Skip Nav Destination
Issues
1 April 2013
- Cover Image
- PDF Icon PDF LinkTable of Contents
ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Topics:
dipeptidyl-peptidase iv inhibitors
,
glucose uptake
,
insulin sensitivity
,
metabolic complications
,
mice
Diabetes March 2013, Vol.62, 1003-1004. doi:https://doi.org/10.2337/db13-ti04
Commentary
Plasma Aβ: A Possible Missing Link Between Alzheimer Disease and Diabetes
Diabetes March 2013, Vol.62, 1005-1006. doi:https://doi.org/10.2337/db12-1549
A Tangled Threesome: Adiponectin, Insulin Sensitivity, and Adiposity: Can Mendelian Randomization Sort Out Causality?
Diabetes March 2013, Vol.62, 1007-1009. doi:https://doi.org/10.2337/db12-1673
Tandem Inhibition of PKC in Diαβetic Nephropathy: It Takes Two to Tango?
Topics:
diabetic nephropathy
,
kidney diseases
,
protein isoforms
,
kidney
,
hyperglycemia
Diabetes March 2013, Vol.62, 1010-1011. doi:https://doi.org/10.2337/db12-1666
Elucidating the Mechanisms Behind the Restoration of Euglycemia After Gastric Bypass Surgery
Diabetes March 2013, Vol.62, 1012-1013. doi:https://doi.org/10.2337/db12-1690
Hypothalamic EphA5 Facilitates Counterregulatory Responses: Possible Role for Bidirectional Signaling Leading to Bistability That Enhances Responsiveness to Hypoglycemia
Topics:
hypoglycemia
,
hypothalamus
,
signal transduction
,
glucose
Diabetes March 2013, Vol.62, 1014-1016. doi:https://doi.org/10.2337/db12-1735
The Suprachiasmatic Nucleus, Circadian Clocks, and the Liver
Topics:
circadian clocks
,
liver
,
suprachiasmatic nucleus
,
glucose metabolism
,
sleep
Diabetes March 2013, Vol.62, 1017-1019. doi:https://doi.org/10.2337/db12-1765
Prediction of Type 1 Diabetes
Diabetes March 2013, Vol.62, 1020-1021. doi:https://doi.org/10.2337/db12-1593
Exploring the Promise of Resveratrol: Where Do We Go From Here?
Topics:
resveratrol
Diabetes March 2013, Vol.62, 1022-1023. doi:https://doi.org/10.2337/db12-1788
ContRac1ion-Mediated Glucose Uptake: A Central Role for Rac1
Topics:
glucose uptake
,
insulin
,
skeletal muscles
Diabetes March 2013, Vol.62, 1024-1025. doi:https://doi.org/10.2337/db12-1789
Epigenetics and Fetal Metabolic Programming: A Call for Integrated Research on Larger Cohorts
Topics:
epigenetics
,
fetus
,
obesity
Diabetes March 2013, Vol.62, 1026-1028. doi:https://doi.org/10.2337/db12-1763
DPP-4 Inhibition and Neuroprotection: Do Mechanisms Matter?
Topics:
dipeptidyl-peptidase iv
,
neuroprotection
,
diabetes mellitus, type 2
,
glucagon-like peptide 1
,
incretin
Diabetes March 2013, Vol.62, 1029-1031. doi:https://doi.org/10.2337/db12-1794
Point-Counterpoint
Mitochondrial Deficiency Is Associated With Insulin Resistance
Topics:
mitochondria
,
lipids
,
insulin resistance
,
fatty acid oxidation
,
obesity
Diabetes March 2013, Vol.62, 1032-1035. doi:https://doi.org/10.2337/db12-1612
“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance
Topics:
diabetes mellitus, type 2
,
insulin
,
insulin resistance
,
mitochondria
,
obesity
Diabetes March 2013, Vol.62, 1036-1040. doi:https://doi.org/10.2337/db12-1107
Methodology Review
Methods for Assessing Mitochondrial Function in Diabetes
Topics:
mitochondria
,
respiration
Diabetes March 2013, Vol.62, 1041-1053. doi:https://doi.org/10.2337/db12-1219
Original Research
Metabolism
A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
C. Lawrence Kien; Janice Y. Bunn; Matthew E. Poynter; Robert Stevens; James Bain; Olga Ikayeva; Naomi K. Fukagawa; Catherine M. Champagne; Karen I. Crain; Timothy R. Koves; Deborah M. Muoio
Topics:
diet
,
lipids
,
insulin resistance
Diabetes March 2013, Vol.62, 1054-1063. doi:https://doi.org/10.2337/db12-0363
Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor
Yan Lu; Xuelian Xiong; Xiaolin Wang; Zhijian Zhang; Jin Li; Guojun Shi; Jian Yang; Huijie Zhang; Guang Ning; Xiaoying Li
Topics:
fasting
,
gluconeogenesis
,
liver
,
mice
,
phosphoenolpyruvate carboxylase
Diabetes March 2013, Vol.62, 1064-1073. doi:https://doi.org/10.2337/db12-0744
Restoration of Euglycemia After Duodenal Bypass Surgery Is Reliant on Central and Peripheral Inputs in Zucker fa/fa Rats
Jian Jiao; Eun Ju Bae; Gautam Bandyopadhyay; Jason Oliver; Chaitra Marathe; Michael Chen; Jer-Yuan Hsu; Yu Chen; Hui Tian; Jerrold M. Olefsky; Maziyar Saberi
Topics:
bypass
,
insulin sensitivity
,
surgery specialty
,
surgical procedures, operative
,
insulin
Diabetes March 2013, Vol.62, 1074-1083. doi:https://doi.org/10.2337/db12-0681
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
Carlos Escande; Veronica Nin; Nathan L. Price; Verena Capellini; Ana P. Gomes; Maria Thereza Barbosa; Luke O’Neil; Thomas A. White; David A. Sinclair; Eduardo N. Chini
Topics:
acetylation
,
cd38
,
quercetin
,
mice
,
metabolic syndrome x
Diabetes March 2013, Vol.62, 1084-1093. doi:https://doi.org/10.2337/db12-1139
The Effect of a Bile Acid Sequestrant on Glucose Metabolism in Subjects With Type 2 Diabetes
Galina Smushkin; Matheni Sathananthan; Francesca Piccinini; Chiara Dalla Man; Jennie H. Law; Claudio Cobelli; Alan R. Zinsmeister; Robert A. Rizza; Adrian Vella
Topics:
colesevelam hydrochloride
,
glucose
,
insulin
,
diabetes mellitus, type 2
,
glucagon-like peptide 1
Diabetes March 2013, Vol.62, 1094-1101. doi:https://doi.org/10.2337/db12-0923
The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity
Claudia P. Coomans; Sjoerd A.A. van den Berg; Eliane A. Lucassen; Thijs Houben; Amanda C.M. Pronk; Rianne D. van der Spek; Andries Kalsbeek; Nienke R. Biermasz; Ko Willems van Dijk; Johannes A. Romijn; Johanna H. Meijer
Topics:
ablation
,
calorimetry, indirect
,
mice
,
insulin sensitivity
,
suprachiasmatic nucleus
Diabetes March 2013, Vol.62, 1102-1108. doi:https://doi.org/10.2337/db12-0507
Sterol Regulatory Element-Binding Factor 2 (SREBF-2) Predicts 7-Year NAFLD Incidence and Severity of Liver Disease and Lipoprotein and Glucose Dysmetabolism
Topics:
non-alcoholic fatty liver disease
,
biopsy
,
glucose
Diabetes March 2013, Vol.62, 1109-1120. doi:https://doi.org/10.2337/db12-0858
Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome: Lessons From the Fructose-Fed Rat Model
Yonit Marcus; Gabi Shefer; Keren Sasson; Fortune Kohen; Rona Limor; Orit Pappo; Nava Nevo; Inbal Biton; Michal Bach; Tamara Berkutzki; Matityahu Fridkin; Dafna Benayahu; Yoram Shechter; Naftali Stern
Topics:
epididymis
,
fructose
,
rats
,
adipose tissue
,
adipocytes
Diabetes March 2013, Vol.62, 1121-1130. doi:https://doi.org/10.2337/db12-0792
Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia
Tricia M. Tan; Benjamin C.T. Field; Katherine A. McCullough; Rachel C. Troke; Edward S. Chambers; Victoria Salem; Juan Gonzalez Maffe; Kevin C.R. Baynes; Akila De Silva; Alexander Viardot; Ali Alsafi; Gary S. Frost; Mohammad A. Ghatei; Stephen R. Bloom
Topics:
glucagon
,
glucagon-like peptide 1
,
infusion procedures
,
hyperglycemia
Diabetes March 2013, Vol.62, 1131-1138. doi:https://doi.org/10.2337/db12-0797
Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle
Lykke Sylow; Thomas E. Jensen; Maximilian Kleinert; Joshua R. Mouatt; Stine J. Maarbjerg; Jacob Jeppesen; Clara Prats; Tim T. Chiu; Shlomit Boguslavsky; Amira Klip; Peter Schjerling; Erik A. Richter
Topics:
ampk
,
glucose uptake
,
mice
,
skeletal muscles
,
treadmills
Diabetes March 2013, Vol.62, 1139-1151. doi:https://doi.org/10.2337/db12-0491
Evidence for a Role of Proline and Hypothalamic Astrocytes in the Regulation of Glucose Metabolism in Rats
Topics:
astrocytes
,
glucose
,
glucose metabolism
,
hypothalamus
,
proline
Diabetes March 2013, Vol.62, 1152-1158. doi:https://doi.org/10.2337/db12-0228
Signal Transduction
Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2
Topics:
insulin
,
insulin resistance
,
liver
,
mice
,
signal transduction
Diabetes March 2013, Vol.62, 1159-1166. doi:https://doi.org/10.2337/db12-0670
Dual Inhibition of Classical Protein Kinase C-α and Protein Kinase C-β Isoforms Protects Against Experimental Murine Diabetic Nephropathy
Jan Menne; Nelli Shushakova; Janina Bartels; Yulia Kiyan; Robert Laudeley; Hermann Haller; Joon-Keun Park; Matthias Meier
Topics:
albuminuria
,
diabetic nephropathy
,
kidney
,
mice
,
protein isoforms
Diabetes March 2013, Vol.62, 1167-1174. doi:https://doi.org/10.2337/db12-0534
Sexually Dimorphic Effects of Maternal Nutrient Reduction on Expression of Genes Regulating Cortisol Metabolism in Fetal Baboon Adipose and Liver Tissues
Topics:
adipose tissue
,
fetus
,
hydrocortisone
,
liver
,
papio
Diabetes March 2013, Vol.62, 1175-1185. doi:https://doi.org/10.2337/db12-0561
Obesity Studies
High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition
Morten M. Poulsen; Poul F. Vestergaard; Berthil F. Clasen; Yulia Radko; Lars P. Christensen; Hans Stødkilde-Jørgensen; Niels Møller; Niels Jessen; Steen B. Pedersen; Jens Otto L. Jørgensen
Topics:
obesity
,
resveratrol
,
glucose
,
insulin sensitivity
,
lipids
Diabetes March 2013, Vol.62, 1186-1195. doi:https://doi.org/10.2337/db12-0975
Islet Studies
Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: Evidence for a Circulating α-Cell Growth Factor
Christine Longuet; Ana M. Robledo; E. Danielle Dean; Chunhua Dai; Safina Ali; Ian McGuinness; Vincent de Chavez; Patricia M. Vuguin; Maureen J. Charron; Alvin C. Powers; Daniel J. Drucker
Topics:
gcgr gene
,
glucagon
,
hyperplasia
,
insulin
,
mice
Diabetes March 2013, Vol.62, 1196-1205. doi:https://doi.org/10.2337/db11-1605
Fetal PGC-1α Overexpression Programs Adult Pancreatic β-Cell Dysfunction
Bérengère Valtat; Jean-Pierre Riveline; Ping Zhang; Amrit Singh-Estivalet; Mathieu Armanet; Nicolas Venteclef; Adrien Besseiche; Daniel P. Kelly; François Tronche; Pascal Ferré; Jean-François Gautier; Bernadette Bréant; Bertrand Blondeau
Topics:
fetus
,
insulin
,
mice
,
pancreas
,
protein overexpression
Diabetes March 2013, Vol.62, 1206-1216. doi:https://doi.org/10.2337/db12-0314
TGFβ Receptor Signaling Is Essential for Inflammation-Induced but Not β-Cell Workload–Induced β-Cell Proliferation
Xiangwei Xiao; John Wiersch; Yousef El-Gohary; Ping Guo; Krishna Prasadan; Jose Paredes; Carey Welsh; Chiyo Shiota; George K. Gittes
Topics:
inflammation
,
insulin
,
mice
,
pancreas
,
signal transduction
Diabetes March 2013, Vol.62, 1217-1226. doi:https://doi.org/10.2337/db12-1428
Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes
Etty Bachar-Wikstrom; Jakob D. Wikstrom; Yafa Ariav; Boaz Tirosh; Nurit Kaiser; Erol Cerasi; Gil Leibowitz
Topics:
autophagy
,
rapamycin
,
stress
,
emergency service, hospital
,
mice
Diabetes March 2013, Vol.62, 1227-1237. doi:https://doi.org/10.2337/db12-1474
Immunology and Transplantation
Fecal Microbiota Composition Differs Between Children With β-Cell Autoimmunity and Those Without
Marcus C. de Goffau; Kristiina Luopajärvi; Mikael Knip; Jorma Ilonen; Terhi Ruohtula; Taina Härkönen; Laura Orivuori; Saara Hakala; Gjalt W. Welling; Hermie J. Harmsen; Outi Vaarala
Topics:
autoantibodies
,
autoimmunity
,
child
,
feces
,
human leukocyte antigens
Diabetes March 2013, Vol.62, 1238-1244. doi:https://doi.org/10.2337/db12-0526
Pathophysiology
Increase of Palmitic Acid Concentration Impairs Endothelial Progenitor Cell and Bone Marrow–Derived Progenitor Cell Bioavailability: Role of the STAT5/PPARγ Transcriptional Complex
Antonella Trombetta; Gabriele Togliatto; Arturo Rosso; Patrizia Dentelli; Cristina Olgasi; Paolo Cotogni; Maria Felice Brizzi
Topics:
binding (molecular function)
,
biological availability
,
bone marrow
,
cell cycle
,
chromatin immunoprecipitation
Diabetes March 2013, Vol.62, 1245-1257. doi:https://doi.org/10.2337/db12-0646
Complications
Activation of the ACE2/Angiotensin-(1–7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors
Yagna P.R. Jarajapu; Ashay D. Bhatwadekar; Sergio Caballero; Sugata Hazra; Vinayak Shenoy; Reinhold Medina; David Kent; Alan W. Stitt; Catherine Thut; Eva M. Finney; Mohan K. Raizada; Maria B. Grant
Topics:
cd34 antigens
Diabetes March 2013, Vol.62, 1258-1269. doi:https://doi.org/10.2337/db12-0808
Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
Diabetes March 2013, Vol.62, 1270-1281. doi:https://doi.org/10.2337/db12-0533
EphA5-EphrinA5 Interactions Within the Ventromedial Hypothalamus Influence Counterregulatory Hormone Release and Local Glutamine/Glutamate Balance During Hypoglycemia
Topics:
glucose
,
glutamate
,
glutamates
,
glutamine
,
hormones
Diabetes March 2013, Vol.62, 1282-1288. doi:https://doi.org/10.2337/db12-0982
The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride
Vladimer Darsalia; Henrik Ortsäter; Anna Olverling; Emilia Darlöf; Petra Wolbert; Thomas Nyström; Thomas Klein; Åke Sjöholm; Cesare Patrone
Topics:
brain
,
cerebrovascular accident
,
dipeptidyl-peptidase iv
,
glimepiride
,
glucagon-like peptide 1
Diabetes March 2013, Vol.62, 1289-1296. doi:https://doi.org/10.2337/db12-0988
Pharmacology and Therapeutics
Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice
Li-Na Zhang; Hua-Yong Zhou; Yan-Yun Fu; Yuan-Yuan Li; Fang Wu; Min Gu; Ling-Yan Wu; Chun-Mei Xia; Tian-Cheng Dong; Jing-Ya Li; Jing-Kang Shen; Jia Li
Topics:
genes
,
glucose
,
luciferases
,
mice
,
mitochondria
Diabetes March 2013, Vol.62, 1297-1307. doi:https://doi.org/10.2337/db12-0703
Rab7 Silencing Prevents μ-Opioid Receptor Lysosomal Targeting and Rescues Opioid Responsiveness to Strengthen Diabetic Neuropathic Pain Therapy
Shaaban A. Mousa; Mohammed Shaqura; Baled I. Khalefa; Christian Zöllner; Laura Schaad; Jonas Schneider; Toni S. Shippenberg; Jan F. Richter; Rainer Hellweg; Mehdi Shakibaei; Michael Schäfer
Topics:
diabetic neuropathies
,
ganglia, spinal
,
neurons, afferent
,
opioid analgesics
,
opioids
Diabetes March 2013, Vol.62, 1308-1319. doi:https://doi.org/10.2337/db12-0590
Genetics / Genomes / Proteomics / Metabolomics
Metabolic Programming of MEST DNA Methylation by Intrauterine Exposure to Gestational Diabetes Mellitus
Nady El Hajj; Galyna Pliushch; Eberhard Schneider; Marcus Dittrich; Tobias Müller; Michael Korenkov; Melanie Aretz; Ulrich Zechner; Harald Lehnen; Thomas Haaf
Topics:
genes
,
gestational diabetes
,
intrauterine route of drug administration
,
methylation
,
pyrosequencing
Diabetes March 2013, Vol.62, 1320-1328. doi:https://doi.org/10.2337/db12-0289
Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile
Gaya Thanabalasingham; Jennifer E. Huffman; Jayesh J. Kattla; Mislav Novokmet; Igor Rudan; Anna L. Gloyn; Caroline Hayward; Barbara Adamczyk; Rebecca M. Reynolds; Ana Muzinic; Neelam Hassanali; Maja Pucic; Amanda J. Bennett; Abdelkader Essafi; Ozren Polasek; Saima A. Mughal; Irma Redzic; Dragan Primorac; Lina Zgaga; Ivana Kolcic; Torben Hansen; Daniela Gasperikova; Erling Tjora; Mark W.J. Strachan; Trine Nielsen; Juraj Stanik; Iwar Klimes; Oluf B. Pedersen; Pål R. Njølstad; Sarah H. Wild; Ulf Gyllensten; Olga Gornik; James F. Wilson; Nicholas D. Hastie; Harry Campbell; Mark I. McCarthy; Pauline M. Rudd; Katharine R. Owen; Gordan Lauc; Alan F. Wright
Diabetes March 2013, Vol.62, 1329-1337. doi:https://doi.org/10.2337/db12-0880
Evidence of a Causal Relationship Between Adiponectin Levels and Insulin Sensitivity: A Mendelian Randomization Study
Topics:
adiponectin
,
insulin sensitivity
Diabetes March 2013, Vol.62, 1338-1344. doi:https://doi.org/10.2337/db12-0935
HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients
Eric Mbunwe; Bart J. Van der Auwera; Ilse Vermeulen; Simke Demeester; Annelien Van Dalem; Eric V. Balti; Sara Van Aken; Luc Derdelinckx; Harry Dorchy; Jean De Schepper; Chris van Schravendijk; Janet M. Wenzlau; John C. Hutton; Daniël Pipeleers; Ilse Weets; Frans K. Gorus; and the Belgian Diabetes Registry
Topics:
hla-a antigens
,
hla-a2 antigen
,
human leukocyte antigens
,
screening
,
autoantibodies
Diabetes March 2013, Vol.62, 1345-1350. doi:https://doi.org/10.2337/db12-0747
Issues and Events
Issues and Events
Topics:
atherosclerosis
,
austria
,
chief complaint
,
cupressus
,
florida
Diabetes March 2013, Vol.62, 1351. doi:https://doi.org/10.2337/db13-ie04
Diabetes Digests
Highlights From the Latest in Diabetes Research
Topics:
adipocytes
,
atrophy
,
diabetes mellitus, type 1
,
mice
,
obesity
Diabetes March 2013, Vol.62, 1352-1353. doi:https://doi.org/10.2337/db13-dd04
