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Volume 61, Issue 2
1 February 2012
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ISSN 0012-1797
EISSN 1939-327X
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Commentary

Role of TRIB3 in Diabetic and Overnutrition-Induced Atherosclerosis
James R. Sowers
View articletitled, Role of TRIB3 in Diabetic and Overnutrition-Induced Atherosclerosis
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Diabetes January 2012, Vol.61, 265-266. doi:https://doi.org/10.2337/db11-1495
Damaging Loss of Self-Control by Stressed β-Cells
Mark J. Holness; Mary C. Sugden
View articletitled, Damaging Loss of Self-Control by Stressed β-Cells
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Diabetes January 2012, Vol.61, 267-269. doi:https://doi.org/10.2337/db11-1647
Prediabetes: Evaluation of β-Cell Function
Ananda Basu; Morten Gram Pedersen; Claudio Cobelli
View articletitled, Prediabetes: Evaluation of β-Cell Function
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Diabetes January 2012, Vol.61, 270-271. doi:https://doi.org/10.2337/db11-1677

Novel Methodologies

Mapping Autophagy on to Your Metabolic Radar
Eijiro Yamada; Rajat Singh
View articletitled, Mapping Autophagy on to Your Metabolic Radar
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Diabetes January 2012, Vol.61, 272-280. doi:https://doi.org/10.2337/db11-1199

Metabolism

The l-α-Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity
José María Moreno-Navarrete; Victoria Catalán; Lauren Whyte; Adenis Díaz-Arteaga; Rafael Vázquez-Martínez; Fernando Rotellar; Rocío Guzmán; Javier Gómez-Ambrosi; Marina R. Pulido; Wendy R. Russell; Mónica Imbernón; Ruth A. Ross; María M. Malagón; Carlos Dieguez; José Manuel Fernández-Real; Gema Frühbeck; Ruben Nogueiras
View articletitled, The <span class="small-caps">l</span>-α-Lysophosphatidylinositol/<em>GPR55</em> System and Its Potential Role in Human Obesity
Supplementary data
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Diabetes January 2012, Vol.61, 281-291. doi:https://doi.org/10.2337/db11-0649
Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Özlem Gögebakan; Janin Andres; Katrin Biedasek; Knut Mai; Peter Kühnen; Heiko Krude; Frank Isken; Natalia Rudovich; Martin A. Osterhoff; Ulrich Kintscher; Michael Nauck; Andreas F.H. Pfeiffer; Joachim Spranger
View articletitled, Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Supplementary data
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Diabetes January 2012, Vol.61, 292-300. doi:https://doi.org/10.2337/db10-0902
Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
Florencia Halperin; Ximena Lopez; Raquel Manning; C. Ronald Kahn; Rohit N. Kulkarni; Allison B. Goldfine
View articletitled, Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
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Diabetes January 2012, Vol.61, 301-309. doi:https://doi.org/10.2337/db11-1067
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
Camille Attané; Camille Foussal; Sophie Le Gonidec; Alexandre Benani; Danièle Daviaud; Estelle Wanecq; Rocío Guzmán-Ruiz; Cédric Dray; Veronic Bezaire; Chloé Rancoule; Keiji Kuba; Mariano Ruiz-Gayo; Thierry Levade; Josef Penninger; Rémy Burcelin; Luc Pénicaud; Philippe Valet; Isabelle Castan-Laurell
View articletitled, Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
Supplementary data
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Diabetes January 2012, Vol.61, 310-320. doi:https://doi.org/10.2337/db11-0100
Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
Mayowa A. Osundiji; Daniel D. Lam; Jill Shaw; Chen-Yu Yueh; S. Pauliina Markkula; Paul Hurst; Carolina Colliva; Aldo Roda; Lora K. Heisler; Mark L. Evans
View articletitled, Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
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Diabetes January 2012, Vol.61, 321-328. doi:https://doi.org/10.2337/db11-1050
Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans
Christina Koutsari; Manpreet S. Mundi; Asem H. Ali; Michael D. Jensen
View articletitled, Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans
Supplementary data
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Diabetes January 2012, Vol.61, 329-338. doi:https://doi.org/10.2337/db11-0748
Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity
Chun-Xia Yi; Ewout Foppen; William Abplanalp; Yuanqing Gao; Anneke Alkemade; Susanne E. la Fleur; Mireille J. Serlie; Eric Fliers; Ruud M. Buijs; Matthias H. Tschöp; Andries Kalsbeek
View articletitled, Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity
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Diabetes January 2012, Vol.61, 339-345. doi:https://doi.org/10.2337/db11-1239
Increased Macrophage Migration Into Adipose Tissue in Obese Mice
Da Young Oh; Hidetaka Morinaga; Saswata Talukdar; Eun Ju Bae; Jerrold M. Olefsky
View articletitled, Increased Macrophage Migration Into Adipose Tissue in Obese Mice
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Diabetes January 2012, Vol.61, 346-354. doi:https://doi.org/10.2337/db11-0860
CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
Caleb C. Lord; Jenna L. Betters; Pavlina T. Ivanova; Stephen B. Milne; David S. Myers; Jennifer Madenspacher; Gwynneth Thomas; Soonkyu Chung; Mingxia Liu; Matthew A. Davis; Richard G. Lee; Rosanne M. Crooke; Mark J. Graham; John S. Parks; Dawn L. Brasaemle; Michael B. Fessler; H. Alex Brown; J. Mark Brown
View articletitled, CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
Supplementary data
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Diabetes January 2012, Vol.61, 355-363. doi:https://doi.org/10.2337/db11-0994

Signal Transduction

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2
Gwen Tolhurst; Helen Heffron; Yu Shan Lam; Helen E. Parker; Abdella M. Habib; Eleftheria Diakogiannaki; Jennifer Cameron; Johannes Grosse; Frank Reimann; Fiona M. Gribble
View articletitled, Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2
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Diabetes January 2012, Vol.61, 364-371. doi:https://doi.org/10.2337/db11-1019

Obesity Studies

Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin
Rafael Simó; Anna Barbosa-Desongles; Albert Lecube; Cristina Hernandez; David M. Selva
View articletitled, Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin
Supplementary data
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Diabetes January 2012, Vol.61, 372-382. doi:https://doi.org/10.2337/db11-0727
Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
John W.M. Creemers; Hélène Choquet; Pieter Stijnen; Vincent Vatin; Marie Pigeyre; Sigri Beckers; Sandra Meulemans; Manuel E. Than; Loïc Yengo; Maithé Tauber; Beverley Balkau; Paul Elliott; Marjo-Riitta Jarvelin; Wim Van Hul; Luc Van Gaal; Fritz Horber; François Pattou; Philippe Froguel; David Meyre
View articletitled, Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
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Diabetes January 2012, Vol.61, 383-390. doi:https://doi.org/10.2337/db11-0305
Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass
Alexandra Groom; Catherine Potter; Daniel C. Swan; Ghazaleh Fatemifar; David M. Evans; Susan M. Ring; Valerie Turcot; Mark S. Pearce; Nicholas D. Embleton; George Davey Smith; John C. Mathers; Caroline L. Relton
View articletitled, Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the <em>TACSTD2</em> Gene and Childhood Fat Mass
Supplementary data
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Diabetes January 2012, Vol.61, 391-400. doi:https://doi.org/10.2337/db11-1039
Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype
Kim van der Weerd; Willem A. Dik; Benjamin Schrijver; Dave H. Schweitzer; Anton W. Langerak; Hemmo A. Drexhage; Rosalie M. Kiewiet; Maarten O. van Aken; Astrid van Huisstede; Jacques J.M. van Dongen; Aart-Jan van der Lelij; Frank J.T. Staal; P. Martin van Hagen
View articletitled, Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4<sup>+</sup> T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype
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Diabetes January 2012, Vol.61, 401-408. doi:https://doi.org/10.2337/db11-1065

Islet Studies

l-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway
Latif Rachdi; Virginie Aïello; Bertrand Duvillié; Raphaël Scharfmann
View articletitled, <span class="small-caps">l</span>-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway
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Diabetes January 2012, Vol.61, 409-417. doi:https://doi.org/10.2337/db11-0765
Regulated and Reversible Induction of Adult Human β-Cell Replication
Karen K. Takane; Jeffery W. Kleinberger; Fatimah G. Salim; Nathalie M. Fiaschi-Taesch; Andrew F. Stewart
View articletitled, Regulated and Reversible Induction of Adult Human β-Cell Replication
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Diabetes January 2012, Vol.61, 418-424. doi:https://doi.org/10.2337/db11-0580

Immunology and Transplantation

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Balasubramanian Krishnamurthy; Jonathan Chee; Gaurang Jhala; Stacey Fynch; Kate L. Graham; Pere Santamaria; Grant Morahan; Janette Allison; David Izon; Helen E. Thomas; Thomas W.H. Kay
View articletitled, Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
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Diabetes January 2012, Vol.61, 425-435. doi:https://doi.org/10.2337/db11-0948
Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes
Suparna A. Sarkar; Catherine E. Lee; Francisco Victorino; Tom T. Nguyen; Jay A. Walters; Adam Burrack; Jens Eberlein; Steven K. Hildemann; Dirk Homann
View articletitled, Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes
Supplementary data
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Diabetes January 2012, Vol.61, 436-446. doi:https://doi.org/10.2337/db11-0853

Pathophysiology

Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
Mustafa Kanat; Andrea Mari; Luke Norton; Diedre Winnier; Ralph A. DeFronzo; Chris Jenkinson; Muhammad A. Abdul-Ghani
View articletitled, Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
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Diabetes January 2012, Vol.61, 447-453. doi:https://doi.org/10.2337/db11-0995
TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice
Rossella Menghini; Viviana Casagrande; Stefano Menini; Arianna Marino; Valeria Marzano; Marta L. Hribal; Paolo Gentileschi; Davide Lauro; Orazio Schillaci; Giuseppe Pugliese; Paolo Sbraccia; Andrea Urbani; Renato Lauro; Massimo Federici
View articletitled, TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice
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Diabetes January 2012, Vol.61, 454-462. doi:https://doi.org/10.2337/db11-0613

Complications

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE−/−/LDL Receptor−/− Mice
Zhi-hao Wang; Yuan-yuan Shang; Shun Zhang; Ming Zhong; Xu-ping Wang; Jing-ti Deng; Jie Pan; Yun Zhang; Wei Zhang
View articletitled, Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE<sup>−/−</sup>/LDL Receptor<sup>−/−</sup> Mice
Supplementary data
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Diabetes January 2012, Vol.61, 463-473. doi:https://doi.org/10.2337/db11-0518
Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice
Garnet J. Lau; Nicolas Godin; Hasna Maachi; Chao-Sheng Lo; Shyh-Jong Wu; Jian-Xin Zhu; Marie-Luise Brezniceanu; Isabelle Chénier; Joelle Fragasso-Marquis; Jean-Baptiste Lattouf; Jean Ethier; Janos G. Filep; Julie R. Ingelfinger; Viji Nair; Matthias Kretzler; Clemens D. Cohen; Shao-Ling Zhang; John S.D. Chan
View articletitled, Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice
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Diabetes January 2012, Vol.61, 474-484. doi:https://doi.org/10.2337/db11-0141
Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression
Ansgar S. Olsen; Michael P. Sarras, Jr.; Alexey Leontovich; Robert V. Intine
View articletitled, Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression
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Diabetes January 2012, Vol.61, 485-491. doi:https://doi.org/10.2337/db11-0588
Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes
Yimin Zhong; Jingming Li; Yanming Chen; Joshua J. Wang; Rajiv Ratan; Sarah X. Zhang
View articletitled, Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes
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Diabetes January 2012, Vol.61, 492-504. doi:https://doi.org/10.2337/db11-0315

Pharmacology and Therapeutics

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
James Mu; Jason Pinkstaff; Zhihua Li; Lillian Skidmore; Nina Li; Heather Myler; Qing Dallas-Yang; Anna-Maria Putnam; Jun Yao; Stuart Bussell; Margaret Wu; Thea C. Norman; Carlos G. Rodriguez; Bruce Kimmel; Joseph M. Metzger; Anthony Manibusan; Darin Lee; Dennis M. Zaller; Bei B. Zhang; Richard D. DiMarchi; Joel P. Berger; Douglas W. Axelrod
View articletitled, FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
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Diabetes January 2012, Vol.61, 505-512. doi:https://doi.org/10.2337/db11-0838
Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis
Robin Winkler; Verena Benz; Markus Clemenz; Mandy Bloch; Anna Foryst-Ludwig; Sami Wardat; Nicole Witte; Manuela Trappiel; Pawel Namsolleck; Knut Mai; Joachim Spranger; Gabriele Matthias; Tim Roloff; Oliver Truee; Kai Kappert; Michael Schupp; Patrick Matthias; Ulrich Kintscher
View articletitled, Histone Deacetylase 6 (<em>HDAC6</em>) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis
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Diabetes January 2012, Vol.61, 513-523. doi:https://doi.org/10.2337/db11-0313

Genetics / Genomes / Proteomics / Metabolomics

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
Marcel Marquez; Marlène Huyvaert; John R.B. Perry; Richard D. Pearson; Mario Falchi; Andrew P. Morris; Sidonie Vivequin; Stéphane Lobbens; Loïc Yengo; Stefan Gaget; Francois Pattou; Odile Poulain-Godefroy; Guillaume Charpentier; Lena M.S. Carlsson; Peter Jacobson; Lars Sjöström; Olivier Lantieri; Barbara Heude; Andrew Walley; Beverley Balkau; Michel Marre; the DIAGRAM Consortium; Philippe Froguel; Stéphane Cauchi
View articletitled, Low-Frequency Variants in <em>HMGA1</em> Are Not Associated With Type 2 Diabetes Risk
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Diabetes January 2012, Vol.61, 524-530. doi:https://doi.org/10.2337/db11-0728
A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
Soo Heon Kwak; Sung-Hoon Kim; Young Min Cho; Min Jin Go; Yoon Shin Cho; Sung Hee Choi; Min Kyong Moon; Hye Seung Jung; Hyoung Doo Shin; Hyun Min Kang; Nam H. Cho; In Kyu Lee; Seong Yeon Kim; Bok-Ghee Han; Hak C. Jang; Kyong Soo Park
View articletitled, A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
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Diabetes January 2012, Vol.61, 531-541. doi:https://doi.org/10.2337/db11-1034
Global DNA Methylation Is Associated With Insulin Resistance: A Monozygotic Twin Study
Jinying Zhao; Jack Goldberg; James D. Bremner; Viola Vaccarino
View articletitled, Global DNA Methylation Is Associated With Insulin Resistance<span class="subtitle-colon">: </span><span class="subtitle">A Monozygotic Twin Study</span>
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Diabetes January 2012, Vol.61, 542-546. doi:https://doi.org/10.2337/db11-1048

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes January 2012, Vol.61, 547. doi:https://doi.org/10.2337/db12-ie02
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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