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1 January 2014
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes December 2013, Vol.63, 1-2. doi:https://doi.org/10.2337/db14-ti01
Perspectives in Diabetes
The β-Cell/EC Axis: How Do Islet Cells Talk to Each Other?
Diabetes December 2013, Vol.63, 3-11. doi:https://doi.org/10.2337/db13-0617
It’s Time to Bring Dendritic Cell Therapy to Type 1 Diabetes
Diabetes December 2013, Vol.63, 20-30. doi:https://doi.org/10.2337/db13-0886
Commentaries
New Thoughts in an Old Player: Role of Nitrite in the Treatment of Ischemic Revascularization
Diabetes December 2013, Vol.63, 39-41. doi:https://doi.org/10.2337/db13-1530
Serum TAG Analysis Differentiates Between Genetic and Obesity-Associated NAFLD
Diabetes December 2013, Vol.63, 42-44. doi:https://doi.org/10.2337/db13-1500
Endoplasmic Reticulum: An Interface Between the Immune System and Metabolism
Diabetes December 2013, Vol.63, 48-49. doi:https://doi.org/10.2337/db13-1478
The Critical Role of Methylglyoxal and Glyoxalase 1 in Diabetic Nephropathy
Diabetes December 2013, Vol.63, 50-52. doi:https://doi.org/10.2337/db13-1606
Diabetes in South Asians: Is the Phenotype Different?
Diabetes December 2013, Vol.63, 53-55. doi:https://doi.org/10.2337/db13-1592
Brain MRI in Children With Type 1 Diabetes: Snapshot or Road Map of Developmental Changes?
Diabetes December 2013, Vol.63, 62-64. doi:https://doi.org/10.2337/db13-1466
Technological Advances
Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases
Yi-Guang Chen; Matthew H. Forsberg; Shamim Khaja; Ashley E. Ciecko; Martin J. Hessner; Aron M. Geurts
Diabetes December 2013, Vol.63, 68-74. doi:https://doi.org/10.2337/db13-0192
Metabolism
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway
Valentina Parra; Hugo E. Verdejo; Myriam Iglewski; Andrea del Campo; Rodrigo Troncoso; Deborah Jones; Yi Zhu; Jovan Kuzmicic; Christian Pennanen; Camila Lopez‑Crisosto; Fabián Jaña; Jorge Ferreira; Eduard Noguera; Mario Chiong; David A. Bernlohr; Amira Klip; Joseph A. Hill; Beverly A. Rothermel; Evan Dale Abel; Antonio Zorzano; Sergio Lavandero
Diabetes December 2013, Vol.63, 75-88. doi:https://doi.org/10.2337/db13-0340
Glutathionylated Lipid Aldehydes Are Products of Adipocyte Oxidative Stress and Activators of Macrophage Inflammation
Diabetes December 2013, Vol.63, 89-100. doi:https://doi.org/10.2337/db13-0777
Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor–Deficient Mice
Diabetes December 2013, Vol.63, 101-110. doi:https://doi.org/10.2337/db13-0710
Impaired Leptin Gene Expression and Release in Cultured Preadipocytes Isolated From Individuals Born With Low Birth Weight
Ninna S. Schultz; Christa Broholm; Linn Gillberg; Brynjulf Mortensen; Sine W. Jørgensen; Heidi S. Schultz; Camilla Scheele; Jørgen F.P. Wojtaszewski; Bente K. Pedersen; Allan Vaag
Diabetes December 2013, Vol.63, 111-121. doi:https://doi.org/10.2337/db13-0621
Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors
Kristy M. Heppner; Carolin L. Piechowski; Anne Müller; Nickki Ottaway; Stephanie Sisley; David L. Smiley; Kirk M. Habegger; Paul T. Pfluger; Richard DiMarchi; Heike Biebermann; Matthias H. Tschöp; Darleen A. Sandoval; Diego Perez-Tilve
Diabetes December 2013, Vol.63, 122-131. doi:https://doi.org/10.2337/db13-0414
Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
Kelsey H. Fisher-Wellman; Todd M. Weber; Brook L. Cathey; Patricia M. Brophy; Laura A.A. Gilliam; Constance L. Kane; Jill M. Maples; Timothy P. Gavin; Joseph A. Houmard; P. Darrell Neufer
Diabetes December 2013, Vol.63, 132-141. doi:https://doi.org/10.2337/db13-0940
Signal Transduction
Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages
Yorihiro Iwasaki; Takayoshi Suganami; Rumi Hachiya; Ibuki Shirakawa; Misa Kim-Saijo; Miyako Tanaka; Miho Hamaguchi; Takako Takai-Igarashi; Michikazu Nakai; Yoshihiro Miyamoto; Yoshihiro Ogawa
Diabetes December 2013, Vol.63, 152-161. doi:https://doi.org/10.2337/db13-0757
Obesity Studies
Growth Differentiation Factor-5 Promotes Brown Adipogenesis in Systemic Energy Expenditure
Eiichi Hinoi; Yukari Nakamura; Saya Takada; Hiroyuki Fujita; Takashi Iezaki; Syota Hashizume; Satoshi Takahashi; Yoshiaki Odaka; Takumi Watanabe; Yukio Yoneda
Diabetes December 2013, Vol.63, 162-175. doi:https://doi.org/10.2337/db13-0808
HDAC9 Knockout Mice Are Protected From Adipose Tissue Dysfunction and Systemic Metabolic Disease During High-Fat Feeding
Tapan K. Chatterjee; Joshua E. Basford; Ellen Knoll; Wilson S. Tong; Victor Blanco; Andra L. Blomkalns; Steven Rudich; Alex B. Lentsch; David Y. Hui; Neal L. Weintraub
Diabetes December 2013, Vol.63, 176-187. doi:https://doi.org/10.2337/db13-1148
Islet Studies
Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
Ercument Dirice; Sevim Kahraman; Wenyu Jiang; Abdelfattah El Ouaamari; Dario F. De Jesus; Adrian K.K. Teo; Jiang Hu; Dan Kawamori; Jason L. Gaglia; Diane Mathis; Rohit N. Kulkarni
Diabetes December 2013, Vol.63, 188-202. doi:https://doi.org/10.2337/db13-0204
Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice
Diabetes December 2013, Vol.63, 203-215. doi:https://doi.org/10.2337/db13-0384
Hepatocyte Growth Factor/c-Met Signaling Is Required for β-Cell Regeneration
Juan Carlos Alvarez-Perez; Sara Ernst; Cem Demirci; Gabriella P. Casinelli; Jose Manuel D. Mellado-Gil; Francisco Rausell-Palamos; Rupangi C. Vasavada; Adolfo Garcia-Ocaña
Diabetes December 2013, Vol.63, 216-223. doi:https://doi.org/10.2337/db13-0333
A Smad Signaling Network Regulates Islet Cell Proliferation
Yousef El-Gohary; Sidhartha Tulachan; John Wiersch; Ping Guo; Carey Welsh; Krishna Prasadan; Jose Paredes; Chiyo Shiota; Xiangwei Xiao; Yoko Wada; Marilyn Diaz; George Gittes
Diabetes December 2013, Vol.63, 224-236. doi:https://doi.org/10.2337/db13-0432
Immunology and Transplantation
Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
Menno van Lummel; Gaby Duinkerken; Peter A. van Veelen; Arnoud de Ru; Robert Cordfunke; Arnaud Zaldumbide; Iria Gomez-Touriño; Sefina Arif; Mark Peakman; Jan W. Drijfhout; Bart O. Roep
Diabetes December 2013, Vol.63, 237-247. doi:https://doi.org/10.2337/db12-1214
Pathophysiology
A 5-Day High-Fat, High-Calorie Diet Impairs Insulin Sensitivity in Healthy, Young South Asian Men but Not in Caucasian Men
Leontine E.H. Bakker; Linda D. van Schinkel; Bruno Guigas; Trea C.M. Streefland; Jacqueline T. Jonker; Jan B. van Klinken; Gerard C.M. van der Zon; Hildo J. Lamb; Johannes W.A. Smit; Hanno Pijl; A. Edo Meinders; Ingrid M. Jazet
Diabetes December 2013, Vol.63, 248-258. doi:https://doi.org/10.2337/db13-0696
Carboxyl-Ester Lipase Maturity-Onset Diabetes of the Young Is Associated With Development of Pancreatic Cysts and Upregulated MAPK Signaling in Secretin-Stimulated Duodenal Fluid
Helge Ræder; Fiona E. McAllister; Erling Tjora; Shweta Bhatt; Ingfrid Haldorsen; Jiang Hu; Stefan M. Willems; Mette Vesterhus; Abdelfattah El Ouaamari; Manway Liu; Maria B. Ræder; Heike Immervoll; Dag Hoem; Georg Dimcevski; Pål R. Njølstad; Anders Molven; Steven P. Gygi; Rohit N. Kulkarni
Diabetes December 2013, Vol.63, 259-269. doi:https://doi.org/10.2337/db13-1012
Complications
Nitrite Anion Therapy Protects Against Chronic Ischemic Tissue Injury in db/db Diabetic Mice in a NO/VEGF-Dependent Manner
Shyamal C. Bir; Christopher B. Pattillo; Sibile Pardue; Gopi K. Kolluru; Xinggui Shen; Tony Giordano; Christopher G. Kevil
Diabetes December 2013, Vol.63, 270-281. doi:https://doi.org/10.2337/db13-0890
Relationship of Glycated Albumin to Blood Glucose and HbA1c Values and to Retinopathy, Nephropathy, and Cardiovascular Outcomes in the DCCT/EDIC Study
Diabetes December 2013, Vol.63, 282-290. doi:https://doi.org/10.2337/db13-0782
Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
Ferdinando Giacco; Xueliang Du; Vivette D. D’Agati; Ross Milne; Guangzhi Sui; Michele Geoffrion; Michael Brownlee
Diabetes December 2013, Vol.63, 291-299. doi:https://doi.org/10.2337/db13-0316
Pharmacology and Therapeutics
Genetic Deletion and Pharmacological Inhibition of Phosphodiesterase 10A Protects Mice From Diet-Induced Obesity and Insulin Resistance
Andrea R. Nawrocki; Carlos G. Rodriguez; Dawn M. Toolan; Olga Price; Melanie Henry; Gail Forrest; Daphne Szeto; Carol Ann Keohane; Yie Pan; Karen M. Smith; Izzat T. Raheem; Christopher D. Cox; Joyce Hwa; John J. Renger; Sean M. Smith
Diabetes December 2013, Vol.63, 300-311. doi:https://doi.org/10.2337/db13-0247
Genetics / Genomes / Proteomics / Metabolomics
Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity
Jenni Hyysalo; Peddinti Gopalacharyulu; Hua Bian; Tuulia Hyötyläinen; Marja Leivonen; Nabil Jaser; Anne Juuti; Miikka-Juhani Honka; Pirjo Nuutila; Vesa M. Olkkonen; Matej Oresic; Hannele Yki-Järvinen
Diabetes December 2013, Vol.63, 312-322. doi:https://doi.org/10.2337/db13-0774
Multiple HLA Epitopes Contribute to Type 1 Diabetes Susceptibility
Christina L. Roark; Kirsten M. Anderson; Lucas J. Simon; Ronald P. Schuyler; Michael T. Aubrey; Brian M. Freed
Diabetes December 2013, Vol.63, 323-331. doi:https://doi.org/10.2337/db13-1153
The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal?
Zheng Ye; Philip C. Haycock; Deepti Gurdasani; Cristina Pomilla; S. Matthijs Boekholdt; Sotirios Tsimikas; Kay-Tee Khaw; Nicholas J. Wareham; Manjinder S. Sandhu; Nita G. Forouhi
Diabetes December 2013, Vol.63, 332-342. doi:https://doi.org/10.2337/db13-1144
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
Matthew J. Marzelli; Paul K. Mazaika; Naama Barnea-Goraly; Tamara Hershey; Eva Tsalikian; William Tamborlane; Nelly Mauras; Neil H. White; Bruce Buckingham; Roy W. Beck; Katrina J. Ruedy; Craig Kollman; Peiyao Cheng; Allan L. Reiss; for the Diabetes Research in Children Network (DirecNet)
Diabetes December 2013, Vol.63, 343-353. doi:https://doi.org/10.2337/db13-0179
Short Leukocyte Telomere Length Predicts Risk of Diabetes in American Indians: the Strong Heart Family Study
Jinying Zhao; Yun Zhu; Jue Lin; Tet Matsuguchi; Elizabeth Blackburn; Ying Zhang; Shelley A. Cole; Lyle G. Best; Elisa T. Lee; Barbara V. Howard
Diabetes December 2013, Vol.63, 354-362. doi:https://doi.org/10.2337/db13-0744
SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength
Courtney Sprouse; Heather Gordish-Dressman; E. Funda Orkunoglu-Suer; Jason S. Lipof; Stephanie Moeckel-Cole; Ronak R. Patel; Kasra Adham; Justin S. Larkin; Monica J. Hubal; Amy K. Kearns; Priscilla M. Clarkson; Paul D. Thompson; Theodore J. Angelopoulos; Paul M. Gordon; Niall M. Moyna; Linda S. Pescatello; Paul S. Visich; Robert F. Zoeller; Eric P. Hoffman; Laura L. Tosi; Joseph M. Devaney
Diabetes December 2013, Vol.63, 363-368. doi:https://doi.org/10.2337/db13-1150
A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes
Robert L. Hanson; Yunhua L. Muller; Sayuko Kobes; Tingwei Guo; Li Bian; Victoria Ossowski; Kim Wiedrich; Jeffrey Sutherland; Christopher Wiedrich; Darin Mahkee; Ke Huang; Maryam Abdussamad; Michael Traurig; E. Jennifer Weil; Robert G. Nelson; Peter H. Bennett; William C. Knowler; Clifton Bogardus; Leslie J. Baier
Diabetes December 2013, Vol.63, 369-376. doi:https://doi.org/10.2337/db13-0416
Erratum
Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes 2013;62:3523–3531
Paola Maffi; Gianpaolo Balzano; Maurilio Ponzoni; Rita Nano; Valeria Sordi; Raffaella Melzi; Alessia Mercalli; Marina Scavini; Antonio Esposito; Jacopo Peccatori; Elisa Cantarelli; Carlo Messina; Massimo Bernardi; Alessandro Del Maschio; Carlo Staudacher; Claudio Doglioni; Fabio Ciceri; Antonio Secchi; Lorenzo Piemonti
Diabetes December 2013, Vol.63, 377. doi:https://doi.org/10.2337/db14-er01