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Issues
1 September 2012
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
Perspectives in Diabetes
Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?
Topics:
glucose
,
kidney
,
sodium-glucose transporter 2 inhibitors
Diabetes August 2012, Vol.61, 2199-2204. doi:https://doi.org/10.2337/db12-0052
Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map
Topics:
cell cycle
,
rodentia
,
signal transduction
,
signal pathway
,
signal transduction pathways
Diabetes August 2012, Vol.61, 2205-2213. doi:https://doi.org/10.2337/db12-0018
Commentary
Immunotherapy in Type 1 Diabetes: A Shorter but More Winding Road?
Topics:
diabetes mellitus, type 1
,
immunotherapy
,
interleukin-2
Diabetes August 2012, Vol.61, 2214-2215. doi:https://doi.org/10.2337/db12-0648
Energizing the Mind and Body
Diabetes August 2012, Vol.61, 2216-2218. doi:https://doi.org/10.2337/db12-0642
Is Endogenous GLP-1 the Only Important Enhancer of Glucose-Induced Insulin Secretion in Type 2 Diabetes?
Topics:
diabetes mellitus, type 2
,
enhancer of transcription
,
glucagon-like peptide 1
,
glucose
,
insulin secretion
Diabetes August 2012, Vol.61, 2219-2220. doi:https://doi.org/10.2337/db12-0649
The Artificial Pancreas
Topics:
artificial pancreas
,
glucose
,
hypoglycemia
,
insulin
,
subcutaneous injections
Diabetes August 2012, Vol.61, 2221-2224. doi:https://doi.org/10.2337/db12-0647
Endothelial Insulin and IGF-1 Receptors: When Yes Means NO
Topics:
endothelium
,
insulin
,
insulin-like-growth factor i receptor
Diabetes August 2012, Vol.61, 2225-2227. doi:https://doi.org/10.2337/db12-0654
Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes?
Topics:
diabetes mellitus, type 2
,
insulin
,
insulin secretion
Diabetes August 2012, Vol.61, 2228-2229. doi:https://doi.org/10.2337/db12-0664
Methodology Review
Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia
Marc Breton; Anne Farret; Daniela Bruttomesso; Stacey Anderson; Lalo Magni; Stephen Patek; Chiara Dalla Man; Jerome Place; Susan Demartini; Simone Del Favero; Chiara Toffanin; Colleen Hughes-Karvetski; Eyal Dassau; Howard Zisser; Francis J. Doyle, III; Giuseppe De Nicolao; Angelo Avogaro; Claudio Cobelli; Eric Renard; Boris Kovatchev; on behalf of The International Artificial Pancreas (iAP) Study Group
Topics:
artificial pancreas
,
diabetes mellitus, type 1
,
glucose
,
glycemic control
,
hypoglycemia
Diabetes August 2012, Vol.61, 2230-2237. doi:https://doi.org/10.2337/db11-1445
Metabolism
Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients
Adeline Bertola; Thomas Ciucci; Déborah Rousseau; Virginie Bourlier; Carine Duffaut; Stéphanie Bonnafous; Claudine Blin-Wakkach; Rodolphe Anty; Antonio Iannelli; Jean Gugenheim; Albert Tran; Anne Bouloumié; Philippe Gual; Abdelilah Wakkach
Topics:
adipose tissue
,
insulin resistance
,
mice
,
obesity
,
t-lymphocytes
Diabetes August 2012, Vol.61, 2238-2247. doi:https://doi.org/10.2337/db11-1274
Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women
Swapnil N. Rajpathak; Meian He; Qi Sun; Robert C. Kaplan; Radhika Muzumdar; Thomas E. Rohan; Marc J. Gunter; Michael Pollak; Mimi Kim; Jeffrey E. Pessin; Jeannette Beasley; Judith Wylie-Rosett; Frank B. Hu; Howard D. Strickler
Topics:
diabetes mellitus, type 2
,
insulin
,
insulin-like growth factor i
,
insulin-like growth-factor binding protein 1
,
igfbp2 protein, human
Diabetes August 2012, Vol.61, 2248-2254. doi:https://doi.org/10.2337/db11-1488
Famine Exposure in the Young and the Risk of Type 2 Diabetes in Adulthood
Annet F.M. van Abeelen; Sjoerd G. Elias; Patrick M.M. Bossuyt; Diederick E. Grobbee; Yvonne T. van der Schouw; Tessa J. Roseboom; Cuno S.P.M. Uiterwaal
Topics:
diabetes mellitus, type 2
,
famine
,
malnutrition
Diabetes August 2012, Vol.61, 2255-2260. doi:https://doi.org/10.2337/db11-1559
Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans
Kamila Jauch-Chara; Alexia Friedrich; Magdalena Rezmer; Uwe H. Melchert; Harald G. Scholand-Engler; Manfred Hallschmid; Kerstin M. Oltmanns
Topics:
brain
,
eating
,
insulin
,
insulin administration
,
polymerase chain reaction
Diabetes August 2012, Vol.61, 2261-2268. doi:https://doi.org/10.2337/db12-0025
Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Aleksey V. Matveyenko; David Liuwantara; Tatyana Gurlo; David Kirakossian; Chiara Dalla Man; Claudio Cobelli; Morris F. White; Kyle D. Copps; Elena Volpi; Satoshi Fujita; Peter C. Butler
Topics:
insulin
,
diabetes mellitus, type 2
,
portal vein
,
signal transduction
,
infusion procedures
Diabetes August 2012, Vol.61, 2269-2279. doi:https://doi.org/10.2337/db11-1462
Signal Transduction
Hyperglycemia Causes Renal Cell Damage via CCN2-Induced Activation of the TrkA Receptor: Implications for Diabetic Nephropathy
Maria Fragiadaki; Nicola Hill; Reiko Hewitt; George Bou-Gharios; Terence Cook; Frederick W. Tam; Jan Domin; Roger M. Mason
Topics:
hypoxia
,
kidney
,
hyperglycemia
,
mice
,
receptor, trka
Diabetes August 2012, Vol.61, 2280-2288. doi:https://doi.org/10.2337/db11-1138
Glypican-4 Enhances Insulin Signaling via Interaction With the Insulin Receptor and Serves as a Novel Adipokine
Topics:
adipocytes
,
insulin
,
insulin receptor
,
mice
,
signal transduction
Diabetes August 2012, Vol.61, 2289-2298. doi:https://doi.org/10.2337/db11-1395
Obesity Studies
Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium
Dong-Hoon Kim; Maureen A. Sartor; James R. Bain; Darleen Sandoval; Robert D. Stevens; Mario Medvedovic; Christopher B. Newgard; Stephen C. Woods; Randy J. Seeley
Topics:
glucose
,
glucose tolerance
,
heart failure
,
insulin
,
mice
Diabetes August 2012, Vol.61, 2299-2310. doi:https://doi.org/10.2337/db11-1579
Adipocytes Secrete Leukotrienes: Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice
Isabelle Mothe-Satney; Chantal Filloux; Hind Amghar; Catherine Pons; Virginie Bourlier; Jean Galitzky; Paul A. Grimaldi; Chloé C. Féral; Anne Bouloumié; Emmanuel Van Obberghen; Jaap G. Neels
Topics:
adipocytes
,
inflammation
,
leukotrienes
,
macrophages
,
mice
Diabetes August 2012, Vol.61, 2311-2319. doi:https://doi.org/10.2337/db11-1455
An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats
Abishek Iyer; Junxian Lim; Hemant Poudyal; Robert C. Reid; Jacky Y. Suen; Julie Webster; Johannes B. Prins; Jonathan P. Whitehead; David P. Fairlie; Lindsay Brown
Topics:
adipocytes
,
adipose tissue
,
diet
,
lipolysis
,
metabolic syndrome x
Diabetes August 2012, Vol.61, 2320-2329. doi:https://doi.org/10.2337/db11-1179
Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver
Maja Stefanovic-Racic; Xiao Yang; Michael S. Turner; Benjamin S. Mantell; Donna B. Stolz; Tina L. Sumpter; Ian J. Sipula; Nikolaos Dedousis; Donald K. Scott; Penelope A. Morel; Angus W. Thomson; Robert M. O’Doherty
Topics:
liver
,
obesity
,
macrophages
,
mice
,
macrophage-1 antigen
Diabetes August 2012, Vol.61, 2330-2339. doi:https://doi.org/10.2337/db11-1523
Immunology and Transplantation
Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function
S. Alice Long; Mary Rieck; Srinath Sanda; Jennifer B. Bollyky; Peter L. Samuels; Robin Goland; Andrew Ahmann; Alex Rabinovitch; Sudeepta Aggarwal; Deborah Phippard; Laurence A. Turka; Mario R. Ehlers; Peter J. Bianchine; Karen D. Boyle; Steven A. Adah; Jeffrey A. Bluestone; Jane H. Buckner; Carla J. Greenbaum; for Diabetes TrialNet and the Immune Tolerance Network
Topics:
combined modality therapy
,
interleukin-2
,
rapamycin
,
c-peptide
Diabetes August 2012, Vol.61, 2340-2348. doi:https://doi.org/10.2337/db12-0049
Pathophysiology
The Role of Endogenous Incretin Secretion as Amplifier of Glucose-Stimulated Insulin Secretion in Healthy Subjects and Patients With Type 2 Diabetes
Topics:
bodily secretions
,
c-peptide
,
diabetes mellitus, type 2
,
glucagon-like peptide 1
,
glucose
Diabetes August 2012, Vol.61, 2349-2358. doi:https://doi.org/10.2337/db11-1701
Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice
Helen Imrie; Hema Viswambharan; Piruthivi Sukumar; Afroze Abbas; Richard M. Cubbon; Nadira Yuldasheva; Matthew Gage; Jessica Smith; Stacey Galloway; Anna Skromna; Sheik Taqweer Rashid; T. Simon Futers; Shouhong Xuan; V. Kate Gatenby; Peter J. Grant; Keith M. Channon; David J. Beech; Stephen B. Wheatcroft; Mark T. Kearney
Topics:
endothelial cells
,
endothelium
,
insulin-like-growth factor i receptor
,
mice
,
nitric oxide synthase
Diabetes August 2012, Vol.61, 2359-2368. doi:https://doi.org/10.2337/db11-1494
Complications
Polycystic Ovary Syndrome Is a Risk Factor for Type 2 Diabetes: Results From a Long-Term Prospective Study
Alessandra Gambineri; Laura Patton; Paola Altieri; Uberto Pagotto; Carmine Pizzi; Lamberto Manzoli; Renato Pasquali
Topics:
diabetes mellitus, type 2
,
follow-up
,
polycystic ovary syndrome
,
glucose
,
sex hormone-binding globulin
Diabetes August 2012, Vol.61, 2369-2374. doi:https://doi.org/10.2337/db11-1360
Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes
Gail Musen; Alan M. Jacobson; Nicolas R. Bolo; Donald C. Simonson; Martha E. Shenton; Richard L. McCartney; Veronica L. Flores; Wouter S. Hoogenboom
Topics:
brain
,
diabetes mellitus, type 2
,
insulin resistance
,
hippocampus
,
functional magnetic resonance imaging
Diabetes August 2012, Vol.61, 2375-2379. doi:https://doi.org/10.2337/db11-1669
Pharmacology and Therapeutics
Postprandial Platelet Activation Is Related to Postprandial Plasma Insulin Rather Than Glucose in Patients With Type 2 Diabetes
Topics:
diabetes mellitus, type 2
,
glucose
,
insulin
,
platelet activation
,
postprandial period
Diabetes August 2012, Vol.61, 2380-2384. doi:https://doi.org/10.2337/db11-1806
Genetics / Genomes / Proteomics / Metabolomics
The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling
Farook Thameem; Sobha Puppala; Jennifer Schneider; Basant Bhandari; Rector Arya; Nedal H. Arar; Tetyana L. Vasylyeva; Vidya S. Farook; Sharon Fowler; Laura Almasy; John Blangero; Ravindranath Duggirala; Hanna E. Abboud
Topics:
diabetes mellitus, type 2
,
genes
,
glomerular filtration rate
,
insulin receptor
,
single nucleotide polymorphism
Diabetes August 2012, Vol.61, 2385-2393. doi:https://doi.org/10.2337/db11-1078
Issues and Events
Issues and Events
Topics:
hawaii
,
hyperphagia
,
louisiana
,
obesity
,
ohio
Diabetes August 2012, Vol.61, 2394. doi:https://doi.org/10.2337/db12-ie09
Diabetes Digests
Highlights From the Latest in Diabetes Research
Topics:
bariatric surgery
,
diabetes mellitus, type 2
,
inflammation
,
medical management
,
obesity
Diabetes August 2012, Vol.61, 2395-2396. doi:https://doi.org/10.2337/db12-dd09
Online Letters to the Editor
Comment on: Gögebakan et al. Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids. Diabetes 2012;61:292–300
Topics:
glucose
,
hydroxysteroids
,
nonesterified fatty acids
,
oxidoreductase
Diabetes August 2012, Vol.61, e12. doi:https://doi.org/10.2337/db12-0219
Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652
Topics:
diet, high-fat
,
hydroxysteroids
,
oxidoreductase
Diabetes August 2012, Vol.61, e13. doi:https://doi.org/10.2337/db12-0556
Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652
Topics:
diet, high-fat
,
hydroxysteroids
,
oxidoreductase
,
heart failure
Diabetes August 2012, Vol.61, e14. doi:https://doi.org/10.2337/db12-0583