Issues

Topics: cognition , cognitive impairment , functional magnetic resonance imaging , brain , chronic hyperglycemia

Diabetes June 2012, Vol.61, 1653-1655. doi:https://doi.org/10.2337/db12-0402

The In Vivo β-to-β-Cell Chat Room: Connexin Connections Matter

Paolo Meda

Abstracts

Topics: gap junction protein , insulin , mice , insulin secretion , glucose

Diabetes June 2012, Vol.61, 1656-1658. doi:https://doi.org/10.2337/db12-0336

Inherited β-Cell Dysfunction in Lean Individuals With Type 2 Diabetes

Anne E.W. Mathews; Clayton E. Mathews

Abstracts

Topics: diabetes mellitus, type 2

Diabetes June 2012, Vol.61, 1659-1660. doi:https://doi.org/10.2337/db12-0373

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes

Decio L. Eizirik; Fabio A. Grieco

Abstracts

Topics: apoptosis , conditioning (psychology) , diabetes mellitus, type 1 , pancreas

Diabetes June 2012, Vol.61, 1661-1663. doi:https://doi.org/10.2337/db12-0397

Is HOT a Cool Treatment for Type 1 Diabetes?

Govindarajan Rajagopalan; Yogish C. Kudva; Chella S. David

Abstracts

Topics: diabetes mellitus, type 1 , mice

Diabetes June 2012, Vol.61, 1664-1666. doi:https://doi.org/10.2337/db12-0527

A New Role for Pancreatic Insulin in the Male Reproductive Axis

Mary R. Loeken

Abstracts

Topics: insulin , pancreas , reproductive physiological process

Diabetes June 2012, Vol.61, 1667-1668. doi:https://doi.org/10.2337/db12-0539

Signal Transduction

Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior

Tina Sartorius; Caroline Ketterer; Stephanie Kullmann; Michelle Balzer; Carola Rotermund; Sonja Binder; Manfred Hallschmid; Jürgen Machann; Fritz Schick; Veronika Somoza; Hubert Preissl; Andreas Fritsche; Hans-Ulrich Häring; Anita M. Hennige

Abstract

Topics: diet , insulin , mice , monounsaturated fatty acids , brain

Diabetes June 2012, Vol.61, 1669-1679. doi:https://doi.org/10.2337/db11-1521

Obesity Studies

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Hironori Kitade; Kazuki Sawamoto; Mayumi Nagashimada; Hiroshi Inoue; Yasuhiko Yamamoto; Yoshimichi Sai; Toshinari Takamura; Hiroshi Yamamoto; Ken-ichi Miyamoto; Henry N. Ginsberg; Naofumi Mukaida; Shuichi Kaneko; Tsuguhito Ota

Abstract

Topics: chemokine (c-c motif) receptor 5 , diet , heart failure , macrophages , mice

Diabetes June 2012, Vol.61, 1680-1690. doi:https://doi.org/10.2337/db11-1506

Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots

Yazmín Macotela; Brice Emanuelli; Marcelo A. Mori; Stephane Gesta; Tim J. Schulz; Yu-Hua Tseng; C. Ronald Kahn

Abstracts

Topics: adipocytes , atrial premature complexes , vaccine information sheets , mice

Diabetes June 2012, Vol.61, 1691-1699. doi:https://doi.org/10.2337/db11-1753

Islet Studies

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

W. Steven Head; Meredith L. Orseth; Craig S. Nunemaker; Leslie S. Satin; David W. Piston; Richard K.P. Benninger

Abstracts

Topics: gap junction protein , glucose , insulin , insulin secretion , mice

Diabetes June 2012, Vol.61, 1700-1707. doi:https://doi.org/10.2337/db11-1312

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Erica P. Cai; Marina Casimir; Stephanie A. Schroer; Cynthia T. Luk; Sally Yu Shi; Diana Choi; Xiao Qing Dai; Catherine Hajmrle; Aliya F. Spigelman; Dan Zhu; Herbert Y. Gaisano; Patrick E. MacDonald; Minna Woo

Abstracts

Topics: actins , glucose , granules , insulin , mice

Diabetes June 2012, Vol.61, 1708-1718. doi:https://doi.org/10.2337/db11-1344

Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-Cells Leads to Relative Hyperinsulinism During Exercise

Timothy J. Pullen; Lykke Sylow; Gao Sun; Andrew P. Halestrap; Erik A. Richter; Guy A. Rutter

Abstract

Topics: doxycycline , glucose , insulin , insulin secretion , mice

Diabetes June 2012, Vol.61, 1719-1725. doi:https://doi.org/10.2337/db11-1531

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes

Abstract

Topics: diabetes mellitus, type 2 , donors , exocytosis , granules , insulin

Diabetes June 2012, Vol.61, 1726-1733. doi:https://doi.org/10.2337/db11-1516

Inhibition of Glucose-Stimulated Insulin Secretion by KCNJ15, a Newly Identified Susceptibility Gene for Type 2 Diabetes

Koji Okamoto; Naoko Iwasaki; Kent Doi; Eisei Noiri; Yasuhiko Iwamoto; Yasuko Uchigata; Toshiro Fujita; Katsushi Tokunaga

Abstracts

Topics: central serous chorioretinopathy , cheyne-stokes respiration , diabetes mellitus, type 2 , glucose , insulin

Diabetes June 2012, Vol.61, 1734-1741. doi:https://doi.org/10.2337/db11-1201

Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice

Elodie Roggli; Sonia Gattesco; Dorothée Caille; Claire Briet; Christian Boitard; Paolo Meda; Romano Regazzi

Abstracts

Topics: endocrine pancreas , insulin , mice , mice, inbred nod , micrornas

Diabetes June 2012, Vol.61, 1742-1751. doi:https://doi.org/10.2337/db11-1086

Immunology and Transplantation

Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Deborah Kronenberg; Robin R. Knight; Megan Estorninho; Richard J. Ellis; Michel G. Kester; Arnoud de Ru; Martin Eichmann; Guo C. Huang; Jake Powrie; Colin M. Dayan; Ania Skowera; Peter A. van Veelen; Mark Peakman

Abstracts

Topics: clone cells , diabetes mellitus, type 1 , hla-a2 antigen , human leukocyte antigens , peptides

Diabetes June 2012, Vol.61, 1752-1759. doi:https://doi.org/10.2337/db11-1520

Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind

Meghan M. Delmastro; Alexis J. Styche; Massimo M. Trucco; Creg J. Workman; Dario A.A. Vignali; Jon D. Piganelli

Abstract

Topics: diabetes mellitus, type 1 , mice , oxidation-reduction , t-lymphocytes , transarterial chemoembolization

Diabetes June 2012, Vol.61, 1760-1768. doi:https://doi.org/10.2337/db11-1591

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy

Gaetano Faleo; Carmen Fotino; Nicola Bocca; R. Damaris Molano; Elsie Zahr-Akrawi; Judith Molina; Susana Villate; Oliver Umland; Jay S. Skyler; Allison L. Bayer; Camillo Ricordi; Antonello Pileggi

Abstracts

Topics: autoimmunity , mice , mice, inbred nod , prediabetes , insulin

Diabetes June 2012, Vol.61, 1769-1778. doi:https://doi.org/10.2337/db11-0516

ZnT8 Is a Major CD8⁺ T Cell–Recognized Autoantigen in Pediatric Type 1 Diabetes

Émmanuelle Énée; Roland Kratzer; Jean-Baptiste Arnoux; Emilie Barilleau; Yamina Hamel; Christophe Marchi; Jacques Beltrand; Bénédicte Michaud; Lucienne Chatenoud; Jean-Jacques Robert; Peter van Endert

Abstracts

Topics: autoantigens , diabetes mellitus, type 1 , enzyme linked immunospot assay , hla-a2 antigen , lymphocytes

Diabetes June 2012, Vol.61, 1779-1784. doi:https://doi.org/10.2337/db12-0071

Pathophysiology

Serum Apolipoproteins Are Associated With Systemic and Retinal Microvascular Function in People With Diabetes

Muhammad Bayu Sasongko; Tien Y. Wong; Thanh T. Nguyen; Ryo Kawasaki; Alicia J. Jenkins; Jonathan Shaw; Carol Robinson; Jie Jin Wang

Abstract

Topics: acetylcholine , achondroplasia , apolipoproteins , apolipoproteins b , diabetic retinopathy

Diabetes June 2012, Vol.61, 1785-1792. doi:https://doi.org/10.2337/db11-1272

Xenin-25 Amplifies GIP-Mediated Insulin Secretion in Humans With Normal and Impaired Glucose Tolerance but Not Type 2 Diabetes

Burton M. Wice; Dominic N. Reeds; Hung D. Tran; Dan L. Crimmins; Bruce W. Patterson; Judit Dunai; Michael J. Wallendorf; Jack H. Ladenson; Dennis T. Villareal; Kenneth S. Polonsky

Abstracts

Topics: diabetes mellitus, type 2 , glucose , insulin , peptides , insulin secretion

Diabetes June 2012, Vol.61, 1793-1800. doi:https://doi.org/10.2337/db11-1451

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

Ivet Elias; Sylvie Franckhauser; Tura Ferré; Laia Vilà; Sabrina Tafuro; Sergio Muñoz; Carles Roca; David Ramos; Anna Pujol; Efren Riu; Jesús Ruberte; Fatima Bosch

Abstracts

Topics: adipose tissue , diet , insulin resistance , macrophages , mice

Diabetes June 2012, Vol.61, 1801-1813. doi:https://doi.org/10.2337/db11-0832

Complications

Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables

Eelco van Duinkerken; Menno M. Schoonheim; Ernesto J. Sanz-Arigita; Richard G. IJzerman; Annette C. Moll; Frank J. Snoek; Christopher M. Ryan; Martin Klein; Michaela Diamant; Frederik Barkhof

Abstracts

Topics: brain , cognitive ability , depressive disorders , functional magnetic resonance imaging , mental processes

Diabetes June 2012, Vol.61, 1814-1821. doi:https://doi.org/10.2337/db11-1358

Cardiovascular Autonomic Neuropathy and Subclinical Cardiovascular Disease in Normoalbuminuric Type 1 Diabetic Patients

Ulrik Madvig Mogensen; Tonny Jensen; Lars Køber; Henning Kelbæk; Anne Sophie Mathiesen; Ulrik Dixen; Peter Rossing; Jannik Hilsted; Klaus Fuglsang Kofoed

Abstract

Topics: blood pressure , cardiovascular diseases , coronary calcium score , coronary stenosis , diabetic autonomic neuropathy

Diabetes June 2012, Vol.61, 1822-1830. doi:https://doi.org/10.2337/db11-1235

Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism

Nicole Glaser; Catherine Ngo; Steven Anderson; Natalie Yuen; Alexandra Trifu; Martha O’Donnell

Abstract

Topics: brain , hyperglycemia , ketosis , rats , metabolism

Diabetes June 2012, Vol.61, 1831-1837. doi:https://doi.org/10.2337/db11-1286

Uncoupling Endothelial Nitric Oxide Synthase Is Ameliorated by Green Tea in Experimental Diabetes by Re-establishing Tetrahydrobiopterin Levels

Aline M. Faria; Alexandros Papadimitriou; Kamila C. Silva; Jacqueline M. Lopes de Faria; José B. Lopes de Faria

Abstract

Topics: kidney , nitric oxide synthase , rats , sapropterin , diabetes mellitus, experimental

Diabetes June 2012, Vol.61, 1838-1847. doi:https://doi.org/10.2337/db11-1241

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

Abstracts

Topics: ceramides , nitric oxide synthase , palmitates , obesity , proto-oncogene proteins c-akt

Diabetes June 2012, Vol.61, 1848-1859. doi:https://doi.org/10.2337/db11-1399

Reactive Oxygen Species Signaling Facilitates FOXO-3a/FBXO-Dependent Vascular BK Channel β₁ Subunit Degradation in Diabetic Mice

Tong Lu; Qiang Chai; Ling Yu; Livius V. d’Uscio; Zvonimir S. Katusic; Tongrong He; Hon-Chi Lee

Abstract

Topics: mice , proto-oncogene proteins c-akt , signal transduction , gw 501516 , coronary artery

Diabetes June 2012, Vol.61, 1860-1868. doi:https://doi.org/10.2337/db11-1658

Insulin Rescues Impaired Spermatogenesis via the Hypothalamic-Pituitary-Gonadal Axis in Akita Diabetic Mice and Restores Male Fertility

Erica L. Schoeller; Gabriella Albanna; Antonina I. Frolova; Kelle H. Moley

Abstracts

Topics: insulin , mice , testis

Diabetes June 2012, Vol.61, 1869-1878. doi:https://doi.org/10.2337/db11-1527

Pharmacology and Therapeutics

PTGS-2–PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

Antje Vennemann; Anemone Gerstner; Niklas Kern; Nerea Ferreiros Bouzas; Shuh Narumiya; Takayuki Maruyama; Rolf M. Nüsing

Abstract

Topics: rna interference , streptozocin , mice , toxic effect

Diabetes June 2012, Vol.61, 1879-1887. doi:https://doi.org/10.2337/db11-1396

Genetics / Genomes / Proteomics / Metabolomics

A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians

Jingyun Yang; Yun Zhu; Shelley A. Cole; Karin Haack; Ying Zhang; Laura A. Beebe; Barbara V. Howard; Lyle G. Best; Richard B. Devereux; Jeffrey A. Henderson; Patricia Henderson; Elisa T. Lee; Jinying Zhao

Abstract

Topics: diabetes mellitus, type 2 , genes , genetics , insulin resistance , single nucleotide polymorphism

Diabetes June 2012, Vol.61, 1888-1894. doi:https://doi.org/10.2337/db11-1393

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

Alena Stančáková; Mete Civelek; Niyas K. Saleem; Pasi Soininen; Antti J. Kangas; Henna Cederberg; Jussi Paananen; Jussi Pihlajamäki; Lori L. Bonnycastle; Mario A. Morken; Michael Boehnke; Päivi Pajukanta; Aldons J. Lusis; Francis S. Collins; Johanna Kuusisto; Mika Ala-Korpela; Markku Laakso

Abstract

Topics: amino acids , diabetes mellitus, type 2 , hyperglycemia

Diabetes June 2012, Vol.61, 1895-1902. doi:https://doi.org/10.2337/db11-1378

Issues and Events

Extract

Topics: hawaii , hyperphagia , louisiana , obesity , ohio

Diabetes June 2012, Vol.61, 1903. doi:https://doi.org/10.2337/db12-ie07

Diabetes Digests

Highlights From the Latest in Diabetes Research

Extract

Topics: biochemical pathways , dapagliflozin , diabetic nephropathy , glucose , insulin

Diabetes June 2012, Vol.61, 1904-1905. doi:https://doi.org/10.2337/db12-dd07

Online Letters to the Editor

Comment on: Winkler et al. Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis. Diabetes 2012;61:513–523

Ranjeet Singh Mahla

Extract

Topics: glucocorticoids , gluconeogenesis , histone deacetylase 6

Diabetes June 2012, Vol.61, e10. doi:https://doi.org/10.2337/db12-0323

Response to Comment on: Winkler et al. Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis. Diabetes 2012;61:513–523

Ulrich Kintscher

Extract

Topics: glucocorticoids , gluconeogenesis , histone deacetylase 6

Diabetes June 2012, Vol.61, e11. doi:https://doi.org/10.2337/db12-0474

Comment on: Kim et al. Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders. Diabetes 2011;60:3159–3168

Sandra E. Gomez-Mejiba; Dario C. Ramirez

Extract

Topics: inflammation , metabolic diseases , obesity

Diabetes June 2012, Vol.61, e6. doi:https://doi.org/10.2337/db12-0128

Response to Comment on: Kim et al. Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders. Diabetes 2011;60:3159–3168

Rina Yu

Extract

Topics: inflammation , metabolic diseases , obesity

Diabetes June 2012, Vol.61, e7. doi:https://doi.org/10.2337/db12-0356

Comment on: Sørensen et al. Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring. Diabetes 2012;61:175–178

Sari Niinistö; Liisa Uusitalo; Maija E. Miettinen; Suvi M. Virtanen

Extract

Topics: diabetes mellitus, type 1 , pregnancy , vitamins

Diabetes June 2012, Vol.61, e8. doi:https://doi.org/10.2337/db12-0220

Response to Comment on: Sørensen et al. Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring. Diabetes 2012;61:175–178

Ingvild M. Sørensen; Geir Joner; Peter A. Torjesen; Lars C. Stene

Extract