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1 January 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
Perspectives in Diabetes
Acylcarnitines: Reflecting or Inflicting Insulin Resistance?
Diabetes December 2012, Vol.62, 1-8. doi:https://doi.org/10.2337/db12-0466
Recent Lessons Learned From Prevention and Recent-Onset Type 1 Diabetes Immunotherapy Trials
Diabetes December 2012, Vol.62, 9-17. doi:https://doi.org/10.2337/db12-0562
Commentary
Dual Trade of Bcl-2 and Bcl-xL in Islet Physiology: Balancing Life and Death With Metabolism Secretion Coupling
Diabetes December 2012, Vol.62, 18-21. doi:https://doi.org/10.2337/db12-1023
Diabetes in Early Pregnancy: Getting to the Heart of the Matter
Diabetes December 2012, Vol.62, 27-28. doi:https://doi.org/10.2337/db12-1117
A Transcriptional Blueprint for Human and Murine Diabetic Kidney Disease
Diabetes December 2012, Vol.62, 31-33. doi:https://doi.org/10.2337/db12-1121
Technological Advances
Metabolism
Plasma Levels of Fetuin-A and Hepatic Enzymes and Risk of Type 2 Diabetes in Women in the U.S.
Diabetes December 2012, Vol.62, 49-55. doi:https://doi.org/10.2337/db12-0372
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
Sebastian Beck Jorgensen; Hayley M. O’Neill; Lykke Sylow; Jane Honeyman; Kimberly A. Hewitt; Rengasamy Palanivel; Morgan D. Fullerton; Lisa Öberg; Anudharan Balendran; Sandra Galic; Chris van der Poel; Ian A. Trounce; Gordon S. Lynch; Jonathan D. Schertzer; Gregory R. Steinberg
Diabetes December 2012, Vol.62, 56-64. doi:https://doi.org/10.2337/db12-0443
Increased Hepatic Glucose Production in Fetal Sheep With Intrauterine Growth Restriction Is Not Suppressed by Insulin
Diabetes December 2012, Vol.62, 65-73. doi:https://doi.org/10.2337/db11-1727
Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog
Christopher J. Ramnanan; Guillaume Kraft; Marta S. Smith; Ben Farmer; Doss Neal; Phillip E. Williams; Margaret Lautz; Tiffany Farmer; E. Patrick Donahue; Alan D. Cherrington; Dale S. Edgerton
Diabetes December 2012, Vol.62, 74-84. doi:https://doi.org/10.2337/db12-0148
PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner
Diabetes December 2012, Vol.62, 85-95. doi:https://doi.org/10.2337/db12-0291
Liver Glycogen Loading Dampens Glycogen Synthesis Seen in Response to Either Hyperinsulinemia or Intraportal Glucose Infusion
Jason J. Winnick; Zhibo An; Guillaume Kraft; Christopher J. Ramnanan; Jose M. Irimia; Marta Smith; Margaret Lautz; Peter J. Roach; Alan D. Cherrington
Diabetes December 2012, Vol.62, 96-101. doi:https://doi.org/10.2337/db11-1773
Signal Transduction
Central Resistin Overexposure Induces Insulin Resistance Through Toll-Like Receptor 4
Yacir Benomar; Arieh Gertler; Pamela De Lacy; Delphine Crépin; Hassina Ould Hamouda; Laure Riffault; Mohammed Taouis
Diabetes December 2012, Vol.62, 102-114. doi:https://doi.org/10.2337/db12-0237
Obesity Studies
Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity
Rumana Yasmeen; Barbara Reichert; Jeffrey Deiuliis; Fangping Yang; Alisha Lynch; Joseph Meyers; Molly Sharlach; Sangsu Shin; Katharina S. Volz; Kari B. Green; Kichoon Lee; Hansjuerg Alder; Gregg Duester; Rudolf Zechner; Sanjay Rajagopalan; Ouliana Ziouzenkova
Diabetes December 2012, Vol.62, 124-136. doi:https://doi.org/10.2337/db11-1779
Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei
Patrícia O. Prada; Paula G.F. Quaresma; Andrea M. Caricilli; Andressa C. Santos; Dioze Guadagnini; Joseane Morari; Laís Weissmann; Eduardo R. Ropelle; José Barreto C. Carvalheira; Lício A. Velloso; Mario J.A. Saad
Diabetes December 2012, Vol.62, 137-148. doi:https://doi.org/10.2337/db11-1388
A Potential Role for Dendritic Cell/Macrophage-Expressing DPP4 in Obesity-Induced Visceral Inflammation
Jixin Zhong; Xiaoquan Rao; Jeffrey Deiuliis; Zachary Braunstein; Vimal Narula; Jeffrey Hazey; Dean Mikami; Bradley Needleman; Abhay R. Satoskar; Sanjay Rajagopalan
Diabetes December 2012, Vol.62, 149-157. doi:https://doi.org/10.2337/db12-0230
Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis
Sana Basseri; Šárka Lhoták; Morgan D. Fullerton; Rengasamy Palanivel; Hua Jiang; Edward G. Lynn; Rebecca J. Ford; Kenneth N. Maclean; Gregory R. Steinberg; Richard C. Austin
Diabetes December 2012, Vol.62, 158-169. doi:https://doi.org/10.2337/db12-0256
Islet Studies
Bcl-2 and Bcl-xL Suppress Glucose Signaling in Pancreatic β-Cells
Dan S. Luciani; Sarah A. White; Scott B. Widenmaier; Varun V. Saran; Farnaz Taghizadeh; Xiaoke Hu; Michael F. Allard; James D. Johnson
Diabetes December 2012, Vol.62, 170-182. doi:https://doi.org/10.2337/db11-1464
The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival
Wendy M. McKimpson; Jeremy Weinberger; Lech Czerski; Min Zheng; Michael T. Crow; Jeffrey E. Pessin; Streamson C. Chua, Jr.; Richard N. Kitsis
Diabetes December 2012, Vol.62, 183-193. doi:https://doi.org/10.2337/db12-0504
Immunology and Transplantation
Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes
Diabetes December 2012, Vol.62, 194-204. doi:https://doi.org/10.2337/db12-0420
Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity
Robin R. Knight; Deborah Kronenberg; Min Zhao; Guo Cai Huang; Martin Eichmann; Anna Bulek; Linda Wooldridge; David K. Cole; Andrew K. Sewell; Mark Peakman; Ania Skowera
Diabetes December 2012, Vol.62, 205-213. doi:https://doi.org/10.2337/db12-0315
The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2β, Are Crucial to Autoantibody Binding in Type 1 Diabetes
Karen T. Elvers; Ivey Geoghegan; Debbie K. Shoemark; Vito Lampasona; Polly J. Bingley; Alistair J.K. Williams
Diabetes December 2012, Vol.62, 214-222. doi:https://doi.org/10.2337/db11-1590
Pathophysiology
Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice
Masao Takeda; Koichi Yamamoto; Yukihiro Takemura; Hikari Takeshita; Kazuhiro Hongyo; Tatsuo Kawai; Hiroko Hanasaki-Yamamoto; Ryosuke Oguro; Yoichi Takami; Yuji Tatara; Yasushi Takeya; Ken Sugimoto; Kei Kamide; Mitsuru Ohishi; Hiromi Rakugi
Diabetes December 2012, Vol.62, 223-233. doi:https://doi.org/10.2337/db12-0177
Hyperglycemia Slows Embryonic Growth and Suppresses Cell Cycle via Cyclin D1 and p21
Diabetes December 2012, Vol.62, 234-242. doi:https://doi.org/10.2337/db12-0161
Complications
C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation
Diabetes December 2012, Vol.62, 243-253. doi:https://doi.org/10.2337/db12-0293
Corneal Confocal Microscopy Detects Early Nerve Regeneration in Diabetic Neuropathy After Simultaneous Pancreas and Kidney Transplantation
Mitra Tavakoli; Maria Mitu-Pretorian; Ioannis N. Petropoulos; Hassan Fadavi; Omar Asghar; Uazman Alam; Georgios Ponirakis; Maria Jeziorska; Andy Marshall; Nathan Efron; Andrew J. Boulton; Titus Augustine; Rayaz A. Malik
Diabetes December 2012, Vol.62, 254-260. doi:https://doi.org/10.2337/db12-0574
Therapeutic Effects of PPARα Agonists on Diabetic Retinopathy in Type 1 Diabetes Models
Ying Chen; Yang Hu; Mingkai Lin; Alicia J. Jenkins; Anthony C. Keech; Robert Mott; Timothy J. Lyons; Jian-xing Ma
Diabetes December 2012, Vol.62, 261-272. doi:https://doi.org/10.2337/db11-0413
Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow
Ashay D. Bhatwadekar; Yuanqing Yan; Xiaoping Qi; Jeffrey S. Thinschmidt; Matthew B. Neu; Sergio Li Calzi; Lynn C. Shaw; James M. Dominiguez; Julia V. Busik; Choogon Lee; Michael E. Boulton; Maria B. Grant
Diabetes December 2012, Vol.62, 273-282. doi:https://doi.org/10.2337/db12-0172
Pharmacology and Therapeutics
Activation of Enteroendocrine Membrane Progesterone Receptors Promotes Incretin Secretion and Improves Glucose Tolerance in Mice
Diabetes December 2012, Vol.62, 283-290. doi:https://doi.org/10.2337/db12-0601
Genetics / Genomes / Proteomics / Metabolomics
A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans
Huaixing Li; Wei Gan; Ling Lu; Xiao Dong; Xueyao Han; Cheng Hu; Zhen Yang; Liang Sun; Wei Bao; Pengtao Li; Meian He; Liangdan Sun; Yiqin Wang; Jingwen Zhu; Qianqian Ning; Yong Tang; Rong Zhang; Jie Wen; Di Wang; Xilin Zhu; Kunquan Guo; Xianbo Zuo; Xiaohui Guo; Handong Yang; Xianghai Zhou; DIAGRAM Consortium; AGEN-T2D Consortium; Xuejun Zhang; Lu Qi; Ruth J.F. Loos; Frank B. Hu; Tangchun Wu; Ying Liu; Liegang Liu; Ze Yang; Renming Hu; Weiping Jia; Linong Ji; Yixue Li; Xu Lin
Diabetes December 2012, Vol.62, 291-298. doi:https://doi.org/10.2337/db12-0454
Identification of Cross-Species Shared Transcriptional Networks of Diabetic Nephropathy in Human and Mouse Glomeruli
Jeffrey B. Hodgin; Viji Nair; Hongyu Zhang; Ann Randolph; Raymond C. Harris; Robert G. Nelson; E. Jennifer Weil; James D. Cavalcoli; Jignesh M. Patel; Frank C. Brosius, III; Matthias Kretzler
Diabetes December 2012, Vol.62, 299-308. doi:https://doi.org/10.2337/db11-1667
Statement of Retraction
Blockade of receptor for advanced glycation end products in a model of type 1 diabetic leukoencephalopathy. Diabetes. 19 November 2012 [Epub ahead of print]
N Rincon; K Xu; J Li; JA Martinez; GS Singh; D Han; P Lalli; A Ayer; K Tse; L Rong; AM Schmidt; CC Toth
Diabetes December 2012, Vol.62, 309. doi:https://doi.org/10.2337/db12-0317
