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1 March 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes February 2013, Vol.62, 667-668. doi:https://doi.org/10.2337/db13-ti03
Perspectives In Diabetes
Challenging the FDA Black Box Warning for High Aspirin Dose With Ticagrelor in Patients With Diabetes
Diabetes February 2013, Vol.62, 669-671. doi:https://doi.org/10.2337/db12-0746
Perspectives in Diabetes
Linking the Metabolic State and Mitochondrial DNA in Chronic Disease, Health, and Aging
Diabetes February 2013, Vol.62, 672-678. doi:https://doi.org/10.2337/db12-1203
Commentary
Diabetic Foot Ulcer Microbiome: One Small Step for Molecular Microbiology . . . One Giant Leap for Understanding Diabetic Foot Ulcers?
Diabetes February 2013, Vol.62, 679-681. doi:https://doi.org/10.2337/db12-1325
Metabolomics, Stable Isotopes, and A−β+ Ketosis-Prone Diabetes
Diabetes February 2013, Vol.62, 682-684. doi:https://doi.org/10.2337/db12-1347
Novel Link Between Inflammation, Endothelial Dysfunction, and Muscle Insulin Resistance
Diabetes February 2013, Vol.62, 688-690. doi:https://doi.org/10.2337/db12-1434
Teaching an Old Drug New Tricks: Can Paroxetine Ease the Burden of Cardiovascular Disease in Diabetes?
Diabetes February 2013, Vol.62, 698-700. doi:https://doi.org/10.2337/db12-1530
Metabolism
Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
Wendy Keung; John R. Ussher; Jagdip S. Jaswal; Monique Raubenheimer; Victoria H.M. Lam; Cory S. Wagg; Gary D. Lopaschuk
Diabetes February 2013, Vol.62, 711-720. doi:https://doi.org/10.2337/db12-0259
C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery
Keiji Tanigaki; Wanpen Vongpatanasin; Jose A. Barrera; Dmitriy N. Atochin; Paul L. Huang; Ezio Bonvini; Philip W. Shaul; Chieko Mineo
Diabetes February 2013, Vol.62, 721-731. doi:https://doi.org/10.2337/db12-0133
Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue
Andrea Galmozzi; Nico Mitro; Alessandra Ferrari; Elise Gers; Federica Gilardi; Cristina Godio; Gaia Cermenati; Alice Gualerzi; Elena Donetti; Dante Rotili; Sergio Valente; Uliano Guerrini; Donatella Caruso; Antonello Mai; Enrique Saez; Emma De Fabiani; Maurizio Crestani
Diabetes February 2013, Vol.62, 732-742. doi:https://doi.org/10.2337/db12-0548
Adiponectin Corrects High-Fat Diet–Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis
Diabetes February 2013, Vol.62, 743-752. doi:https://doi.org/10.2337/db12-0687
Hepatic Glucose Metabolism in Late Pregnancy: Normal Versus High-Fat and -Fructose Diet
Katie C. Coate; Marta S. Smith; Masakazu Shiota; Jose M. Irimia; Peter J. Roach; Ben Farmer; Phillip E. Williams; Mary Courtney Moore
Diabetes February 2013, Vol.62, 753-761. doi:https://doi.org/10.2337/db12-0875
Telmisartan Improves Insulin Resistance of Skeletal Muscle Through Peroxisome Proliferator–Activated Receptor-δ Activation
Li Li; Zhidan Luo; Hao Yu; Xiaoli Feng; Peijian Wang; Jian Chen; Yunfei Pu; Yu Zhao; Hongbo He; Jian Zhong; Daoyan Liu; Zhiming Zhu
Diabetes February 2013, Vol.62, 762-774. doi:https://doi.org/10.2337/db12-0570
Adipocyte Fatty Acid Storage Factors Enhance Subcutaneous Fat Storage in Postmenopausal Women
Diabetes February 2013, Vol.62, 775-782. doi:https://doi.org/10.2337/db12-0912
Kinetics of Saturated, Monounsaturated, and Polyunsaturated Fatty Acids in Humans
Robert H. Nelson; Manpreet S. Mundi; Danielle T. Vlazny; Almira Smailovic; Kalpana Muthusamy; Jaime P. Almandoz; Ekta Singh; Michael D. Jensen; John M. Miles
Diabetes February 2013, Vol.62, 783-788. doi:https://doi.org/10.2337/db12-0367
Signal Transduction
The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis
Weijuan Shao; Dingyan Wang; Yu-Ting Chiang; Wilfred Ip; Lingyun Zhu; Fenghao Xu; Joshua Columbus; Denise D. Belsham; David M. Irwin; Haibo Zhang; Xiaoyan Wen; Qinghua Wang; Tianru Jin
Diabetes February 2013, Vol.62, 789-800. doi:https://doi.org/10.2337/db12-0365
Gliotransmission and Brain Glucose Sensing: Critical Role of Endozepines
Damien Lanfray; Sébastien Arthaud; Johanne Ouellet; Vincent Compère; Jean-Luc Do Rego; Jérôme Leprince; Benjamin Lefranc; Hélène Castel; Cynthia Bouchard; Boris Monge-Roffarello; Denis Richard; Georges Pelletier; Hubert Vaudry; Marie-Christine Tonon; Fabrice Morin
Diabetes February 2013, Vol.62, 801-810. doi:https://doi.org/10.2337/db11-0785
Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver
Toshiki Otoda; Toshinari Takamura; Hirofumi Misu; Tsuguhito Ota; Shigeo Murata; Hiroto Hayashi; Hiroaki Takayama; Akihiro Kikuchi; Takehiro Kanamori; Kosuke R. Shima; Fei Lan; Takashi Takeda; Seiichiro Kurita; Kazuhide Ishikura; Yuki Kita; Kaito Iwayama; Ken-ichiro Kato; Masafumi Uno; Yumie Takeshita; Miyuki Yamamoto; Kunpei Tokuyama; Shoichi Iseki; Keiji Tanaka; Shuichi Kaneko
Diabetes February 2013, Vol.62, 811-824. doi:https://doi.org/10.2337/db11-1652
Obesity Studies
Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus
George D. Mcilroy; Mirela Delibegovic; Carl Owen; Patrick N. Stoney; Kirsty D. Shearer; Peter J. McCaffery; Nimesh Mody
Diabetes February 2013, Vol.62, 825-836. doi:https://doi.org/10.2337/db12-0458
Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia
Romy Kursawe; Sonia Caprio; Cosimo Giannini; Deepak Narayan; Aiping Lin; Ebe D’Adamo; Melissa Shaw; Bridget Pierpont; Samuel W. Cushman; Gerald I. Shulman
Diabetes February 2013, Vol.62, 837-844. doi:https://doi.org/10.2337/db12-0889
Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome
Peng Xue; Yongyong Hou; Yanyan Chen; Bei Yang; Jingqi Fu; Hongzhi Zheng; Kathy Yarborough; Courtney G. Woods; Dianxin Liu; Masayuki Yamamoto; Qiang Zhang; Melvin E. Andersen; Jingbo Pi
Diabetes February 2013, Vol.62, 845-854. doi:https://doi.org/10.2337/db12-0584
Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients
Mohammed Qatanani; Yejun Tan; Radu Dobrin; Danielle M. Greenawalt; Guanghui Hu; Wenqing Zhao; Jerrold M. Olefsky; Dorothy D. Sears; Lee M. Kaplan; Daniel M. Kemp
Diabetes February 2013, Vol.62, 855-863. doi:https://doi.org/10.2337/db12-0399
Lessons on Conditional Gene Targeting in Mouse Adipose Tissue
Kevin Y. Lee; Steven J. Russell; Siegfried Ussar; Jeremie Boucher; Cecile Vernochet; Marcelo A. Mori; Graham Smyth; Michael Rourk; Carly Cederquist; Evan D. Rosen; Barbara B. Kahn; C. Ronald Kahn
Diabetes February 2013, Vol.62, 864-874. doi:https://doi.org/10.2337/db12-1089
Islet Studies
Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
Chad S. Hunter; Shilpy Dixit; Tsadok Cohen; Benjamin Ediger; Crystal Wilcox; Mark Ferreira; Heiner Westphal; Roland Stein; Catherine Lee May
Diabetes February 2013, Vol.62, 875-886. doi:https://doi.org/10.2337/db12-0952
MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells
Diabetes February 2013, Vol.62, 887-895. doi:https://doi.org/10.2337/db12-0451
Immunology and Transplantation
PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant
Diabetes February 2013, Vol.62, 896-904. doi:https://doi.org/10.2337/db12-0929
Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts
Gonnie M. Alkemade; Xavier Clemente-Casares; Zhenguo Yu; Bao-You Xu; Jinguo Wang; Sue Tsai; James R. Wright, Jr.; Bart O. Roep; Pere Santamaria
Diabetes February 2013, Vol.62, 905-911. doi:https://doi.org/10.2337/db12-0600
Pathophysiology
Pathogenesis of A−β+ Ketosis-Prone Diabetes
Sanjeet G. Patel; Jean W. Hsu; Farook Jahoor; Ivonne Coraza; James R. Bain; Robert D. Stevens; Dinakar Iyer; Ramaswami Nalini; Kerem Ozer; Christiane S. Hampe; Christopher B. Newgard; Ashok Balasubramanyam
Diabetes February 2013, Vol.62, 912-922. doi:https://doi.org/10.2337/db12-0624
Complications
The Neuropathic Diabetic Foot Ulcer Microbiome Is Associated With Clinical Factors
Diabetes February 2013, Vol.62, 923-930. doi:https://doi.org/10.2337/db12-0771
RAGE Deficiency Improves Postinjury Sciatic Nerve Regeneration in Type 1 Diabetic Mice
Judyta K. Juranek; Matthew S. Geddis; Fei Song; Jinghua Zhang; Jose Garcia; Rosa Rosario; Shi Fang Yan; Thomas H. Brannagan; Ann Marie Schmidt
Diabetes February 2013, Vol.62, 931-943. doi:https://doi.org/10.2337/db12-0632
Endoplasmic Reticulum Stress Plays a Key Role in the Pathogenesis of Diabetic Peripheral Neuropathy
Diabetes February 2013, Vol.62, 944-952. doi:https://doi.org/10.2337/db12-0716
Cell-Based Screening Identifies Paroxetine as an Inhibitor of Diabetic Endothelial Dysfunction
Domokos Gerö; Petra Szoleczky; Kunihiro Suzuki; Katalin Módis; Gabor Oláh; Ciro Coletta; Csaba Szabo
Diabetes February 2013, Vol.62, 953-964. doi:https://doi.org/10.2337/db12-0789
Genetics / Genomes / Proteomics / Metabolomics
Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study
Maggie C.Y. Ng; Richa Saxena; Jiang Li; Nicholette D. Palmer; Latchezar Dimitrov; Jianzhao Xu; Laura J. Rasmussen-Torvik; Joseph M. Zmuda; David S. Siscovick; Sanjay R. Patel; Errol D. Crook; Mario Sims; Yii-Der I. Chen; Alain G. Bertoni; Mingyao Li; Struan F.A. Grant; Josée Dupuis; James B. Meigs; Bruce M. Psaty; James S. Pankow; Carl D. Langefeld; Barry I. Freedman; Jerome I. Rotter; James G. Wilson; Donald W. Bowden
Diabetes February 2013, Vol.62, 965-976. doi:https://doi.org/10.2337/db12-0266
Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21
Rubina Tabassum; Ganesh Chauhan; Om Prakash Dwivedi; Anubha Mahajan; Alok Jaiswal; Ismeet Kaur; Khushdeep Bandesh; Tejbir Singh; Benan John Mathai; Yogesh Pandey; Manickam Chidambaram; Amitabh Sharma; Sreenivas Chavali; Shantanu Sengupta; Lakshmi Ramakrishnan; Pradeep Venkatesh; Sanjay K. Aggarwal; Saurabh Ghosh; Dorairaj Prabhakaran; Reddy K. Srinath; Madhukar Saxena; Monisha Banerjee; Sandeep Mathur; Anil Bhansali; Viral N. Shah; Sri Venkata Madhu; Raman K. Marwaha; Analabha Basu; Vinod Scaria; Mark I. McCarthy; DIAGRAM; INDICO; Radha Venkatesan; Viswanathan Mohan; Nikhil Tandon; Dwaipayan Bharadwaj
Diabetes February 2013, Vol.62, 977-986. doi:https://doi.org/10.2337/db12-0406
Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
Mary E. Travers; Deborah J.G. Mackay; Marloes Dekker Nitert; Andrew P. Morris; Cecilia M. Lindgren; Andrew Berry; Paul R. Johnson; Neil Hanley; Leif C. Groop; Mark I. McCarthy; Anna L. Gloyn
Diabetes February 2013, Vol.62, 987-992. doi:https://doi.org/10.2337/db12-0819
GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency
Elisa De Franco; Charles Shaw-Smith; Sarah E. Flanagan; Maggie H. Shepherd; International NDM Consortium; Andrew T. Hattersley; Sian Ellard
Diabetes February 2013, Vol.62, 993-997. doi:https://doi.org/10.2337/db12-0885
Errata
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. Diabetes 2011;60:614–624
M Al-Shabrawey; R Mussell; K Kahook; A Tawfik; M Eladl; V Sarthy; J Nussbaum; A El-Marakby; SY Park; Z Gurel; N Sheibani; KR Maddipati
Diabetes February 2013, Vol.62, 998. doi:https://doi.org/10.2337/db13-er03
Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations. Diabetes 2012;61:2922–2931
Diabetes February 2013, Vol.62, 998. doi:https://doi.org/10.2337/db13-er03a
Statement of Retraction
AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity. Diabetes 2012;61:3114–3125
W Zhang; X Zhang; H Wang; X Guo; H Li; Y Wang; X Xu; L Tan; MT Mashek; C Zhang; Y Chen; DG Mashek; M Foretz; C Zhu; H Zhou; X Liu; B Viollet; C Wu; Y Huo
Diabetes February 2013, Vol.62, 998. doi:https://doi.org/10.2337/db13-rt03
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes February 2013, Vol.62, 1000-1001. doi:https://doi.org/10.2337/db13-dd03
