Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Search within issue:

Search within issue

Perspectives in Diabetes

Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?

Jiwen (Jim) Liu; TaeWeon Lee; Ralph A. DeFronzo

Abstract

View articletitled, Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?

Supplementary data

Click here to open pdf in another window PDF for

Topics: glucose , kidney , sodium-glucose transporter 2 inhibitors

Diabetes August 2012, Vol.61, 2199-2204. doi:https://doi.org/10.2337/db12-0052

Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

Rohit N. Kulkarni; Ernesto-Bernal Mizrachi; Adolfo Garcia Ocana; Andrew F. Stewart

Abstract

View articletitled, Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

Click here to open pdf in another window PDF for

Topics: cell cycle , rodentia , signal transduction , signal pathway , signal transduction pathways

Diabetes August 2012, Vol.61, 2205-2213. doi:https://doi.org/10.2337/db12-0018

Commentary

Immunotherapy in Type 1 Diabetes: A Shorter but More Winding Road?

Ezio Bonifacio

Abstracts

View articletitled, Immunotherapy in Type 1 Diabetes: A Shorter but More Winding Road?

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 1 , immunotherapy , interleukin-2

Diabetes August 2012, Vol.61, 2214-2215. doi:https://doi.org/10.2337/db12-0648

Energizing the Mind and Body

Paul Kievit; Jonathan Q. Purnell

Abstracts

View articletitled, Energizing the Mind and Body

Click here to open pdf in another window PDF for

Topics: brain , eating , hormones , insulin , leptin

Diabetes August 2012, Vol.61, 2216-2218. doi:https://doi.org/10.2337/db12-0642

Is Endogenous GLP-1 the Only Important Enhancer of Glucose-Induced Insulin Secretion in Type 2 Diabetes?

Carolyn F. Deacon

Abstracts

View articletitled, Is Endogenous GLP-1 the Only Important Enhancer of Glucose-Induced Insulin Secretion in Type 2 Diabetes?

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , enhancer of transcription , glucagon-like peptide 1 , glucose , insulin secretion

Diabetes August 2012, Vol.61, 2219-2220. doi:https://doi.org/10.2337/db12-0649

The Artificial Pancreas

Jerry Radziuk

Abstracts

View articletitled, The Artificial Pancreas

Click here to open pdf in another window PDF for

Topics: artificial pancreas , glucose , hypoglycemia , insulin , subcutaneous injections

Diabetes August 2012, Vol.61, 2221-2224. doi:https://doi.org/10.2337/db12-0647

Endothelial Insulin and IGF-1 Receptors: When Yes Means NO

Ranganath Muniyappa; James R. Sowers

Abstracts

View articletitled, Endothelial Insulin and IGF-1 Receptors: When Yes Means NO

Click here to open pdf in another window PDF for

Topics: endothelium , insulin , insulin-like-growth factor i receptor

Diabetes August 2012, Vol.61, 2225-2227. doi:https://doi.org/10.2337/db12-0654

Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes?

John Wahren; Åsa Kallas

Abstracts

View articletitled, Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes?

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , insulin , insulin secretion

Diabetes August 2012, Vol.61, 2228-2229. doi:https://doi.org/10.2337/db12-0664

Methodology Review

Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia

Abstracts

View articletitled, Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia

Supplementary data

Click here to open pdf in another window PDF for

Topics: artificial pancreas , diabetes mellitus, type 1 , glucose , glycemic control , hypoglycemia

Diabetes August 2012, Vol.61, 2230-2237. doi:https://doi.org/10.2337/db11-1445

Metabolism

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

Adeline Bertola; Thomas Ciucci; Déborah Rousseau; Virginie Bourlier; Carine Duffaut; Stéphanie Bonnafous; Claudine Blin-Wakkach; Rodolphe Anty; Antonio Iannelli; Jean Gugenheim; Albert Tran; Anne Bouloumié; Philippe Gual; Abdelilah Wakkach

Abstracts

View articletitled, Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

Click here to open pdf in another window PDF for

Topics: adipose tissue , insulin resistance , mice , obesity , t-lymphocytes

Diabetes August 2012, Vol.61, 2238-2247. doi:https://doi.org/10.2337/db11-1274

Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women

Swapnil N. Rajpathak; Meian He; Qi Sun; Robert C. Kaplan; Radhika Muzumdar; Thomas E. Rohan; Marc J. Gunter; Michael Pollak; Mimi Kim; Jeffrey E. Pessin; Jeannette Beasley; Judith Wylie-Rosett; Frank B. Hu; Howard D. Strickler

Abstracts

View articletitled, Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , insulin , insulin-like growth factor i , insulin-like growth-factor binding protein 1 , igfbp2 protein, human

Diabetes August 2012, Vol.61, 2248-2254. doi:https://doi.org/10.2337/db11-1488

Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood

Annet F.M. van Abeelen; Sjoerd G. Elias; Patrick M.M. Bossuyt; Diederick E. Grobbee; Yvonne T. van der Schouw; Tessa J. Roseboom; Cuno S.P.M. Uiterwaal

Abstract

View articletitled, Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , famine , malnutrition

Diabetes August 2012, Vol.61, 2255-2260. doi:https://doi.org/10.2337/db11-1559

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

Kamila Jauch-Chara; Alexia Friedrich; Magdalena Rezmer; Uwe H. Melchert; Harald G. Scholand-Engler; Manfred Hallschmid; Kerstin M. Oltmanns

Abstracts

View articletitled, Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

Click here to open pdf in another window PDF for

Topics: brain , eating , insulin , insulin administration , polymerase chain reaction

Diabetes August 2012, Vol.61, 2261-2268. doi:https://doi.org/10.2337/db12-0025

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

Aleksey V. Matveyenko; David Liuwantara; Tatyana Gurlo; David Kirakossian; Chiara Dalla Man; Claudio Cobelli; Morris F. White; Kyle D. Copps; Elena Volpi; Satoshi Fujita; Peter C. Butler

Abstracts

View articletitled, Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

Supplementary data

Click here to open pdf in another window PDF for

Topics: insulin , diabetes mellitus, type 2 , portal vein , signal transduction , infusion procedures

Diabetes August 2012, Vol.61, 2269-2279. doi:https://doi.org/10.2337/db11-1462

Signal Transduction

Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy

Maria Fragiadaki; Nicola Hill; Reiko Hewitt; George Bou-Gharios; Terence Cook; Frederick W. Tam; Jan Domin; Roger M. Mason

Abstract

View articletitled, Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy

Click here to open pdf in another window PDF for

Topics: hypoxia , kidney , hyperglycemia , mice , receptor, trka

Diabetes August 2012, Vol.61, 2280-2288. doi:https://doi.org/10.2337/db11-1138

Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine

Siegfried Ussar; Olivier Bezy; Matthias Blüher; C. Ronald Kahn

Abstract

View articletitled, Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine

Supplementary data

Click here to open pdf in another window PDF for

Topics: adipocytes , insulin , insulin receptor , mice , signal transduction

Diabetes August 2012, Vol.61, 2289-2298. doi:https://doi.org/10.2337/db11-1395

Obesity Studies

Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium

Dong-Hoon Kim; Maureen A. Sartor; James R. Bain; Darleen Sandoval; Robert D. Stevens; Mario Medvedovic; Christopher B. Newgard; Stephen C. Woods; Randy J. Seeley

Abstract

View articletitled, Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium

Supplementary data

Click here to open pdf in another window PDF for

Topics: glucose , glucose tolerance , heart failure , insulin , mice

Diabetes August 2012, Vol.61, 2299-2310. doi:https://doi.org/10.2337/db11-1579

Adipocytes Secrete Leukotrienes: Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice

Isabelle Mothe-Satney; Chantal Filloux; Hind Amghar; Catherine Pons; Virginie Bourlier; Jean Galitzky; Paul A. Grimaldi; Chloé C. Féral; Anne Bouloumié; Emmanuel Van Obberghen; Jaap G. Neels

Abstracts

View articletitled, Adipocytes Secrete Leukotrienes: Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice

Supplementary data

Click here to open pdf in another window PDF for

Topics: adipocytes , inflammation , leukotrienes , macrophages , mice

Diabetes August 2012, Vol.61, 2311-2319. doi:https://doi.org/10.2337/db11-1455

An Inhibitor of Phospholipase A₂ Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats

Abishek Iyer; Junxian Lim; Hemant Poudyal; Robert C. Reid; Jacky Y. Suen; Julie Webster; Johannes B. Prins; Jonathan P. Whitehead; David P. Fairlie; Lindsay Brown

Abstracts

View articletitled, An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats

Supplementary data

Click here to open pdf in another window PDF for

Topics: adipocytes , adipose tissue , diet , lipolysis , metabolic syndrome x

Diabetes August 2012, Vol.61, 2320-2329. doi:https://doi.org/10.2337/db11-1179

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c⁺ Cells in Adipose Tissue and Liver

Maja Stefanovic-Racic; Xiao Yang; Michael S. Turner; Benjamin S. Mantell; Donna B. Stolz; Tina L. Sumpter; Ian J. Sipula; Nikolaos Dedousis; Donald K. Scott; Penelope A. Morel; Angus W. Thomson; Robert M. O’Doherty

Abstract

View articletitled, Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

Supplementary data

Click here to open pdf in another window PDF for

Topics: liver , obesity , macrophages , mice , macrophage-1 antigen

Diabetes August 2012, Vol.61, 2330-2339. doi:https://doi.org/10.2337/db11-1523

Immunology and Transplantation

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

S. Alice Long; Mary Rieck; Srinath Sanda; Jennifer B. Bollyky; Peter L. Samuels; Robin Goland; Andrew Ahmann; Alex Rabinovitch; Sudeepta Aggarwal; Deborah Phippard; Laurence A. Turka; Mario R. Ehlers; Peter J. Bianchine; Karen D. Boyle; Steven A. Adah; Jeffrey A. Bluestone; Jane H. Buckner; Carla J. Greenbaum; for Diabetes TrialNet and the Immune Tolerance Network

Abstracts

View articletitled, Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

Supplementary data

Click here to open pdf in another window PDF for

Topics: combined modality therapy , interleukin-2 , rapamycin , c-peptide

Diabetes August 2012, Vol.61, 2340-2348. doi:https://doi.org/10.2337/db12-0049

Pathophysiology

The Role of Endogenous Incretin Secretion as Amplifier of Glucose-Stimulated Insulin Secretion in Healthy Subjects and Patients With Type 2 Diabetes

Hans Juergen Woerle; Lucianno Carneiro; Ayman Derani; Burkhard Göke; Jörg Schirra

Abstracts

View articletitled, The Role of Endogenous Incretin Secretion as Amplifier of Glucose-Stimulated Insulin Secretion in Healthy Subjects and Patients With Type 2 Diabetes

Click here to open pdf in another window PDF for

Topics: bodily secretions , c-peptide , diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose

Diabetes August 2012, Vol.61, 2349-2358. doi:https://doi.org/10.2337/db11-1701

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

Helen Imrie; Hema Viswambharan; Piruthivi Sukumar; Afroze Abbas; Richard M. Cubbon; Nadira Yuldasheva; Matthew Gage; Jessica Smith; Stacey Galloway; Anna Skromna; Sheik Taqweer Rashid; T. Simon Futers; Shouhong Xuan; V. Kate Gatenby; Peter J. Grant; Keith M. Channon; David J. Beech; Stephen B. Wheatcroft; Mark T. Kearney

Abstracts

View articletitled, Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

Supplementary data

Click here to open pdf in another window PDF for

Topics: endothelial cells , endothelium , insulin-like-growth factor i receptor , mice , nitric oxide synthase

Diabetes August 2012, Vol.61, 2359-2368. doi:https://doi.org/10.2337/db11-1494

Complications

Polycystic Ovary Syndrome Is a Risk Factor for Type 2 Diabetes: Results From a Long-Term Prospective Study

Alessandra Gambineri; Laura Patton; Paola Altieri; Uberto Pagotto; Carmine Pizzi; Lamberto Manzoli; Renato Pasquali

Abstract

View articletitled, Polycystic Ovary Syndrome Is a Risk Factor for Type 2 Diabetes: Results From a Long-Term Prospective Study

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , follow-up , polycystic ovary syndrome , glucose , sex hormone-binding globulin

Diabetes August 2012, Vol.61, 2369-2374. doi:https://doi.org/10.2337/db11-1360

Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

Gail Musen; Alan M. Jacobson; Nicolas R. Bolo; Donald C. Simonson; Martha E. Shenton; Richard L. McCartney; Veronica L. Flores; Wouter S. Hoogenboom

Abstract

View articletitled, Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

Click here to open pdf in another window PDF for

Topics: brain , diabetes mellitus, type 2 , insulin resistance , hippocampus , functional magnetic resonance imaging

Diabetes August 2012, Vol.61, 2375-2379. doi:https://doi.org/10.2337/db11-1669

Pharmacology and Therapeutics

Postprandial Platelet Activation Is Related to Postprandial Plasma Insulin Rather Than Glucose in Patients With Type 2 Diabetes

Galia Spectre; Claes-Göran Östenson; Nailin Li; Paul Hjemdahl

Abstracts

View articletitled, Postprandial Platelet Activation Is Related to Postprandial Plasma Insulin Rather Than Glucose in Patients With Type 2 Diabetes

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , glucose , insulin , platelet activation , postprandial period

Diabetes August 2012, Vol.61, 2380-2384. doi:https://doi.org/10.2337/db11-1806

Genetics / Genomes / Proteomics / Metabolomics

The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling

Farook Thameem; Sobha Puppala; Jennifer Schneider; Basant Bhandari; Rector Arya; Nedal H. Arar; Tetyana L. Vasylyeva; Vidya S. Farook; Sharon Fowler; Laura Almasy; John Blangero; Ravindranath Duggirala; Hanna E. Abboud

Abstract

View articletitled, The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling

Supplementary data

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , genes , glomerular filtration rate , insulin receptor , single nucleotide polymorphism

Diabetes August 2012, Vol.61, 2385-2393. doi:https://doi.org/10.2337/db11-1078

Issues and Events

Extract

View articletitled, Issues and Events

Click here to open pdf in another window PDF for

Topics: hawaii , hyperphagia , louisiana , obesity , ohio

Diabetes August 2012, Vol.61, 2394. doi:https://doi.org/10.2337/db12-ie09

Diabetes Digests

Highlights From the Latest in Diabetes Research

Extract

View articletitled, Highlights From the Latest in Diabetes Research

Click here to open pdf in another window PDF for

Topics: bariatric surgery , diabetes mellitus, type 2 , inflammation , medical management , obesity

Diabetes August 2012, Vol.61, 2395-2396. doi:https://doi.org/10.2337/db12-dd09

Online Letters to the Editor

Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300

Filip K. Knop; Mikkel Christensen

Extract

View articletitled, Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300

Click here to open pdf in another window PDF for

Topics: glucose , hydroxysteroids , nonesterified fatty acids , oxidoreductase

Diabetes August 2012, Vol.61, e12. doi:https://doi.org/10.2337/db12-0219

Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Jun-Li Liu; Coimbatore B. Srikant; Subrata Chowdhury

Extract

View articletitled, Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Click here to open pdf in another window PDF for

Topics: diet, high-fat , hydroxysteroids , oxidoreductase

Diabetes August 2012, Vol.61, e13. doi:https://doi.org/10.2337/db12-0556

Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Sophie Turban; Jonathan R. Seckl; Nicholas M. Morton

Extract

View articletitled, Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

Click here to open pdf in another window PDF for

Topics: diet, high-fat , hydroxysteroids , oxidoreductase , heart failure

Diabetes August 2012, Vol.61, e14. doi:https://doi.org/10.2337/db12-0583

Response to Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530

Philippe Froguel; Marcel Marquez; Stéphane Cauchi

Extract

View articletitled, Response to Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , hmga1b protein , hmga1c protein , staphylococcal protein a

Diabetes August 2012, Vol.61, e15. doi:https://doi.org/10.2337/db12-0800

Issues

Cover Image

Perspectives in Diabetes

Commentary

Methodology Review

Metabolism

Signal Transduction

Obesity Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics / Genomes / Proteomics / Metabolomics

Issues and Events

Diabetes Digests

Online Letters to the Editor

Email alerts

RSS Feeds

Journals

Books

Clinical Compendia

News

Other

About

Resources

This Feature Is Available To Subscribers Only