Issues

Topics: metabolism , pharmacokinetics , tcf7l2 gene , diabetes mellitus, type 2 , protein isoforms

Diabetes October 2012, Vol.61, 2657-2658. doi:https://doi.org/10.2337/db12-0891

Seeing Is Believing: Dietary Fatty Acids Hurry Up From the Stomach to the Heart of Patients With Impaired Glucose Tolerance

Patricia Iozzo

Abstracts

Topics: diet , fatty acids , glucose intolerance , heart , stomach

Diabetes October 2012, Vol.61, 2659-2660. doi:https://doi.org/10.2337/db12-0803

Methodology Reviews

Muscle Perfusion: Its Measurement and Role in Metabolic Regulation

Eugene J. Barrett; Stephen Rattigan

Extract

Topics: glucose , insulin , limb , perfusion , vascular flow

Diabetes October 2012, Vol.61, 2661-2668. doi:https://doi.org/10.2337/db12-0271

³¹P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism

Douglas E. Befroy; Douglas L. Rothman; Kitt Falk Petersen; Gerald I. Shulman

Abstracts

Topics: magnetic resonance spectroscopy , metabolism , mitochondria , skeletal muscles , transfer technique

Diabetes October 2012, Vol.61, 2669-2678. doi:https://doi.org/10.2337/db12-0558

Metabolism

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

Madeleen Bosma; Matthijs K.C. Hesselink; Lauren M. Sparks; Silvie Timmers; Maria João Ferraz; Frits Mattijssen; Denis van Beurden; Gert Schaart; Marc H. de Baets; Fons K. Verheyen; Sander Kersten; Patrick Schrauwen

Abstract

Topics: adipophilin , lipids , protein overexpression , palmitates

Diabetes October 2012, Vol.61, 2679-2690. doi:https://doi.org/10.2337/db11-1402

Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals

Ahmed Saad; Chiara Dalla Man; Debashis K. Nandy; James A. Levine; Adil E. Bharucha; Robert A. Rizza; Rita Basu; Rickey E. Carter; Claudio Cobelli; Yogish C. Kudva; Ananda Basu

Abstracts

Topics: glucose , insulin , postprandial period

Diabetes October 2012, Vol.61, 2691-2700. doi:https://doi.org/10.2337/db11-1478

Increased Myocardial Uptake of Dietary Fatty Acids Linked to Cardiac Dysfunction in Glucose-Intolerant Humans

Sébastien M. Labbé; Thomas Grenier-Larouche; Christophe Noll; Serge Phoenix; Brigitte Guérin; Eric E. Turcotte; André C. Carpentier

Abstracts

Topics: diet , fatty acids , myocardium , positron-emission tomography , postprandial period

Diabetes October 2012, Vol.61, 2701-2710. doi:https://doi.org/10.2337/db11-1805

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

Clare Flannery; Sylvie Dufour; Rasmus Rabøl; Gerald I. Shulman; Kitt Falk Petersen

Abstract

Topics: carbohydrates , glycogen , hyperlipidemia , insulin resistance , lipids

Diabetes October 2012, Vol.61, 2711-2717. doi:https://doi.org/10.2337/db12-0206

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

Jeb S. Orr; Michael J. Puglisi; Kate L.J. Ellacott; Carey N. Lumeng; David H. Wasserman; Alyssa H. Hasty

Abstracts

Topics: toll-like receptor 4 , heart failure , mice

Diabetes October 2012, Vol.61, 2718-2727. doi:https://doi.org/10.2337/db11-1595

Effect of Glycemia on Plasma Incretins and the Incretin Effect During Oral Glucose Tolerance Test

Marzieh Salehi; Benedict Aulinger; David A. D’Alessio

Abstract

Topics: glucagon-like peptide 1 , glucose , hyperglycemia , incretin , ingestion

Diabetes October 2012, Vol.61, 2728-2733. doi:https://doi.org/10.2337/db11-1825

Caloric Restriction Chronically Impairs Metabolic Programming in Mice

Henriette Kirchner; Susanna M. Hofmann; Antje Fischer-Rosinský; Jazzminn Hembree; William Abplanalp; Nickki Ottaway; Elizabeth Donelan; Radha Krishna; Stephen C. Woods; Timo D. Müller; Joachim Spranger; Diego Perez-Tilve; Paul T. Pfluger; Matthias H. Tschöp; Kirk M. Habegger

Abstract

Topics: glucose , insulin , mice , obesity , hyperphagia

Diabetes October 2012, Vol.61, 2734-2742. doi:https://doi.org/10.2337/db11-1621

Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4

Christian Pehmøller; Nina Brandt; Jesper B. Birk; Louise D. Høeg; Kim A. Sjøberg; Laurie J. Goodyear; Bente Kiens; Erik A. Richter; Jørgen F.P. Wojtaszewski

Abstracts

Topics: glucose , infusion procedures , insulin , insulin resistance , intravenous fat emulsions

Diabetes October 2012, Vol.61, 2743-2752. doi:https://doi.org/10.2337/db11-1572

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling

Sarah H. Lockie; Kristy M. Heppner; Nilika Chaudhary; Joseph R. Chabenne; Donald A. Morgan; Christelle Veyrat-Durebex; Gayathri Ananthakrishnan; Françoise Rohner-Jeanrenaud; Daniel J. Drucker; Richard DiMarchi; Kamal Rahmouni; Brian J. Oldfield; Matthias H. Tschöp; Diego Perez-Tilve

Abstracts

Topics: fasting , glucagon-like peptide 1 , mice , peptides , signal transduction

Diabetes October 2012, Vol.61, 2753-2762. doi:https://doi.org/10.2337/db11-1556

Signal Transduction

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Daniel A. Cunha; Mariana Igoillo-Esteve; Esteban N. Gurzov; Carla M. Germano; Najib Naamane; Ihsane Marhfour; Makiko Fukaya; Jean-Marie Vanderwinden; Conny Gysemans; Chantal Mathieu; Lorella Marselli; Piero Marchetti; Heather P. Harding; David Ron; Décio L. Eizirik; Miriam Cnop

Abstracts

Topics: apoptosis , mitochondria , palmitates , stress , mice

Diabetes October 2012, Vol.61, 2763-2775. doi:https://doi.org/10.2337/db12-0123

Obesity Studies

Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance

Meilian Liu; Ruihua Xiang; Sarah Ann Wilk; Ning Zhang; Lauren B. Sloane; Kian Azarnoush; Lijun Zhou; Hongzhi Chen; Guangda Xiang; Christi A. Walter; Steven N. Austad; Nicolas Musi; Ralph A. DeFronzo; Reto Asmis; Philipp E. Scherer; Lily Q. Dong; Feng Liu

Abstract

Topics: adiponectin , diet , mice , obesity , protein overexpression

Diabetes October 2012, Vol.61, 2776-2786. doi:https://doi.org/10.2337/db12-0169

Effects of Aerobic Versus Resistance Exercise Without Caloric Restriction on Abdominal Fat, Intrahepatic Lipid, and Insulin Sensitivity in Obese Adolescent Boys: A Randomized, Controlled Trial

SoJung Lee; Fida Bacha; Tamara Hannon; Jennifer L. Kuk; Chris Boesch; Silva Arslanian

Abstracts

Topics: abdomen , adolescent , boys , calorie restricted diet , insulin sensitivity

Diabetes October 2012, Vol.61, 2787-2795. doi:https://doi.org/10.2337/db12-0214

Depressed Levels of Prostaglandin F_2α in Mice Lacking Akr1b7 Increase Basal Adiposity and Predispose to Diet-Induced Obesity

Fanny E. Volat; Jean-Christophe Pointud; Emilie Pastel; Béatrice Morio; Benoit Sion; Ghislaine Hamard; Michel Guichardant; Romain Colas; Anne-Marie Lefrançois-Martinez; Antoine Martinez

Abstracts

Topics: adipose tissue , diet , mice , obesity

Diabetes October 2012, Vol.61, 2796-2806. doi:https://doi.org/10.2337/db11-1297

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

Dorota Kaminska; Tiina Kuulasmaa; Sari Venesmaa; Pirjo Käkelä; Maija Vaittinen; Leena Pulkkinen; Matti Pääkkönen; Helena Gylling; Markku Laakso; Jussi Pihlajamäki

Abstracts

Topics: adipose tissue , glucose , insulin , liver , obesity

Diabetes October 2012, Vol.61, 2807-2813. doi:https://doi.org/10.2337/db12-0239

Membrane-Tethered Delta-Like 1 Homolog (DLK1) Restricts Adipose Tissue Size by Inhibiting Preadipocyte Proliferation

Sussi B. Mortensen; Charlotte H. Jensen; Mikael Schneider; Mads Thomassen; Torben A. Kruse; Jorge Laborda; Søren P. Sheikh; Ditte C. Andersen

Abstract

Topics: adipose tissue , cell count , cell cycle , genes , mice

Diabetes October 2012, Vol.61, 2814-2822. doi:https://doi.org/10.2337/db12-0176

Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

Abstract

Topics: adipokines , emergency service, hospital , ligands , liver , mice

Diabetes October 2012, Vol.61, 2823-2832. doi:https://doi.org/10.2337/db12-0232

Maternal High-Fat Diet During Gestation or Suckling Differentially Affects Offspring Leptin Sensitivity and Obesity

Bo Sun; Ryan H. Purcell; Chantelle E. Terrillion; Jianqun Yan; Timothy H. Moran; Kellie L.K. Tamashiro

Abstract

Topics: diet , heart failure , leptin , obesity , pregnancy

Diabetes October 2012, Vol.61, 2833-2841. doi:https://doi.org/10.2337/db11-0957

Islet Studies

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

Ning Li; Bin Li; Thierry Brun; Christine Deffert-Delbouille; Zahia Mahiout; Youssef Daali; Xiao-Juan Ma; Karl-Heinz Krause; Pierre Maechler

Abstracts

Topics: cybb gene , cyclic amp , endocrine pancreas , glucose , insulin

Diabetes October 2012, Vol.61, 2842-2850. doi:https://doi.org/10.2337/db12-0009

Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass

Judith Agudo; Eduard Ayuso; Veronica Jimenez; Alba Casellas; Cristina Mallol; Ariana Salavert; Sabrina Tafuro; Mercè Obach; Albert Ruzo; Marta Moya; Anna Pujol; Fatima Bosch

Abstracts

Topics: inflammation , mice , vascular endothelial growth factor a , insulin

Diabetes October 2012, Vol.61, 2851-2861. doi:https://doi.org/10.2337/db12-0134

Immunology and Transplantation

Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic β-Cells

Vineeth Varanasi; Lia Avanesyan; Desiree M. Schumann; Alexander V. Chervonsky

Abstract

Topics: mice , t-lymphocytes , tumor necrosis factors , tumor necrosis factor ligand superfamily member 6 , clone cells

Diabetes October 2012, Vol.61, 2862-2870. doi:https://doi.org/10.2337/db11-1784

Long-Term Remission of Diabetes in NOD Mice Is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies

Zuoan Yi; Ramiro Diz; Aaron J. Martin; Yves Maurice Morillon; Douglas E. Kline; Li Li; Bo Wang; Roland Tisch

Abstracts

Topics: disease remission , mice, inbred nod , pancreas , t-lymphocytes , mice

Diabetes October 2012, Vol.61, 2871-2880. doi:https://doi.org/10.2337/db12-0098

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

Roham Parsa; Pernilla Andresen; Alan Gillett; Sohel Mia; Xing-Mei Zhang; Sofia Mayans; Dan Holmberg; Robert A. Harris

Abstracts

Topics: macrophages , interleukin-10 , interleukin-4 , mice , mice, inbred nod

Diabetes October 2012, Vol.61, 2881-2892. doi:https://doi.org/10.2337/db11-1635

B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes

Eliana Mariño; Bernice Tan; Lauren Binge; Charles R. Mackay; Shane T. Grey

Abstract

Topics: b-lymphocytes , t-lymphocytes , autoantigens , mice

Diabetes October 2012, Vol.61, 2893-2905. doi:https://doi.org/10.2337/db12-0006

Pathophysiology

The Role of MicroRNA-146a in the Pathogenesis of the Diabetic Wound-Healing Impairment: Correction With Mesenchymal Stem Cell Treatment

Junwang Xu; Wenjie Wu; Liping Zhang; Wanda Dorset-Martin; Michael W. Morris; Marc E. Mitchell; Kenneth W. Liechty

Abstract

Topics: mice , micrornas , wound healing , mesenchymal stem cells , gene expression

Diabetes October 2012, Vol.61, 2906-2912. doi:https://doi.org/10.2337/db12-0145

High Glucose Inhibits the Aspirin-Induced Activation of the Nitric Oxide/cGMP/cGMP-Dependent Protein Kinase Pathway and Does Not Affect the Aspirin-Induced Inhibition of Thromboxane Synthesis in Human Platelets

Isabella Russo; Michela Viretto; Cristina Barale; Luigi Mattiello; Gabriella Doronzo; Andrea Pagliarino; Franco Cavalot; Mariella Trovati; Giovanni Anfossi

Abstracts

Topics: aspirin , blood platelets , current good manufacturing practice , cyclic gmp , glucose

Diabetes October 2012, Vol.61, 2913-2921. doi:https://doi.org/10.2337/db12-0040

Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations

Angela R. Subauste; Arun K. Das; Xiangquan Li; Brandon Elliot; Charles Evans; Mahmoud El Azzouny; Mary Treutelaar; Elif Oral; Todd Leff; Charles F. Burant

Abstract

Topics: 1-phosphatidylinositol 3-kinase , adipocytes , biopsy , cell death , insulin

Diabetes October 2012, Vol.61, 2922-2931. doi:https://doi.org/10.2337/db12-0004

C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome

Kyung Mook Choi; Soon Young Hwang; Ho Cheol Hong; Sae Jeong Yang; Hae Yoon Choi; Hye Jin Yoo; Kwan Woo Lee; Moon Suk Nam; Yong Soo Park; Jeong Taek Woo; Young Seol Kim; Dong Seop Choi; Byung-Soo Youn; Sei Hyun Baik

Abstracts

Topics: diabetes mellitus, type 2 , epithelium , metabolic syndrome x , pigment , prediabetes

Diabetes October 2012, Vol.61, 2932-2936. doi:https://doi.org/10.2337/db12-0217

Complications

Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration

Thanh Dinh; Francesco Tecilazich; Antonios Kafanas; John Doupis; Charalambos Gnardellis; Ermelindo Leal; Ana Tellechea; Leena Pradhan; Thomas E. Lyons; John M. Giurini; Aristidis Veves

Abstracts

Topics: biopsy , diabetic foot ulcer , foot , foot ulcer , forearm

Diabetes October 2012, Vol.61, 2937-2947. doi:https://doi.org/10.2337/db12-0227

Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy

Kyungwon Lee; Yang Hu; Lexi Ding; Ying Chen; Yusuke Takahashi; Robert Mott; Jian-xing Ma

Abstract

Topics: antibodies , attenuation , diabetic retinopathy , endothelial cells , glucose

Diabetes October 2012, Vol.61, 2948-2957. doi:https://doi.org/10.2337/db11-0300

Vegfa Protects the Glomerular Microvasculature in Diabetes

Gavasker A. Sivaskandarajah; Marie Jeansson; Yoshiro Maezawa; Vera Eremina; Hans J. Baelde; Susan E. Quaggin

Abstract

Topics: kidney glomerulus , mice , streptozocin , podocytes

Diabetes October 2012, Vol.61, 2958-2966. doi:https://doi.org/10.2337/DB11-1655

Protective Effects of GLP-1 on Glomerular Endothelium and Its Inhibition by PKCβ Activation in Diabetes

Akira Mima; Junko Hiraoka-Yamomoto; Qian Li; Munehiro Kitada; Chenzhong Li; Pedro Geraldes; Motonobu Matsumoto; Koji Mizutani; Kyoungmin Park; Christopher Cahill; Shin-Ichi Nishikawa; Christian Rask-Madsen; George L. King

Abstract

Topics: angiotensin ii , exenatide , glucagon-like peptide 1 , kidney glomerulus , mice

Diabetes October 2012, Vol.61, 2967-2979. doi:https://doi.org/10.2337/db11-1824

Increased Inner Ear Susceptibility to Noise Injury in Mice With Streptozotocin-Induced Diabetes

Takeshi Fujita; Daisuke Yamashita; Sayaka Katsunuma; Shingo Hasegawa; Hitoshi Tanimoto; Ken-ichi Nibu

Abstract

Topics: auditory brainstem responses , mice , noise , noise exposure , streptozocin

Diabetes October 2012, Vol.61, 2980-2986. doi:https://doi.org/10.2337/db11-1845

Improvements in the Life Expectancy of Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study Cohort

Rachel G. Miller; Aaron M. Secrest; Ravi K. Sharma; Thomas J. Songer; Trevor J. Orchard

Abstract

Topics: diabetes mellitus, type 1 , diabetes mellitus complications , epidemiology , child

Diabetes October 2012, Vol.61, 2987-2992. doi:https://doi.org/10.2337/db11-1625

Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes

Antonio Ceriello; Anna Novials; Emilio Ortega; Lucia La Sala; Gemma Pujadas; Roberto Testa; Anna Rita Bonfigli; Katherine Esposito; Dario Giugliano

Abstract

Topics: diabetes mellitus, type 1 , hyperglycemia , hypoglycemia , inflammation , oxidative stress

Diabetes October 2012, Vol.61, 2993-2997. doi:https://doi.org/10.2337/db12-0224

Genetics / Genomes / Proteomics / Metabolomics

A Prospective Study of Leukocyte Telomere Length and Risk of Type 2 Diabetes in Postmenopausal Women

Nai-chieh Y. You; Brian H. Chen; Yiqing Song; XuYang Lu; Yilin Chen; JoAnn E. Manson; Mo Kang; Barbara V. Howard; Karen L. Margolis; J. David Curb; Lawrence S. Phillips; Marcia L. Stefanick; Lesley F. Tinker; Simin Liu

Abstract

Topics: diabetes mellitus, type 2 , leukocytes , postmenopause , single nucleotide polymorphism , telomere

Diabetes October 2012, Vol.61, 2998-3004. doi:https://doi.org/10.2337/db12-0241

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

Joanna M.M. Howson; Jason D. Cooper; Deborah J. Smyth; Neil M. Walker; Helen Stevens; Jin-Xiong She; George S. Eisenbarth; Marian Rewers; John A. Todd; Beena Akolkar; Patrick Concannon; Henry A. Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Flemming Pociot; Stephen S. Rich; and the Type 1 Diabetes Genetics Consortium

Abstracts

Topics: diabetes mellitus, type 1 , human leukocyte antigens , single nucleotide polymorphism , genotype , gene interaction

Diabetes October 2012, Vol.61, 3012-3017. doi:https://doi.org/10.2337/db11-1694

Constitutive and Inflammatory Immunopeptidome of Pancreatic β-Cells

Nadine L. Dudek; Chor Teck Tan; Dhana G. Gorasia; Nathan P. Croft; Patricia T. Illing; Anthony W. Purcell

Abstract

Topics: peptides , epitopes

Diabetes October 2012, Vol.61, 3018-3025. doi:https://doi.org/10.2337/db11-1333

Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies

Qibin Qi; John P. Forman; Majken K. Jensen; Alan Flint; Gary C. Curhan; Eric B. Rimm; Frank B. Hu; Lu Qi

Abstract

Topics: diabetes mellitus, type 2 , genetic predisposition to disease , hypertension , heart disease risk factors , diet

Diabetes October 2012, Vol.61, 3026-3032. doi:https://doi.org/10.2337/db12-0225

Original Research

Genetics / Genomes / Proteomics / Metabolomics

FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss Diets: The POUNDS LOST Trial

Xiaomin Zhang; Qibin Qi; Cuilin Zhang; Steven R. Smith; Frank B. Hu; Frank M. Sacks; George A. Bray; Lu Qi

Abstract

Topics: body composition , body fat distribution , diet , fto gene , genotype

Diabetes October 2012, Vol.61, 3005-3011. doi:https://doi.org/10.2337/db11-1799

Issues and Events

Extract

Topics: obesity , ohio , prehypertension , spain , hypertension

Diabetes October 2012, Vol.61, 3033. doi:https://doi.org/10.2337/db12-ie11

Diabetes Digests

Highlights From the Latest in Diabetes Research

Extract