Issues

Topics: antigens , diabetes mellitus, type 1 , peptides , autoantigens

Diabetes July 2012, Vol.61, 1907-1914. doi:https://doi.org/10.2337/db11-1675

Commentary

Modulating Mitochondrial Fission to Lower Diabetic Oxidative Stress

Rocco Barazzoni

Abstracts

Topics: mitochondria , oxidative stress , protons

Diabetes July 2012, Vol.61, 1915-1917. doi:https://doi.org/10.2337/db12-0463

Sweet and Low: Measuring Brain Glucose During Hypoglycemia

Elizabeth R. Seaquist; Gülin Öz

Abstracts

Topics: brain , glucose , hypoglycemia

Diabetes July 2012, Vol.61, 1918-1919. doi:https://doi.org/10.2337/db12-0571

More News About NUCB2/Nesfatin-1: A New Factor in the Hypothalamic Control of Glucose Homeostasis?

Andrew A. Butler

Abstracts

Topics: glucose homeostasis , hypothalamus , insulin , glucose , obesity

Diabetes July 2012, Vol.61, 1920-1922. doi:https://doi.org/10.2337/db12-0576

The Challenging Search for Diabetic Nephropathy Genes

Donald W. Bowden; Barry I. Freedman

Abstracts

Topics: diabetic nephropathy , genes

Diabetes July 2012, Vol.61, 1923-1924. doi:https://doi.org/10.2337/db12-0596

Identifying Biomarkers of Subclinical Diabetes

Rohit N. Kulkarni

Abstracts

Topics: biological markers , diabetes mellitus, type 2

Diabetes July 2012, Vol.61, 1925-1926. doi:https://doi.org/10.2337/db12-0599

Methodology Reviews

What Do Magnetic Resonance–Based Measurements of Pi→ATP Flux Tell Us About Skeletal Muscle Metabolism?

Graham J. Kemp; Kevin M. Brindle

Abstract

Topics: insulin , mitochondria , insulin resistance , skeletal muscles , polymerase chain reaction

Diabetes July 2012, Vol.61, 1927-1934. doi:https://doi.org/10.2337/db11-1725

Metabolism

Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance

Yoshinaga Kawano; Jun Nakae; Nobuyuki Watanabe; Shiho Fujisaka; Kristy Iskandar; Risa Sekioka; Yoshitake Hayashi; Kazuyuki Tobe; Masato Kasuga; Tetsuo Noda; Akihiko Yoshimura; Masafumi Onodera; Hiroshi Itoh

Abstract

Topics: forkhead box protein o1 , insulin resistance , macrophages , mice , adipose tissue

Diabetes July 2012, Vol.61, 1935-1948. doi:https://doi.org/10.2337/db11-0770

Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance

Elaine Xu; Alexandre Charbonneau; Yannève Rolland; Kerstin Bellmann; Lily Pao; Katherine A. Siminovitch; Benjamin G. Neel; Nicole Beauchemin; André Marette

Abstracts

Topics: hematopoietic cell phosphatase , hepatocytes , insulin , insulin resistance , liver

Diabetes July 2012, Vol.61, 1949-1958. doi:https://doi.org/10.2337/db11-1502

Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance

Mengliu Yang; Zhihong Zhang; Chong Wang; Ke Li; Shengbing Li; Guenther Boden; Ling Li; Gangyi Yang

Abstracts

Topics: diet , glucose , insulin , insulin sensitivity , phosphoenolpyruvate carboxylase

Diabetes July 2012, Vol.61, 1959-1968. doi:https://doi.org/10.2337/db11-1755

Body Composition and Circulating High-Molecular-Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age : Breast- Versus Formula-Feeding

Francis de Zegher; Giorgia Sebastiani; Marta Diaz; David Sánchez-Infantes; Abel Lopez-Bermejo; Lourdes Ibáñez

Abstract

Topics: adiponectin , body composition , infant , infant, small for gestational age , insulin-like growth factor i

Diabetes July 2012, Vol.61, 1969-1973. doi:https://doi.org/10.2337/db11-1797

Steady-State Brain Glucose Concentrations During Hypoglycemia in Healthy Humans and Patients With Type 1 Diabetes

Kim C.C. van de Ven; Marinette van der Graaf; Cees J. Tack; Arend Heerschap; Bastiaan E. de Galan

Abstracts

Topics: brain , glucose , hypoglycemia , plasma glucose , hypoglycemic agents

Diabetes July 2012, Vol.61, 1974-1977. doi:https://doi.org/10.2337/db11-1778

Signal Transduction

G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta

Kumiko Taguchi; Takayuki Matsumoto; Katsuo Kamata; Tsuneo Kobayashi

Abstract

Topics: aorta , arrestin , insulin , mice , nitric oxide synthase

Diabetes July 2012, Vol.61, 1978-1985. doi:https://doi.org/10.2337/db11-1729

Obesity Studies

Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity

Erik Arner; Niklas Mejhert; Agné Kulyté; Piotr J. Balwierz; Mikhail Pachkov; Mireille Cormont; Silvia Lorente-Cebrián; Anna Ehrlund; Jurga Laurencikiene; Per Hedén; Karin Dahlman-Wright; Jean-François Tanti; Yoshihide Hayashizaki; Mikael Rydén; Ingrid Dahlman; Erik van Nimwegen; Carsten O. Daub; Peter Arner

Abstracts

Topics: adipocytes , micrornas , monocyte chemoattractant protein-1 , obesity , bodily secretions

Diabetes July 2012, Vol.61, 1986-1993. doi:https://doi.org/10.2337/db11-1508

A Novel Anti-inflammatory Role for Spleen-Derived Interleukin-10 in Obesity-Induced Inflammation in White Adipose Tissue and Liver

Koro Gotoh; Megumi Inoue; Takayuki Masaki; Seiichi Chiba; Takanobu Shimasaki; Hisae Ando; Kansuke Fujiwara; Isao Katsuragi; Tetsuya Kakuma; Masataka Seike; Toshiie Sakata; Hironobu Yoshimatsu

Abstract

Topics: heart failure , interleukin-10 , liver , obesity , spleen

Diabetes July 2012, Vol.61, 1994-2003. doi:https://doi.org/10.2337/db11-1688

Islet Studies

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation

Mallikarjuna R. Metukuri; Pili Zhang; Mahesh K. Basantani; Connie Chin; Rachel E. Stamateris; Laura C. Alonso; Karen K. Takane; Roberto Gramignoli; Stephen C. Strom; Robert M. O’Doherty; Andrew F. Stewart; Rupangi C. Vasavada; Adolfo Garcia-Ocaña; Donald K. Scott

Abstract

Topics: glucose

Diabetes July 2012, Vol.61, 2004-2015. doi:https://doi.org/10.2337/db11-0802

Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Alireza Rezania; Jennifer E. Bruin; Michael J. Riedel; Majid Mojibian; Ali Asadi; Jean Xu; Rebecca Gauvin; Kavitha Narayan; Francis Karanu; John J. O’Neil; Ziliang Ao; Garth L. Warnock; Timothy J. Kieffer

Abstracts

Topics: insulin , mice , pancreas , tissue transplants , transplantation

Diabetes July 2012, Vol.61, 2016-2029. doi:https://doi.org/10.2337/db11-1711

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection

Barbara M. Schulte; Kjerstin H.W. Lanke; Jon D. Piganelli; Esther D. Kers-Rebel; Rita Bottino; Massimo Trucco; Richard J.F. Huijbens; Timothy R.D.J. Radstake; Marten A. Engelse; Eelco J.P. de Koning; Jochem M. Galama; Gosse J. Adema; Frank J.M. van Kuppeveld

Abstract

Topics: chemokines , cytokine , infections , endocrine pancreas , enterovirus infections

Diabetes July 2012, Vol.61, 2030-2036. doi:https://doi.org/10.2337/db11-1547

Immunology and Transplantation

Autoantigen-Specific B-Cell Depletion Overcomes Failed Immune Tolerance in Type 1 Diabetes

Rachel A. Henry; Peggy L. Kendall; James W. Thomas

Abstract

Topics: autoantigens , b-lymphocytes , insulin , monoclonal antibodies , mice, inbred nod

Diabetes July 2012, Vol.61, 2037-2044. doi:https://doi.org/10.2337/db11-1746

Inhibition of Gelatinase B (Matrix Metalloprotease-9) Activity Reduces Cellular Inflammation and Restores Function of Transplanted Pancreatic Islets

Neelam Lingwal; Manju Padmasekar; Balaji Samikannu; Reinhard G. Bretzel; Klaus T. Preissner; Thomas Linn

Abstract

Topics: captopril , gelatinase a , gelatinase b , gelatinases , islets of langerhans transplantation

Diabetes July 2012, Vol.61, 2045-2053. doi:https://doi.org/10.2337/db11-1143

Mechanisms Underlying Antigen-Specific Tolerance of Stable and Convertible Th17 Cells During Suppression of Autoimmune Diabetes

Xiaoxiao Wan; F. Betul Guloglu; Amie M. VanMorlan; Linda M. Rowland; Renu Jain; Cara L. Haymaker; Jason A. Cascio; Mermagya Dhakal; Christine M. Hoeman; Danielle M. Tartar; Habib Zaghouani

Abstract

Topics: immunoglobulins , th1 cells , th17 cells , transfer technique , mice

Diabetes July 2012, Vol.61, 2054-2065. doi:https://doi.org/10.2337/db11-1723

Pathophysiology

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

Carla J. Greenbaum; Craig A. Beam; David Boulware; Stephen E. Gitelman; Peter A. Gottlieb; Kevan C. Herold; John M. Lachin; Paula McGee; Jerry P. Palmer; Mark D. Pescovitz; Heidi Krause-Steinrauf; Jay S. Skyler; Jay M. Sosenko; on behalf of the Type 1 Diabetes TrialNet Study Group

Abstracts

Topics: c-peptide , diabetes mellitus, type 1

Diabetes July 2012, Vol.61, 2066-2073. doi:https://doi.org/10.2337/db11-1538

Complications

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

Mariana G. Rosca; Edwin J. Vazquez; Qun Chen; Janos Kerner; Timothy S. Kern; Charles L. Hoppel

Abstract

Topics: mitochondria , oxidation , kidney , renal tubule , enzymes

Diabetes July 2012, Vol.61, 2074-2083. doi:https://doi.org/10.2337/db11-1437

Oxidative Stress–Induced JNK1/2 Activation Triggers Proapoptotic Signaling and Apoptosis That Leads to Diabetic Embryopathy

Xuezheng Li; Hongbo Weng; Cheng Xu; E. Albert Reece; Peixin Yang

Abstracts

Topics: apoptosis , embryo , hyperglycemia , mice , signal transduction

Diabetes July 2012, Vol.61, 2084-2092. doi:https://doi.org/10.2337/db11-1624

Transgenic Control of Mitochondrial Fission Induces Mitochondrial Uncoupling and Relieves Diabetic Oxidative Stress

Chad A. Galloway; Hakjoo Lee; Souad Nejjar; Bong Sook Jhun; Tianzheng Yu; Wei Hsu; Yisang Yoon

Abstracts

Topics: mitochondria , mice , oxidative stress , protons , hepatocytes

Diabetes July 2012, Vol.61, 2093-2104. doi:https://doi.org/10.2337/db11-1640

Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice

Anna M.D. Watson; Stephen P. Gray; Li Jiaze; Aino Soro-Paavonen; Benedict Wong; Mark E. Cooper; Angelika Bierhaus; Raelene Pickering; Christos Tikellis; Despina Tsorotes; Merlin C. Thomas; Karin A.M. Jandeleit-Dahm

Abstract

Topics: apolipoprotein e , inflammation , kidney , kidney glomerulus , mice

Diabetes July 2012, Vol.61, 2105-2113. doi:https://doi.org/10.2337/db11-1546

Early-Outgrowth Bone Marrow Cells Attenuate Renal Injury and Dysfunction via an Antioxidant Effect in a Mouse Model of Type 2 Diabetes

Yanling Zhang; Darren A. Yuen; Andrew Advani; Kerri Thai; Suzanne L. Advani; David Kepecs; M. Golam Kabir; Kim A. Connelly; Richard E. Gilbert

Abstracts

Topics: kidney , mice , attenuation , epithelial cells , infusion procedures

Diabetes July 2012, Vol.61, 2114-2125. doi:https://doi.org/10.2337/db11-1365

Metanx Alleviates Multiple Manifestations of Peripheral Neuropathy and Increases Intraepidermal Nerve Fiber Density in Zucker Diabetic Fatty Rats

Hanna Shevalye; Pierre Watcho; Roman Stavniichuk; Elena Dyukova; Sergey Lupachyk; Irina G. Obrosova

Abstracts

Topics: nitric oxide synthase , rats , 3-nitrotyrosine , pyruvaldehyde , nerve fibers

Diabetes July 2012, Vol.61, 2126-2133. doi:https://doi.org/10.2337/db11-1524

Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes

Zongwei Wang; Zhiyong Cheng; Vivian Cristofaro; Jijun Li; Xingyuan Xiao; Pablo Gomez; Rongbin Ge; Edward Gong; Klemen Strle; Maryrose P. Sullivan; Rosalyn M. Adam; Morris F. White; Aria F. Olumi

Abstract

Topics: mice , neurogenic bladder , tumor necrosis factors , urinary bladder , smooth muscle

Diabetes July 2012, Vol.61, 2134-2145. doi:https://doi.org/10.2337/db11-1763

Pharmacology and Therapeutics

Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo

Nicky Konstantopoulos; Juan C. Molero; Sean L. McGee; Briana Spolding; Tim Connor; Melissa de Vries; Stephen Wanyonyi; Richard Fahey; Shona Morrison; Courtney Swinton; Sharon Jones; Adrian Cooper; Lucia Garcia-Guerra; Victoria C. Foletta; Guy Krippner; Sofianos Andrikopoulos; Ken R. Walder

Abstracts

Topics: glucose , insulin , methazolamide , mice , blood glucose

Diabetes July 2012, Vol.61, 2146-2154. doi:https://doi.org/10.2337/db11-0578

Transient Receptor Potential Vanilloid 1 Activation Enhances Gut Glucagon-Like Peptide-1 Secretion and Improves Glucose Homeostasis

Peijian Wang; Zhencheng Yan; Jian Zhong; Jing Chen; Yinxing Ni; Li Li; Liqun Ma; Zhigang Zhao; Daoyan Liu; Zhiming Zhu

Abstracts

Topics: bodily secretions , capsaicin , diet , glucagon-like peptide 1 , mice

Diabetes July 2012, Vol.61, 2155-2165. doi:https://doi.org/10.2337/db11-1503

Genetics / Genomes / Proteomics / Metabolomics

Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced β-Cell Mass

Simone Renner; Werner Römisch-Margl; Cornelia Prehn; Stefan Krebs; Jerzy Adamski; Burkhard Göke; Helmut Blum; Karsten Suhre; Adelbert A. Roscher; Eckhard Wolf

Abstracts

Topics: amino acids , animals, transgenic , metabolites , plasma , prediabetes

Diabetes July 2012, Vol.61, 2166-2175. doi:https://doi.org/10.2337/db11-1133

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Abstracts

Topics: diabetes mellitus, type 2 , fasting blood glucose measurement , single nucleotide polymorphism , follow-up , genes

Diabetes July 2012, Vol.61, 2176-2186. doi:https://doi.org/10.2337/db11-1515

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy

Abstracts

Topics: diabetes mellitus, type 1 , diabetic nephropathy , genotype determination , kidney failure, chronic , phenotype

Diabetes July 2012, Vol.61, 2187-2194. doi:https://doi.org/10.2337/db11-0751

Erratum

Extract

Topics: cyclic amp-responsive dna-binding protein , dysplasia , exenatide , glucagon-like peptide-1 receptor , k-ras oncogene

Diabetes July 2012, Vol.61, 2195. doi:https://doi.org/10.2337/db12-er08

Issues and Events

Extract

Topics: hawaii , hyperphagia , louisiana , obesity , ohio

Diabetes July 2012, Vol.61, 2196. doi:https://doi.org/10.2337/db12-ie08

Diabetes Digests

Highlights From the Latest in Diabetes Research

Extract