Impairment of Postischemic Neovascularization
Dong Broquères-You; Carole Leré-Déan; Tatiana Merkulova-Rainon; Chris S. Mantsounga; David Allanic; Patricia Hainaud; Jean-Olivier Contrères; Yu Wang; José Vilar; Marie Virally; Jean-Jacques Mourad; Pierre-Jean Guillausseau; Jean-Sébastien Silvestre; Bernard I. Lévy
View articletitled, Ephrin-B2–Activated Peripheral Blood Mononuclear Cells From Diabetic Patients Restore Diabetes-Induced Impairment of Postischemic Neovascularization
Supplementary data
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Diabetes September 2012, Vol.61, 2621-2632. doi:https://doi.org/10.2337/db11-1768
Diabetes-Impaired Wound Healing Is Improved by Matrix Therapy With Heparan Sulfate Glycosaminoglycan Mimetic OTR4120 in Rats
Miao Tong; Bastiaan Tuk; Peng Shang; Ineke M. Hekking; Esther M.G. Fijneman; Marnix Guijt; Steven E.R. Hovius; Johan W. van Neck
View articletitled, Diabetes-Impaired Wound Healing Is Improved by Matrix Therapy With Heparan Sulfate Glycosaminoglycan Mimetic OTR4120 in Rats
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Diabetes September 2012, Vol.61, 2633-2641. doi:https://doi.org/10.2337/db11-1329

Genetics / Genomes / Proteomics / Metabolomics

Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
Chia-Wei Liou; Jin-Bor Chen; Mao-Meng Tiao; Shao-Wen Weng; Tiao-Lai Huang; Jiin-Haur Chuang; Shang-Der Chen; Yao-Chung Chuang; Wen-Chin Lee; Tsu-Kung Lin; Pei-Wen Wang
View articletitled, Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
Supplementary data
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Diabetes September 2012, Vol.61, 2642-2651. doi:https://doi.org/10.2337/db11-1369

Withdrawn

Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes. Diabetes 2005;54:3089–3094
C Scheede-Bergdahl; M Penkowa; J Hidalgo; DB Olsen; P Schjerling; C Prats; R Boushel; F Dela
View articletitled, Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes. Diabetes 2005;54:3089–3094
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Diabetes September 2012, Vol.61, 2652. doi:https://doi.org/10.2337/db12-wd10

Erratum

Endurance exercise as a countermeasure for aging. Diabetes 2008;57:2933–2942
IR Lanza; DK Short; KR Short; S Raghavakaimal; R Basu; MJ Joyner; JP McConnell; KS Nair
View articletitled, Endurance exercise as a countermeasure for aging. Diabetes 2008;57:2933–2942
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Diabetes September 2012, Vol.61, 2653. doi:https://doi.org/10.2337/db12-er10

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes September 2012, Vol.61, 2654. doi:https://doi.org/10.2337/db12-ie10

Diabetes Digests

Highlights From the Latest in Diabetes Research
View articletitled, Highlights From the Latest in Diabetes Research
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Diabetes September 2012, Vol.61, 2655-2656. doi:https://doi.org/10.2337/db12-dd10

Online Letters to the Editor

Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975
Guy A. Rutter; Timothy J. Pullen
View articletitled, Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975
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Diabetes September 2012, Vol.61, e16. doi:https://doi.org/10.2337/db12-0775
Response to Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975
Frans Schuit
View articletitled, Response to Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975
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Diabetes September 2012, Vol.61, e17. doi:https://doi.org/10.2337/db12-0888
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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