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Volume 62, Issue 2
February 2013
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Mineralocorticoid Receptor–Mediated Vascular Insulin Resistance: An Early Contributor to Diabetes-Related Vascular Disease?
Shawn B. Bender; Adam P. McGraw; Iris Z. Jaffe; James R. Sowers
View articletitled, Mineralocorticoid Receptor–Mediated Vascular Insulin Resistance<span class="subtitle-colon">: </span><span class="subtitle">An Early Contributor to Diabetes-Related Vascular Disease?</span>
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Topics: aldosterone , insulin , insulin resistance , vascular diseases , signal transduction
Diabetes January 2013, Vol.62, 313-319. doi:https://doi.org/10.2337/db12-0905
Diabetes Research: A Perspective From the National Institute of Diabetes and Digestive and Kidney Diseases
Judith E. Fradkin; Griffin P. Rodgers
View articletitled, Diabetes Research: A Perspective From the National Institute of Diabetes and Digestive and Kidney Diseases
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Topics: diabetes mellitus complications , diabetes mellitus, type 1 , diabetes mellitus, type 2 , kidney diseases , obesity
Diabetes January 2013, Vol.62, 320-326. doi:https://doi.org/10.2337/db12-0269
β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
Safia Costes; Ralf Langen; Tatyana Gurlo; Aleksey V. Matveyenko; Peter C. Butler
View articletitled, β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
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Topics: amyloid , diabetes mellitus, type 2 , iapp gene , oligomers , insulin
Diabetes January 2013, Vol.62, 327-335. doi:https://doi.org/10.2337/db12-1326

Commentary

Novel Insights Into the Regulation of Postprandial Lipemia by Glucagon-Like Peptides: Significance for Diabetes
Gerald F. Watts; Dick C. Chan
View articletitled, Novel Insights Into the Regulation of Postprandial Lipemia by Glucagon-Like Peptides: Significance for Diabetes
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Topics: bodily secretions , chylomicrons , glucagon-like peptide 1 , glucagon-like peptide 2 , glucagon-like peptides
Diabetes January 2013, Vol.62, 336-338. doi:https://doi.org/10.2337/db12-1098
LADA: Time for a New Definition
Maria J. Redondo
View articletitled, LADA: Time for a New Definition
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Topics: latent autoimmune diabetes of adulthood
Diabetes January 2013, Vol.62, 339-340. doi:https://doi.org/10.2337/db12-1171
Understanding the Diabetic Brain: New Technologies but Old Challenges
Elisabeth A. Northam; Fergus J. Cameron
View articletitled, Understanding the Diabetic Brain: New Technologies but Old Challenges
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Topics: brain , technology , diabetes mellitus, type 1
Diabetes January 2013, Vol.62, 341-342. doi:https://doi.org/10.2337/db12-1181
Microvascular Contributions to Insulin Resistance
Stephen Rattigan; Stephen M. Richards; Michelle A. Keske
View articletitled, Microvascular Contributions to Insulin Resistance
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Topics: glucose , insulin , insulin resistance , vascular endothelial growth factor a , blood capillaries
Diabetes January 2013, Vol.62, 343-345. doi:https://doi.org/10.2337/db12-1193
Aging and Insulin Resistance: Just Say iNOS
Joseph L. Evans; Ira D. Goldfine
View articletitled, Aging and Insulin Resistance: Just Say iNOS
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Topics: aging , insulin , insulin resistance , nitric oxide synthase , insulin receptor
Diabetes January 2013, Vol.62, 346-348. doi:https://doi.org/10.2337/db12-1239
Targeted Metabolomics Finds Its Mark in Diabetes Research
James R. Bain
View articletitled, Targeted Metabolomics Finds Its Mark in Diabetes Research
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Topics: diabetes mellitus, type 2 , metabolites , metabolomics
Diabetes January 2013, Vol.62, 349-351. doi:https://doi.org/10.2337/db12-1189
Plasma Ceramides Target Skeletal Muscle in Type 2 Diabetes
John P. Kirwan
View articletitled, Plasma Ceramides Target Skeletal Muscle in Type 2 Diabetes
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Topics: ceramides , diabetes mellitus, type 2 , plasma , skeletal muscles , low-density lipoproteins
Diabetes January 2013, Vol.62, 352-354. doi:https://doi.org/10.2337/db12-1427

Metabolism

Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
Lake Q. Jiang; Daniella E. Duque-Guimaraes; Ubiratan F. Machado; Juleen R. Zierath; Anna Krook
View articletitled, Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
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Topics: glucose , interleukin-6 , skeletal myocytes , skeletal muscles
Diabetes January 2013, Vol.62, 355-361. doi:https://doi.org/10.2337/db11-1790
A Role for Adipose Tissue De Novo Lipogenesis in Glucose Homeostasis During Catch-up Growth: A Randle Cycle Favoring Fat Storage
Helena Marcelino; Christelle Veyrat-Durebex; Serge Summermatter; Delphine Sarafian; Jennifer Miles-Chan; Denis Arsenijevic; Fabio Zani; Jean-Pierre Montani; Josiane Seydoux; Giovanni Solinas; Françoise Rohner-Jeanrenaud; Abdul G. Dulloo
View articletitled, A Role for Adipose Tissue De Novo Lipogenesis in Glucose Homeostasis During Catch-up Growth<span class="subtitle-colon">: </span><span class="subtitle">A Randle Cycle Favoring Fat Storage</span>
Supplementary data
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Topics: adipose tissue , diet , dietary fats , glucose , heart failure
Diabetes January 2013, Vol.62, 362-372. doi:https://doi.org/10.2337/db12-0255
GLP-1 and GLP-2 as Yin and Yang of Intestinal Lipoprotein Production: Evidence for Predominance of GLP-2–Stimulated Postprandial Lipemia in Normal and Insulin-Resistant States
Gustavo J. Hein; Chris Baker; Joanne Hsieh; Sarah Farr; Khosrow Adeli
View articletitled, GLP-1 and GLP-2 as Yin and Yang of Intestinal Lipoprotein Production<span class="subtitle-colon">: </span><span class="subtitle">Evidence for Predominance of GLP-2–Stimulated Postprandial Lipemia in Normal and Insulin-Resistant States</span>
Supplementary data
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Topics: glucagon-like peptide 1 , glucagon-like peptide 2 , intestines , lipoproteins , cricetinae
Diabetes January 2013, Vol.62, 373-381. doi:https://doi.org/10.2337/db12-0202
Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice
David G. Kuhel; Eddy S. Konaniah; Joshua E. Basford; Courtney McVey; Colleen T. Goodin; Tapan K. Chatterjee; Neal L. Weintraub; David Y. Hui
View articletitled, Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice
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Topics: diet , inflammation , mice , obesity , postprandial period
Diabetes January 2013, Vol.62, 382-391. doi:https://doi.org/10.2337/db12-0390
Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs
Katie C. Coate; Guillaume Kraft; Jose M. Irimia; Marta S. Smith; Ben Farmer; Doss W. Neal; Peter J. Roach; Masakazu Shiota; Alan D. Cherrington
View articletitled, Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs
Supplementary data
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Topics: dog, domestic , glucose , hyperglycemia , hyperinsulinism , liver
Diabetes January 2013, Vol.62, 392-400. doi:https://doi.org/10.2337/db12-0417
Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
James Boon; Andrew J. Hoy; Romana Stark; Russell D. Brown; Ruth C. Meex; Darren C. Henstridge; Simon Schenk; Peter J. Meikle; Jeffrey F. Horowitz; Bronwyn A. Kingwell; Clinton R. Bruce; Matthew J. Watt
View articletitled, Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
Supplementary data
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Topics: ceramides , low-density lipoproteins , inflammation
Diabetes January 2013, Vol.62, 401-410. doi:https://doi.org/10.2337/db12-0686
Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance
Lin Zhu; William C. Brown; Qing Cai; Andrée Krust; Pierre Chambon; Owen P. McGuinness; John M. Stafford
View articletitled, Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance
Supplementary data
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Topics: estrogen , insulin , liver , triglycerides , mice
Diabetes January 2013, Vol.62, 424-434. doi:https://doi.org/10.2337/db11-1718

Original Research

Intrahypothalamic Estradiol Regulates Glucose Metabolism via the Sympathetic Nervous System in Female Rats
Ji Liu; Peter H. Bisschop; Leslie Eggels; Ewout Foppen; Mariette T. Ackermans; Jiang-Ning Zhou; Eric Fliers; Andries Kalsbeek
View articletitled, Intrahypothalamic Estradiol Regulates Glucose Metabolism via the Sympathetic Nervous System in Female Rats
Supplementary data
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Topics: antagonists , denervation , estradiol , glucose , glucose metabolism
Diabetes January 2013, Vol.62, 435-443. doi:https://doi.org/10.2337/db12-0488
Metabolism
Neuronal Androgen Receptor Regulates Insulin Sensitivity via Suppression of Hypothalamic NF-κB–Mediated PTP1B Expression
I-Chen Yu; Hung-Yun Lin; Ning-Chun Liu; Janet D. Sparks; Shuyuan Yeh; Lei-Ya Fang; Lumin Chen; Chawnshang Chang
View articletitled, Neuronal Androgen Receptor Regulates Insulin Sensitivity via Suppression of Hypothalamic NF-κB–Mediated PTP1B Expression
Supplementary data
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Topics: hypothalamus , insulin , insulin resistance , mice , signal transduction
Diabetes January 2013, Vol.62, 411-423. doi:https://doi.org/10.2337/db12-0135
Islet Studies
Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides
Ayako Fukami; Yusuke Seino; Nobuaki Ozaki; Michiyo Yamamoto; Chisato Sugiyama; Eriko Sakamoto-Miura; Tatsuhito Himeno; Yoshiko Takagishi; Shin Tsunekawa; Safina Ali; Daniel J. Drucker; Yoshiharu Murata; Yutaka Seino; Yutaka Oiso; Yoshitaka Hayashi
View articletitled, Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides
Supplementary data
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Topics: insulin , insulin secretion , mice , pancreas , glucose
Diabetes January 2013, Vol.62, 510-518. doi:https://doi.org/10.2337/db12-0294
Pathophysiology
Sterol Regulatory Element–Binding Protein-1c Mediates Increase of Postprandial Stearic Acid, a Potential Target for Improving Insulin Resistance, in Hyperlipidemia
Xia Chu; Liyan Liu; Lixin Na; Huimin Lu; Songtao Li; Ying Li; Changhao Sun
View articletitled, Sterol Regulatory Element–Binding Protein-1c Mediates Increase of Postprandial Stearic Acid, a Potential Target for Improving Insulin Resistance, in Hyperlipidemia
Supplementary data
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Topics: glucose , insulin , insulin sensitivity , mice , postprandial period
Diabetes January 2013, Vol.62, 561-571. doi:https://doi.org/10.2337/db12-0139
Complications
Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice
Marie-Amélie Papon; Noura B. El Khoury; François Marcouiller; Carl Julien; Françoise Morin; Alexis Bretteville; Franck R. Petry; Simon Gaudreau; Abdelaziz Amrani; Paul M. Mathews; Sébastien S. Hébert; Emmanuel Planel
View articletitled, Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice
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Topics: diabetes mellitus, type 1 , mice , mice, inbred nod , phosphorylation , epitopes
Diabetes January 2013, Vol.62, 609-617. doi:https://doi.org/10.2337/db12-0187
Genetics / Genomes / Proteomics / Metabolomics
Plasma Resistin Is Associated With Single Nucleotide Polymorphisms of a Possible Resistin Receptor, the Decorin Gene, in the General Japanese Population
Hiroshi Onuma; Yasuharu Tabara; Ryoichi Kawamura; Jun Ohashi; Wataru Nishida; Yasunori Takata; Masaaki Ochi; Tatsuya Nishimiya; Ryuichi Kawamoto; Katsuhiko Kohara; Tetsuro Miki; Haruhiko Osawa
View articletitled, Plasma Resistin Is Associated With Single Nucleotide Polymorphisms of a Possible Resistin Receptor, the Decorin Gene, in the General Japanese Population
Supplementary data
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Topics: plasma , resistin , single nucleotide polymorphism
Diabetes January 2013, Vol.62, 649-652. doi:https://doi.org/10.2337/db12-0058

Signal Transduction

PAQR3 Modulates Insulin Signaling by Shunting Phosphoinositide 3-Kinase p110α to the Golgi Apparatus
Xiao Wang; Lingdi Wang; Lu Zhu; Yi Pan; Fei Xiao; Weizhong Liu; Zhenzhen Wang; Feifan Guo; Yong Liu; Walter G. Thomas; Yan Chen
View articletitled, PAQR3 Modulates Insulin Signaling by Shunting Phosphoinositide 3-Kinase p110α to the Golgi Apparatus
Supplementary data
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Topics: 1-phosphatidylinositol 3-kinase , golgi apparatus , insulin , phosphoinositide 3-kinase , signal transduction
Diabetes January 2013, Vol.62, 444-456. doi:https://doi.org/10.2337/db12-0244
Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
Fredirick Mashili; Alexander V. Chibalin; Anna Krook; Juleen R. Zierath
View articletitled, Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
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Topics: diabetes mellitus, type 2 , insulin , stat3 protein , insulin resistance , rna, small interfering
Diabetes January 2013, Vol.62, 457-465. doi:https://doi.org/10.2337/db12-0337
Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
Eduardo R. Ropelle; José R. Pauli; Dennys E. Cintra; Adelino S. da Silva; Cláudio T. De Souza; Dioze Guadagnini; Bruno M. Carvalho; Andrea M. Caricilli; Carlos K. Katashima; Marco A. Carvalho-Filho; Sandro Hirabara; Rui Curi; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
View articletitled, Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, <em>S</em>-Nitrosation, and Insulin Resistance in Muscle of Male Mice
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Topics: aging , insulin , insulin resistance , mice , nitric oxide synthase
Diabetes January 2013, Vol.62, 466-470. doi:https://doi.org/10.2337/db12-0339
Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression
Su-Jin Kim; Cuilan Nian; Christopher H.S. McIntosh
View articletitled, Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression
Supplementary data
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Topics: adipocytes , resistin , mice , glucose , fatty acids
Diabetes January 2013, Vol.62, 471-477. doi:https://doi.org/10.2337/db12-0257

Obesity Studies

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice: Involvement of Toll-Like Receptor 2
Masayo Monden; Hidenori Koyama; Yoshiko Otsuka; Tomoaki Morioka; Katsuhito Mori; Takuhito Shoji; Yohei Mima; Koka Motoyama; Shinya Fukumoto; Atsushi Shioi; Masanori Emoto; Yasuhiko Yamamoto; Hiroshi Yamamoto; Yoshiki Nishizawa; Masafumi Kurajoh; Tetsuya Yamamoto; Masaaki Inaba
View articletitled, Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice<span class="subtitle-colon">: </span><span class="subtitle">Involvement of Toll-Like Receptor 2</span>
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Topics: adipocytes , hypertrophy , insulin , mice , obesity
Diabetes January 2013, Vol.62, 478-489. doi:https://doi.org/10.2337/db11-1116
Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques
Paul Kievit; Heather Halem; Daniel L. Marks; Jesse Z. Dong; Maria M. Glavas; Puspha Sinnayah; Lindsay Pranger; Michael A. Cowley; Kevin L. Grove; Michael D. Culler
View articletitled, Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques
Supplementary data
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Topics: agonists , diet , eating , heart rate , macaca mulatta
Diabetes January 2013, Vol.62, 490-497. doi:https://doi.org/10.2337/db12-0598
Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction
Yinan Hua; Yingmei Zhang; Julia Dolence; Guo-Ping Shi; Jun Ren; Sreejayan Nair
View articletitled, Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction
Supplementary data
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Topics: cathepsin k , diet, high-fat
Diabetes January 2013, Vol.62, 498-509. doi:https://doi.org/10.2337/db12-0350

Islet Studies

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion
Ya-Chi Huang; Marjan S. Rupnik; Negar Karimian; Pedro L. Herrera; Patrick Gilon; Zhong-Ping Feng; Herbert Y. Gaisano
View articletitled, In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion
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Topics: glucagon , mice , pancreas , streptozocin
Diabetes January 2013, Vol.62, 519-530. doi:https://doi.org/10.2337/db11-0786
The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
Éva Korpos; Nadir Kadri; Reinhild Kappelhoff; Jeannine Wegner; Christopher M. Overall; Ekkehard Weber; Dan Holmberg; Susanna Cardell; Lydia Sorokin
View articletitled, The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
Supplementary data
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Topics: cathepsins , diabetes mellitus, type 1 , endocrine pancreas , insulin , laminin
Diabetes January 2013, Vol.62, 531-542. doi:https://doi.org/10.2337/db12-0432

Immunology and Transplantation

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study
Zhiguang Zhou; Yufei Xiang; Linong Ji; Weiping Jia; Guang Ning; Gan Huang; Lin Yang; Jian Lin; Zhenqi Liu; William A. Hagopian; R. David Leslie; on behalf of the LADA China Study Group
View articletitled, Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study)<span class="subtitle-colon">: </span><span class="subtitle">A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study</span>
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Topics: china , latent autoimmune diabetes of adulthood
Diabetes January 2013, Vol.62, 543-550. doi:https://doi.org/10.2337/db12-0207
Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice
Xavier M. Anguela; Sabrina Tafuro; Carles Roca; David Callejas; Judith Agudo; Mercè Obach; Albert Ribera; Albert Ruzo; Christopher J. Mann; Alba Casellas; Fatima Bosch
View articletitled, Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice
Supplementary data
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Topics: insulin-like growth factor i , liver , mice , plasmids , regulatory t-lymphocytes
Diabetes January 2013, Vol.62, 551-560. doi:https://doi.org/10.2337/db11-1776

Pathophysiology

Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
Jeffrey S. Bonner; Louise Lantier; Clinton M. Hasenour; Freyja D. James; Deanna P. Bracy; David H. Wasserman
View articletitled, Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
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Topics: blood capillaries , glucose , insulin , mice , vascular endothelial growth factor a
Diabetes January 2013, Vol.62, 572-580. doi:https://doi.org/10.2337/db12-0354
White Matter Microstructural Integrity in Youth With Type 1 Diabetes
Jo Ann V. Antenor-Dorsey; Erin Meyer; Jerrel Rutlin; Dana C. Perantie; Neil H. White; Ana Maria Arbelaez; Joshua S. Shimony; Tamara Hershey
View articletitled, White Matter Microstructural Integrity in Youth With Type 1 Diabetes
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Topics: adolescent , anisotropy , diabetes mellitus, type 1 , hyperglycemia , hyperglycemic agents
Diabetes January 2013, Vol.62, 581-589. doi:https://doi.org/10.2337/db12-0696
Perivascular Adipose Tissue Control of Insulin-Induced Vasoreactivity in Muscle Is Impaired in db/db Mice
Rick I. Meijer; Wineke Bakker; Caro-Lynn A.F. Alta; Pieter Sipkema; John S. Yudkin; Benoit Viollet; Erik A. Richter; Yvo M. Smulders; Victor W.M. van Hinsbergh; Erik H. Serné; Etto C. Eringa
View articletitled, Perivascular Adipose Tissue Control of Insulin-Induced Vasoreactivity in Muscle Is Impaired in <em>db</em>/<em>db</em> Mice
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Topics: adiponectin , insulin , mice , vasodilation , mice, inbred c57bl
Diabetes January 2013, Vol.62, 590-598. doi:https://doi.org/10.2337/db11-1603

Complications

c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy
Xuezheng Li; Cheng Xu; Peixin Yang
View articletitled, c-Jun NH<sub>2</sub>-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy
Supplementary data
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Topics: embryo , emergency service, hospital , hyperglycemia , stress , glucose
Diabetes January 2013, Vol.62, 599-608. doi:https://doi.org/10.2337/db12-0026

Pharmacology and Therapeutics

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds
Yunan Tang; Michael J. Zhang; Jason Hellmann; Madhavi Kosuri; Aruni Bhatnagar; Matthew Spite
View articletitled, Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds
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Topics: macrophages , mice , peritonitis, acute , phagocytosis , wound healing
Diabetes January 2013, Vol.62, 618-627. doi:https://doi.org/10.2337/db12-0684
Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models
Feng-Lin Hsu; Chun-Fa Huang; Ya-Wen Chen; Yuan-Peng Yen; Cheng-Tien Wu; Biing-Jiun Uang; Rong-Sen Yang; Shing-Hwa Liu
View articletitled, Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models
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Topics: mice , insulin
Diabetes January 2013, Vol.62, 628-638. doi:https://doi.org/10.2337/db12-0585

Genetics / Genomes / Proteomics / Metabolomics

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
Anna Floegel; Norbert Stefan; Zhonghao Yu; Kristin Mühlenbruch; Dagmar Drogan; Hans-Georg Joost; Andreas Fritsche; Hans-Ulrich Häring; Martin Hrabě de Angelis; Annette Peters; Michael Roden; Cornelia Prehn; Rui Wang-Sattler; Thomas Illig; Matthias B. Schulze; Jerzy Adamski; Heiner Boeing; Tobias Pischon
View articletitled, Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
Supplementary data
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Topics: diabetes mellitus, type 2 , metabolites , metabolomics
Diabetes January 2013, Vol.62, 639-648. doi:https://doi.org/10.2337/db12-0495
Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2)
Peter Spégel; Ella Ekholm; Tiinamaija Tuomi; Leif Groop; Hindrik Mulder; Karin Filipsson
View articletitled, Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2)
Supplementary data
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Topics: diabetes mellitus, type 2 , maturity onset diabetes mellitus in young , metabolites , glucokinase , mutation
Diabetes January 2013, Vol.62, 653-661. doi:https://doi.org/10.2337/db12-0827

Errata

B-Cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 2012;61:2893–2905
E Mariño; B Tan; L Binge; CR Mackay; ST Grey
View articletitled, B-Cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 2012;61:2893–2905
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Topics: autoantigens , b-lymphocytes
Diabetes January 2013, Vol.62, 662. doi:https://doi.org/10.2337/db13-er02
FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST trial. Diabetes 2012;61:3005–3011
X Zhang; Q Qi; C Zhang; FB Hu; FM Sacks; L Qi
View articletitled, <em>FTO</em> genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST trial. Diabetes 2012;61:3005–3011
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Topics: body composition , body fat distribution , fto gene , genotype , reducing diet
Diabetes January 2013, Vol.62, 662. doi:https://doi.org/10.2337/db13-er02a

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Topics: chief complaint , cupressus , florida , wisconsin
Diabetes January 2013, Vol.62, 663. doi:https://doi.org/10.2337/db13-ie02

Diabetes Digests

Highlights From the Latest in Diabetes Research
View articletitled, Highlights From the Latest in Diabetes Research
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Topics: cholesterol , hyperalgesia , low density lipoprotein increased , neuropathic pain , statins
Diabetes January 2013, Vol.62, 664-665. doi:https://doi.org/10.2337/db13-dd02
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective
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