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June 2013
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes June 2013, Vol.62, 1771-1772. doi:https://doi.org/10.2337/db13-ti06
Editor’s Note
Banting Lecture
Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease
Diabetes May 2013, Vol.62, 1774-1782. doi:https://doi.org/10.2337/db12-1665
Perspectives in Diabetes
Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes
Diabetes May 2013, Vol.62, 1783-1790. doi:https://doi.org/10.2337/db12-1430
Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
Diabetes May 2013, Vol.62, 1791-1799. doi:https://doi.org/10.2337/db12-1215
SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory: Bringing All the Strands Together
Diabetes May 2013, Vol.62, 1800-1807. doi:https://doi.org/10.2337/db12-1648
Using the Past to Inform the Future: Anti-VEGF Therapy as a Road Map to Develop Novel Therapies for Diabetic Retinopathy
Diabetes May 2013, Vol.62, 1808-1815. doi:https://doi.org/10.2337/db12-1744
Commentary
Treatment of Hyaluronan Accumulation Ameliorates High-Fat Diet–Induced Insulin Resistance in Mice
Diabetes May 2013, Vol.62, 1816-1817. doi:https://doi.org/10.2337/db13-0261
Opportunity “Nox”: A Novel Approach to Preventing Endothelial Dysfunction in the Context of Insulin Resistance
Diabetes May 2013, Vol.62, 1818-1820. doi:https://doi.org/10.2337/db13-0255
β-Cells, Autoimmunity, and the Innate Immune System: “un Ménage á Trois”?
Diabetes May 2013, Vol.62, 1821-1822. doi:https://doi.org/10.2337/db13-0276
Sweet and Sour β-Cells: ROS and Hif1α Induce Warburg-Like Lactate Production During Type 2 Diabetes
Diabetes May 2013, Vol.62, 1823-1825. doi:https://doi.org/10.2337/db13-0272
Disrupting Rhythms: Diet-Induced Obesity Impairs Diurnal Rhythms in Metabolic Tissues
Diabetes May 2013, Vol.62, 1829-1830. doi:https://doi.org/10.2337/db13-0353
Original Research
Metabolism
Mitochondrial Function in Diabetes: Novel Methodology and New Insight
Diabetes May 2013, Vol.62, 1833-1842. doi:https://doi.org/10.2337/db12-1152
Reduced Adipose Tissue Macrophage Content Is Associated With Improved Insulin Sensitivity in Thiazolidinedione-Treated Diabetic Humans
Sudha Koppaka; Sylvia Kehlenbrink; Michelle Carey; Weijie Li; Elizabeth Sanchez; Do-Eun Lee; Hanna Lee; Julie Chen; Emilce Carrasco; Preeti Kishore; Kehao Zhang; Meredith Hawkins
Diabetes May 2013, Vol.62, 1843-1854. doi:https://doi.org/10.2337/db12-0868
Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet–Induced Obesity and Insulin Resistance in Mice
Kwang Min Lee; Seung-Joo Yang; Yong Deuk Kim; Yoo Duk Choi; Jong Hee Nam; Cheol Soo Choi; Hueng-Sik Choi; Chul-Seung Park
Diabetes May 2013, Vol.62, 1855-1864. doi:https://doi.org/10.2337/db12-1030
Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle
Lykke Sylow; Thomas E. Jensen; Maximilian Kleinert; Kurt Højlund; Bente Kiens; Jørgen Wojtaszewski; Clara Prats; Peter Schjerling; Erik A. Richter
Diabetes May 2013, Vol.62, 1865-1875. doi:https://doi.org/10.2337/db12-1148
PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice
Jinhan He; Jie Gao; Meishu Xu; Songrong Ren; Maja Stefanovic-Racic; Robert Martin O'Doherty; Wen Xie
Diabetes May 2013, Vol.62, 1876-1887. doi:https://doi.org/10.2337/db12-1039
Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance
Li Kang; Louise Lantier; Arion Kennedy; Jeffrey S. Bonner; Wesley H. Mayes; Deanna P. Bracy; Louis H. Bookbinder; Alyssa H. Hasty; Curtis B. Thompson; David H. Wasserman
Diabetes May 2013, Vol.62, 1888-1896. doi:https://doi.org/10.2337/db12-1502
Spillover of Fatty Acids During Dietary Fat Storage in Type 2 Diabetes: Relationship to Body Fat Depots and Effects of Weight Loss
Jaime P. Almandoz; Ekta Singh; Lisa A. Howell; Karen Grothe; Danielle T. Vlazny; Almira Smailovic; Brian A. Irving; Robert H. Nelson; John M. Miles
Diabetes May 2013, Vol.62, 1897-1903. doi:https://doi.org/10.2337/db12-1407
Signal Transduction
Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion
Michelle E. Kimple; Mark P. Keller; Mary R. Rabaglia; Renee L. Pasker; Joshua C. Neuman; Nathan A. Truchan; Harpreet K. Brar; Alan D. Attie
Diabetes May 2013, Vol.62, 1904-1912. doi:https://doi.org/10.2337/db12-0769
VASP Increases Hepatic Fatty Acid Oxidation by Activating AMPK in Mice
Sanshiro Tateya; Norma Rizzo-De Leon; Priya Handa; Andrew M. Cheng; Vicki Morgan-Stevenson; Kayoko Ogimoto; Jenny E. Kanter; Karin E. Bornfeldt; Guenter Daum; Alexander W. Clowes; Alan Chait; Francis Kim
Diabetes May 2013, Vol.62, 1913-1922. doi:https://doi.org/10.2337/db12-0325
Obesity Studies
Decreased RB1 mRNA, Protein, and Activity Reflect Obesity-Induced Altered Adipogenic Capacity in Human Adipose Tissue
José María Moreno-Navarrete; Petar Petrov; Marta Serrano; Francisco Ortega; Estefanía García-Ruiz; Paula Oliver; Joan Ribot; Wifredo Ricart; Andreu Palou; Mª Luisa Bonet; José Manuel Fernández-Real
Diabetes May 2013, Vol.62, 1923-1931. doi:https://doi.org/10.2337/db12-0977
Galectin-3 Deficiency Accelerates High-Fat Diet–Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets
Nada N. Pejnovic; Jelena M. Pantic; Ivan P. Jovanovic; Gordana D. Radosavljevic; Marija Z. Milovanovic; Ivana G. Nikolic; Nemanja S. Zdravkovic; Aleksandar L. Djukic; Nebojsa N. Arsenijevic; Miodrag L. Lukic
Diabetes May 2013, Vol.62, 1932-1944. doi:https://doi.org/10.2337/db12-0222
Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation
Angelika Neuhofer; Maximilian Zeyda; Daniel Mascher; Bianca K. Itariu; Incoronata Murano; Lukas Leitner; Eva E. Hochbrugger; Peter Fraisl; Saverio Cinti; Charles N. Serhan; Thomas M. Stulnig
Diabetes May 2013, Vol.62, 1945-1956. doi:https://doi.org/10.2337/db12-0828
Apelin Inhibits Diet-Induced Obesity by Enhancing Lymphatic and Blood Vessel Integrity
Diabetes May 2013, Vol.62, 1970-1980. doi:https://doi.org/10.2337/db12-0604
Diurnal Variation in Vascular and Metabolic Function in Diet-Induced Obesity: Divergence of Insulin Resistance and Loss of Clock Rhythm
Madhu J. Prasai; Romana S. Mughal; Stephen B. Wheatcroft; Mark T. Kearney; Peter J. Grant; Eleanor M. Scott
Diabetes May 2013, Vol.62, 1981-1989. doi:https://doi.org/10.2337/db11-1740
Weight Loss Improves the Adipogenic Capacity of Human Preadipocytes and Modulates Their Secretory Profile
Lenka Rossmeislová; Lucia Mališová; Jana Kračmerová; Michaela Tencerová; Zuzana Kováčová; Michal Koc; Michaela Šiklová-Vítková; Nathalie Viquerie; Dominique Langin; Vladimír Štich
Diabetes May 2013, Vol.62, 1990-1995. doi:https://doi.org/10.2337/db12-0986
Islet Studies
Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction
Mayumi Sasaki; Shimpei Fujimoto; Yuichi Sato; Yuichi Nishi; Eri Mukai; Gen Yamano; Hiroki Sato; Yumiko Tahara; Kasane Ogura; Kazuaki Nagashima; Nobuya Inagaki
Diabetes May 2013, Vol.62, 1996-2003. doi:https://doi.org/10.2337/db12-0903
The Type 2 Diabetes–Associated Gene Ide Is Required for Insulin Secretion and Suppression of α-Synuclein Levels in β-Cells
Pär Steneberg; Lisandro Bernardo; Sara Edfalk; Lisa Lundberg; Fredrik Backlund; Claes-Göran Östenson; Helena Edlund
Diabetes May 2013, Vol.62, 2004-2014. doi:https://doi.org/10.2337/db12-1045
Antidiabetic Actions of an Estrogen Receptor β Selective Agonist
Paloma Alonso-Magdalena; Ana B. Ropero; Marta García-Arévalo; Sergi Soriano; Iván Quesada; Sarheed J. Muhammed; Albert Salehi; Jan-Ake Gustafsson; Ángel Nadal
Diabetes May 2013, Vol.62, 2015-2025. doi:https://doi.org/10.2337/db12-1562
The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice
Joanne S.J. Chia; Jennifer L. McRae; Helen E. Thomas; Stacey Fynch; Lorraine Elkerbout; Prue Hill; Lisa Murray-Segal; Simon C. Robson; Jiang-Fan Chen; Anthony J.F. d’Apice; Peter J. Cowan; Karen M. Dwyer
Diabetes May 2013, Vol.62, 2026-2035. doi:https://doi.org/10.2337/db12-0625
Immunology and Transplantation
Promotion of Autoimmune Diabetes by Cereal Diet in the Presence or Absence of Microbes Associated With Gut Immune Activation, Regulatory Imbalance, and Altered Cathelicidin Antimicrobial Peptide
Christopher Patrick; Gen-Sheng Wang; David E. Lefebvre; Jennifer A. Crookshank; Brigitte Sonier; Chandra Eberhard; Majid Mojibian; Christopher R. Kennedy; Stephen P.J. Brooks; Martin L. Kalmokoff; Mariantonia Maglio; Riccardo Troncone; Philippe Poussier; Fraser W. Scott
Diabetes May 2013, Vol.62, 2036-2047. doi:https://doi.org/10.2337/db12-1243
TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity
Diabetes May 2013, Vol.62, 2048-2058. doi:https://doi.org/10.2337/db12-0931
Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity
Anne-Kristin Heninger; Paolo Monti; Carmen Wilhelm; Petra Schwaiger; Denise Kuehn; Anette-G. Ziegler; Ezio Bonifacio
Diabetes May 2013, Vol.62, 2059-2066. doi:https://doi.org/10.2337/db12-0942
Humoral Responses to Islet Antigen-2 and Zinc Transporter 8 Are Attenuated in Patients Carrying HLA-A*24 Alleles at the Onset of Type 1 Diabetes
Anna E. Long; Kathleen M. Gillespie; Rachel J. Aitken; Julia C. Goode; Polly J. Bingley; Alistair J.K. Williams
Diabetes May 2013, Vol.62, 2067-2071. doi:https://doi.org/10.2337/db12-1468
Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes
Andrea Valle; Gian Maria Giamporcaro; Marina Scavini; Angela Stabilini; Pauline Grogan; Eleonora Bianconi; Guido Sebastiani; Matilde Masini; Norma Maugeri; Laura Porretti; Riccardo Bonfanti; Franco Meschi; Maurizio De Pellegrin; Arianna Lesma; Silvano Rossini; Lorenzo Piemonti; Piero Marchetti; Francesco Dotta; Emanuele Bosi; Manuela Battaglia
Diabetes May 2013, Vol.62, 2072-2077. doi:https://doi.org/10.2337/db12-1345
Pathophysiology
Enhanced NF-κB Activity Impairs Vascular Function Through PARP-1–, SP-1–, and COX-2–Dependent Mechanisms in Type 2 Diabetes
Modar Kassan; Soo-Kyoung Choi; Maria Galán; Alexander Bishop; Kazuo Umezawa; Mohamed Trebak; Souad Belmadani; Khalid Matrougui
Diabetes May 2013, Vol.62, 2078-2087. doi:https://doi.org/10.2337/db12-1374
Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance
Emma Ahlqvist; Peter Osmark; Tiina Kuulasmaa; Kasper Pilgaard; Bilal Omar; Charlotte Brøns; Olga Kotova; Anna V. Zetterqvist; Alena Stančáková; Anna Jonsson; Ola Hansson; Johanna Kuusisto; Timothy J. Kieffer; Tiinamaija Tuomi; Bo Isomaa; Sten Madsbad; Maria F. Gomez; Pernille Poulsen; Markku Laakso; Eva Degerman; Jussi Pihlajamäki; Nils Wierup; Allan Vaag; Leif Groop; Valeriya Lyssenko
Diabetes May 2013, Vol.62, 2088-2094. doi:https://doi.org/10.2337/db12-0976
Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress
Stanley M.H. Chan; Ruo-Qiong Sun; Xiao-Yi Zeng; Zi-Heng Choong; Hao Wang; Matthew J. Watt; Ji-Ming Ye
Diabetes May 2013, Vol.62, 2095-2105. doi:https://doi.org/10.2337/db12-1397
Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans
Robert Wagner; Gabriele Kaiser; Felicia Gerst; Elisabeth Christiansen; Maria E. Due-Hansen; Manuel Grundmann; Fausto Machicao; Andreas Peter; Evi Kostenis; Trond Ulven; Andreas Fritsche; Hans-Ulrich Häring; Susanne Ullrich
Diabetes May 2013, Vol.62, 2106-2111. doi:https://doi.org/10.2337/db12-1249
Complications
Disruption of the Cerebral White Matter Network Is Related to Slowing of Information Processing Speed in Patients With Type 2 Diabetes
Yael D. Reijmer; Alexander Leemans; Manon Brundel; L. Jaap Kappelle; Geert Jan Biessels; on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group
Diabetes May 2013, Vol.62, 2112-2115. doi:https://doi.org/10.2337/db12-1644
sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death
Elizabeth Selvin; Marc K. Halushka; Andreea M. Rawlings; Ron C. Hoogeveen; Christie M. Ballantyne; Josef Coresh; Brad C. Astor
Diabetes May 2013, Vol.62, 2116-2121. doi:https://doi.org/10.2337/db12-1528
Pharmacology and Therapeutics
Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats
Julien Lamontagne; Élise Jalbert-Arsenault; Émilie Pepin; Marie-Line Peyot; Neil B. Ruderman; Christopher J. Nolan; Erik Joly; S.R. Murthy Madiraju; Vincent Poitout; Marc Prentki
Diabetes May 2013, Vol.62, 2122-2129. doi:https://doi.org/10.2337/db12-0428
Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction
Piruthivi Sukumar; Hema Viswambharan; Helen Imrie; Richard M. Cubbon; Nadira Yuldasheva; Matthew Gage; Stacey Galloway; Anna Skromna; Parkavi Kandavelu; Celio X. Santos; V. Kate Gatenby; Jessica Smith; David J. Beech; Stephen B. Wheatcroft; Keith M. Channon; Ajay M. Shah; Mark T. Kearney
Diabetes May 2013, Vol.62, 2130-2134. doi:https://doi.org/10.2337/db12-1294
Genetics / Genomes / Proteomics / Metabolomics
Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms
Diabetes May 2013, Vol.62, 2135-2140. doi:https://doi.org/10.2337/db12-1398
Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
Weijia Xie; Andrew R. Wood; Valeriya Lyssenko; Michael N. Weedon; Joshua W. Knowles; Sami Alkayyali; Themistocles L. Assimes; Thomas Quertermous; Fahim Abbasi; Jussi Paananen; Hans Häring; Torben Hansen; Oluf Pedersen; Ulf Smith; Markku Laakso; the MAGIC Investigators; the DIAGRAM Consortium; the GENESIS Consortium; the RISC Consortium; Jacqueline M. Dekker; John J. Nolan; Leif Groop; Ele Ferrannini; Klaus-Peter Adam; Walter E. Gall; Timothy M. Frayling; Mark Walker
Diabetes May 2013, Vol.62, 2141-2150. doi:https://doi.org/10.2337/db12-0876
Original Article
Obesity Studies
Cbl-b Is a Critical Regulator of Macrophage Activation Associated With Obesity-Induced Insulin Resistance in Mice
Tomoki Abe; Katsuya Hirasaka; Sachiko Kagawa; Shohei Kohno; Arisa Ochi; Kenro Utsunomiya; Atsuko Sakai; Ayako Ohno; Shigetada Teshima-Kondo; Yuushi Okumura; Motoko Oarada; Yoichi Maekawa; Junji Terao; Edward M. Mills; Takeshi Nikawa
Diabetes May 2013, Vol.62, 1957-1969. doi:https://doi.org/10.2337/db12-0677
