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May 2012
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
Perspectives in Diabetes
β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
Frans Schuit; Leentje Van Lommel; Mikaela Granvik; Lotte Goyvaerts; Geoffroy de Faudeur; Anica Schraenen; Katleen Lemaire
Diabetes April 2012, Vol.61, 969-975. doi:https://doi.org/10.2337/db11-1564
Commentary
PGC-1α: The Missing Ingredient for Mesenchymal Stem Cell–Mediated Angiogenesis
Diabetes April 2012, Vol.61, 979-980. doi:https://doi.org/10.2337/db12-0078
Challenges of Linking Early-Life Conditions and Disease Susceptibility
Diabetes April 2012, Vol.61, 981-982. doi:https://doi.org/10.2337/db12-0087
Do Acute Exercise and Diet Reveal the Molecular Basis for Metabolic Flexibility in Skeletal Muscle?
Diabetes April 2012, Vol.61, 983. doi:https://doi.org/10.2337/db12-0152
Selective Insulin Receptor Modulators (SIRM): A New Class of Antidiabetes Drugs?
Diabetes April 2012, Vol.61, 984-985. doi:https://doi.org/10.2337/db12-0192
GLP-1–Based Therapies and the Exocrine Pancreas: More Light, or Just More Heat?
Diabetes April 2012, Vol.61, 986-988. doi:https://doi.org/10.2337/db11-1838
A Sweet New Role for Ubiquitin-Specific Protease 2 in Controlling Hepatic Gluconeogenesis
Diabetes April 2012, Vol.61, 993-994. doi:https://doi.org/10.2337/db12-0198
Methodology Review
A Novel Method to Measure Glucose Uptake and Myosin Heavy Chain Isoform Expression of Single Fibers From Rat Skeletal Muscle
Diabetes April 2012, Vol.61, 995-1003. doi:https://doi.org/10.2337/db11-1299
Metabolism
Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes
Tumpa Dutta; High Seng Chai; Lawrence E. Ward; Aditya Ghosh; Xuan-Mai T. Persson; G. Charles Ford; Yogish C. Kudva; Zhifu Sun; Yan W. Asmann; Jean-Pierre A. Kocher; K. Sreekumaran Nair
Diabetes April 2012, Vol.61, 1004-1016. doi:https://doi.org/10.2337/db11-0874
The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes
Dumitru Constantin-Teodosiu; Despina Constantin; Francis Stephens; David Laithwaite; Paul L. Greenhaff
Diabetes April 2012, Vol.61, 1017-1024. doi:https://doi.org/10.2337/db11-0799
Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1
Diabetes April 2012, Vol.61, 1025-1035. doi:https://doi.org/10.2337/db11-0970
Calorie Restriction Reduces the Influence of Glucoregulatory Dysfunction on Regional Brain Volume in Aged Rhesus Monkeys
Auriel A. Willette; Barbara B. Bendlin; Ricki J. Colman; Erik K. Kastman; Aaron S. Field; Andrew L. Alexander; Aadhavi Sridharan; David B. Allison; Rozalyn Anderson; Mary-Lou Voytko; Joseph W. Kemnitz; Richard H. Weindruch; Sterling C. Johnson
Diabetes April 2012, Vol.61, 1036-1042. doi:https://doi.org/10.2337/db11-1187
Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System
Eveline Bruinstroop; Lei Pei; Mariëtte T. Ackermans; Ewout Foppen; Anke J. Borgers; Joan Kwakkel; Anneke Alkemade; Eric Fliers; Andries Kalsbeek
Diabetes April 2012, Vol.61, 1043-1050. doi:https://doi.org/10.2337/db11-1142
Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle
Diabetes April 2012, Vol.61, 1051-1061. doi:https://doi.org/10.2337/db11-1180
Liver X Receptor α Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene
Li-Feng Zhao; Yasumasa Iwasaki; Mitsuru Nishiyama; Takafumi Taguchi; Makoto Tsugita; Mizuho Okazaki; Shuichi Nakayama; Machiko Kambayashi; Shimpei Fujimoto; Koshi Hashimoto; Koji Murao; Yoshio Terada
Diabetes April 2012, Vol.61, 1062-1071. doi:https://doi.org/10.2337/db11-1255
Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis
Kerry J. McInnes; Lee B. Smith; Nicole I. Hunger; Philippa T.K. Saunders; Ruth Andrew; Brian R. Walker
Diabetes April 2012, Vol.61, 1072-1081. doi:https://doi.org/10.2337/db11-1136
Diabetes-Associated Common Genetic Variation and Its Association With GLP-1 Concentrations and Response to Exogenous GLP-1
Galina Smushkin; Matheni Sathananthan; Airani Sathananthan; Chiara Dalla Man; Francesco Micheletto; Alan R. Zinsmeister; Claudio Cobelli; Adrian Vella
Diabetes April 2012, Vol.61, 1082-1089. doi:https://doi.org/10.2337/db11-1732
Signal Transduction
GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance
Rasmus S. Biensø; Stine Ringholm; Kristian Kiilerich; Niels-Jacob Aachmann-Andersen; Rikke Krogh-Madsen; Borja Guerra; Peter Plomgaard; Gerrit van Hall; Jonas T. Treebak; Bengt Saltin; Carsten Lundby; Jose A.L. Calbet; Henriette Pilegaard; Jørgen F.P. Wojtaszewski
Diabetes April 2012, Vol.61, 1090-1099. doi:https://doi.org/10.2337/db11-0884
HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
Jannick Pétremand; Julien Puyal; Jean-Yves Chatton; Jessica Duprez; Florent Allagnat; Miguel Frias; Richard W. James; Gérard Waeber; Jean-Christophe Jonas; Christian Widmann
Diabetes April 2012, Vol.61, 1100-1111. doi:https://doi.org/10.2337/db11-1221
Obesity Studies
Retinoic Acid Upregulates Preadipocyte Genes to Block Adipogenesis and Suppress Diet-Induced Obesity
Diabetes April 2012, Vol.61, 1112-1121. doi:https://doi.org/10.2337/db11-1620
The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity
Sherley Visinoni; Nurul Fathiah Izzati Khalid; Christos N. Joannides; Arthur Shulkes; Mildred Yim; Jon Whitehead; Tony Tiganis; Benjamin J. Lamont; Jenny M. Favaloro; Joseph Proietto; Sofianos Andrikopoulos; Barbara C. Fam
Diabetes April 2012, Vol.61, 1122-1132. doi:https://doi.org/10.2337/db11-1511
Islet Studies
Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
Guo-Lian Ding; Fang-Fang Wang; Jing Shu; Shen Tian; Ying Jiang; Dan Zhang; Ning Wang; Qiong Luo; Yu Zhang; Fan Jin; Peter C.K. Leung; Jian-Zhong Sheng; He-Feng Huang
Diabetes April 2012, Vol.61, 1133-1142. doi:https://doi.org/10.2337/db11-1314
Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
Cem Demirci; Sara Ernst; Juan C. Alvarez-Perez; Taylor Rosa; Shelley Valle; Varsha Shridhar; Gabriella P. Casinelli; Laura C. Alonso; Rupangi C. Vasavada; Adolfo García-Ocana
Diabetes April 2012, Vol.61, 1143-1152. doi:https://doi.org/10.2337/db11-1154
Immunology and Transplantation
Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Enhances Engraftment and Angiogenesis of Mesenchymal Stem Cells in Diabetic Hindlimb Ischemia
Debin Lu; Ling Zhang; Haihui Wang; Yan Zhang; Jian Liu; Jing Xu; Ziwen Liang; Wuquan Deng; Youzhao Jiang; Qinan Wu; Shufa Li; Zhihua Ai; Yuxu Zhong; Ying Ying; Hongyan Liu; Feng Gao; Zhonghui Zhang; Bing Chen
Diabetes April 2012, Vol.61, 1153-1159. doi:https://doi.org/10.2337/db11-1271
Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor Antibody: Vβ13 as a Therapeutic Target and Biomarker
Zhijun Liu; Laura Cort; Ryan Eberwine; Thomas Herrmann; Jean H. Leif; Dale L. Greiner; Barak Yahalom; Elizabeth P. Blankenhorn; John P. Mordes
Diabetes April 2012, Vol.61, 1160-1168. doi:https://doi.org/10.2337/db11-0867
Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
Georgia Fousteri; Jean Jasinski; Amy Dave; Maki Nakayama; Philippe Pagni; Florence Lambolez; Therese Juntti; Ghanashyam Sarikonda; Yang Cheng; Michael Croft; Hilde Cheroutre; George Eisenbarth; Matthias von Herrath
Diabetes April 2012, Vol.61, 1169-1179. doi:https://doi.org/10.2337/db11-0671
Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice
Shounan Yi; Ming Ji; Jingjing Wu; Xiaoqian Ma; Peta Phillips; Wayne J. Hawthorne; Philip J. O’Connell
Diabetes April 2012, Vol.61, 1180-1191. doi:https://doi.org/10.2337/db11-1306
Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes: A Twin and Population Study
Huriya Beyan; Harriette Riese; Mohammed I. Hawa; Guisi Beretta; Howard W. Davidson; John C. Hutton; Huibert Burger; Michael Schlosser; Harold Snieder; Bernhard O. Boehm; R. David Leslie
Diabetes April 2012, Vol.61, 1192-1198. doi:https://doi.org/10.2337/db11-0971
The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation
Yasuharu Watanabe; Tomoya Nakamura; Sho Ishikawa; Shiho Fujisaka; Isao Usui; Koichi Tsuneyama; Yoshinori Ichihara; Tsutomu Wada; Yoichiro Hirata; Takayoshi Suganami; Hirofumi Izaki; Shizuo Akira; Kensuke Miyake; Hiro-omi Kanayama; Michio Shimabukuro; Masataka Sata; Toshiyasu Sasaoka; Yoshihiro Ogawa; Kazuyuki Tobe; Kiyoshi Takatsu; Yoshinori Nagai
Diabetes April 2012, Vol.61, 1199-1209. doi:https://doi.org/10.2337/db11-1182
Pathophysiology
Short-Term Hyperinsulinemia and Hyperglycemia Increase Myocardial Lipid Content in Normal Subjects
Yvonne Winhofer; Martin Krššák; Draženka Janković; Christian-Heinz Anderwald; Gert Reiter; Astrid Hofer; Siegfried Trattnig; Anton Luger; Michael Krebs
Diabetes April 2012, Vol.61, 1210-1216. doi:https://doi.org/10.2337/db11-1275
The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans
Diabetes April 2012, Vol.61, 1217-1224. doi:https://doi.org/10.2337/db11-1419
Complications
Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid
Diabetes April 2012, Vol.61, 1225-1233. doi:https://doi.org/10.2337/db11-1189
Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
Cristina Carvalho; Susana Cardoso; Sónia C. Correia; Renato X. Santos; Maria S. Santos; Inês Baldeiras; Catarina R. Oliveira; Paula I. Moreira
Diabetes April 2012, Vol.61, 1234-1242. doi:https://doi.org/10.2337/db11-1186
Pharmacology and Therapeutics
The Human GLP-1 Analog Liraglutide and the Pancreas: Evidence for the Absence of Structural Pancreatic Changes in Three Species
Diabetes April 2012, Vol.61, 1243-1249. doi:https://doi.org/10.2337/db11-0936
A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control
Vinay Bhaskar; Ira D. Goldfine; Daniel H. Bedinger; Angela Lau; Hua F. Kuan; Lisa M. Gross; Masahisa Handa; Betty A. Maddux; Susan R. Watson; Shirley Zhu; Ajay J. Narasimha; Raphael Levy; Lynn Webster; Sujeewa D. Wijesuriya; Naichi Liu; Xiaorong Wu; David Chemla-Vogel; Catarina Tran; Steve R. Lee; Steve Wong; Diane Wilcock; Mark L. White; John A. Corbin
Diabetes April 2012, Vol.61, 1263-1271. doi:https://doi.org/10.2337/db11-1578
Genetics / Genomes / Proteomics / Metabolomics
Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes
Katharine M. Irvine; Patricia Gallego; Xiaoyu An; Shannon E. Best; Gethin Thomas; Christine Wells; Mark Harris; Andrew Cotterill; Ranjeny Thomas
Diabetes April 2012, Vol.61, 1281-1290. doi:https://doi.org/10.2337/db11-1549
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Robert A. Scott; Audrey Y. Chu; Niels Grarup; Alisa K. Manning; Marie-France Hivert; Dmitry Shungin; Anke Tönjes; Ajay Yesupriya; Daniel Barnes; Nabila Bouatia-Naji; Nicole L. Glazer; Anne U. Jackson; Zoltán Kutalik; Vasiliki Lagou; Diana Marek; Laura J. Rasmussen-Torvik; Heather M. Stringham; Toshiko Tanaka; Mette Aadahl; Dan E. Arking; Sven Bergmann; Eric Boerwinkle; Lori L. Bonnycastle; Stefan R. Bornstein; Eric Brunner; Suzannah J. Bumpstead; Soren Brage; Olga D. Carlson; Han Chen; Yii-Der Ida Chen; Peter S. Chines; Francis S. Collins; David J. Couper; Elaine M. Dennison; Nicole F. Dowling; Josephine S. Egan; Ulf Ekelund; Michael R. Erdos; Nita G. Forouhi; Caroline S. Fox; Mark O. Goodarzi; Jürgen Grässler; Stefan Gustafsson; Göran Hallmans; Torben Hansen; Aroon Hingorani; John W. Holloway; Frank B. Hu; Bo Isomaa; Karen A. Jameson; Ingegerd Johansson; Anna Jonsson; Torben Jørgensen; Mika Kivimaki; Peter Kovacs; Meena Kumari; Johanna Kuusisto; Markku Laakso; Cécile Lecoeur; Claire Lévy-Marchal; Guo Li; Ruth J.F. Loos; Valeri Lyssenko; Michael Marmot; Pedro Marques-Vidal; Mario A. Morken; Gabriele Müller; Kari E. North; James S. Pankow; Felicity Payne; Inga Prokopenko; Bruce M. Psaty; Frida Renström; Ken Rice; Jerome I. Rotter; Denis Rybin; Camilla H. Sandholt; Avan A. Sayer; Peter Shrader; Peter E.H. Schwarz; David S. Siscovick; Alena Stančáková; Michael Stumvoll; Tanya M. Teslovich; Gérard Waeber; Gordon H. Williams; Daniel R. Witte; Andrew R. Wood; Weijia Xie; Michael Boehnke; Cyrus Cooper; Luigi Ferrucci; Philippe Froguel; Leif Groop; W.H. Linda Kao; Peter Vollenweider; Mark Walker; Richard M. Watanabe; Oluf Pedersen; James B. Meigs; Erik Ingelsson; Inês Barroso; Jose C. Florez; Paul W. Franks; Josée Dupuis; Nicholas J. Wareham; Claudia Langenberg
Diabetes April 2012, Vol.61, 1291-1296. doi:https://doi.org/10.2337/db11-0973
Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
Liling L. Warren; Li Li; Matthew R. Nelson; Margaret G. Ehm; Judong Shen; Dana J. Fraser; Jennifer L. Aponte; Keith L. Nangle; Andrew J. Slater; Peter M. Woollard; Matt D. Hall; Simon D. Topp; Xin Yuan; Lon R. Cardon; Stephanie L. Chissoe; Vincent Mooser; Andrew D. Morris; Colin N.A. Palmer; John R. Perry; Timothy M. Frayling; John C. Whittaker; Dawn M. Waterworth
Diabetes April 2012, Vol.61, 1297-1301. doi:https://doi.org/10.2337/db11-0985
Erratum
Erratum: Gutierrez DA, Kennedy A, Orr JS, Anderson EK, Webb CD, Gerrald WK, Hasty AH. Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity. Diabetes 2011;60:2820–2829
Diabetes April 2012, Vol.61, 1302-1304. doi:https://doi.org/10.2337/db12-er05
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes April 2012, Vol.61, 1306-1307. doi:https://doi.org/10.2337/db12-dd05
Online Letters to the Editor
Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530
Antonio Brunetti; Eusebio Chiefari; Clive R. Pullinger; Sinan Tanyolac; Daniela Foti; Vincent Durlach; Ira D. Goldfine
Diabetes April 2012, Vol.61, e3. doi:https://doi.org/10.2337/db12-0051
