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1 September 2013
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes August 2013, Vol.62, 2995-2996. doi:https://doi.org/10.2337/db13-ti09
Perspectives in Diabetes
Restricted Adipogenesis in Hypertrophic Obesity: The Role of WISP2, WNT, and BMP4
Diabetes August 2013, Vol.62, 2997-3004. doi:https://doi.org/10.2337/db13-0473
Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes
Diabetes August 2013, Vol.62, 3005-3013. doi:https://doi.org/10.2337/db13-0523
Commentary
Does Losartan Prevent Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes?
Diabetes August 2013, Vol.62, 3014-3016. doi:https://doi.org/10.2337/db13-0748
Does Caloric Restriction Alone Explain the Effects of Roux-en-Y Gastric Bypass on Glucose Metabolism? Not by a Long Limb
Diabetes August 2013, Vol.62, 3017-3018. doi:https://doi.org/10.2337/db13-0806
Pharmacogenetic Perturbations in Humans as a Tool to Generate Mechanistic Insight
Diabetes August 2013, Vol.62, 3019-3021. doi:https://doi.org/10.2337/db13-0871
Unraveling the Mechanisms Underlying Olanzapine-Induced Insulin Resistance
Diabetes August 2013, Vol.62, 3022-3023. doi:https://doi.org/10.2337/db13-0804
The Diabetic Brain During Hypoglycemia: In the Midst of Plenty of Lactate
Diabetes August 2013, Vol.62, 3024-3026. doi:https://doi.org/10.2337/db13-0914
Original Research
Metabolism
Very Low–Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and β-Cell Function in Type 2 Diabetic Patients
Clifton Jackness; Wahida Karmally; Gerardo Febres; Irene M. Conwell; Leaque Ahmed; Marc Bessler; Donald J. McMahon; Judith Korner
Diabetes August 2013, Vol.62, 3027-3032. doi:https://doi.org/10.2337/db12-1762
Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase–Dependent Manner in Diabetic Mice
Abulizi Abudukadier; Yoshihito Fujita; Akio Obara; Akiko Ohashi; Toru Fukushima; Yuichi Sato; Masahito Ogura; Yasuhiko Nakamura; Shimpei Fujimoto; Masaya Hosokawa; Hiroyuki Hasegawa; Nobuya Inagaki
Diabetes August 2013, Vol.62, 3033-3043. doi:https://doi.org/10.2337/db12-1242
Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes
Nils B. Jørgensen; Carsten Dirksen; Kirstine N. Bojsen-Møller; Siv H. Jacobsen; Dorte Worm; Dorte L. Hansen; Viggo B. Kristiansen; Lars Naver; Sten Madsbad; Jens J. Holst
Diabetes August 2013, Vol.62, 3044-3052. doi:https://doi.org/10.2337/db13-0022
Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding
Nurit Hadad; Olga Burgazliev; Vered Elgazar-Carmon; Yulia Solomonov; Stephan Wueest; Flurin Item; Daniel Konrad; Assaf Rudich; Rachel Levy
Diabetes August 2013, Vol.62, 3053-3063. doi:https://doi.org/10.2337/db12-1300
Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice
Birgitte Lindegaard; Vance B. Matthews; Claus Brandt; Pernille Hojman; Tamara L. Allen; Emma Estevez; Matthew J. Watt; Clinton R. Bruce; Ole H. Mortensen; Susanne Syberg; Caroline Rudnicka; Julie Abildgaard; Henriette Pilegaard; Juan Hidalgo; Susanne Ditlevsen; Thomas J. Alsted; Andreas N. Madsen; Bente K. Pedersen; Mark A. Febbraio
Diabetes August 2013, Vol.62, 3064-3074. doi:https://doi.org/10.2337/db12-1095
Increased Brain Lactate Concentrations Without Increased Lactate Oxidation During Hypoglycemia in Type 1 Diabetic Individuals
Diabetes August 2013, Vol.62, 3075-3080. doi:https://doi.org/10.2337/db13-0313
Contraction and AICAR Stimulate IL-6 Vesicle Depletion From Skeletal Muscle Fibers In Vivo
Hans P.M.M. Lauritzen; Josef Brandauer; Peter Schjerling; Ho-Jin Koh; Jonas T. Treebak; Michael F. Hirshman; Henrik Galbo; Laurie J. Goodyear
Diabetes August 2013, Vol.62, 3081-3092. doi:https://doi.org/10.2337/db12-1261
Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis
Don-Kyu Kim; Gil-Tae Gang; Dongryeol Ryu; Minseob Koh; Yo-Na Kim; Su Sung Kim; Jinyoung Park; Yong-Hoon Kim; Taebo Sim; In-Kyu Lee; Cheol Soo Choi; Seung Bum Park; Chul-Ho Lee; Seung-Hoi Koo; Hueng-Sik Choi
Diabetes August 2013, Vol.62, 3093-3102. doi:https://doi.org/10.2337/db12-0946
PRLR Regulates Hepatic Insulin Sensitivity in Mice via STAT5
Junjie Yu; Fei Xiao; Qian Zhang; Bin Liu; Yajie Guo; Ziquan Lv; Tingting Xia; Shanghai Chen; Kai Li; Ying Du; Feifan Guo
Diabetes August 2013, Vol.62, 3103-3113. doi:https://doi.org/10.2337/db13-0182
Impaired Tethering and Fusion of GLUT4 Vesicles in Insulin-Resistant Human Adipose Cells
Vladimir A. Lizunov; Jo-Ping Lee; Monica C. Skarulis; Joshua Zimmerberg; Samuel W. Cushman; Karin G. Stenkula
Diabetes August 2013, Vol.62, 3114-3119. doi:https://doi.org/10.2337/db12-1741
Immunology and Transplantation
Limitations of IL-2 and Rapamycin in Immunotherapy of Type 1 Diabetes
Audrey Baeyens; Louis Pérol; Gwladys Fourcade; Nicolas Cagnard; Wassila Carpentier; Janine Woytschak; Onur Boyman; Agnès Hartemann; Eliane Piaggio
Diabetes August 2013, Vol.62, 3120-3131. doi:https://doi.org/10.2337/db13-0214
Protection of Islet Grafts Through Transforming Growth Factor-β–Induced Tolerogenic Dendritic Cells
Diabetes August 2013, Vol.62, 3132-3142. doi:https://doi.org/10.2337/db12-1740
Transient B-Cell Depletion Combined With Apoptotic Donor Splenocytes Induces Xeno-Specific T- and B-Cell Tolerance to Islet Xenografts
Shusen Wang; James Tasch; Taba Kheradmand; Jodie Ulaszek; Sora Ely; Xiaomin Zhang; Bernhard J. Hering; Stephen D. Miller; Xunrong Luo
Diabetes August 2013, Vol.62, 3143-3150. doi:https://doi.org/10.2337/db12-1678
Pathophysiology
Transforming Growth Factor-β–Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy
Supriya D. Deshpande; Sumanth Putta; Mei Wang; Jennifer Y. Lai; Markus Bitzer; Robert G. Nelson; Linda L. Lanting; Mitsuo Kato; Rama Natarajan
Diabetes August 2013, Vol.62, 3151-3162. doi:https://doi.org/10.2337/db13-0305
Relation Between Serum Free Fatty Acids and Adiposity, Insulin Resistance, and Cardiovascular Risk Factors From Adolescence to Adulthood
Brigitte I. Frohnert; David R. Jacobs, Jr.; Julia Steinberger; Antoinette Moran; Lyn M. Steffen; Alan R. Sinaiko
Diabetes August 2013, Vol.62, 3163-3169. doi:https://doi.org/10.2337/db12-1122
Plasminogen Activator Inhibitor-1 Is Involved in Streptozotocin-Induced Bone Loss in Female Mice
Yukinori Tamura; Naoyuki Kawao; Kiyotaka Okada; Masato Yano; Katsumi Okumoto; Osamu Matsuo; Hiroshi Kaji
Diabetes August 2013, Vol.62, 3170-3179. doi:https://doi.org/10.2337/db12-1552
Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance
Diabetes August 2013, Vol.62, 3180-3188. doi:https://doi.org/10.2337/db12-1076
NH2-Terminal Pro–Brain Natriuretic Peptide and Risk of Diabetes
Mariana Lazo; J. Hunter Young; Frederick L. Brancati; Josef Coresh; Seamus Whelton; Chiadi E. Ndumele; Ron Hoogeveen; Christie M. Ballantyne; Elizabeth Selvin
Diabetes August 2013, Vol.62, 3189-3193. doi:https://doi.org/10.2337/db13-0478
MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic β-Cell Dysfunction
Yunxia Zhu; Weiyan You; Hongdong Wang; Yating Li; Nan Qiao; Yuguang Shi; Chenyu Zhang; David Bleich; Xiao Han
Diabetes August 2013, Vol.62, 3194-3206. doi:https://doi.org/10.2337/db13-0151
Complications
Quality-Control Culture System Restores Diabetic Endothelial Progenitor Cell Vasculogenesis and Accelerates Wound Closure
Rica Tanaka; Max Vaynrub; Haruchika Masuda; Rie Ito; Michiru Kobori; Muneo Miyasaka; Hiroshi Mizuno; Stephen M. Warren; Takayuki Asahara
Diabetes August 2013, Vol.62, 3207-3217. doi:https://doi.org/10.2337/db12-1621
Haptoglobin Genotype and the Rate of Renal Function Decline in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
Trevor J. Orchard; Wanjie Sun; Patricia A. Cleary; Saul M. Genuth; John M. Lachin; Paula McGee; Andrew D. Paterson; Philip Raskin; Yefim Anbinder; Andrew P. Levy; the DCCT/EDIC Research Group
Diabetes August 2013, Vol.62, 3218-3223. doi:https://doi.org/10.2337/db13-0256
Pharmacology and Therapeutics
Effect of Losartan on Prevention and Progression of Early Diabetic Nephropathy in American Indians With Type 2 Diabetes
E. Jennifer Weil; Gudeta Fufaa; Lois I. Jones; Tracy Lovato; Kevin V. Lemley; Robert L. Hanson; William C. Knowler; Peter H. Bennett; Berne Yee; Bryan D. Myers; Robert G. Nelson
Diabetes August 2013, Vol.62, 3224-3231. doi:https://doi.org/10.2337/db12-1512
Antipsychotic-Induced Insulin Resistance and Postprandial Hormonal Dysregulation Independent of Weight Gain or Psychiatric Disease
Diabetes August 2013, Vol.62, 3232-3240. doi:https://doi.org/10.2337/db13-0430
DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy
Yusuke Kaida; Kei Fukami; Takanori Matsui; Yuichiro Higashimoto; Yuri Nishino; Nana Obara; Yosuke Nakayama; Ryotaro Ando; Maki Toyonaga; Seiji Ueda; Masayoshi Takeuchi; Hiroyoshi Inoue; Seiya Okuda; Sho-ichi Yamagishi
Diabetes August 2013, Vol.62, 3241-3250. doi:https://doi.org/10.2337/db12-1608
Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet
Jeffrey S. Bonner; Louise Lantier; Kyle M. Hocking; Li Kang; Mark Owolabi; Freyja D. James; Deanna P. Bracy; Colleen M. Brophy; David H. Wasserman
Diabetes August 2013, Vol.62, 3251-3260. doi:https://doi.org/10.2337/db13-0033
GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats
Kirk M. Habegger; Henriette Kirchner; Chun-Xia Yi; Kristy M. Heppner; Dan Sweeney; Nickki Ottaway; Jenna Holland; Sarah Amburgy; Christine Raver; Radhakrishna Krishna; Timo D. Müller; Diego Perez-Tilve; Paul T. Pfluger; Silvana Obici; Richard D. DiMarchi; David A. D’Alessio; Randy J. Seeley; Matthias H. Tschöp
Diabetes August 2013, Vol.62, 3261-3267. doi:https://doi.org/10.2337/db13-0117
Genetics / Genomes / Proteomics / Metabolomics
Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes
Matej Orešič; Peddinti Gopalacharyulu; Juha Mykkänen; Niina Lietzen; Marjaana Mäkinen; Heli Nygren; Satu Simell; Ville Simell; Heikki Hyöty; Riitta Veijola; Jorma Ilonen; Marko Sysi-Aho; Mikael Knip; Tuulia Hyötyläinen; Olli Simell
Diabetes August 2013, Vol.62, 3268-3274. doi:https://doi.org/10.2337/db13-0159
The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway
Leen M. ‘t Hart; Andreas Fritsche; Giel Nijpels; Nienke van Leeuwen; Louise A. Donnelly; Jacqueline M. Dekker; Marjan Alssema; Joao Fadista; Françoise Carlotti; Anette P. Gjesing; Colin N.A. Palmer; Timon W. van Haeften; Silke A. Herzberg-Schäfer; Annemarie M.C. Simonis-Bik; Jeanine J. Houwing-Duistermaat; Quinta Helmer; Joris Deelen; Bruno Guigas; Torben Hansen; Fausto Machicao; Gonneke Willemsen; Robert J. Heine; Mark H.H. Kramer; Jens J. Holst; Eelco J.P. de Koning; Hans-Ulrich Häring; Oluf Pedersen; Leif Groop; Eco J.C. de Geus; P. Eline Slagboom; Dorret I. Boomsma; Elisabeth M.W. Eekhoff; Ewan R. Pearson; Michaela Diamant
Diabetes August 2013, Vol.62, 3275-3281. doi:https://doi.org/10.2337/db13-0227
Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association Studies
M. Geoffrey Hayes; Margrit Urbanek; Marie-France Hivert; Loren L. Armstrong; Jean Morrison; Cong Guo; Lynn P. Lowe; Douglas A. Scheftner; Anna Pluzhnikov; David M. Levine; Caitlin P. McHugh; Christine M. Ackerman; Luigi Bouchard; Diane Brisson; Brian T. Layden; Daniel Mirel; Kimberly F. Doheny; Marysa V. Leya; Rachel N. Lown-Hecht; Alan R. Dyer; Boyd E. Metzger; Timothy E. Reddy; Nancy J. Cox; William L. Lowe, Jr.; for the HAPO Study Cooperative Research Group
Diabetes August 2013, Vol.62, 3282-3291. doi:https://doi.org/10.2337/db12-1692
HLA Class II Genotyping of African American Type 1 Diabetic Patients Reveals Associations Unique to African Haplotypes
Diabetes August 2013, Vol.62, 3292-3299. doi:https://doi.org/10.2337/db13-0094
Erratum
Systemic regulation of the age-related decline of pancreatic β-cell replication. Diabetes 2013;62:2843–2848
Diabetes August 2013, Vol.62, 3300. doi:https://doi.org/10.2337/db13-er09
Issues and Events
Diabetes Digests
Highlights From the Latest in Diabetes Research
Diabetes August 2013, Vol.62, 3302-3303. doi:https://doi.org/10.2337/db13-dd09
