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Issues
1 September 2012
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
Perspectives in Diabetes
Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?
Diabetes August 2012, Vol.61, 2199-2204. doi:https://doi.org/10.2337/db12-0052
Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map
Diabetes August 2012, Vol.61, 2205-2213. doi:https://doi.org/10.2337/db12-0018
Commentary
Is Endogenous GLP-1 the Only Important Enhancer of Glucose-Induced Insulin Secretion in Type 2 Diabetes?
Diabetes August 2012, Vol.61, 2219-2220. doi:https://doi.org/10.2337/db12-0649
The Artificial Pancreas
Diabetes August 2012, Vol.61, 2221-2224. doi:https://doi.org/10.2337/db12-0647
Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes?
Diabetes August 2012, Vol.61, 2228-2229. doi:https://doi.org/10.2337/db12-0664
Methodology Review
Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia
Marc Breton; Anne Farret; Daniela Bruttomesso; Stacey Anderson; Lalo Magni; Stephen Patek; Chiara Dalla Man; Jerome Place; Susan Demartini; Simone Del Favero; Chiara Toffanin; Colleen Hughes-Karvetski; Eyal Dassau; Howard Zisser; Francis J. Doyle, III; Giuseppe De Nicolao; Angelo Avogaro; Claudio Cobelli; Eric Renard; Boris Kovatchev; on behalf of The International Artificial Pancreas (iAP) Study Group
Diabetes August 2012, Vol.61, 2230-2237. doi:https://doi.org/10.2337/db11-1445
Metabolism
Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients
Adeline Bertola; Thomas Ciucci; Déborah Rousseau; Virginie Bourlier; Carine Duffaut; Stéphanie Bonnafous; Claudine Blin-Wakkach; Rodolphe Anty; Antonio Iannelli; Jean Gugenheim; Albert Tran; Anne Bouloumié; Philippe Gual; Abdelilah Wakkach
Diabetes August 2012, Vol.61, 2238-2247. doi:https://doi.org/10.2337/db11-1274
Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women
Swapnil N. Rajpathak; Meian He; Qi Sun; Robert C. Kaplan; Radhika Muzumdar; Thomas E. Rohan; Marc J. Gunter; Michael Pollak; Mimi Kim; Jeffrey E. Pessin; Jeannette Beasley; Judith Wylie-Rosett; Frank B. Hu; Howard D. Strickler
Diabetes August 2012, Vol.61, 2248-2254. doi:https://doi.org/10.2337/db11-1488
Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood
Annet F.M. van Abeelen; Sjoerd G. Elias; Patrick M.M. Bossuyt; Diederick E. Grobbee; Yvonne T. van der Schouw; Tessa J. Roseboom; Cuno S.P.M. Uiterwaal
Diabetes August 2012, Vol.61, 2255-2260. doi:https://doi.org/10.2337/db11-1559
Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans
Kamila Jauch-Chara; Alexia Friedrich; Magdalena Rezmer; Uwe H. Melchert; Harald G. Scholand-Engler; Manfred Hallschmid; Kerstin M. Oltmanns
Diabetes August 2012, Vol.61, 2261-2268. doi:https://doi.org/10.2337/db12-0025
Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Aleksey V. Matveyenko; David Liuwantara; Tatyana Gurlo; David Kirakossian; Chiara Dalla Man; Claudio Cobelli; Morris F. White; Kyle D. Copps; Elena Volpi; Satoshi Fujita; Peter C. Butler
Diabetes August 2012, Vol.61, 2269-2279. doi:https://doi.org/10.2337/db11-1462
Signal Transduction
Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy
Maria Fragiadaki; Nicola Hill; Reiko Hewitt; George Bou-Gharios; Terence Cook; Frederick W. Tam; Jan Domin; Roger M. Mason
Diabetes August 2012, Vol.61, 2280-2288. doi:https://doi.org/10.2337/db11-1138
Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine
Diabetes August 2012, Vol.61, 2289-2298. doi:https://doi.org/10.2337/db11-1395
Obesity Studies
Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium
Dong-Hoon Kim; Maureen A. Sartor; James R. Bain; Darleen Sandoval; Robert D. Stevens; Mario Medvedovic; Christopher B. Newgard; Stephen C. Woods; Randy J. Seeley
Diabetes August 2012, Vol.61, 2299-2310. doi:https://doi.org/10.2337/db11-1579
Adipocytes Secrete Leukotrienes: Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice
Isabelle Mothe-Satney; Chantal Filloux; Hind Amghar; Catherine Pons; Virginie Bourlier; Jean Galitzky; Paul A. Grimaldi; Chloé C. Féral; Anne Bouloumié; Emmanuel Van Obberghen; Jaap G. Neels
Diabetes August 2012, Vol.61, 2311-2319. doi:https://doi.org/10.2337/db11-1455
An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats
Abishek Iyer; Junxian Lim; Hemant Poudyal; Robert C. Reid; Jacky Y. Suen; Julie Webster; Johannes B. Prins; Jonathan P. Whitehead; David P. Fairlie; Lindsay Brown
Diabetes August 2012, Vol.61, 2320-2329. doi:https://doi.org/10.2337/db11-1179
Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver
Maja Stefanovic-Racic; Xiao Yang; Michael S. Turner; Benjamin S. Mantell; Donna B. Stolz; Tina L. Sumpter; Ian J. Sipula; Nikolaos Dedousis; Donald K. Scott; Penelope A. Morel; Angus W. Thomson; Robert M. O’Doherty
Diabetes August 2012, Vol.61, 2330-2339. doi:https://doi.org/10.2337/db11-1523
Immunology and Transplantation
Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function
S. Alice Long; for Diabetes TrialNet and the Immune Tolerance Network; Mary Rieck; for Diabetes TrialNet and the Immune Tolerance Network; Srinath Sanda; for Diabetes TrialNet and the Immune Tolerance Network; Jennifer B. Bollyky; for Diabetes TrialNet and the Immune Tolerance Network; Peter L. Samuels; for Diabetes TrialNet and the Immune Tolerance Network; Robin Goland; for Diabetes TrialNet and the Immune Tolerance Network; Andrew Ahmann; for Diabetes TrialNet and the Immune Tolerance Network; Alex Rabinovitch; for Diabetes TrialNet and the Immune Tolerance Network; Sudeepta Aggarwal; for Diabetes TrialNet and the Immune Tolerance Network; Deborah Phippard; for Diabetes TrialNet and the Immune Tolerance Network; Laurence A. Turka; for Diabetes TrialNet and the Immune Tolerance Network; Mario R. Ehlers; for Diabetes TrialNet and the Immune Tolerance Network; Peter J. Bianchine; for Diabetes TrialNet and the Immune Tolerance Network; Karen D. Boyle; for Diabetes TrialNet and the Immune Tolerance Network; Steven A. Adah; for Diabetes TrialNet and the Immune Tolerance Network; Jeffrey A. Bluestone; for Diabetes TrialNet and the Immune Tolerance Network; Jane H. Buckner; for Diabetes TrialNet and the Immune Tolerance Network; Carla J. Greenbaum; for Diabetes TrialNet and the Immune Tolerance Network
Diabetes August 2012, Vol.61, 2340-2348. doi:https://doi.org/10.2337/db12-0049
Pathophysiology
The Role of Endogenous Incretin Secretion as Amplifier of Glucose-Stimulated Insulin Secretion in Healthy Subjects and Patients With Type 2 Diabetes
Diabetes August 2012, Vol.61, 2349-2358. doi:https://doi.org/10.2337/db11-1701
Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice
Helen Imrie; Hema Viswambharan; Piruthivi Sukumar; Afroze Abbas; Richard M. Cubbon; Nadira Yuldasheva; Matthew Gage; Jessica Smith; Stacey Galloway; Anna Skromna; Sheik Taqweer Rashid; T. Simon Futers; Shouhong Xuan; V. Kate Gatenby; Peter J. Grant; Keith M. Channon; David J. Beech; Stephen B. Wheatcroft; Mark T. Kearney
Diabetes August 2012, Vol.61, 2359-2368. doi:https://doi.org/10.2337/db11-1494
Complications
Polycystic Ovary Syndrome Is a Risk Factor for Type 2 Diabetes: Results From a Long-Term Prospective Study
Alessandra Gambineri; Laura Patton; Paola Altieri; Uberto Pagotto; Carmine Pizzi; Lamberto Manzoli; Renato Pasquali
Diabetes August 2012, Vol.61, 2369-2374. doi:https://doi.org/10.2337/db11-1360
Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes
Gail Musen; Alan M. Jacobson; Nicolas R. Bolo; Donald C. Simonson; Martha E. Shenton; Richard L. McCartney; Veronica L. Flores; Wouter S. Hoogenboom
Diabetes August 2012, Vol.61, 2375-2379. doi:https://doi.org/10.2337/db11-1669
Pharmacology and Therapeutics
Postprandial Platelet Activation Is Related to Postprandial Plasma Insulin Rather Than Glucose in Patients With Type 2 Diabetes
Diabetes August 2012, Vol.61, 2380-2384. doi:https://doi.org/10.2337/db11-1806
Genetics / Genomes / Proteomics / Metabolomics
The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
Farook Thameem; Sobha Puppala; Jennifer Schneider; Basant Bhandari; Rector Arya; Nedal H. Arar; Tetyana L. Vasylyeva; Vidya S. Farook; Sharon Fowler; Laura Almasy; John Blangero; Ravindranath Duggirala; Hanna E. Abboud
Diabetes August 2012, Vol.61, 2385-2393. doi:https://doi.org/10.2337/db11-1078
Issues and Events
Diabetes Digests
Online Letters to the Editor
Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300
Diabetes August 2012, Vol.61, e12. doi:https://doi.org/10.2337/db12-0219
