Skip Nav Destination
Issues
August 2013
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes July 2013, Vol.62, 2627-2628. doi:https://doi.org/10.2337/db13-ti08
Perspectives in Diabetes
Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?
Diabetes July 2013, Vol.62, 2629-2634. doi:https://doi.org/10.2337/db12-1605
Remodeling of Lipid Metabolism by Dietary Restriction of Essential Amino Acids
Diabetes July 2013, Vol.62, 2635-2644. doi:https://doi.org/10.2337/db12-1613
Commentary
ON NO—The Continuing Story of Nitric Oxide, Diabetes, and Cardiovascular Disease
Diabetes July 2013, Vol.62, 2645-2647. doi:https://doi.org/10.2337/db13-0542
Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue
Diabetes July 2013, Vol.62, 2656-2658. doi:https://doi.org/10.2337/db13-0608
Therapeutic Targeting of B Cells and T Cells in Autoimmune Diabetes: Is It a Solution?
Diabetes July 2013, Vol.62, 2659-2661. doi:https://doi.org/10.2337/db13-0684
Frail HDLs and Stiff Arteries in Type 2 Diabetes in Juveniles
Diabetes July 2013, Vol.62, 2662-2664. doi:https://doi.org/10.2337/db13-0784
Methodology Review
Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms
Diabetes July 2013, Vol.62, 2674-2682. doi:https://doi.org/10.2337/db13-0106
Original Research
Technological Advances
Potential of Protein Phosphatase Inhibitor 1 As Biomarker of Pancreatic β-Cell Injury In Vitro and In Vivo
Lei Jiang; Benedicte Brackeva; Zhidong Ling; Gertjan Kramer; Johannes M. Aerts; Frans Schuit; Bart Keymeulen; Daniel Pipeleers; Frans Gorus; Geert A. Martens
Diabetes July 2013, Vol.62, 2683-2688. doi:https://doi.org/10.2337/db12-1507
Metabolism
Metabolite Profiles During Oral Glucose Challenge
Jennifer E. Ho; Martin G. Larson; Ramachandran S. Vasan; Anahita Ghorbani; Susan Cheng; Eugene P. Rhee; Jose C. Florez; Clary B. Clish; Robert E. Gerszten; Thomas J. Wang
Diabetes July 2013, Vol.62, 2689-2698. doi:https://doi.org/10.2337/db12-0754
Roles of Insulin, Age, and Asymmetric Dimethylarginine on Nitric Oxide Synthesis In Vivo
Paolo Tessari; Diego Cecchet; Carlo Artusi; Monica Vettore; Renato Millioni; Mario Plebani; Lucia Puricelli; Monica Vedovato
Diabetes July 2013, Vol.62, 2699-2708. doi:https://doi.org/10.2337/db12-1127
FAT/CD36: A Major Regulator of Neuronal Fatty Acid Sensing and Energy Homeostasis in Rats and Mice
Diabetes July 2013, Vol.62, 2709-2716. doi:https://doi.org/10.2337/db12-1689
Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks
Sarah J. Lessard; Donato A. Rivas; Ana B. Alves-Wagner; Michael F. Hirshman; Iain J. Gallagher; Dumitru Constantin-Teodosiu; Ryan Atkins; Paul L. Greenhaff; Nathan R. Qi; Thomas Gustafsson; Roger A. Fielding; James A. Timmons; Steven L. Britton; Lauren G. Koch; Laurie J. Goodyear
Diabetes July 2013, Vol.62, 2717-2727. doi:https://doi.org/10.2337/db13-0062
Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2)
Kim S. Bell-Anderson; Alister P. Funnell; Helen Williams; Hanapi Mat Jusoh; Tiffany Scully; Wooi F. Lim; Jon G. Burdach; Ka Sin Mak; Alexander J. Knights; Andrew J. Hoy; Hannah R. Nicholas; Amanda Sainsbury; Nigel Turner; Richard C. Pearson; Merlin Crossley
Diabetes July 2013, Vol.62, 2728-2737. doi:https://doi.org/10.2337/db12-1745
Leptin Administration Enhances Islet Transplant Performance in Diabetic Mice
Heather C. Denroche; Whitney L. Quong; Jennifer E. Bruin; Eva Tudurí; Ali Asadi; Maria M. Glavas; Jessica K. Fox; Timothy J. Kieffer
Diabetes July 2013, Vol.62, 2738-2746. doi:https://doi.org/10.2337/db12-1684
Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese
Jetro J. Tuulari; Henry K. Karlsson; Jussi Hirvonen; Jarna C. Hannukainen; Marco Bucci; Mika Helmiö; Jari Ovaska; Minna Soinio; Paulina Salminen; Nina Savisto; Lauri Nummenmaa; Pirjo Nuutila
Diabetes July 2013, Vol.62, 2747-2751. doi:https://doi.org/10.2337/db12-1460
Direct Effects of Exendin-(9,39) and GLP-1-(9,36)amide on Insulin Action, β-Cell Function, and Glucose Metabolism in Nondiabetic Subjects
Matheni Sathananthan; Luca P. Farrugia; John M. Miles; Francesca Piccinini; Chiara Dalla Man; Alan R. Zinsmeister; Claudio Cobelli; Robert A. Rizza; Adrian Vella
Diabetes July 2013, Vol.62, 2752-2756. doi:https://doi.org/10.2337/db13-0140
Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism
Faidon Magkos; David Bradley; George G. Schweitzer; Brian N. Finck; J. Christopher Eagon; Olga Ilkayeva; Christopher B. Newgard; Samuel Klein
Diabetes July 2013, Vol.62, 2757-2761. doi:https://doi.org/10.2337/db13-0185
Obesity Studies
Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4+ T Cells in Mice
David L. Morris; Kae Won Cho; Jennifer L. DelProposto; Kelsie E. Oatmen; Lynn M. Geletka; Gabriel Martinez-Santibanez; Kanakadurga Singer; Carey N. Lumeng
Diabetes July 2013, Vol.62, 2762-2772. doi:https://doi.org/10.2337/db12-1404
Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice
Ge Li; John J. Kohorst; Wenjuan Zhang; Eleonora Laritsky; Govindarajan Kunde-Ramamoorthy; Maria S. Baker; Marta L. Fiorotto; Robert A. Waterland
Diabetes July 2013, Vol.62, 2773-2783. doi:https://doi.org/10.2337/db12-1306
Identification of a Loss-of-Function Mutation in Ube2l6 Associated With Obesity Resistance
Diabetes July 2013, Vol.62, 2784-2795. doi:https://doi.org/10.2337/db12-1054
Islet Studies
Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A
Diabetes July 2013, Vol.62, 2796-2807. doi:https://doi.org/10.2337/db12-1394
Npas4 Is a Novel Activity–Regulated Cytoprotective Factor in Pancreatic β-Cells
Paul V. Sabatini; Nicole A.J. Krentz; Bader Zarrouki; Clara Y. Westwell-Roper; Cuilan Nian; Ryan A. Uy; A.M. James Shapiro; Vincent Poitout; Francis C. Lynn
Diabetes July 2013, Vol.62, 2808-2820. doi:https://doi.org/10.2337/db12-1527
Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells
Maria João Lima; Kenneth R. Muir; Hilary M. Docherty; Robert Drummond; Neil W.A. McGowan; Shareen Forbes; Yves Heremans; Isabelle Houbracken; James A. Ross; Stuart J. Forbes; Philippe Ravassard; Harry Heimberg; John Casey; Kevin Docherty
Diabetes July 2013, Vol.62, 2821-2833. doi:https://doi.org/10.2337/db12-1256
Microphthalmia Transcription Factor Regulates Pancreatic β-Cell Function
Magdalena A. Mazur; Marcus Winkler; Elvira Ganić; Jesper K. Colberg; Jenny K. Johansson; Hedvig Bennet; Malin Fex; Ulrike A. Nuber; Isabella Artner
Diabetes July 2013, Vol.62, 2834-2842. doi:https://doi.org/10.2337/db12-1464
Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication
Diabetes July 2013, Vol.62, 2843-2848. doi:https://doi.org/10.2337/db13-0160
Immunology and Transplantation
Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes
Diabetes July 2013, Vol.62, 2849-2858. doi:https://doi.org/10.2337/db12-1175
PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4+ T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes
Diabetes July 2013, Vol.62, 2859-2869. doi:https://doi.org/10.2337/db12-1475
Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function
S. Armando Villalta; Jiena Lang; Samantha Kubeck; Beniwende Kabre; Gregory L. Szot; Boris Calderon; Clive Wasserfall; Mark A. Atkinson; Rolf A. Brekken; Nick Pullen; Robert H. Arch; Jeffrey A. Bluestone
Diabetes July 2013, Vol.62, 2870-2878. doi:https://doi.org/10.2337/db12-1619
Recovery From Overt Type 1 Diabetes Ensues When Immune Tolerance and β-Cell Formation Are Coupled With Regeneration of Endothelial Cells in the Pancreatic Islets
Xiaoxiao Wan; F. Betul Guloglu; Amie M. VanMorlan; Linda M. Rowland; Sarah Zaghouani; Jason A. Cascio; Mermagya Dhakal; Christine M. Hoeman; Habib Zaghouani
Diabetes July 2013, Vol.62, 2879-2889. doi:https://doi.org/10.2337/db12-1281
Improvement in β-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol
Michael R. Rickels; Chengyang Liu; Richard D. Shlansky-Goldberg; Scott A. Soleimanpour; Kumar Vivek; Malek Kamoun; Zaw Min; Eileen Markmann; Maral Palangian; Cornelia Dalton-Bakes; Carissa Fuller; Allen J. Chiou; Clyde F. Barker; Eline T. Luning Prak; Ali Naji
Diabetes July 2013, Vol.62, 2890-2897. doi:https://doi.org/10.2337/db12-1802
Pathophysiology
Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes
Larissa W. van Golen; Marc C. Huisman; Richard G. Ijzerman; Nikie J. Hoetjes; Lothar A. Schwarte; Adriaan A. Lammertsma; Michaela Diamant
Diabetes July 2013, Vol.62, 2898-2904. doi:https://doi.org/10.2337/db12-1159
Carotid Body Denervation Prevents the Development of Insulin Resistance and Hypertension Induced by Hypercaloric Diets
Maria J. Ribeiro; Joana F. Sacramento; Constancio Gonzalez; Maria P. Guarino; Emília C. Monteiro; Sílvia V. Conde
Diabetes July 2013, Vol.62, 2905-2916. doi:https://doi.org/10.2337/db12-1463
β-Cell Lipotoxicity in Response to Free Fatty Acid Elevation in Prepubertal Youth: African American Versus Caucasian Contrast
Sara F. Michaliszyn; Riccardo C. Bonadonna; Lindsey A. Sjaarda; SoJung Lee; Lama Farchoukh; Silva A. Arslanian
Diabetes July 2013, Vol.62, 2917-2922. doi:https://doi.org/10.2337/db12-1664
Complications
Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice
Diabetes July 2013, Vol.62, 2923-2934. doi:https://doi.org/10.2337/db13-0135
Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury
Assaad A. Eid; Bridget M. Ford; Basant Bhandary; Rita de Cassia Cavaglieri; Karen Block; Jeffrey L. Barnes; Yves Gorin; Goutam Ghosh Choudhury; Hanna E. Abboud
Diabetes July 2013, Vol.62, 2935-2947. doi:https://doi.org/10.2337/db12-1504
PKCδ Impaired Vessel Formation and Angiogenic Factor Expression in Diabetic Ischemic Limbs
Diabetes July 2013, Vol.62, 2948-2957. doi:https://doi.org/10.2337/db12-1432
The Effects of Type 2 Diabetes on Lipoprotein Composition and Arterial Stiffness in Male Youth
Scott M. Gordon; W. Sean Davidson; Elaine M. Urbina; Lawrence M. Dolan; Anna Heink; Huaiyu Zang; L. Jason Lu; Amy S. Shah
Diabetes July 2013, Vol.62, 2958-2967. doi:https://doi.org/10.2337/db12-1753
Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats
Negar Karimian; Tairan Qin; Tao Liang; Mayowa Osundiji; Yachi Huang; Trevor Teich; Michael C. Riddell; Mark S. Cattral; David H. Coy; Mladen Vranic; Herbert Y. Gaisano
Diabetes July 2013, Vol.62, 2968-2977. doi:https://doi.org/10.2337/db13-0164
Genetics / Genomes / Proteomics / Metabolomics
Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
Anna Jonsson; Claes Ladenvall; Tarunveer Singh Ahluwalia; Jasmina Kravic; Ulrika Krus; Jalal Taneera; Bo Isomaa; Tiinamaija Tuomi; Erik Renström; Leif Groop; Valeriya Lyssenko
Diabetes July 2013, Vol.62, 2978-2983. doi:https://doi.org/10.2337/db12-1627
Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants With Type 2 Diabetes in American Indians
Robert L. Hanson; Tingwei Guo; Yunhua L. Muller; Jamie Fleming; William C. Knowler; Sayuko Kobes; Clifton Bogardus; Leslie J. Baier
Diabetes July 2013, Vol.62, 2984-2991. doi:https://doi.org/10.2337/db12-1767
Issues and Events
Diabetes Digests
Online Letters to the Editor
Comment on: Allister et al. UCP2 Regulates the Glucagon Response to Fasting and Starvation. Diabetes 2013;62:1623–1633
Diabetes July 2013, Vol.62, e11. doi:https://doi.org/10.2337/db13-0397
