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1 October 2014
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes September 2014, Vol.63, 3161-3162. doi:https://doi.org/10.2337/db14-ti10
Commentaries
Mitochondria-Associated Endoplasmic Reticulum Membranes in Insulin Signaling
Diabetes September 2014, Vol.63, 3163-3165. doi:https://doi.org/10.2337/db14-0812
Application of a Novel Curcumin Analog in the Management of Diabetic Cardiomyopathy
Diabetes September 2014, Vol.63, 3166-3168. doi:https://doi.org/10.2337/db14-0863
HIF-2α Blows Out the Flames of Adipose Tissue Macrophages to Keep Obesity in a Safe Zone
Diabetes September 2014, Vol.63, 3169-3171. doi:https://doi.org/10.2337/db14-0878
GLP-1 as a Mediator in the Remission of Type 2 Diabetes After Gastric Bypass and Sleeve Gastrectomy Surgery
Diabetes September 2014, Vol.63, 3172-3174. doi:https://doi.org/10.2337/db14-0935
Adaptive Thermogenesis in White Adipose Tissue: Is Lactate the New Brown(ing)?
Diabetes September 2014, Vol.63, 3175-3176. doi:https://doi.org/10.2337/db14-0815
The Proliferative Gene Cyclin D1 and Gluconeogenesis—Could Suppressing Glucose Production Also Promote Cancer?
Diabetes September 2014, Vol.63, 3177-3179. doi:https://doi.org/10.2337/db14-0857
Methodology Review
Androgen Receptor Roles in Insulin Resistance and Obesity in Males: The Linkage of Androgen-Deprivation Therapy to Metabolic Syndrome
Diabetes September 2014, Vol.63, 3180-3188. doi:https://doi.org/10.2337/db13-1505
Metabolism
Altered Glucose Metabolism in Mouse and Humans Conceived by IVF
Miaoxin Chen; Linda Wu; Junli Zhao; Fang Wu; Michael J. Davies; Gary A. Wittert; Robert J. Norman; Rebecca L. Robker; Leonie K. Heilbronn
Diabetes September 2014, Vol.63, 3189-3198. doi:https://doi.org/10.2337/db14-0103
Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1α Pathway
Kadiombo Bantubungi; Sarah-Anissa Hannou; Sandrine Caron-Houde; Emmanuelle Vallez; Morgane Baron; Anthony Lucas; Emmanuel Bouchaert; Réjane Paumelle; Anne Tailleux; Bart Staels
Diabetes September 2014, Vol.63, 3199-3209. doi:https://doi.org/10.2337/db13-1921
Peroxiredoxin 6, a Novel Player in the Pathogenesis of Diabetes
Francesca Pacifici; Roberto Arriga; Gian Pio Sorice; Barbara Capuani; Maria Giovanna Scioli; Donatella Pastore; Giulia Donadel; Alfonso Bellia; Sara Caratelli; Andrea Coppola; Francesca Ferrelli; Massimo Federici; Giuseppe Sconocchia; Manfredi Tesauro; Paolo Sbraccia; David Della-Morte; Andrea Giaccari; Augusto Orlandi; Davide Lauro
Diabetes September 2014, Vol.63, 3210-3220. doi:https://doi.org/10.2337/db14-0144
GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6–Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering
Florian Kahles; Christina Meyer; Julia Möllmann; Sebastian Diebold; Hannes M. Findeisen; Corinna Lebherz; Christian Trautwein; Alexander Koch; Frank Tacke; Nikolaus Marx; Michael Lehrke
Diabetes September 2014, Vol.63, 3221-3229. doi:https://doi.org/10.2337/db14-0100
Sleep Fragmentation During Late Gestation Induces Metabolic Perturbations and Epigenetic Changes in Adiponectin Gene Expression in Male Adult Offspring Mice
Diabetes September 2014, Vol.63, 3230-3241. doi:https://doi.org/10.2337/db14-0202
Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin
Su Gao; Ryan P. McMillan; Jordi Jacas; Qingzhang Zhu; Xuesen Li; Ganesh K. Kumar; Núria Casals; Fausto G. Hegardt; Paul D. Robbins; Gary D. Lopaschuk; Matthew W. Hulver; Andrew A. Butler
Diabetes September 2014, Vol.63, 3242-3252. doi:https://doi.org/10.2337/db14-0388
Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure
Audrey Carrière; Yannick Jeanson; Sandra Berger-Müller; Mireille André; Vanessa Chenouard; Emmanuelle Arnaud; Corinne Barreau; Romy Walther; Anne Galinier; Brigitte Wdziekonski; Phi Villageois; Katie Louche; Philippe Collas; Cédric Moro; Christian Dani; Francesc Villarroya; Louis Casteilla
Diabetes September 2014, Vol.63, 3253-3265. doi:https://doi.org/10.2337/db13-1885
Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α
Kavita Bhalla; Wan-Ju Liu; Keyata Thompson; Lars Anders; Srikripa Devarakonda; Ruby Dewi; Stephanie Buckley; Bor-Jang Hwang; Brian Polster; Susan G. Dorsey; Yezhou Sun; Piotr Sicinski; Geoffrey D. Girnun
Diabetes September 2014, Vol.63, 3266-3278. doi:https://doi.org/10.2337/db13-1283
Signal Transduction
Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance
Emily Tubbs; Pierre Theurey; Guillaume Vial; Nadia Bendridi; Amélie Bravard; Marie-Agnès Chauvin; Jingwei Ji-Cao; Fabien Zoulim; Birke Bartosch; Michel Ovize; Hubert Vidal; Jennifer Rieusset
Diabetes September 2014, Vol.63, 3279-3294. doi:https://doi.org/10.2337/db13-1751
Obesity Studies
Liver-Restricted Repin1 Deficiency Improves Whole-Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice
Matthias Kern; Joanna Kosacka; Nico Hesselbarth; Julia Brückner; John T. Heiker; Gesine Flehmig; Ingrid Klöting; Peter Kovacs; Madlen Matz-Soja; Rolf Gebhardt; Knut Krohn; Susanne Sales; Kerstin Abshagen; Andrej Shevchenko; Michael Stumvoll; Matthias Blüher; Nora Klöting
Diabetes September 2014, Vol.63, 3295-3309. doi:https://doi.org/10.2337/db13-0933
Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction
Tanit L. Gabriel; Marc J. Tol; Roelof Ottenhof; Cindy van Roomen; Jan Aten; Nike Claessen; Berend Hooibrink; Barbara de Weijer; Mireille J. Serlie; Carmen Argmann; Leonie van Elsenburg; Johannes M.F.G. Aerts; Marco van Eijk
Diabetes September 2014, Vol.63, 3310-3323. doi:https://doi.org/10.2337/db13-1720
HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction
Lea Rahtu-Korpela; Sara Karsikas; Sohvi Hörkkö; Roberto Blanco Sequeiros; Eveliina Lammentausta; Kari A. Mäkelä; Karl-Heinz Herzig; Gail Walkinshaw; Kari I. Kivirikko; Johanna Myllyharju; Raisa Serpi; Peppi Koivunen
Diabetes September 2014, Vol.63, 3324-3333. doi:https://doi.org/10.2337/db14-0472
IKKε Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity
Laís Weissmann; Paula G.F. Quaresma; Andressa C. Santos; Alexandre H.B. de Matos; Vínicius D’Ávila Bittencourt Pascoal; Tamires M. Zanotto; Gisele Castro; Dioze Guadagnini; Joelcimar Martins da Silva; Licio A. Velloso; Jackson C. Bittencourt; Iscia Lopes-Cendes; Mario J.A. Saad; Patricia O. Prada
Diabetes September 2014, Vol.63, 3334-3345. doi:https://doi.org/10.2337/db13-1817
GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK
Daniel Beiroa; Monica Imbernon; Rosalía Gallego; Ana Senra; Daniel Herranz; Francesc Villarroya; Manuel Serrano; Johan Fernø; Javier Salvador; Javier Escalada; Carlos Dieguez; Miguel Lopez; Gema Frühbeck; Ruben Nogueiras
Diabetes September 2014, Vol.63, 3346-3358. doi:https://doi.org/10.2337/db14-0302
Macrophage HIF-2α Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity
Diabetes September 2014, Vol.63, 3359-3371. doi:https://doi.org/10.2337/db13-1965
GLP-1 and Glucose Tolerance After Sleeve Gastrectomy in Morbidly Obese Subjects With Type 2 Diabetes
Diabetes September 2014, Vol.63, 3372-3377. doi:https://doi.org/10.2337/db14-0357
Islet Studies
BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency
Diabetes September 2014, Vol.63, 3378-3387. doi:https://doi.org/10.2337/db13-1814
Chronological Analysis With Fluorescent Timer Reveals Unique Features of Newly Generated β-Cells
Takeshi Miyatsuka; Taka-aki Matsuoka; Shugo Sasaki; Fumiyo Kubo; Iichiro Shimomura; Hirotaka Watada; Michael S. German; Manami Hara
Diabetes September 2014, Vol.63, 3388-3393. doi:https://doi.org/10.2337/db13-1312
Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion
Masashi Yosida; Katsuya Dezaki; Kunitoshi Uchida; Shiho Kodera; Nien V. Lam; Kiyonori Ito; Rauza S. Rita; Hodaka Yamada; Kenju Shimomura; San-e Ishikawa; Hitoshi Sugawara; Masanobu Kawakami; Makoto Tominaga; Toshihiko Yada; Masafumi Kakei
Diabetes September 2014, Vol.63, 3394-3403. doi:https://doi.org/10.2337/db13-1868
Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway
Masayuki Hatanaka; Bernhard Maier; Emily K. Sims; Andrew T. Templin; Rohit N. Kulkarni; Carmella Evans-Molina; Raghavendra G. Mirmira
Diabetes September 2014, Vol.63, 3404-3415. doi:https://doi.org/10.2337/db14-0105
Maternal Protein Restriction Leads to Pancreatic Failure in Offspring: Role of Misexpressed MicroRNA-375
Olivier Dumortier; Charlotte Hinault; Nadine Gautier; Stéphanie Patouraux; Virginie Casamento; Emmanuel Van Obberghen
Diabetes September 2014, Vol.63, 3416-3427. doi:https://doi.org/10.2337/db13-1431
Positron Emission Tomography Ligand [11C]5-Hydroxy-Tryptophan Can Be Used as a Surrogate Marker for the Human Endocrine Pancreas
Olof Eriksson; Daniel Espes; Ram K. Selvaraju; Emma Jansson; Gunnar Antoni; Jens Sörensen; Mark Lubberink; Ali-Reza Biglarnia; Jan W. Eriksson; Anders Sundin; Håkan Ahlström; Barbro Eriksson; Lars Johansson; Per-Ola Carlsson; Olle Korsgren
Diabetes September 2014, Vol.63, 3428-3437. doi:https://doi.org/10.2337/db13-1877
Immunology and Transplantation
ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
Diabetes September 2014, Vol.63, 3438-3448. doi:https://doi.org/10.2337/db13-1882
Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline
Tihamer Orban; Craig A. Beam; Ping Xu; Keith Moore; Qi Jiang; Jun Deng; Sarah Muller; Peter Gottlieb; Lisa Spain; Mark Peakman; the Type 1 Diabetes TrialNet Abatacept Study Group
Diabetes September 2014, Vol.63, 3449-3457. doi:https://doi.org/10.2337/db14-0047
Immunosuppressive Effect of Compound K on Islet Transplantation in an STZ-Induced Diabetic Mouse Model
Peng-Fei Ma; Jie Jiang; Chang Gao; Pan-Pan Cheng; Jia-Li Li; Xin Huang; Ying-Ying Lin; Qing Li; Yuan-Zheng Peng; Mei-Chun Cai; Wei Shao; Qi Zhu; Sai Han; Qing Qin; Jun-Jie Xia; Zhong-Quan Qi
Diabetes September 2014, Vol.63, 3458-3469. doi:https://doi.org/10.2337/db14-0012
Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development
Ilian A. Radichev; Lilia V. Maneva-Radicheva; Christina Amatya; Camille Parker; Jacob Ellefson; Clive Wasserfall; Mark Atkinson; Paul Burn; Alexei Y. Savinov
Diabetes September 2014, Vol.63, 3470-3482. doi:https://doi.org/10.2337/db14-0213
Complications
Catalase Overexpression Prevents Nuclear Factor Erythroid 2–Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice
Shaaban Abdo; Yixuan Shi; Abouzar Otoukesh; Anindya Ghosh; Chao-Sheng Lo; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao Ling Zhang; John S.D. Chan
Diabetes September 2014, Vol.63, 3483-3496. doi:https://doi.org/10.2337/db13-1830
Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy
Yong Pan; Yi Wang; Yunjie Zhao; Kesong Peng; Weixin Li; Yonggang Wang; Jingjing Zhang; Shanshan Zhou; Quan Liu; Xiaokun Li; Lu Cai; Guang Liang
Diabetes September 2014, Vol.63, 3497-3511. doi:https://doi.org/10.2337/db13-1577
Cerebral Microvascular Lesions on High-Resolution 7-Tesla MRI in Patients With Type 2 Diabetes
Manon Brundel; Yael D. Reijmer; Susanne J. van Veluw; Hugo J. Kuijf; Peter R. Luijten; L. Jaap Kappelle; Geert Jan Biessels; on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group
Diabetes September 2014, Vol.63, 3523-3529. doi:https://doi.org/10.2337/db14-0122
Pharmacology and Therapeutics
Orally Active Osteoanabolic Agent GTDF Binds to Adiponectin Receptors, With a Preference for AdipoR1, Induces Adiponectin-Associated Signaling, and Improves Metabolic Health in a Rodent Model of Diabetes
Abhishek Kumar Singh; Amit Arvind Joharapurkar; Mohd. Parvez Khan; Jay Sharan Mishra; Nidhi Singh; Manisha Yadav; Zakir Hossain; Kainat Khan; Sudhir Kumar; Nirav Anilkumar Dhanesha; Devendra Pratap Mishra; Rakesh Maurya; Sharad Sharma; Mukul Rameshchandra Jain; Arun Kumar Trivedi; Madan Madhav Godbole; Jiaur Rahaman Gayen; Naibedya Chattopadhyay; Sabyasachi Sanyal
Diabetes September 2014, Vol.63, 3530-3544. doi:https://doi.org/10.2337/db13-1619
Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects
Arvinder K. Dhalla; Ming Yang; Yun Ning; Kristopher M. Kahlig; Michael Krause; Sridharan Rajamani; Luiz Belardinelli
Diabetes September 2014, Vol.63, 3545-3556. doi:https://doi.org/10.2337/db13-1562
Genetics / Genomes / Proteomics / Metabolomics
Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes
Deimante Simaite; Julia Kofent; Maolian Gong; Franz Rüschendorf; Shiqi Jia; Pamela Arn; Kristi Bentler; Carolyn Ellaway; Peter Kühnen; Georg F. Hoffmann; Nenad Blau; Francesca M. Spagnoli; Norbert Hübner; Klemens Raile
Diabetes September 2014, Vol.63, 3557-3564. doi:https://doi.org/10.2337/db13-1784
