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February 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
Perspectives in Diabetes
Mineralocorticoid Receptor–Mediated Vascular Insulin Resistance: An Early Contributor to Diabetes-Related Vascular Disease?
Diabetes January 2013, Vol.62, 313-319. doi:https://doi.org/10.2337/db12-0905
Diabetes Research: A Perspective From the National Institute of Diabetes and Digestive and Kidney Diseases
Diabetes January 2013, Vol.62, 320-326. doi:https://doi.org/10.2337/db12-0269
β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
Diabetes January 2013, Vol.62, 327-335. doi:https://doi.org/10.2337/db12-1326
Commentary
Novel Insights Into the Regulation of Postprandial Lipemia by Glucagon-Like Peptides: Significance for Diabetes
Diabetes January 2013, Vol.62, 336-338. doi:https://doi.org/10.2337/db12-1098
LADA: Time for a New Definition
Diabetes January 2013, Vol.62, 339-340. doi:https://doi.org/10.2337/db12-1171
Understanding the Diabetic Brain: New Technologies but Old Challenges
Diabetes January 2013, Vol.62, 341-342. doi:https://doi.org/10.2337/db12-1181
Metabolism
Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
Diabetes January 2013, Vol.62, 355-361. doi:https://doi.org/10.2337/db11-1790
A Role for Adipose Tissue De Novo Lipogenesis in Glucose Homeostasis During Catch-up Growth: A Randle Cycle Favoring Fat Storage
Helena Marcelino; Christelle Veyrat-Durebex; Serge Summermatter; Delphine Sarafian; Jennifer Miles-Chan; Denis Arsenijevic; Fabio Zani; Jean-Pierre Montani; Josiane Seydoux; Giovanni Solinas; Françoise Rohner-Jeanrenaud; Abdul G. Dulloo
Diabetes January 2013, Vol.62, 362-372. doi:https://doi.org/10.2337/db12-0255
Apolipoprotein E2 Accentuates Postprandial Inflammation and Diet-Induced Obesity to Promote Hyperinsulinemia in Mice
David G. Kuhel; Eddy S. Konaniah; Joshua E. Basford; Courtney McVey; Colleen T. Goodin; Tapan K. Chatterjee; Neal L. Weintraub; David Y. Hui
Diabetes January 2013, Vol.62, 382-391. doi:https://doi.org/10.2337/db12-0390
Portal Vein Glucose Entry Triggers a Coordinated Cellular Response That Potentiates Hepatic Glucose Uptake and Storage in Normal but Not High-Fat/High-Fructose–Fed Dogs
Katie C. Coate; Guillaume Kraft; Jose M. Irimia; Marta S. Smith; Ben Farmer; Doss W. Neal; Peter J. Roach; Masakazu Shiota; Alan D. Cherrington
Diabetes January 2013, Vol.62, 392-400. doi:https://doi.org/10.2337/db12-0417
Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
James Boon; Andrew J. Hoy; Romana Stark; Russell D. Brown; Ruth C. Meex; Darren C. Henstridge; Simon Schenk; Peter J. Meikle; Jeffrey F. Horowitz; Bronwyn A. Kingwell; Clinton R. Bruce; Matthew J. Watt
Diabetes January 2013, Vol.62, 401-410. doi:https://doi.org/10.2337/db12-0686
Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance
Lin Zhu; William C. Brown; Qing Cai; Andrée Krust; Pierre Chambon; Owen P. McGuinness; John M. Stafford
Diabetes January 2013, Vol.62, 424-434. doi:https://doi.org/10.2337/db11-1718
Original Research
Intrahypothalamic Estradiol Regulates Glucose Metabolism via the Sympathetic Nervous System in Female Rats
Ji Liu; Peter H. Bisschop; Leslie Eggels; Ewout Foppen; Mariette T. Ackermans; Jiang-Ning Zhou; Eric Fliers; Andries Kalsbeek
Diabetes January 2013, Vol.62, 435-443. doi:https://doi.org/10.2337/db12-0488
Metabolism
Neuronal Androgen Receptor Regulates Insulin Sensitivity via Suppression of Hypothalamic NF-κB–Mediated PTP1B Expression
I-Chen Yu; Hung-Yun Lin; Ning-Chun Liu; Janet D. Sparks; Shuyuan Yeh; Lei-Ya Fang; Lumin Chen; Chawnshang Chang
Diabetes January 2013, Vol.62, 411-423. doi:https://doi.org/10.2337/db12-0135
Islet Studies
Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides
Ayako Fukami; Yusuke Seino; Nobuaki Ozaki; Michiyo Yamamoto; Chisato Sugiyama; Eriko Sakamoto-Miura; Tatsuhito Himeno; Yoshiko Takagishi; Shin Tsunekawa; Safina Ali; Daniel J. Drucker; Yoshiharu Murata; Yutaka Seino; Yutaka Oiso; Yoshitaka Hayashi
Diabetes January 2013, Vol.62, 510-518. doi:https://doi.org/10.2337/db12-0294
Pathophysiology
Complications
Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice
Marie-Amélie Papon; Noura B. El Khoury; François Marcouiller; Carl Julien; Françoise Morin; Alexis Bretteville; Franck R. Petry; Simon Gaudreau; Abdelaziz Amrani; Paul M. Mathews; Sébastien S. Hébert; Emmanuel Planel
Diabetes January 2013, Vol.62, 609-617. doi:https://doi.org/10.2337/db12-0187
Genetics / Genomes / Proteomics / Metabolomics
Plasma Resistin Is Associated With Single Nucleotide Polymorphisms of a Possible Resistin Receptor, the Decorin Gene, in the General Japanese Population
Hiroshi Onuma; Yasuharu Tabara; Ryoichi Kawamura; Jun Ohashi; Wataru Nishida; Yasunori Takata; Masaaki Ochi; Tatsuya Nishimiya; Ryuichi Kawamoto; Katsuhiko Kohara; Tetsuro Miki; Haruhiko Osawa
Diabetes January 2013, Vol.62, 649-652. doi:https://doi.org/10.2337/db12-0058
Signal Transduction
PAQR3 Modulates Insulin Signaling by Shunting Phosphoinositide 3-Kinase p110α to the Golgi Apparatus
Xiao Wang; Lingdi Wang; Lu Zhu; Yi Pan; Fei Xiao; Weizhong Liu; Zhenzhen Wang; Feifan Guo; Yong Liu; Walter G. Thomas; Yan Chen
Diabetes January 2013, Vol.62, 444-456. doi:https://doi.org/10.2337/db12-0244
Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
Diabetes January 2013, Vol.62, 457-465. doi:https://doi.org/10.2337/db12-0337
Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
Eduardo R. Ropelle; José R. Pauli; Dennys E. Cintra; Adelino S. da Silva; Cláudio T. De Souza; Dioze Guadagnini; Bruno M. Carvalho; Andrea M. Caricilli; Carlos K. Katashima; Marco A. Carvalho-Filho; Sandro Hirabara; Rui Curi; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
Diabetes January 2013, Vol.62, 466-470. doi:https://doi.org/10.2337/db12-0339
Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression
Diabetes January 2013, Vol.62, 471-477. doi:https://doi.org/10.2337/db12-0257
Obesity Studies
Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice: Involvement of Toll-Like Receptor 2
Masayo Monden; Hidenori Koyama; Yoshiko Otsuka; Tomoaki Morioka; Katsuhito Mori; Takuhito Shoji; Yohei Mima; Koka Motoyama; Shinya Fukumoto; Atsushi Shioi; Masanori Emoto; Yasuhiko Yamamoto; Hiroshi Yamamoto; Yoshiki Nishizawa; Masafumi Kurajoh; Tetsuya Yamamoto; Masaaki Inaba
Diabetes January 2013, Vol.62, 478-489. doi:https://doi.org/10.2337/db11-1116
Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques
Paul Kievit; Heather Halem; Daniel L. Marks; Jesse Z. Dong; Maria M. Glavas; Puspha Sinnayah; Lindsay Pranger; Michael A. Cowley; Kevin L. Grove; Michael D. Culler
Diabetes January 2013, Vol.62, 490-497. doi:https://doi.org/10.2337/db12-0598
Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction
Diabetes January 2013, Vol.62, 498-509. doi:https://doi.org/10.2337/db12-0350
Islet Studies
In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion
Ya-Chi Huang; Marjan S. Rupnik; Negar Karimian; Pedro L. Herrera; Patrick Gilon; Zhong-Ping Feng; Herbert Y. Gaisano
Diabetes January 2013, Vol.62, 519-530. doi:https://doi.org/10.2337/db11-0786
The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
Éva Korpos; Nadir Kadri; Reinhild Kappelhoff; Jeannine Wegner; Christopher M. Overall; Ekkehard Weber; Dan Holmberg; Susanna Cardell; Lydia Sorokin
Diabetes January 2013, Vol.62, 531-542. doi:https://doi.org/10.2337/db12-0432
Immunology and Transplantation
Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study
Zhiguang Zhou; Yufei Xiang; Linong Ji; Weiping Jia; Guang Ning; Gan Huang; Lin Yang; Jian Lin; Zhenqi Liu; William A. Hagopian; R. David Leslie; on behalf of the LADA China Study Group
Diabetes January 2013, Vol.62, 543-550. doi:https://doi.org/10.2337/db12-0207
Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice
Xavier M. Anguela; Sabrina Tafuro; Carles Roca; David Callejas; Judith Agudo; Mercè Obach; Albert Ribera; Albert Ruzo; Christopher J. Mann; Alba Casellas; Fatima Bosch
Diabetes January 2013, Vol.62, 551-560. doi:https://doi.org/10.2337/db11-1776
Pathophysiology
Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
Jeffrey S. Bonner; Louise Lantier; Clinton M. Hasenour; Freyja D. James; Deanna P. Bracy; David H. Wasserman
Diabetes January 2013, Vol.62, 572-580. doi:https://doi.org/10.2337/db12-0354
White Matter Microstructural Integrity in Youth With Type 1 Diabetes
Jo Ann V. Antenor-Dorsey; Erin Meyer; Jerrel Rutlin; Dana C. Perantie; Neil H. White; Ana Maria Arbelaez; Joshua S. Shimony; Tamara Hershey
Diabetes January 2013, Vol.62, 581-589. doi:https://doi.org/10.2337/db12-0696
Perivascular Adipose Tissue Control of Insulin-Induced Vasoreactivity in Muscle Is Impaired in db/db Mice
Rick I. Meijer; Wineke Bakker; Caro-Lynn A.F. Alta; Pieter Sipkema; John S. Yudkin; Benoit Viollet; Erik A. Richter; Yvo M. Smulders; Victor W.M. van Hinsbergh; Erik H. Serné; Etto C. Eringa
Diabetes January 2013, Vol.62, 590-598. doi:https://doi.org/10.2337/db11-1603
Complications
c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy
Diabetes January 2013, Vol.62, 599-608. doi:https://doi.org/10.2337/db12-0026
Pharmacology and Therapeutics
Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds
Diabetes January 2013, Vol.62, 618-627. doi:https://doi.org/10.2337/db12-0684
Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models
Feng-Lin Hsu; Chun-Fa Huang; Ya-Wen Chen; Yuan-Peng Yen; Cheng-Tien Wu; Biing-Jiun Uang; Rong-Sen Yang; Shing-Hwa Liu
Diabetes January 2013, Vol.62, 628-638. doi:https://doi.org/10.2337/db12-0585
Genetics / Genomes / Proteomics / Metabolomics
Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach
Anna Floegel; Norbert Stefan; Zhonghao Yu; Kristin Mühlenbruch; Dagmar Drogan; Hans-Georg Joost; Andreas Fritsche; Hans-Ulrich Häring; Martin Hrabě de Angelis; Annette Peters; Michael Roden; Cornelia Prehn; Rui Wang-Sattler; Thomas Illig; Matthias B. Schulze; Jerzy Adamski; Heiner Boeing; Tobias Pischon
Diabetes January 2013, Vol.62, 639-648. doi:https://doi.org/10.2337/db12-0495
Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2)
Diabetes January 2013, Vol.62, 653-661. doi:https://doi.org/10.2337/db12-0827
Errata
B-Cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 2012;61:2893–2905
Diabetes January 2013, Vol.62, 662. doi:https://doi.org/10.2337/db13-er02
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes January 2013, Vol.62, 664-665. doi:https://doi.org/10.2337/db13-dd02