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1 November 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes October 2013, Vol.62, 3645-3646. doi:https://doi.org/10.2337/db13-ti11
Perspectives in Diabetes
Endothelial-Podocyte Crosstalk: The Missing Link Between Endothelial Dysfunction and Albuminuria in Diabetes
Diabetes October 2013, Vol.62, 3647-3655. doi:https://doi.org/10.2337/db13-0795
Commentary
Location, Location, Location?: Is the Pain of Diabetic Neuropathy Generated by Hyperactive Sensory Neurons?
Diabetes October 2013, Vol.62, 3658-3660. doi:https://doi.org/10.2337/db13-1158
Cholesterol Accumulation in Podocytes: A Potential Novel Targetable Pathway in Diabetic Nephropathy
Diabetes October 2013, Vol.62, 3661-3662. doi:https://doi.org/10.2337/db13-1167
How Does Pioglitazone Prevent Progression of Impaired Glucose Tolerance to Diabetes?
Diabetes October 2013, Vol.62, 3663-3665. doi:https://doi.org/10.2337/db13-1175
ATP and Sulfonylurea Linkage in the KATP Channel Solves a Diabetes Puzzler
Diabetes October 2013, Vol.62, 3666-3668. doi:https://doi.org/10.2337/db13-1194
Depleting T Cells in Newly Diagnosed Autoimmune (Type 1) Diabetes—Are We Getting Anywhere?
Diabetes October 2013, Vol.62, 3669-3670. doi:https://doi.org/10.2337/db13-1207
Going With the Flow: Adaptation of β-Cell Function to Glucose Fluxes After Bariatric Surgery
Diabetes October 2013, Vol.62, 3671-3673. doi:https://doi.org/10.2337/db13-1213
GABAergic System in β-Cells: From Autoimmunity Target to Regeneration Tool
Diabetes October 2013, Vol.62, 3674-3676. doi:https://doi.org/10.2337/db13-1243
Methodology Review
Assessing Decreased Sensation and Increased Sensory Phenomena in Diabetic Polyneuropathies
Diabetes October 2013, Vol.62, 3677-3686. doi:https://doi.org/10.2337/db13-0352
Original Research
Technological Advances
Age-Dependent Labeling and Imaging of Insulin Secretory Granules
Anna Ivanova; Yannis Kalaidzidis; Ronald Dirkx; Mihail Sarov; Michael Gerlach; Britta Schroth-Diez; Andreas Müller; Yanmei Liu; Cordula Andree; Bernard Mulligan; Carla Münster; Thomas Kurth; Marc Bickle; Stephan Speier; Konstantinos Anastassiadis; Michele Solimena
Diabetes October 2013, Vol.62, 3687-3696. doi:https://doi.org/10.2337/db12-1819
Metabolism
Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
Stefania Carobbio; Rachel M. Hagen; Christopher J. Lelliott; Marc Slawik; Gema Medina-Gomez; Chong-Yew Tan; Audrey Sicard; Helen J. Atherton; Nuria Barbarroja; Mikael Bjursell; Mohammad Bohlooly-Y; Sam Virtue; Antoinette Tuthill; Etienne Lefai; Martine Laville; Tingting Wu; Robert V. Considine; Hubert Vidal; Dominique Langin; Matej Oresic; Francisco J. Tinahones; Jose Manuel Fernandez-Real; Julian L. Griffin; Jaswinder K. Sethi; Miguel López; Antonio Vidal-Puig
Diabetes October 2013, Vol.62, 3697-3708. doi:https://doi.org/10.2337/db12-1748
Obesity Studies
Long-Term Effects of Bariatric Surgery on Meal Disposal and β-Cell Function in Diabetic and Nondiabetic Patients
Stefania Camastra; Elza Muscelli; Amalia Gastaldelli; Jens J. Holst; Brenno Astiarraga; Simona Baldi; Monica Nannipieri; Demetrio Ciociaro; Marco Anselmino; Andrea Mari; Ele Ferrannini
Diabetes October 2013, Vol.62, 3709-3717. doi:https://doi.org/10.2337/db13-0321
Profilin-1 Haploinsufficiency Protects Against Obesity-Associated Glucose Intolerance and Preserves Adipose Tissue Immune Homeostasis
Diabetes October 2013, Vol.62, 3718-3726. doi:https://doi.org/10.2337/db13-0050
Maternal Obesity Induces Epigenetic Modifications to Facilitate Zfp423 Expression and Enhance Adipogenic Differentiation in Fetal Mice
Diabetes October 2013, Vol.62, 3727-3735. doi:https://doi.org/10.2337/db13-0433
Overnutrition Stimulates Intestinal Epithelium Proliferation Through β-Catenin Signaling in Obese Mice
Jiaming Mao; Xiaomin Hu; Yao Xiao; Chao Yang; Yi Ding; Ning Hou; Jue Wang; Heping Cheng; Xiuqin Zhang
Diabetes October 2013, Vol.62, 3736-3746. doi:https://doi.org/10.2337/db13-0035
Downregulation of CPPED1 Expression Improves Glucose Metabolism In Vitro in Adipocytes
Maija Vaittinen; Dorota Kaminska; Pirjo Käkelä; Matti Eskelinen; Marjukka Kolehmainen; Jussi Pihlajamäki; Matti Uusitupa; Leena Pulkkinen
Diabetes October 2013, Vol.62, 3747-3750. doi:https://doi.org/10.2337/db13-0830
Islet Studies
High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator–Activated Receptor γ Signaling
Wing Yan So; Qianni Cheng; Lihua Chen; Carmella Evans-Molina; Aimin Xu; Karen S.L. Lam; Po Sing Leung
Diabetes October 2013, Vol.62, 3751-3759. doi:https://doi.org/10.2337/db13-0645
γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells
Diabetes October 2013, Vol.62, 3760-3765. doi:https://doi.org/10.2337/db13-0931
Immunology and Transplantation
Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial: Metabolic and Immunologic Features at Baseline Identify a Subgroup of Responders
Kevan C. Herold; Stephen E. Gitelman; Mario R. Ehlers; Peter A. Gottlieb; Carla J. Greenbaum; William Hagopian; Karen D. Boyle; Lynette Keyes-Elstein; Sudeepta Aggarwal; Deborah Phippard; Peter H. Sayre; James McNamara; Jeffrey A. Bluestone; and the AbATE Study Team
Diabetes October 2013, Vol.62, 3766-3774. doi:https://doi.org/10.2337/db13-0345
β-Cell–Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice
Mark C. Johnson; Alaina L. Garland; Sarah C. Nicolson; Chengwen Li; R. Jude Samulski; Bo Wang; Roland Tisch
Diabetes October 2013, Vol.62, 3775-3784. doi:https://doi.org/10.2337/db13-0669
Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation: Role of Suppressive Macrophages
Liana Ghazarian; Julien Diana; Lucie Beaudoin; Pär G. Larsson; Raj K. Puri; Nico van Rooijen; Malin Flodström-Tullberg; Agnès Lehuen
Diabetes October 2013, Vol.62, 3785-3796. doi:https://doi.org/10.2337/db12-0958
Pathophysiology
A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1
Kenju Shimomura; Maija Tusa; Michaela Iberl; Melissa F. Brereton; Stephan Kaizik; Peter Proks; Carolina Lahmann; Nagendra Yaluri; Shalem Modi; Hanna Huopio; Jarkko Ustinov; Timo Otonkoski; Markku Laakso; Frances M. Ashcroft
Diabetes October 2013, Vol.62, 3797-3806. doi:https://doi.org/10.2337/db12-1611
Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice
Sébastien Blaise; Béatrice Romier; Charlotte Kawecki; Maxime Ghirardi; Fanja Rabenoelina; Stéphanie Baud; Laurent Duca; Pascal Maurice; Andrea Heinz; Christian E.H. Schmelzer; Michel Tarpin; Laurent Martiny; Christian Garbar; Manuel Dauchez; Laurent Debelle; Vincent Durlach
Diabetes October 2013, Vol.62, 3807-3816. doi:https://doi.org/10.2337/db13-0508
Complications
Cyclodextrin Protects Podocytes in Diabetic Kidney Disease
Sandra Merscher-Gomez; Johanna Guzman; Christopher E. Pedigo; Markku Lehto; Robier Aguillon-Prada; Armando Mendez; Mariann I. Lassenius; Carol Forsblom; TaeHyun Yoo; Rodrigo Villarreal; Dony Maiguel; Kevin Johnson; Ronald Goldberg; Viji Nair; Ann Randolph; Matthias Kretzler; Robert G. Nelson; George W. Burke, III; Per-Henrik Groop; Alessia Fornoni; the FinnDiane Study Group
Diabetes October 2013, Vol.62, 3817-3827. doi:https://doi.org/10.2337/db13-0399
Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Cav3.2 T-Type Calcium Channels
Peihan Orestes; Hari Prasad Osuru; William E. McIntire; Megan O. Jacus; Reza Salajegheh; Miljen M. Jagodic; WonJoo Choe; JeongHan Lee; Sang-Soo Lee; Kirstin E. Rose; Nathan Poiro; Michael R. DiGruccio; Katiresan Krishnan; Douglas F. Covey; Jung-Ha Lee; Paula Q. Barrett; Vesna Jevtovic-Todorovic; Slobodan M. Todorovic
Diabetes October 2013, Vol.62, 3828-3838. doi:https://doi.org/10.2337/db13-0813
Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase
Varadarajan Sudhahar; Norifumi Urao; Jin Oshikawa; Ronald D. McKinney; Roxana M. Llanos; Julian F.B. Mercer; Masuko Ushio-Fukai; Tohru Fukai
Diabetes October 2013, Vol.62, 3839-3850. doi:https://doi.org/10.2337/db12-1228
C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes
Diabetes October 2013, Vol.62, 3851-3862. doi:https://doi.org/10.2337/db13-0039
VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy
Murilo Rodrigues; Xiaoban Xin; Kathleen Jee; Savalan Babapoor-Farrokhran; Fabiana Kashiwabuchi; Tao Ma; Imran Bhutto; Syed Junaid Hassan; Yassine Daoud; David Baranano; Sharon Solomon; Gerard Lutty; Gregg L. Semenza; Silvia Montaner; Akrit Sodhi
Diabetes October 2013, Vol.62, 3863-3873. doi:https://doi.org/10.2337/db13-0014
Inhibition of Src Kinase Blocks High Glucose–Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice
Kanta Taniguchi; Ling Xia; Howard J. Goldberg; Ken W.K. Lee; Anu Shah; Laura Stavar; Elodie A.Y. Masson; Abdul Momen; Eric A. Shikatani; Rohan John; Mansoor Husain; I. George Fantus
Diabetes October 2013, Vol.62, 3874-3886. doi:https://doi.org/10.2337/db12-1010
Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance
Yajuan Qi; Zihui Xu; Qinglei Zhu; Candice Thomas; Rajesh Kumar; Hao Feng; David E. Dostal; Morris F. White; Kenneth M. Baker; Shaodong Guo
Diabetes October 2013, Vol.62, 3887-3900. doi:https://doi.org/10.2337/db13-0095
Pharmacology and Therapeutics
Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protégé Trial
William Hagopian; Robert J. Ferry, Jr.; Nicole Sherry; David Carlin; Ezio Bonvini; Syd Johnson; Kathryn E. Stein; Scott Koenig; Anastasia G. Daifotis; Kevan C. Herold; Johnny Ludvigsson; for the Protégé Trial Investigators
Diabetes October 2013, Vol.62, 3901-3908. doi:https://doi.org/10.2337/db13-0236
Molecular Mechanism of Sulphonylurea Block of KATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes
Diabetes October 2013, Vol.62, 3909-3919. doi:https://doi.org/10.2337/db13-0531
Prevention of Diabetes With Pioglitazone in ACT NOW: Physiologic Correlates
Ralph A. DeFronzo; Devjit Tripathy; Dawn C. Schwenke; MaryAnn Banerji; George A. Bray; Thomas A. Buchanan; Stephen C. Clement; Amalia Gastaldelli; Robert R. Henry; Abbas E. Kitabchi; Sunder Mudaliar; Robert E. Ratner; Frankie B. Stentz; Nicolas Musi; Peter D. Reaven; for the ACT NOW Study
Diabetes October 2013, Vol.62, 3920-3926. doi:https://doi.org/10.2337/db13-0265
Rhein Protects Pancreatic β-Cells From Dynamin-Related Protein-1–Mediated Mitochondrial Fission and Cell Apoptosis Under Hyperglycemia
Jing Liu; Zhaohong Chen; Yujing Zhang; Mingchao Zhang; Xiaodong Zhu; Yun Fan; Shaolin Shi; Ke Zen; Zhihong Liu
Diabetes October 2013, Vol.62, 3927-3935. doi:https://doi.org/10.2337/db13-0251
Genetics / Genomes / Proteomics / Metabolomics
A New Strategy for Early Diagnosis of Type 2 Diabetes by Standard-Free, Label-Free LC-MS/MS Quantification of Glycated Peptides
Diabetes October 2013, Vol.62, 3936-3942. doi:https://doi.org/10.2337/db13-0347
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation
Lori L. Bonnycastle; Peter S. Chines; Takashi Hara; Jeroen R. Huyghe; Amy J. Swift; Pirkko Heikinheimo; Jana Mahadevan; Sirkku Peltonen; Hanna Huopio; Pirjo Nuutila; Narisu Narisu; Rachel L. Goldfeder; Michael L. Stitzel; Simin Lu; Michael Boehnke; Fumihiko Urano; Francis S. Collins; Markku Laakso
Diabetes October 2013, Vol.62, 3943-3950. doi:https://doi.org/10.2337/db13-0571
Decreased Cord-Blood Phospholipids in Young Age–at–Onset Type 1 Diabetes
Daria La Torre; Tuulikki Seppänen-Laakso; Helena E. Larsson; Tuulia Hyötyläinen; Sten A. Ivarsson; Åke Lernmark; Matej Orešič; and the DiPiS Study Group
Diabetes October 2013, Vol.62, 3951-3956. doi:https://doi.org/10.2337/db13-0215
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes October 2013, Vol.62, 3958-3959. doi:https://doi.org/10.2337/db13-dd11
