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1 May 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes April 2013, Vol.62, 1355-1356. doi:https://doi.org/10.2337/db13-ti05
Perspectives in Diabetes
Toward Engineering a Novel Transplantation Site for Human Pancreatic Islets
Diabetes April 2013, Vol.62, 1357-1364. doi:https://doi.org/10.2337/db12-1553
Commentary
Does Obesity-Induced τ Phosphorylation Tip the Scale Toward Dementia?
Diabetes April 2013, Vol.62, 1365-1366. doi:https://doi.org/10.2337/db12-1784
The Brain–Liver Connection Between BDNF and Glucose Control
Diabetes April 2013, Vol.62, 1367-1368. doi:https://doi.org/10.2337/db12-1824
New Insights and New Conundrums in Neonatal Hypoglycemia: Enigmas Wrapped in Mystery
Diabetes April 2013, Vol.62, 1373-1375. doi:https://doi.org/10.2337/db12-1839
A Role for Natriuretic Peptides in the Central Control of Energy Balance?
Diabetes April 2013, Vol.62, 1379-1381. doi:https://doi.org/10.2337/db12-1841
Fetal Pancreas as a Source for Islet Transplantation: Sweet Promise and Current Challenges
Diabetes April 2013, Vol.62, 1382-1383. doi:https://doi.org/10.2337/db13-0018
“Prediction Is Very Hard, Especially About the Future”: New Biomarkers for Type 2 Diabetes?
Diabetes April 2013, Vol.62, 1384-1385. doi:https://doi.org/10.2337/db13-0057
Changing the Way We Think About Endothelial Cell Insulin Sensitivity, Nitric Oxide, and the Pathophysiology of Type 2 Diabetes: The FoxO Is Loose
Diabetes April 2013, Vol.62, 1386-1388. doi:https://doi.org/10.2337/db13-0183
Glucose Control of Glucagon Secretion: There Is More to It Than KATP Channels
Diabetes April 2013, Vol.62, 1391-1393. doi:https://doi.org/10.2337/db13-0193
Point-Counterpoint
Original Research
Metabolism
Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
Christian Høst; Lars C. Gormsen; Britt Christensen; Niels Jessen; David M. Hougaard; Jens S. Christiansen; Steen B. Pedersen; Michael D. Jensen; Søren Nielsen; Claus H. Gravholt
Diabetes April 2013, Vol.62, 1409-1416. doi:https://doi.org/10.2337/db12-0440
Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity
Diabetes April 2013, Vol.62, 1417-1425. doi:https://doi.org/10.2337/db12-1032
Epigenetic Regulation of Adipogenesis by PHF2 Histone Demethylase
Yosuke Okuno; Fumiaki Ohtake; Katsuhide Igarashi; Jun Kanno; Takahiro Matsumoto; Ichiro Takada; Shigeaki Kato; Yuuki Imai
Diabetes April 2013, Vol.62, 1426-1434. doi:https://doi.org/10.2337/db12-0628
Dietary Proteins Contribute Little to Glucose Production, Even Under Optimal Gluconeogenic Conditions in Healthy Humans
Claire Fromentin; Daniel Tomé; Françoise Nau; Laurent Flet; Catherine Luengo; Dalila Azzout-Marniche; Pascal Sanders; Gilles Fromentin; Claire Gaudichon
Diabetes April 2013, Vol.62, 1435-1442. doi:https://doi.org/10.2337/db12-1208
Nogo-A Downregulation Improves Insulin Secretion in Mice
Claire B. Bonal; Delphine E. Baronnier; Caroline Pot; Mahdia Benkhoucha; Martin E. Schwab; Patrice H. Lalive; Pedro L. Herrera
Diabetes April 2013, Vol.62, 1443-1452. doi:https://doi.org/10.2337/db12-0949
Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
Kirk M. Habegger; Kerstin Stemmer; Christine Cheng; Timo D. Müller; Kristy M. Heppner; Nickki Ottaway; Jenna Holland; Jazzminn L. Hembree; David Smiley; Vasily Gelfanov; Radha Krishna; Ayman M. Arafat; Anish Konkar; Sara Belli; Martin Kapps; Stephen C. Woods; Susanna M. Hofmann; David D’Alessio; Paul T. Pfluger; Diego Perez-Tilve; Randy J. Seeley; Morichika Konishi; Nobuyujki Itoh; Alexei Kharitonenkov; Joachim Spranger; Richard D. DiMarchi; Matthias H. Tschöp
Diabetes April 2013, Vol.62, 1453-1463. doi:https://doi.org/10.2337/db12-1116
Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy
Thomas Pulinilkunnil; Petra C. Kienesberger; Jeevan Nagendran; Terri J. Waller; Martin E. Young; Erin E. Kershaw; Gregory Korbutt; Guenter Haemmerle; Rudolf Zechner; Jason R.B. Dyck
Diabetes April 2013, Vol.62, 1464-1477. doi:https://doi.org/10.2337/db12-0927
Liver Sinusoidal Endothelial Cells Link Hyperinsulinemia to Hepatic Insulin Resistance
Diabetes April 2013, Vol.62, 1478-1489. doi:https://doi.org/10.2337/db12-1296
LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
Jacob Jeppesen; Stine J. Maarbjerg; Andreas B. Jordy; Andreas M. Fritzen; Christian Pehmøller; Lykke Sylow; Annette Karen Serup; Niels Jessen; Kasper Thorsen; Clara Prats; Klaus Qvortrup; Jason R.B. Dyck; Roger W. Hunter; Kei Sakamoto; David M. Thomson; Peter Schjerling; Jørgen F.P. Wojtaszewski; Erik A. Richter; Bente Kiens
Diabetes April 2013, Vol.62, 1490-1499. doi:https://doi.org/10.2337/db12-1160
Intracerebroventricular Administration of C-Type Natriuretic Peptide Suppresses Food Intake via Activation of the Melanocortin System in Mice
Nobuko Yamada-Goto; Goro Katsuura; Ken Ebihara; Megumi Inuzuka; Yukari Ochi; Yui Yamashita; Toru Kusakabe; Akihiro Yasoda; Noriko Satoh-Asahara; Hiroyuki Ariyasu; Kiminori Hosoda; Kazuwa Nakao
Diabetes April 2013, Vol.62, 1500-1504. doi:https://doi.org/10.2337/db12-0718
Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs
Simone Renner; Christina Braun-Reichhart; Andreas Blutke; Nadja Herbach; Daniela Emrich; Elisabeth Streckel; Annegret Wünsch; Barbara Kessler; Mayuko Kurome; Andrea Bähr; Nikolai Klymiuk; Stefan Krebs; Oliver Puk; Hiroshi Nagashima; Jochen Graw; Helmut Blum; Ruediger Wanke; Eckhard Wolf
Diabetes April 2013, Vol.62, 1505-1511. doi:https://doi.org/10.2337/db12-1065
Signal Transduction
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells
Cesar Osorio-Fuentealba; Ariel E. Contreras-Ferrat; Francisco Altamirano; Alejandra Espinosa; Qing Li; Wenyan Niu; Sergio Lavandero; Amira Klip; Enrique Jaimovich
Diabetes April 2013, Vol.62, 1519-1526. doi:https://doi.org/10.2337/db12-1066
β-Cell–Specific Protein Kinase A Activation Enhances the Efficiency of Glucose Control by Increasing Acute-Phase Insulin Secretion
Kelly A. Kaihara; Lorna M. Dickson; David A. Jacobson; Natalia Tamarina; Michael W. Roe; Louis H. Philipson; Barton Wicksteed
Diabetes April 2013, Vol.62, 1527-1536. doi:https://doi.org/10.2337/db12-1013
Obesity Studies
Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation
Ting-Wen A. Lee; Hyokjoon Kwon; Haihong Zong; Eijiro Yamada; Manu Vatish; Jeffrey E. Pessin; Claire C. Bastie
Diabetes April 2013, Vol.62, 1537-1546. doi:https://doi.org/10.2337/db12-0920
Islet Studies
G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion
Lynley D. Pound; James K. Oeser; Tracy P. O’Brien; Yingda Wang; Chandler J. Faulman; Prasanna K. Dadi; David A. Jacobson; John C. Hutton; Owen P. McGuinness; Masakazu Shiota; Richard M. O’Brien
Diabetes April 2013, Vol.62, 1547-1556. doi:https://doi.org/10.2337/db12-1067
Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
Cristina Aguayo-Mazzucato; Ann Marie Zavacki; Alejandra Marinelarena; Jennifer Hollister-Lock; Ilham El Khattabi; Alessandro Marsili; Gordon C. Weir; Arun Sharma; P. Reed Larsen; Susan Bonner-Weir
Diabetes April 2013, Vol.62, 1569-1580. doi:https://doi.org/10.2337/db12-0849
Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs
Diabetes April 2013, Vol.62, 1581-1592. doi:https://doi.org/10.2337/db12-0167
Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx
Diabetes April 2013, Vol.62, 1593-1601. doi:https://doi.org/10.2337/db11-1593
Dicer1 Is Required to Repress Neuronal Fate During Endocrine Cell Maturation
Diabetes April 2013, Vol.62, 1602-1611. doi:https://doi.org/10.2337/db12-0841
Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose: Involvement of KATP Channels From Both α-Cells and δ-Cells
Rui Cheng-Xue; Ana Gómez-Ruiz; Nancy Antoine; Laura A. Noël; Hee-Young Chae; Magalie A. Ravier; Fabrice Chimienti; Frans C. Schuit; Patrick Gilon
Diabetes April 2013, Vol.62, 1612-1622. doi:https://doi.org/10.2337/db12-0347
UCP2 Regulates the Glucagon Response to Fasting and Starvation
Emma M. Allister; Christine A. Robson-Doucette; Kacey J. Prentice; Alexandre B. Hardy; Sobia Sultan; Herbert Y. Gaisano; Dong Kong; Patrick Gilon; Pedro L. Herrera; Bradford B. Lowell; Michael B. Wheeler
Diabetes April 2013, Vol.62, 1623-1633. doi:https://doi.org/10.2337/db12-0981
β-Cells Are Not Generated in Pancreatic Duct Ligation–Induced Injury in Adult Mice
Matthew M. Rankin; Christopher J. Wilbur; Kimberly Rak; Emily J. Shields; Anne Granger; Jake A. Kushner
Diabetes April 2013, Vol.62, 1634-1645. doi:https://doi.org/10.2337/db12-0848
Immunology and Transplantation
Fetal Pancreas Transplants Are Dependent on Prolactin for Their Development and Prevent Type 1 Diabetes in Syngeneic but Not Allogeneic Mice
Gwladys Fourcade; Bruno M. Colombo; Sylvie Grégoire; Audrey Baeyens; Latif Rachdi; Fanny Guez; Vincent Goffin; Raphael Scharfmann; Benoît L. Salomon
Diabetes April 2013, Vol.62, 1646-1655. doi:https://doi.org/10.2337/db12-0448
Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes
Lorenzo Piemonti; Matthew J. Everly; Paola Maffi; Marina Scavini; Francesca Poli; Rita Nano; Massimo Cardillo; Raffaella Melzi; Alessia Mercalli; Valeria Sordi; Vito Lampasona; Alejandro Espadas de Arias; Mario Scalamogna; Emanuele Bosi; Ezio Bonifacio; Antonio Secchi; Paul I. Terasaki
Diabetes April 2013, Vol.62, 1656-1664. doi:https://doi.org/10.2337/db12-1258
Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection
Andrea Vergani; Carmen Fotino; Francesca D’Addio; Sara Tezza; Michele Podetta; Francesca Gatti; Melissa Chin; Roberto Bassi; Ruth D. Molano; Domenico Corradi; Rita Gatti; Maria E. Ferrero; Antonio Secchi; Fabio Grassi; Camillo Ricordi; Mohamed H. Sayegh; Paola Maffi; Antonello Pileggi; Paolo Fiorina
Diabetes April 2013, Vol.62, 1665-1675. doi:https://doi.org/10.2337/db12-0242
Pathophysiology
Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice
Antoine Leboucher; Cyril Laurent; Francisco-José Fernandez-Gomez; Sylvie Burnouf; Laetitia Troquier; Sabiha Eddarkaoui; Dominique Demeyer; Raphaëlle Caillierez; Nadège Zommer; Emmanuelle Vallez; Kadiombo Bantubungi; Christophe Breton; Pascal Pigny; Valérie Buée-Scherrer; Bart Staels; Malika Hamdane; Anne Tailleux; Luc Buée; David Blum
Diabetes April 2013, Vol.62, 1681-1688. doi:https://doi.org/10.2337/db12-0866
Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells
Jean-Claude Henquin; Christine Sempoux; Joelle Marchandise; Sebastien Godecharles; Yves Guiot; Myriam Nenquin; Jacques Rahier
Diabetes April 2013, Vol.62, 1689-1696. doi:https://doi.org/10.2337/db12-1414
Complications
Glucagon-Like Peptide-1 Protects Against Cardiac Microvascular Injury in Diabetes via a cAMP/PKA/Rho-Dependent Mechanism
Dongjuan Wang; Peng Luo; Yabin Wang; Weijie Li; Chen Wang; Dongdong Sun; Rongqing Zhang; Tao Su; Xiaowei Ma; Chao Zeng; Haichang Wang; Jun Ren; Feng Cao
Diabetes April 2013, Vol.62, 1697-1708. doi:https://doi.org/10.2337/db12-1025
Pharmacology and Therapeutics
Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance
Michael Spencer; Brian S. Finlin; Resat Unal; Beibei Zhu; Andrew J. Morris; Lindsey R. Shipp; Jonah Lee; R. Grace Walton; Akosua Adu; Rod Erfani; Marilyn Campbell; Robert E. McGehee, Jr.; Charlotte A. Peterson; Philip A. Kern
Diabetes April 2013, Vol.62, 1709-1717. doi:https://doi.org/10.2337/db12-1042
Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy
David Callejas; Christopher J. Mann; Eduard Ayuso; Ricardo Lage; Iris Grifoll; Carles Roca; Anna Andaluz; Rafael Ruiz-de Gopegui; Joel Montané; Sergio Muñoz; Tura Ferre; Virginia Haurigot; Shangzhen Zhou; Jesús Ruberte; Federico Mingozzi; Katherine A. High; Felix Garcia; Fatima Bosch
Diabetes April 2013, Vol.62, 1718-1729. doi:https://doi.org/10.2337/db12-1113
Genetics / Genomes / Proteomics / Metabolomics
Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
Ele Ferrannini; Andrea Natali; Stefania Camastra; Monica Nannipieri; Andrea Mari; Klaus-Peter Adam; Michael V. Milburn; Gabi Kastenmüller; Jerzy Adamski; Tiinamaija Tuomi; Valeriya Lyssenko; Leif Groop; Walter E. Gall
Diabetes April 2013, Vol.62, 1730-1737. doi:https://doi.org/10.2337/db12-0707
Genetic and Molecular Insights Into the Role of PROX1 in Glucose Metabolism
Sophie Lecompte; Gianni Pasquetti; Xavier Hermant; Benjamin Grenier-Boley; Marcela Gonzalez-Gross; Stephan De Henauw; Denes Molnar; Peter Stehle; Laurent Béghin; Luis A. Moreno; Philippe Amouyel; Jean Dallongeville; Aline Meirhaeghe
Diabetes April 2013, Vol.62, 1738-1745. doi:https://doi.org/10.2337/db12-0864
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India
Richa Saxena; Danish Saleheen; Latonya F. Been; Martha L. Garavito; Timothy Braun; Andrew Bjonnes; Robin Young; Weang Kee Ho; Asif Rasheed; Philippe Frossard; Xueling Sim; Neelam Hassanali; Venkatesan Radha; Manickam Chidambaram; Samuel Liju; Simon D. Rees; Daniel Peng-Keat Ng; Tien-Yin Wong; Toshimasa Yamauchi; Kazuo Hara; Yasushi Tanaka; Hiroshi Hirose; Mark I. McCarthy; Andrew P. Morris; DIAGRAM; MuTHER; AGEN; Abdul Basit; Anthony H. Barnett; Prasad Katulanda; David Matthews; Viswanathan Mohan; Gurpreet S. Wander; Jai Rup Singh; Narinder K. Mehra; Sarju Ralhan; M. Ilyas Kamboh; John J. Mulvihill; Hiroshi Maegawa; Kazuyuki Tobe; Shiro Maeda; Yoon S. Cho; E. Shyong Tai; M. Ann Kelly; John C. Chambers; Jaspal S. Kooner; Takashi Kadowaki; Panos Deloukas; Daniel J. Rader; John Danesh; Dharambir K. Sanghera
Diabetes April 2013, Vol.62, 1746-1755. doi:https://doi.org/10.2337/db12-1077
Brief Report
Metabolism
BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production
Thomas H. Meek; Brent E. Wisse; Joshua P. Thaler; Stephan J. Guyenet; Miles E. Matsen; Jonathan D. Fischer; Gerald J. Taborsky, Jr.; Michael W. Schwartz; Gregory J. Morton
Diabetes April 2013, Vol.62, 1512-1518. doi:https://doi.org/10.2337/db12-0837
Immunology and Transplantation
Immune Therapy and β-Cell Death in Type 1 Diabetes
Jasmin Lebastchi; Songyan Deng; Amir H. Lebastchi; Isabel Beshar; Stephen Gitelman; Steven Willi; Peter Gottlieb; Eitan M. Akirav; Jeffrey A. Bluestone; Kevan C. Herold
Diabetes April 2013, Vol.62, 1676-1680. doi:https://doi.org/10.2337/db12-1207
Genetics / Genomes / Proteomics / Metabolomics
The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study
Mariaelisa Graff; Penny Gordon-Larsen; Unhee Lim; Jay H. Fowke; Shelly-Ann Love; Megan Fesinmeyer; Lynne R. Wilkens; Shawyntee Vertilus; Marilyn D. Ritchie; Ross L. Prentice; Jim Pankow; Kristine Monroe; JoAnn E. Manson; Loïc Le Marchand; Lewis H. Kuller; Laurence N. Kolonel; Ching P. Hong; Brian E. Henderson; Jeff Haessler; Myron D. Gross; Robert Goodloe; Nora Franceschini; Christopher S. Carlson; Steven Buyske; Petra Bůžková; Lucia A. Hindorff; Tara C. Matise; Dana C. Crawford; Christopher A. Haiman; Ulrike Peters; Kari E. North
Diabetes April 2013, Vol.62, 1763-1767. doi:https://doi.org/10.2337/db12-0863
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes April 2013, Vol.62, 1769-1770. doi:https://doi.org/10.2337/db13-dd05
