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Volume 61, Issue 4
April 2012
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes
John Wahren; Åsa Kallas; Anders A.F. Sima
View articletitled, The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes
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Diabetes March 2012, Vol.61, 761-772. doi:https://doi.org/10.2337/db11-1423

Commentary

Is Insulin Action in the Brain Clinically Relevant?
Beatrice M. Filippi; Patricia I. Mighiu; Tony K.T. Lam
View articletitled, Is Insulin Action in the Brain Clinically Relevant?
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Diabetes March 2012, Vol.61, 773-775. doi:https://doi.org/10.2337/db12-0048
Smokeless Weight Loss
Colleen M. Novak; Chaitanya K. Gavini
View articletitled, Smokeless Weight Loss
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Diabetes March 2012, Vol.61, 776-777. doi:https://doi.org/10.2337/db12-0074
Insulin Resistance and Type 2 Diabetes
Roy Taylor
View articletitled, Insulin Resistance and Type 2 Diabetes
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Diabetes March 2012, Vol.61, 778-779. doi:https://doi.org/10.2337/db12-0073
ER Stress as a Trigger for β-Cell Dysfunction and Autoimmunity in Type 1 Diabetes
Bryan O’Sullivan-Murphy; Fumihiko Urano
View articletitled, ER Stress as a Trigger for β-Cell Dysfunction and Autoimmunity in Type 1 Diabetes
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Diabetes March 2012, Vol.61, 780-781. doi:https://doi.org/10.2337/db12-0091

Metabolism

Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
Manfred Hallschmid; Suzanne Higgs; Matthias Thienel; Volker Ott; Hendrik Lehnert
View articletitled, Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
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Diabetes March 2012, Vol.61, 782-789. doi:https://doi.org/10.2337/db11-1390
Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization
Mark Nixon; Deborah J. Wake; Dawn E. Livingstone; Roland H. Stimson; Cristina L. Esteves; Jonathan R. Seckl; Karen E. Chapman; Ruth Andrew; Brian R. Walker
View articletitled, Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization
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Diabetes March 2012, Vol.61, 790-796. doi:https://doi.org/10.2337/db11-0931
Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Huating Li; Zhanguo Gao; Jin Zhang; Xin Ye; Aimin Xu; Jianping Ye; Weiping Jia
View articletitled, Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Supplementary data
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Diabetes March 2012, Vol.61, 797-806. doi:https://doi.org/10.2337/db11-0846

Obesity Studies

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
Pablo B. Martínez de Morentin; Andrew J. Whittle; Johan Fernø; Rubén Nogueiras; Carlos Diéguez; Antonio Vidal-Puig; Miguel López
View articletitled, Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
Supplementary data
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Diabetes March 2012, Vol.61, 807-817. doi:https://doi.org/10.2337/db11-1079

Islet Studies

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
Sarah A. Tersey; Yurika Nishiki; Andrew T. Templin; Susanne M. Cabrera; Natalie D. Stull; Stephanie C. Colvin; Carmella Evans-Molina; Jenna L. Rickus; Bernhard Maier; Raghavendra G. Mirmira
View articletitled, Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
Supplementary data
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Diabetes March 2012, Vol.61, 818-827. doi:https://doi.org/10.2337/db11-1293
Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes
Ming Liu; Roberto Lara-Lemus; Shu-ou Shan; Jordan Wright; Leena Haataja; Fabrizio Barbetti; Huan Guo; Dennis Larkin; Peter Arvan
View articletitled, Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes
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Diabetes March 2012, Vol.61, 828-837. doi:https://doi.org/10.2337/db11-0878
Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
Tatsuya Kondo; Kazunari Sasaki; Rina Matsuyama; Saori Morino-Koga; Hironori Adachi; Mary Ann Suico; Junji Kawashima; Hiroyuki Motoshima; Noboru Furukawa; Hirofumi Kai; Eiichi Araki
View articletitled, Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
Supplementary data
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Diabetes March 2012, Vol.61, 838-847. doi:https://doi.org/10.2337/db11-1098
Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers
Guanlan Xu; Junqin Chen; Gu Jing; Anath Shalev
View articletitled, Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers
Supplementary data
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Diabetes March 2012, Vol.61, 848-856. doi:https://doi.org/10.2337/db11-0955

Immunology and Transplantation

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
Maki Nakayama; Todd Castoe; Tomasz Sosinowski; XiangLing He; Kelly Johnson; Kathryn Haskins; Dario A.A. Vignali; Laurent Gapin; David Pollock; George S. Eisenbarth
View articletitled, Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
Supplementary data
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Diabetes March 2012, Vol.61, 857-865. doi:https://doi.org/10.2337/db11-1113
Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization
Shinae Kang; Ho Seon Park; Anna Jo; Shin Hee Hong; Han Na Lee; Yeon Yi Lee; Joong Shin Park; Hye Seung Jung; Sung Soo Chung; Kyong Soo Park
View articletitled, Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization
Supplementary data
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Diabetes March 2012, Vol.61, 866-876. doi:https://doi.org/10.2337/db10-1492

Pathophysiology

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
Katsutaro Morino; Kitt Falk Petersen; Saki Sono; Cheol Soo Choi; Varman T. Samuel; Aiping Lin; Amy Gallo; Hongyu Zhao; Atsunori Kashiwagi; Ira J. Goldberg; Hong Wang; Robert H. Eckel; Hiroshi Maegawa; Gerald I. Shulman
View articletitled, Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
Supplementary data
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Diabetes March 2012, Vol.61, 877-887. doi:https://doi.org/10.2337/db11-1391
Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism
Weidong Chai; Zhenhua Dong; Nasui Wang; Wenhui Wang; Lijian Tao; Wenhong Cao; Zhenqi Liu
View articletitled, Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism
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Diabetes March 2012, Vol.61, 888-896. doi:https://doi.org/10.2337/db11-1073

Complications

Cholecystokinin Plays a Novel Protective Role in Diabetic Kidney Through Anti-inflammatory Actions on Macrophage: Anti-inflammatory Effect of Cholecystokinin
Satoshi Miyamoto; Kenichi Shikata; Kyoko Miyasaka; Shinichi Okada; Motofumi Sasaki; Ryo Kodera; Daisho Hirota; Nobuo Kajitani; Tetsuharu Takatsuka; Hitomi Usui Kataoka; Shingo Nishishita; Chikage Sato; Akihiro Funakoshi; Hisakazu Nishimori; Haruhito Adam Uchida; Daisuke Ogawa; Hirofumi Makino
View articletitled, Cholecystokinin Plays a Novel Protective Role in Diabetic Kidney Through Anti-inflammatory Actions on Macrophage<span class="subtitle-colon">: </span><span class="subtitle">Anti-inflammatory Effect of Cholecystokinin</span>
Supplementary data
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Diabetes March 2012, Vol.61, 897-907. doi:https://doi.org/10.2337/db11-0402
Endothelial Progenitor Cells Carrying Monocyte Markers Are Selectively Abnormal in Type 1 Diabetic Patients With Early Retinopathy
Gianpaolo Zerbini; Anna Maestroni; Alessio Palini; Gemma Tremolada; Rosangela Lattanzio; Silvia Maestroni; Matteo Rocco Pastore; Antonio Secchi; Riccardo Bonfanti; Chiara Gerhardinger; Mara Lorenzi
View articletitled, Endothelial Progenitor Cells Carrying Monocyte Markers Are Selectively Abnormal in Type 1 Diabetic Patients With Early Retinopathy
Supplementary data
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Diabetes March 2012, Vol.61, 908-914. doi:https://doi.org/10.2337/db11-1197
Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
Adil Rajwani; Vivienne Ezzat; Jessica Smith; Nadira Y. Yuldasheva; Edward R. Duncan; Matthew Gage; Richard M. Cubbon; Matthew B. Kahn; Helen Imrie; Afroze Abbas; Hema Viswambharan; Amir Aziz; Piruthivi Sukumar; Antonio Vidal-Puig; Jaswinder K. Sethi; Shouhong Xuan; Ajay M. Shah; Peter J. Grant; Karen E. Porter; Mark T. Kearney; Stephen B. Wheatcroft
View articletitled, Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
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Diabetes March 2012, Vol.61, 915-924. doi:https://doi.org/10.2337/db11-0963
Candesartan Cilexetil Improves Angiotensin II Type 2 Receptor–Mediated Neurite Outgrowth via the PI3K-Akt Pathway in Fructose-Induced Insulin-Resistant Rats
Narumi Hashikawa-Hobara; Naoya Hashikawa; Yusuke Inoue; Hitomi Sanda; Yoshito Zamami; Shingo Takatori; Hiromu Kawasaki
View articletitled, Candesartan Cilexetil Improves Angiotensin II Type 2 Receptor–Mediated Neurite Outgrowth via the PI3K-Akt Pathway in Fructose-Induced Insulin-Resistant Rats
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Diabetes March 2012, Vol.61, 925-932. doi:https://doi.org/10.2337/db11-1468

Pharmacology and Therapeutics

Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression
Hai-Lu Zhao; Yi Sui; Chun-Feng Qiao; Kevin Y. Yip; Ross K.K. Leung; Stephen K.W. Tsui; Heung-Man Lee; Harriet K.T. Wong; Xun Zhu; Jennifer J. Siu; Lan He; Jing Guan; Li-Zhong Liu; Hong-Xi Xu; Peter C.Y. Tong; Juliana C.N. Chan
View articletitled, Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression
Supplementary data
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Diabetes March 2012, Vol.61, 933-943. doi:https://doi.org/10.2337/db11-1164
Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
Antonio Cittadini; Raffaele Napoli; Maria Gaia Monti; Domenica Rea; Salvatore Longobardi; Paolo Antonio Netti; Marion Walser; Mariateresa Samà; Gianluca Aimaretti; Jörgen Isgaard; Luigi Saccà
View articletitled, Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
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Diabetes March 2012, Vol.61, 944-953. doi:https://doi.org/10.2337/db11-1132

Genetics / Genomes / Proteomics / Metabolomics

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Regine Bergholdt; Caroline Brorsson; Albert Palleja; Lukas A. Berchtold; Tina Fløyel; Claus Heiner Bang-Berthelsen; Klaus Stensgaard Frederiksen; Lars Juhl Jensen; Joachim Størling; Flemming Pociot
View articletitled, Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Supplementary data
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Diabetes March 2012, Vol.61, 954-962. doi:https://doi.org/10.2337/db11-1263
Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity
Johanna Lempainen; Robert Hermann; Riitta Veijola; Olli Simell; Mikael Knip; Jorma Ilonen
View articletitled, Effect of the <em>PTPN22</em> and <em>INS</em> Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity
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Diabetes March 2012, Vol.61, 963-966. doi:https://doi.org/10.2337/db11-0386

Erratum

Erratum
View articletitled, Erratum
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Diabetes March 2012, Vol.61, 967. doi:https://doi.org/10.2337/db12-er04

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes March 2012, Vol.61, 968. doi:https://doi.org/10.2337/db12-ie04
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
  • Online ISSN 1939-327X
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