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1 October 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes September 2013, Vol.62, 3305-3306. doi:https://doi.org/10.2337/db13-ti10
Perspectives in Diabetes
Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
Richard J. Johnson; Takahiko Nakagawa; L. Gabriela Sanchez-Lozada; Mohamed Shafiu; Shikha Sundaram; Myphuong Le; Takuji Ishimoto; Yuri Y. Sautin; Miguel A. Lanaspa
Diabetes September 2013, Vol.62, 3307-3315. doi:https://doi.org/10.2337/db12-1814
Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls
Diabetes September 2013, Vol.62, 3316-3323. doi:https://doi.org/10.2337/db13-0822
Novel Hypothesis to Explain Why SGLT2 Inhibitors Inhibit Only 30–50% of Filtered Glucose Load in Humans
Diabetes September 2013, Vol.62, 3324-3328. doi:https://doi.org/10.2337/db13-0604
Commentary
Diabetes and the Heart: Is There Objective Evidence of a Human Diabetic Cardiomyopathy?
Diabetes September 2013, Vol.62, 3329-3330. doi:https://doi.org/10.2337/db13-0683
A New Home for Pancreatic Islet Transplants: The Bone Marrow
Diabetes September 2013, Vol.62, 3333-3335. doi:https://doi.org/10.2337/db13-1039
How Sweet It Is: Intestinal Sweet Taste Receptors in Type 2 Diabetes
Diabetes September 2013, Vol.62, 3336-3337. doi:https://doi.org/10.2337/db13-1018
Genetic Dissection of Diabetes: Facing the Giant
Diabetes September 2013, Vol.62, 3338-3340. doi:https://doi.org/10.2337/db13-1154
Methodology Review
Assessing the Human Gut Microbiota in Metabolic Diseases
Diabetes September 2013, Vol.62, 3341-3349. doi:https://doi.org/10.2337/db13-0844
Original Research
Metabolism
Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity
Mitch T. Sitnick; Mahesh K. Basantani; Lingzhi Cai; Gabriele Schoiswohl; Cynthia F. Yazbeck; Giovanna Distefano; Vladimir Ritov; James P. DeLany; Renate Schreiber; Donna B. Stolz; Noah P. Gardner; Petra C. Kienesberger; Thomas Pulinilkunnil; Rudolf Zechner; Bret H. Goodpaster; Paul Coen; Erin E. Kershaw
Diabetes September 2013, Vol.62, 3350-3361. doi:https://doi.org/10.2337/db13-0500
Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats
Barbara E. Hasek; Anik Boudreau; Jeho Shin; Daorong Feng; Matthew Hulver; Nancy T. Van; Amanda Laque; Laura K. Stewart; Kirsten P. Stone; Desiree Wanders; Sujoy Ghosh; Jeffrey E. Pessin; Thomas W. Gettys
Diabetes September 2013, Vol.62, 3362-3372. doi:https://doi.org/10.2337/db13-0501
Blunted Refeeding Response and Increased Locomotor Activity in Mice Lacking FoxO1 in Synapsin-Cre–Expressing Neurons
Hongxia Ren; Leona Plum-Morschel; Roger Gutierrez-Juarez; Taylor Y. Lu; Ja Young Kim-Muller; Garrett Heinrich; Sharon L. Wardlaw; Rae Silver; Domenico Accili
Diabetes September 2013, Vol.62, 3373-3383. doi:https://doi.org/10.2337/db13-0597
Dissociation of Intestinal and Hepatic Activities of FXR and LXRα Supports Metabolic Effects of Terminal Ileum Interposition in Rodents
Andrea Mencarelli; Barbara Renga; Claudio D’Amore; Chiara Santorelli; Luigina Graziosi; Angela Bruno; Maria Chiara Monti; Eleonora Distrutti; Sabrina Cipriani; Annibale Donini; Stefano Fiorucci
Diabetes September 2013, Vol.62, 3384-3393. doi:https://doi.org/10.2337/db13-0299
Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization
Diabetes September 2013, Vol.62, 3394-3403. doi:https://doi.org/10.2337/db12-1327
Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation
Enxuan Jing; Brian T. O’Neill; Matthew J. Rardin; André Kleinridders; Olga R. Ilkeyeva; Siegfried Ussar; James R. Bain; Kevin Y. Lee; Eric M. Verdin; Christopher B. Newgard; Bradford W. Gibson; C. Ronald Kahn
Diabetes September 2013, Vol.62, 3404-3417. doi:https://doi.org/10.2337/db12-1650
Oxytocin Reduces Reward-Driven Food Intake in Humans
Volker Ott; Graham Finlayson; Hendrik Lehnert; Birte Heitmann; Markus Heinrichs; Jan Born; Manfred Hallschmid
Diabetes September 2013, Vol.62, 3418-3425. doi:https://doi.org/10.2337/db13-0663
Mitochondrial Substrate Availability and Its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signaling in Skeletal Muscle
Christopher Lipina; Katherine Macrae; Tamara Suhm; Cora Weigert; Agnieszka Blachnio-Zabielska; Marcin Baranowski; Jan Gorski; Karl Burgess; Harinder S. Hundal
Diabetes September 2013, Vol.62, 3426-3436. doi:https://doi.org/10.2337/db13-0264
Signal Transduction
Impairments in Site-Specific AS160 Phosphorylation and Effects of Exercise Training
Leslie A. Consitt; Jessica Van Meter; Christopher A. Newton; David N. Collier; Moahad S. Dar; Jørgen F.P. Wojtaszewski; Jonas T. Treebak; Charles J. Tanner; Joseph A. Houmard
Diabetes September 2013, Vol.62, 3437-3447. doi:https://doi.org/10.2337/db13-0229
Islet Studies
Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells
Jun Shirakawa; Yu Togashi; Eri Sakamoto; Mitsuyo Kaji; Kazuki Tajima; Kazuki Orime; Hideaki Inoue; Naoto Kubota; Takashi Kadowaki; Yasuo Terauchi
Diabetes September 2013, Vol.62, 3448-3458. doi:https://doi.org/10.2337/db13-0052
PDX1 in Ducts Is Not Required for Postnatal Formation of β-Cells but Is Necessary for Their Subsequent Maturation
Lili Guo; Akari Inada; Cristina Aguayo-Mazzucato; Jennifer Hollister-Lock; Yoshio Fujitani; Gordon C. Weir; Christopher V.E. Wright; Arun Sharma; Susan Bonner-Weir
Diabetes September 2013, Vol.62, 3459-3468. doi:https://doi.org/10.2337/db12-1833
Consequences of Exposure to Light at Night on the Pancreatic Islet Circadian Clock and Function in Rats
Diabetes September 2013, Vol.62, 3469-3478. doi:https://doi.org/10.2337/db12-1543
Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development
Carmen Capito; Marie-Thérèse Simon; Virginie Aiello; Anne Clark; Yves Aigrain; Philippe Ravassard; Raphael Scharfmann
Diabetes September 2013, Vol.62, 3479-3487. doi:https://doi.org/10.2337/db13-0554
Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
Jennifer L. Fiori; Yu-Kyong Shin; Wook Kim; Susan M. Krzysik-Walker; Isabel González-Mariscal; Olga D. Carlson; Mitesh Sanghvi; Ruin Moaddel; Kathleen Farhang; Shekhar K. Gadkaree; Maire E. Doyle; Kevin J. Pearson; Julie A. Mattison; Rafael de Cabo; Josephine M. Egan
Diabetes September 2013, Vol.62, 3500-3513. doi:https://doi.org/10.2337/db13-0266
Development of the Human Pancreas From Foregut to Endocrine Commitment
Rachel E. Jennings; Andrew A. Berry; Rebecca Kirkwood-Wilson; Neil A. Roberts; Thomas Hearn; Rachel J. Salisbury; Jennifer Blaylock; Karen Piper Hanley; Neil A. Hanley
Diabetes September 2013, Vol.62, 3514-3522. doi:https://doi.org/10.2337/db12-1479
Immunology and Transplantation
Autologous Pancreatic Islet Transplantation in Human Bone Marrow
Paola Maffi; Gianpaolo Balzano; Maurilio Ponzoni; Rita Nano; Valeria Sordi; Raffaella Melzi; Alessia Mercalli; Marina Scavini; Antonio Esposito; Jacopo Peccatori; Elisa Cantarelli; Carlo Messina; Massimo Bernardi; Alessandro Del Maschio; Carlo Staudacher; Claudio Doglioni; Fabio Ciceri; Antonio Secchi; Lorenzo Piemonti
Diabetes September 2013, Vol.62, 3523-3531. doi:https://doi.org/10.2337/db13-0465
Pathophysiology
Disordered Control of Intestinal Sweet Taste Receptor Expression and Glucose Absorption in Type 2 Diabetes
Richard L. Young; Bridgette Chia; Nicole J. Isaacs; Jing Ma; Joan Khoo; Tongzhi Wu; Michael Horowitz; Christopher K. Rayner
Diabetes September 2013, Vol.62, 3532-3541. doi:https://doi.org/10.2337/db13-0581
More Than 20 Years of Registration of Type 1 Diabetes in Sardinian Children: Temporal Variations of Incidence With Age, Period of Diagnosis, and Year of Birth
Graziella Bruno; Milena Maule; Annibale Biggeri; Alessia Ledda; Carla Mannu; Franco Merletti; Marco Songini; the Sardinian Group for Diabetes Epidemiology
Diabetes September 2013, Vol.62, 3542-3546. doi:https://doi.org/10.2337/db12-1771
Complications
Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor
Emily Jane Gallagher; Nyosha Alikhani; Aviva Tobin-Hess; Jeffrey Blank; Nicholas J. Buffin; Zara Zelenko; Norbert Tennagels; Ulrich Werner; Derek LeRoith
Diabetes September 2013, Vol.62, 3553-3560. doi:https://doi.org/10.2337/db13-0249
Effects of Prior Intensive Versus Conventional Therapy and History of Glycemia on Cardiac Function in Type 1 Diabetes in the DCCT/EDIC
Saul M. Genuth; Jye-Yu C. Backlund; Margaret Bayless; David A. Bluemke; Patricia A. Cleary; Jill Crandall; John M. Lachin; Joao A.C. Lima; Culian Miao; Evrim B. Turkbey; for the DCCT/EDIC Research Group
Diabetes September 2013, Vol.62, 3561-3569. doi:https://doi.org/10.2337/db12-0546
Severe Hypoglycemia–Induced Lethal Cardiac Arrhythmias Are Mediated by Sympathoadrenal Activation
Candace M. Reno; Dorit Daphna-Iken; Y. Stefanie Chen; Jennifer VanderWeele; Krishan Jethi; Simon J. Fisher
Diabetes September 2013, Vol.62, 3570-3581. doi:https://doi.org/10.2337/db13-0216
Pharmacology and Therapeutics
Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats
Jana Mahadevan; Susan Parazzoli; Elizabeth Oseid; Ann V. Hertzel; David A. Bernlohr; Sara N. Vallerie; Chang-qin Liu; Melissa Lopez; Jamie S. Harmon; R. Paul Robertson
Diabetes September 2013, Vol.62, 3582-3588. doi:https://doi.org/10.2337/db13-0357
Genetics / Genomes / Proteomics / Metabolomics
Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
Hanieh Yaghootkar; Claudia Lamina; Robert A. Scott; Zari Dastani; Marie-France Hivert; Liling L. Warren; Alena Stancáková; Sarah G. Buxbaum; Leo-Pekka Lyytikäinen; Peter Henneman; Ying Wu; Chloe Y.Y. Cheung; James S. Pankow; Anne U. Jackson; Stefan Gustafsson; Jing Hua Zhao; Christie M. Ballantyne; Weijia Xie; Richard N. Bergman; Michael Boehnke; Fatiha el Bouazzaoui; Francis S. Collins; Sandra H. Dunn; Josee Dupuis; Nita G. Forouhi; Christopher Gillson; Andrew T. Hattersley; Jaeyoung Hong; Mika Kähönen; Johanna Kuusisto; Lyudmyla Kedenko; Florian Kronenberg; Alessandro Doria; Themistocles L. Assimes; Ele Ferrannini; Torben Hansen; Ke Hao; Hans Häring; Joshua W. Knowles; Cecilia M. Lindgren; John J. Nolan; Jussi Paananen; Oluf Pedersen; Thomas Quertermous; Ulf Smith; the GENESIS Consortium; the RISC Consortium; Terho Lehtimäki; Ching-Ti Liu; Ruth J.F. Loos; Mark I. McCarthy; Andrew D. Morris; Ramachandran S. Vasan; Tim D. Spector; Tanya M. Teslovich; Jaakko Tuomilehto; Ko Willems van Dijk; Jorma S. Viikari; Na Zhu; Claudia Langenberg; Erik Ingelsson; Robert K. Semple; Alan R. Sinaiko; Colin N.A. Palmer; Mark Walker; Karen S.L. Lam; Bernhard Paulweber; Karen L. Mohlke; Cornelia van Duijn; Olli T. Raitakari; Aurelian Bidulescu; Nick J. Wareham; Markku Laakso; Dawn M. Waterworth; Debbie A. Lawlor; James B. Meigs; J. Brent Richards; Timothy M. Frayling
Diabetes September 2013, Vol.62, 3589-3598. doi:https://doi.org/10.2337/db13-0128
ADAMTS13 Predicts Renal and Cardiovascular Events in Type 2 Diabetic Patients and Response to Therapy
Erica Rurali; Marina Noris; Antonietta Chianca; Roberta Donadelli; Federica Banterla; Miriam Galbusera; Giulia Gherardi; Sara Gastoldi; Aneliya Parvanova; Ilian Iliev; Antonio Bossi; Carolina Haefliger; Roberto Trevisan; Giuseppe Remuzzi; Piero Ruggenenti; for the BENEDICT Study Group
Diabetes September 2013, Vol.62, 3599-3609. doi:https://doi.org/10.2337/db13-0530
Genetic Risk Score of 46 Type 2 Diabetes Risk Variants Associates With Changes in Plasma Glucose and Estimates of Pancreatic β-Cell Function Over 5 Years of Follow-Up
Ehm A. Andersson; Kristine H. Allin; Camilla H. Sandholt; Anders Borglykke; Cathrine J. Lau; Rasmus Ribel-Madsen; Thomas Sparsø; Johanne M. Justesen; Marie N. Harder; Marit E. Jørgensen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Diabetes September 2013, Vol.62, 3610-3617. doi:https://doi.org/10.2337/db13-0362
Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men
Yuvaraj Mahendran; Jagadish Vangipurapu; Henna Cederberg; Alena Stančáková; Jussi Pihlajamäki; Pasi Soininen; Antti J. Kangas; Jussi Paananen; Mete Civelek; Niyas K. Saleem; Päivi Pajukanta; Aldons J. Lusis; Lori L. Bonnycastle; Mario A. Morken; Francis S. Collins; Karen L. Mohlke; Michael Boehnke; Mika Ala-Korpela; Johanna Kuusisto; Markku Laakso
Diabetes September 2013, Vol.62, 3618-3626. doi:https://doi.org/10.2337/db12-1363
Genetic Modifiers of Cystic Fibrosis–Related Diabetes
Scott M. Blackman; Clayton W. Commander; Christopher Watson; Kristin M. Arcara; Lisa J. Strug; Jaclyn R. Stonebraker; Fred A. Wright; Johanna M. Rommens; Lei Sun; Rhonda G. Pace; Sarah A. Norris; Peter R. Durie; Mitchell L. Drumm; Michael R. Knowles; Garry R. Cutting
Diabetes September 2013, Vol.62, 3627-3635. doi:https://doi.org/10.2337/db13-0510
Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life
Jorma Ilonen; Anna Hammais; Antti-Pekka Laine; Johanna Lempainen; Outi Vaarala; Riitta Veijola; Olli Simell; Mikael Knip
Diabetes September 2013, Vol.62, 3636-3640. doi:https://doi.org/10.2337/db13-0300
Original Article
Islet Studies
Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development
Sachin Supale; Fabrizio Thorel; Carsten Merkwirth; Asllan Gjinovci; Pedro L. Herrera; Luca Scorrano; Paolo Meda; Thomas Langer; Pierre Maechler
Diabetes September 2013, Vol.62, 3488-3499. doi:https://doi.org/10.2337/db13-0152
Pathophysiology
Combination Pravastatin and Valsartan Treatment Has Additive Beneficial Effects to Simultaneously Improve Both Metabolic and Cardiovascular Phenotypes Beyond That of Monotherapy With Either Drug in Patients With Primary Hypercholesterolemia
Kwang Kon Koh; Soo Lim; Hanul Choi; Yonghee Lee; Seung Hwan Han; Kyounghoon Lee; Pyung Chun Oh; Ichiro Sakuma; Eak Kyun Shin; Michael J. Quon
Diabetes September 2013, Vol.62, 3547-3552. doi:https://doi.org/10.2337/db13-0566
Erratum
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes 2013;62:3282–3291
MG Hayes; M Urbanek; M-F Hivert; LL Armstrong; J Morrison; C Guo; LP Lowe; DA Scheftner; A Pluzhnikov; DM Levine; CP McHugh; CM Ackerman; L Bouchard; D Brisson; BT Layden; D Mirel; KF Doheny; MV Leya; RN Lown-Hecht; AR Dyer; BE Metzger; TE Reddy; NJ Cox; WL Lowe, Jr.; for the HAPO Study Cooperative Research Group.
Diabetes September 2013, Vol.62, 3641. doi:https://doi.org/10.2337/db13-er10
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes September 2013, Vol.62, 3643-3644. doi:https://doi.org/10.2337/db13-dd10
Online Letters to the Editor
Comment on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604
Diabetes September 2013, Vol.62, e16-e17. doi:https://doi.org/10.2337/db13-0690
Comment on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604
Diabetes September 2013, Vol.62, e18. doi:https://doi.org/10.2337/db13-0525
Reponse to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604
Alexandra E. Butler; Martha Campbell-Thompson; Tatyana Gurlo; David W. Dawson; Mark Atkinson; Peter C. Butler
Diabetes September 2013, Vol.62, e19-e22. doi:https://doi.org/10.2337/db13-0996
Comment on: Selvin et al. sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death. Diabetes 2013;62:2116–2121
Diabetes September 2013, Vol.62, e25. doi:https://doi.org/10.2337/db13-1031
Comment on: Selvin et al. sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death. Diabetes 2013;62:2116–2121
Diabetes September 2013, Vol.62, e26. doi:https://doi.org/10.2337/db13-1004
Response to Comments on: Selvin et al. sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death. Diabetes 2013;62:2116–2121
Diabetes September 2013, Vol.62, e27. doi:https://doi.org/10.2337/db13-1152