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In This Issue of Diabetes

Extract

View articletitled, In This Issue of Diabetes

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Topics: cardiomyopathy , curcumin , cyclin d1 , gluconeogenesis , homeostasis

Diabetes September 2014, Vol.63, 3161-3162. doi:https://doi.org/10.2337/db14-ti10

Commentaries

Mitochondria-Associated Endoplasmic Reticulum Membranes in Insulin Signaling

Guy A. Rutter; Paolo Pinton

Abstracts

View articletitled, Mitochondria-Associated Endoplasmic Reticulum Membranes in Insulin Signaling

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Topics: endoplasmic reticulum , insulin , mitochondria , signal transduction , tissue membrane

Diabetes September 2014, Vol.63, 3163-3165. doi:https://doi.org/10.2337/db14-0812

Application of a Novel Curcumin Analog in the Management of Diabetic Cardiomyopathy

Jun Ren; James R. Sowers

Abstracts

View articletitled, Application of a Novel Curcumin Analog in the Management of Diabetic Cardiomyopathy

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Topics: curcumin , diabetic cardiomyopathy

Diabetes September 2014, Vol.63, 3166-3168. doi:https://doi.org/10.2337/db14-0863

HIF-2α Blows Out the Flames of Adipose Tissue Macrophages to Keep Obesity in a Safe Zone

Myriam Aouadi

Abstracts

View articletitled, HIF-2α Blows Out the Flames of Adipose Tissue Macrophages to Keep Obesity in a Safe Zone

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Topics: adipose tissue , macrophages , obesity , inflammation

Diabetes September 2014, Vol.63, 3169-3171. doi:https://doi.org/10.2337/db14-0878

GLP-1 as a Mediator in the Remission of Type 2 Diabetes After Gastric Bypass and Sleeve Gastrectomy Surgery

Sten Madsbad; Jens J. Holst

Abstracts

View articletitled, GLP-1 as a Mediator in the Remission of Type 2 Diabetes After Gastric Bypass and Sleeve Gastrectomy Surgery

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Topics: diabetes mellitus, type 2 , disease remission , gastric bypass , glucagon-like peptide 1 , sleeve gastrectomy, laparoscopic

Diabetes September 2014, Vol.63, 3172-3174. doi:https://doi.org/10.2337/db14-0935

Adaptive Thermogenesis in White Adipose Tissue: Is Lactate the New Brown(ing)?

Laurent Vergnes; Karen Reue

Abstracts

View articletitled, Adaptive Thermogenesis in White Adipose Tissue: Is Lactate the New Brown(ing)?

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Topics: lactates , thermogenesis , white adipose tissue , ucp1 gene

Diabetes September 2014, Vol.63, 3175-3176. doi:https://doi.org/10.2337/db14-0815

The Proliferative Gene Cyclin D1 and Gluconeogenesis—Could Suppressing Glucose Production Also Promote Cancer?

Sofianos Andrikopoulos

Abstracts

View articletitled, The Proliferative Gene Cyclin D1 and Gluconeogenesis—Could Suppressing Glucose Production Also Promote Cancer?

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Topics: cancer , cyclin d1 , genes , gluconeogenesis , glucose

Diabetes September 2014, Vol.63, 3177-3179. doi:https://doi.org/10.2337/db14-0857

Methodology Review

Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome

I-Chen Yu; Hung-Yun Lin; Janet D. Sparks; Shuyuan Yeh; Chawnshang Chang

Abstract

View articletitled, Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome

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Topics: androgens , insulin resistance , metabolic syndrome x , mice , obesity

Diabetes September 2014, Vol.63, 3180-3188. doi:https://doi.org/10.2337/db13-1505

Metabolism

Altered Glucose Metabolism in Mouse and Humans Conceived by IVF

Miaoxin Chen; Linda Wu; Junli Zhao; Fang Wu; Michael J. Davies; Gary A. Wittert; Robert J. Norman; Rebecca L. Robker; Leonie K. Heilbronn

Abstracts

View articletitled, Altered Glucose Metabolism in Mouse and Humans Conceived by IVF

Supplementary data

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Topics: fertilization in vitro , mice , diet , insulin

Diabetes September 2014, Vol.63, 3189-3198. doi:https://doi.org/10.2337/db14-0103

Cdkn2a/p16^Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1α Pathway

Kadiombo Bantubungi; Sarah-Anissa Hannou; Sandrine Caron-Houde; Emmanuelle Vallez; Morgane Baron; Anthony Lucas; Emmanuel Bouchaert; Réjane Paumelle; Anne Tailleux; Bart Staels

Abstracts

View articletitled, Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1α Pathway

Supplementary data

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Topics: cyclic amp-responsive dna-binding protein , fasting , genes, p16 , glucose , hepatocytes

Diabetes September 2014, Vol.63, 3199-3209. doi:https://doi.org/10.2337/db13-1921

Peroxiredoxin 6, a Novel Player in the Pathogenesis of Diabetes

Francesca Pacifici; Roberto Arriga; Gian Pio Sorice; Barbara Capuani; Maria Giovanna Scioli; Donatella Pastore; Giulia Donadel; Alfonso Bellia; Sara Caratelli; Andrea Coppola; Francesca Ferrelli; Massimo Federici; Giuseppe Sconocchia; Manfredi Tesauro; Paolo Sbraccia; David Della-Morte; Andrea Giaccari; Augusto Orlandi; Davide Lauro

Abstracts

View articletitled, Peroxiredoxin 6, a Novel Player in the Pathogenesis of Diabetes

Supplementary data

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Topics: insulin , mice , glucose , endocrine pancreas , signal transduction

Diabetes September 2014, Vol.63, 3210-3220. doi:https://doi.org/10.2337/db14-0144

GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6–Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

Florian Kahles; Christina Meyer; Julia Möllmann; Sebastian Diebold; Hannes M. Findeisen; Corinna Lebherz; Christian Trautwein; Alexander Koch; Frank Tacke; Nikolaus Marx; Michael Lehrke

Abstract

View articletitled, GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6–Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

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Topics: blood glucose , bodily secretions , glucagon-like peptide 1 , hyperinsulinism , interleukin-6

Diabetes September 2014, Vol.63, 3221-3229. doi:https://doi.org/10.2337/db14-0100

Sleep Fragmentation During Late Gestation Induces Metabolic Perturbations and Epigenetic Changes in Adiponectin Gene Expression in Male Adult Offspring Mice

Abdelnaby Khalyfa; Vesco Mutskov; Alba Carreras; Ahamed A. Khalyfa; Fahed Hakim; David Gozal

Abstract

View articletitled, Sleep Fragmentation During Late Gestation Induces Metabolic Perturbations and Epigenetic Changes in Adiponectin Gene Expression in Male Adult Offspring Mice

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Topics: dna , epigenetics , mice , pregnancy , sleep

Diabetes September 2014, Vol.63, 3230-3241. doi:https://doi.org/10.2337/db14-0202

Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin

Su Gao; Ryan P. McMillan; Jordi Jacas; Qingzhang Zhu; Xuesen Li; Ganesh K. Kumar; Núria Casals; Fausto G. Hegardt; Paul D. Robbins; Gary D. Lopaschuk; Matthew W. Hulver; Andrew A. Butler

Abstract

View articletitled, Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin

Supplementary data

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Topics: fasting , mice , oxidation , peptide hormone , glucose

Diabetes September 2014, Vol.63, 3242-3252. doi:https://doi.org/10.2337/db14-0388

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

Audrey Carrière; Yannick Jeanson; Sandra Berger-Müller; Mireille André; Vanessa Chenouard; Emmanuelle Arnaud; Corinne Barreau; Romy Walther; Anne Galinier; Brigitte Wdziekonski; Phi Villageois; Katie Louche; Philippe Collas; Cédric Moro; Christian Dani; Francesc Villarroya; Louis Casteilla

Abstracts

View articletitled, Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

Supplementary data

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Topics: adipocytes , lactates , ucp1 gene , mice , oxidation-reduction

Diabetes September 2014, Vol.63, 3253-3265. doi:https://doi.org/10.2337/db13-1885

Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α

Kavita Bhalla; Wan-Ju Liu; Keyata Thompson; Lars Anders; Srikripa Devarakonda; Ruby Dewi; Stephanie Buckley; Bor-Jang Hwang; Brian Polster; Susan G. Dorsey; Yezhou Sun; Piotr Sicinski; Geoffrey D. Girnun

Abstracts

View articletitled, Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α

Supplementary data

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Topics: cyclin d1 , gene expression , cyclin-dependent kinase 4 , phosphoenolpyruvate carboxylase , gluconeogenesis

Diabetes September 2014, Vol.63, 3266-3278. doi:https://doi.org/10.2337/db13-1283

Signal Transduction

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

Emily Tubbs; Pierre Theurey; Guillaume Vial; Nadia Bendridi; Amélie Bravard; Marie-Agnès Chauvin; Jingwei Ji-Cao; Fabien Zoulim; Birke Bartosch; Michel Ovize; Hubert Vidal; Jennifer Rieusset

Abstracts

View articletitled, Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

Supplementary data

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Topics: emergency service, hospital , insulin , insulin resistance , mitochondria , signal transduction

Diabetes September 2014, Vol.63, 3279-3294. doi:https://doi.org/10.2337/db13-1751

Obesity Studies

Liver-Restricted Repin1 Deficiency Improves Whole-Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice

Matthias Kern; Joanna Kosacka; Nico Hesselbarth; Julia Brückner; John T. Heiker; Gesine Flehmig; Ingrid Klöting; Peter Kovacs; Madlen Matz-Soja; Rolf Gebhardt; Knut Krohn; Susanne Sales; Kerstin Abshagen; Andrej Shevchenko; Michael Stumvoll; Matthias Blüher; Nora Klöting

Abstracts

View articletitled, Liver-Restricted Repin1 Deficiency Improves Whole-Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice

Supplementary data

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Topics: liver , mice , insulin , insulin sensitivity

Diabetes September 2014, Vol.63, 3295-3309. doi:https://doi.org/10.2337/db13-0933

Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction

Tanit L. Gabriel; Marc J. Tol; Roelof Ottenhof; Cindy van Roomen; Jan Aten; Nike Claessen; Berend Hooibrink; Barbara de Weijer; Mireille J. Serlie; Carmen Argmann; Leonie van Elsenburg; Johannes M.F.G. Aerts; Marco van Eijk

Abstract

View articletitled, Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction

Supplementary data

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Topics: macrophages , mice , mitf protein , obesity , stress

Diabetes September 2014, Vol.63, 3310-3323. doi:https://doi.org/10.2337/db13-1720

HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction

Lea Rahtu-Korpela; Sara Karsikas; Sohvi Hörkkö; Roberto Blanco Sequeiros; Eveliina Lammentausta; Kari A. Mäkelä; Karl-Heinz Herzig; Gail Walkinshaw; Kari I. Kivirikko; Johanna Myllyharju; Raisa Serpi; Peppi Koivunen

Abstract

View articletitled, HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction

Supplementary data

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Topics: metabolic disturbance , mice , glucose

Diabetes September 2014, Vol.63, 3324-3333. doi:https://doi.org/10.2337/db14-0472

IKKε Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity

Laís Weissmann; Paula G.F. Quaresma; Andressa C. Santos; Alexandre H.B. de Matos; Vínicius D’Ávila Bittencourt Pascoal; Tamires M. Zanotto; Gisele Castro; Dioze Guadagnini; Joelcimar Martins da Silva; Licio A. Velloso; Jackson C. Bittencourt; Iscia Lopes-Cendes; Mario J.A. Saad; Patricia O. Prada

Abstract

View articletitled, IKKε Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity

Supplementary data

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Topics: hypothalamus , insulin , leptin , mice , obesity

Diabetes September 2014, Vol.63, 3334-3345. doi:https://doi.org/10.2337/db13-1817

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

Daniel Beiroa; Monica Imbernon; Rosalía Gallego; Ana Senra; Daniel Herranz; Francesc Villarroya; Manuel Serrano; Johan Fernø; Javier Salvador; Javier Escalada; Carlos Dieguez; Miguel Lopez; Gema Frühbeck; Ruben Nogueiras

Abstract

View articletitled, GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

Supplementary data

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Topics: ampk , glucagon-like peptide 1 , hypothalamus , liraglutide , mice

Diabetes September 2014, Vol.63, 3346-3358. doi:https://doi.org/10.2337/db14-0302

Macrophage HIF-2α Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

Sung Sik Choe; Kyung Cheul Shin; Sojeong Ka; Yun Kyung Lee; Jang-Soo Chun; Jae Bum Kim

Abstracts

View articletitled, Macrophage HIF-2α Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

Supplementary data

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Topics: adipocytes , adipose tissue , inflammation , insulin resistance , macrophages

Diabetes September 2014, Vol.63, 3359-3371. doi:https://doi.org/10.2337/db13-1965

GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes

Amanda Jiménez; Andrea Mari; Roser Casamitjana; Antonio Lacy; Ele Ferrannini; Josep Vidal

Abstracts

View articletitled, GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose tolerance , sleeve gastrectomy, laparoscopic , disease remission

Diabetes September 2014, Vol.63, 3372-3377. doi:https://doi.org/10.2337/db14-0357

Islet Studies

BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency

Decheng Ren; Juan Sun; Liqun Mao; Honggang Ye; Kenneth S. Polonsky

Abstract

View articletitled, BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency

Supplementary data

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Topics: irs2 protein, human , mice , psychological suppression , apoptosis , molecule

Diabetes September 2014, Vol.63, 3378-3387. doi:https://doi.org/10.2337/db13-1814

Chronological Analysis With Fluorescent Timer Reveals Unique Features of Newly Generated β-Cells

Takeshi Miyatsuka; Taka-aki Matsuoka; Shugo Sasaki; Fumiyo Kubo; Iichiro Shimomura; Hirotaka Watada; Michael S. German; Manami Hara

Abstract

View articletitled, Chronological Analysis With Fluorescent Timer Reveals Unique Features of Newly Generated β-Cells

Supplementary data

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Topics: timer device , pancreas , insulin , flow cytometry

Diabetes September 2014, Vol.63, 3388-3393. doi:https://doi.org/10.2337/db13-1312

Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion

Masashi Yosida; Katsuya Dezaki; Kunitoshi Uchida; Shiho Kodera; Nien V. Lam; Kiyonori Ito; Rauza S. Rita; Hodaka Yamada; Kenju Shimomura; San-e Ishikawa; Hitoshi Sugawara; Masanobu Kawakami; Makoto Tominaga; Toshihiko Yada; Masafumi Kakei

Abstract

View articletitled, Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion

Supplementary data

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Topics: clusterin , cyclic amp , glucose , insulin secretion , incretin

Diabetes September 2014, Vol.63, 3394-3403. doi:https://doi.org/10.2337/db13-1868

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Masayuki Hatanaka; Bernhard Maier; Emily K. Sims; Andrew T. Templin; Rohit N. Kulkarni; Carmella Evans-Molina; Raghavendra G. Mirmira

Abstract

View articletitled, Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Supplementary data

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Topics: mtor serine-threonine kinases , palmitates , translation, genetic , rapamycin

Diabetes September 2014, Vol.63, 3404-3415. doi:https://doi.org/10.2337/db14-0105

Maternal Protein Restriction Leads to Pancreatic Failure in Offspring: Role of Misexpressed MicroRNA-375

Olivier Dumortier; Charlotte Hinault; Nadine Gautier; Stéphanie Patouraux; Virginie Casamento; Emmanuel Van Obberghen

Abstract

View articletitled, Maternal Protein Restriction Leads to Pancreatic Failure in Offspring: Role of Misexpressed MicroRNA-375

Supplementary data

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Topics: child , endocrine pancreas , fetus , insulin secretion , micrornas

Diabetes September 2014, Vol.63, 3416-3427. doi:https://doi.org/10.2337/db13-1431

Positron Emission Tomography Ligand [¹¹C]5-Hydroxy-Tryptophan Can Be Used as a Surrogate Marker for the Human Endocrine Pancreas

Olof Eriksson; Daniel Espes; Ram K. Selvaraju; Emma Jansson; Gunnar Antoni; Jens Sörensen; Mark Lubberink; Ali-Reza Biglarnia; Jan W. Eriksson; Anders Sundin; Håkan Ahlström; Barbro Eriksson; Lars Johansson; Per-Ola Carlsson; Olle Korsgren

Abstracts

View articletitled, Positron Emission Tomography Ligand [11C]5-Hydroxy-Tryptophan Can Be Used as a Surrogate Marker for the Human Endocrine Pancreas

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Topics: 5-hydroxytryptophan , diabetes mellitus, type 2 , pancreas , positron-emission tomography , endocrine pancreas

Diabetes September 2014, Vol.63, 3428-3437. doi:https://doi.org/10.2337/db13-1877

Immunology and Transplantation

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions

Deepak K. Nayak; Boris Calderon; Anthony N. Vomund; Emil R. Unanue

Abstract

View articletitled, ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions

Supplementary data

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Topics: antigens , peptides , slc30a8 gene , t-lymphocytes , transfer technique

Diabetes September 2014, Vol.63, 3438-3448. doi:https://doi.org/10.2337/db13-1882

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

Tihamer Orban; Craig A. Beam; Ping Xu; Keith Moore; Qi Jiang; Jun Deng; Sarah Muller; Peter Gottlieb; Lisa Spain; Mark Peakman; the Type 1 Diabetes TrialNet Abatacept Study Group

Abstracts

View articletitled, Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

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Topics: abatacept , c-peptide , diabetes mellitus, type 1 , lymphocyte costimulation , t-lymphocytes

Diabetes September 2014, Vol.63, 3449-3457. doi:https://doi.org/10.2337/db14-0047

Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

Peng-Fei Ma; Jie Jiang; Chang Gao; Pan-Pan Cheng; Jia-Li Li; Xin Huang; Ying-Ying Lin; Qing Li; Yuan-Zheng Peng; Mei-Chun Cai; Wei Shao; Qi Zhu; Sai Han; Qing Qin; Jun-Jie Xia; Zhong-Quan Qi

Abstracts

View articletitled, Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model

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Topics: islets of langerhans transplantation , mice , streptozocin , t-lymphocytes , rapamycin

Diabetes September 2014, Vol.63, 3458-3469. doi:https://doi.org/10.2337/db14-0012

Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

Ilian A. Radichev; Lilia V. Maneva-Radicheva; Christina Amatya; Camille Parker; Jacob Ellefson; Clive Wasserfall; Mark Atkinson; Paul Burn; Alexei Y. Savinov

Abstract

View articletitled, Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

Supplementary data

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Topics: antibodies , atrial premature complexes , diabetes mellitus, type 1 , enzyme-linked immunosorbent assay , immunoblotting

Diabetes September 2014, Vol.63, 3470-3482. doi:https://doi.org/10.2337/db14-0213

Complications

Catalase Overexpression Prevents Nuclear Factor Erythroid 2–Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice

Shaaban Abdo; Yixuan Shi; Abouzar Otoukesh; Anindya Ghosh; Chao-Sheng Lo; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao Ling Zhang; John S.D. Chan

Abstract

View articletitled, Catalase Overexpression Prevents Nuclear Factor Erythroid 2–Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice

Supplementary data

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Topics: gene expression , kidney , mice , oltipraz , rna, messenger

Diabetes September 2014, Vol.63, 3483-3496. doi:https://doi.org/10.2337/db13-1830

Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

Yong Pan; Yi Wang; Yunjie Zhao; Kesong Peng; Weixin Li; Yonggang Wang; Jingjing Zhang; Shanshan Zhou; Quan Liu; Xiaokun Li; Lu Cai; Guang Liang

Abstracts

View articletitled, Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

Supplementary data

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Topics: apoptosis , cardiac myocytes , caspase-3 , curcumin , cytokine

Diabetes September 2014, Vol.63, 3497-3511. doi:https://doi.org/10.2337/db13-1577

Increased DNA Methyltransferase 3b (Dnmt3b)-Mediated CpG Island Methylation Stimulated by Oxidative Stress Inhibits Expression of a Gene Required for Neural Tube and Neural Crest Development in Diabetic Pregnancy

Dan Wei; Mary R. Loeken

Abstracts

View articletitled, Increased DNA Methyltransferase 3b (Dnmt3b)-Mediated CpG Island Methylation Stimulated by Oxidative Stress Inhibits Expression of a Gene Required for Neural Tube and Neural Crest Development in Diabetic Pregnancy

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Topics: cpg islands , dna modification methylases , embryo , european society of cardiology , methylation

Diabetes September 2014, Vol.63, 3512-3522. doi:https://doi.org/10.2337/db14-0231

Cerebral Microvascular Lesions on High-Resolution 7-Tesla MRI in Patients With Type 2 Diabetes

Manon Brundel; Yael D. Reijmer; Susanne J. van Veluw; Hugo J. Kuijf; Peter R. Luijten; L. Jaap Kappelle; Geert Jan Biessels; on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group

Abstracts

View articletitled, Cerebral Microvascular Lesions on High-Resolution 7-Tesla MRI in Patients With Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , magnetic resonance imaging , microbleed , brain

Diabetes September 2014, Vol.63, 3523-3529. doi:https://doi.org/10.2337/db14-0122

Pharmacology and Therapeutics

Orally Active Osteoanabolic Agent GTDF Binds to Adiponectin Receptors, With a Preference for AdipoR1, Induces Adiponectin-Associated Signaling, and Improves Metabolic Health in a Rodent Model of Diabetes

Abhishek Kumar Singh; Amit Arvind Joharapurkar; Mohd. Parvez Khan; Jay Sharan Mishra; Nidhi Singh; Manisha Yadav; Zakir Hossain; Kainat Khan; Sudhir Kumar; Nirav Anilkumar Dhanesha; Devendra Pratap Mishra; Rakesh Maurya; Sharad Sharma; Mukul Rameshchandra Jain; Arun Kumar Trivedi; Madan Madhav Godbole; Jiaur Rahaman Gayen; Naibedya Chattopadhyay; Sabyasachi Sanyal

Abstracts

View articletitled, Orally Active Osteoanabolic Agent GTDF Binds to Adiponectin Receptors, With a Preference for AdipoR1, Induces Adiponectin-Associated Signaling, and Improves Metabolic Health in a Rodent Model of Diabetes

Supplementary data

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Topics: adiponectin , mice , signal transduction , receptors, adiponectin , protein overexpression

Diabetes September 2014, Vol.63, 3530-3544. doi:https://doi.org/10.2337/db13-1619

Blockade of Na⁺ Channels in Pancreatic α-Cells Has Antidiabetic Effects

Arvinder K. Dhalla; Ming Yang; Yun Ning; Kristopher M. Kahlig; Michael Krause; Sridharan Rajamani; Luiz Belardinelli

Abstracts

View articletitled, Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects

Supplementary data

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Topics: glucagon , glucose , ranolazine , rats , endocrine pancreas

Diabetes September 2014, Vol.63, 3545-3556. doi:https://doi.org/10.2337/db13-1562

Genetics / Genomes / Proteomics / Metabolomics

Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes

Deimante Simaite; Julia Kofent; Maolian Gong; Franz Rüschendorf; Shiqi Jia; Pamela Arn; Kristi Bentler; Carolyn Ellaway; Peter Kühnen; Georg F. Hoffmann; Nenad Blau; Francesca M. Spagnoli; Norbert Hübner; Klemens Raile

Abstracts

View articletitled, Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes

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Topics: genes , hnf1a gene , insulin , mice , mutation

Diabetes September 2014, Vol.63, 3557-3564. doi:https://doi.org/10.2337/db13-1784

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: podcasts

Diabetes September 2014, Vol.63, 3565. doi:https://doi.org/10.2337/db14-ie10

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In This Issue

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Methodology Review

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

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