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Issues
1 November 2014
ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Topics:
diabetes mellitus, type 1
,
diabetic retinopathy
,
insulin resistance
,
metabolic disturbance
,
vitamin d
Diabetes October 2014, Vol.63, 3567-3568. doi:https://doi.org/10.2337/db14-ti11
Commentaries
Statin-Induced Insulin Resistance Through Inflammasome Activation: Sailing Between Scylla and Charybdis
Topics:
inflammasomes
,
insulin resistance
,
statins
,
nlr family, pyrin domain-containing 3 protein
,
diabetes mellitus, type 2
Diabetes October 2014, Vol.63, 3569-3571. doi:https://doi.org/10.2337/db14-1059
Losing a Grip on the Notion of β-Cell Specificity for Immune Responses in Type 1 Diabetes: Can We Handle the Truth?
Topics:
diabetes mellitus, type 1
,
immune response
,
pancreas
,
exocrine pancreas
Diabetes October 2014, Vol.63, 3572-3574. doi:https://doi.org/10.2337/db14-1069
A Lifetime on the Hips: Programming Lower-Body Fat to Protect Against Metabolic Disease
Topics:
hip region
,
metabolic diseases
,
obesity
,
abcb7 gene
,
dyslipidemias
Diabetes October 2014, Vol.63, 3575-3577. doi:https://doi.org/10.2337/db14-1085
Characterizing Subgroups of Type 1 Diabetes
Topics:
diabetes mellitus, type 1
,
autoantibodies
,
infiltrates
Diabetes October 2014, Vol.63, 3578-3580. doi:https://doi.org/10.2337/db14-1160
The Type 1 Diabetes Signature: Hardwired to Trigger Inflammation?
Diabetes October 2014, Vol.63, 3581-3583. doi:https://doi.org/10.2337/db14-0824
Clocking Up GLP-1: Considering Intestinal Rhythms in the Incretin Effect
Topics:
glucagon-like peptide 1
,
incretin
,
intestines
,
rhythm
Diabetes October 2014, Vol.63, 3584-3586. doi:https://doi.org/10.2337/db14-0781
Dicarbonyl Stress and Atherosclerosis: Is It All RAGE?
Topics:
atherosclerosis
,
rage
,
stress
Diabetes October 2014, Vol.63, 3587-3589. doi:https://doi.org/10.2337/db14-0953
Neuroretinal Degeneration in Relation to Vasculopathy in Diabetes
Topics:
tissue degeneration
,
vascular diseases
Diabetes October 2014, Vol.63, 3590-3592. doi:https://doi.org/10.2337/db14-0888
PTH-Vitamin D-Glycemia Interactions Reloaded
Topics:
vitamin d
,
vitamin d deficiency
,
vitamins
Diabetes October 2014, Vol.63, 3593-3595. doi:https://doi.org/10.2337/db14-0956
Technological Advances
White Matter Integrity Disruptions Associated With Cognitive Impairments in Type 2 Diabetic Patients
Topics:
cognitive impairment
,
diabetes mellitus, type 2
,
personal integrity
,
voxel
,
neuropsychological tests
Diabetes October 2014, Vol.63, 3596-3605. doi:https://doi.org/10.2337/db14-0342
Metabolism
Free Fatty Acid Uptake in Humans With CD36 Deficiency
Topics:
cd36 antigens
,
palmitates
,
positron-emission tomography
,
nonesterified fatty acids
,
homozygote
Diabetes October 2014, Vol.63, 3606-3614. doi:https://doi.org/10.2337/db14-0369
NT-PGC-1α Activation Attenuates High-Fat Diet–Induced Obesity by Enhancing Brown Fat Thermogenesis and Adipose Tissue Oxidative Metabolism
Topics:
adipocytes
,
mice
,
obesity
,
thermogenesis
,
diet
Diabetes October 2014, Vol.63, 3615-3625. doi:https://doi.org/10.2337/db13-1837
Mangiferin Stimulates Carbohydrate Oxidation and Protects Against Metabolic Disorders Induced by High-Fat Diets
Pasha Apontes; Zhongbo Liu; Kai Su; Outhiriaradjou Benard; Dou Y. Youn; Xisong Li; Wei Li; Raihan H. Mirza; Claire C. Bastie; Linda A. Jelicks; Jeffrey E. Pessin; Radhika H. Muzumdar; Anthony A. Sauve; Yuling Chi
Topics:
carbohydrates
,
fatty acids
,
glucose
,
mice
,
oxidation
Diabetes October 2014, Vol.63, 3626-3636. doi:https://doi.org/10.2337/db14-0006
SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis
Fen Xu; Zhuo Li; Xiaobin Zheng; Hongxia Liu; Hua Liang; Haixia Xu; Zonglan Chen; Kejing Zeng; Jianping Weng
Topics:
exenatide
,
fatty liver
,
liver
,
mice
Diabetes October 2014, Vol.63, 3637-3646. doi:https://doi.org/10.2337/db14-0263
Hypothalamic Neurogenesis Is Not Required for the Improved Insulin Sensitivity Following Exercise Training
Melissa L. Borg; Moyra Lemus; Alex Reichenbach; Ahrathy Selathurai; Brian J. Oldfield; Zane B. Andrews; Matthew J. Watt
Topics:
cell proliferation
,
hypothalamus
,
insulin
,
insulin sensitivity
,
mice
Diabetes October 2014, Vol.63, 3647-3658. doi:https://doi.org/10.2337/db13-1762
SIK2 Is Critical in the Regulation of Lipid Homeostasis and Adipogenesis In Vivo
Jinyoung Park; Young-Sil Yoon; Hye-Sook Han; Yong-Hoon Kim; Yoshihiro Ogawa; Keun-Gyu Park; Chul-Ho Lee; Seong-Tae Kim; Seung-Hoi Koo
Topics:
adipocytes
,
adiponectin
,
glucose
,
insulin
,
mice
Diabetes October 2014, Vol.63, 3659-3673. doi:https://doi.org/10.2337/db13-1423
Circadian Secretion of the Intestinal Hormone GLP-1 by the Rodent L Cell
Topics:
glucagon-like peptide 1
,
glucose
,
insulin
,
bodily secretions
,
l cells (cell line)
Diabetes October 2014, Vol.63, 3674-3685. doi:https://doi.org/10.2337/db13-1501
Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
Paul Lee; Sheila Smith; Joyce Linderman; Amber B. Courville; Robert J. Brychta; William Dieckmann; Charlotte D. Werner; Kong Y. Chen; Francesco S. Celi
Topics:
acclimatization
,
body temperature
,
cold sensation
,
cold temperature
,
common cold
Diabetes October 2014, Vol.63, 3686-3698. doi:https://doi.org/10.2337/db14-0513
Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
Li Kang; Chunhua Dai; Mary E. Lustig; Jeffrey S. Bonner; Wesley H. Mayes; Shilpa Mokshagundam; Freyja D. James; Courtney S. Thompson; Chien-Te Lin; Christopher G.R. Perry; Ethan J. Anderson; P. Darrell Neufer; David H. Wasserman; Alvin C. Powers
Topics:
glucose
,
heart failure
,
insulin
,
insulin secretion
,
mice
Diabetes October 2014, Vol.63, 3699-3710. doi:https://doi.org/10.2337/db13-1845
Coinfusion of Low-Dose GLP-1 and Glucagon in Man Results in a Reduction in Food Intake
Jaimini Cegla; Rachel C. Troke; Ben Jones; George Tharakan; Julia Kenkre; Katherine A. McCullough; Chung Thong Lim; Nassim Parvizi; Mohamed Hussein; Edward S. Chambers; James Minnion; Joyceline Cuenco; Mohammad A. Ghatei; Karim Meeran; Tricia M. Tan; Stephen R. Bloom
Topics:
glucagon
,
glucagon-like peptide 1
,
infusion procedures
,
eating
Diabetes October 2014, Vol.63, 3711-3720. doi:https://doi.org/10.2337/db14-0242
Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
Topics:
diet
,
insulin
,
methionine
,
mice
,
proto-oncogene proteins c-akt
Diabetes October 2014, Vol.63, 3721-3733. doi:https://doi.org/10.2337/db14-0464
Prohibitin Overexpression in Adipocytes Induces Mitochondrial Biogenesis, Leads to Obesity Development, and Affects Glucose Homeostasis in a Sex-Specific Manner
Sudharsana R. Ande; K. Hoa Nguyen; G. Pauline Padilla-Meier; Wahida Wahida; B.L. Grégoire Nyomba; Suresh Mishra
Topics:
adipocytes
,
adipose tissue
,
mice
,
mitochondria
,
mitomycin
Diabetes October 2014, Vol.63, 3734-3741. doi:https://doi.org/10.2337/db13-1807
Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance
Brandyn D. Henriksbo; Trevor C. Lau; Joseph F. Cavallari; Emmanuel Denou; Wendy Chi; James S. Lally; Justin D. Crane; Brittany M. Duggan; Kevin P. Foley; Morgan D. Fullerton; Mark A. Tarnopolsky; Gregory R. Steinberg; Jonathan D. Schertzer
Topics:
fluvastatin
,
inflammasomes
,
insulin
,
nlr family, pyrin domain-containing 3 protein
,
statins
Diabetes October 2014, Vol.63, 3742-3747. doi:https://doi.org/10.2337/db13-1398
Signal Transduction
The Adaptor Protein APPL2 Inhibits Insulin-Stimulated Glucose Uptake by Interacting With TBC1D1 in Skeletal Muscle
Kenneth K.Y. Cheng; Weidong Zhu; Bin Chen; Yu Wang; Donghai Wu; Gary Sweeney; Baile Wang; Karen S.L. Lam; Aimin Xu
Topics:
glucose uptake
,
insulin
,
skeletal muscles
,
mice
,
skeletal myocytes
Diabetes October 2014, Vol.63, 3748-3758. doi:https://doi.org/10.2337/db14-0337
Obesity Studies
Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat Diet
Sian Geldenhuys; Prue H. Hart; Raelene Endersby; Peter Jacoby; Martin Feelisch; Richard B. Weller; Vance Matthews; Shelley Gorman
Topics:
diet
,
diet, high-fat
,
mice
,
obesity
,
vitamin d
Diabetes October 2014, Vol.63, 3759-3769. doi:https://doi.org/10.2337/db13-1675
Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity
Joseane Morari; Gabriel F. Anhe; Lucas F. Nascimento; Rodrigo F. de Moura; Daniela Razolli; Carina Solon; Dioze Guadagnini; Gabriela Souza; Alexandre H. Mattos; Natalia Tobar; Celso D. Ramos; Vinicius D. Pascoal; Mario J. Saad; Iscia Lopes-Cendes; Juliana C. Moraes; Licio A. Velloso
Topics:
diet
,
hypothalamus
,
inflammation
,
obesity
,
mice
Diabetes October 2014, Vol.63, 3770-3784. doi:https://doi.org/10.2337/db13-1495
Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications
Katherine E. Pinnick; George Nicholson; Konstantinos N. Manolopoulos; Siobhán E. McQuaid; Philippe Valet; Keith N. Frayn; Nathan Denton; Josine L. Min; Krina T. Zondervan; Jan Fleckner; the MolPAGE Consortium; Mark I. McCarthy; Chris C. Holmes; Fredrik Karpe
Topics:
abcb7 gene
,
obesity
,
genes
,
adipokines
,
transcription, genetic
Diabetes October 2014, Vol.63, 3785-3797. doi:https://doi.org/10.2337/db14-0385
Effect of Guanylate Cyclase-C Activity on Energy and Glucose Homeostasis
Denovan P. Begg; Kris A. Steinbrecher; Joram D. Mul; Adam P. Chambers; Rohit Kohli; April Haller; Mitchell B. Cohen; Stephen C. Woods; Randy J. Seeley
Topics:
mice
,
uroguanylin
,
obesity
,
cyclic gmp
,
diet
Diabetes October 2014, Vol.63, 3798-3804. doi:https://doi.org/10.2337/db14-0160
Islet Studies
Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion
Mufaddal S. Soni; Mary E. Rabaglia; Sushant Bhatnagar; Jin Shang; Olga Ilkayeva; Randall Mynatt; Yun-Ping Zhou; Eric E. Schadt; Nancy A. Thornberry; Deborah M. Muoio; Mark P. Keller; Alan D. Attie
Topics:
carnitine
,
glucose
,
micrornas
,
oligonucleotides
,
oxidation
Diabetes October 2014, Vol.63, 3805-3814. doi:https://doi.org/10.2337/db13-1677
Immunology and Transplantation
Nucleotides Released From Palmitate-Challenged Muscle Cells Through Pannexin-3 Attract Monocytes
Nicolas J. Pillon; Yujin E. Li; Lisbeth N. Fink; Joseph T. Brozinick; Alexander Nikolayev; Ming-Shang Kuo; Philip J. Bilan; Amira Klip
Topics:
monocytes
,
nucleotides
,
palmitates
,
skeletal myocytes
,
cytokine
Diabetes October 2014, Vol.63, 3815-3826. doi:https://doi.org/10.2337/db14-0150
Type 1 Diabetes in NOD Mice Unaffected by Mast Cell Deficiency
Dario A. Gutierrez; Wenxian Fu; Susann Schonefeldt; Thorsten B. Feyerabend; Adriana Ortiz-Lopez; Yulia Lampi; Adrian Liston; Diane Mathis; Hans-Reimer Rodewald
Topics:
mast cells
,
mice
,
mice, inbred nod
,
diabetes mellitus, type 1
,
pancreas
Diabetes October 2014, Vol.63, 3827-3834. doi:https://doi.org/10.2337/db14-0372
Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes
Sefina Arif; Pia Leete; Vy Nguyen; Katherine Marks; Nurhanani Mohamed Nor; Megan Estorninho; Deborah Kronenberg-Versteeg; Polly J. Bingley; John A. Todd; Catherine Guy; David B. Dunger; Jake Powrie; Abby Willcox; Alan K. Foulis; Sarah J. Richardson; Emanuele de Rinaldis; Noel G. Morgan; Anna Lorenc; Mark Peakman
Topics:
diabetes mellitus, type 1
,
phenotype
,
child
,
autoimmunity
,
t-lymphocytes
Diabetes October 2014, Vol.63, 3835-3845. doi:https://doi.org/10.2337/db14-0365
Pathophysiology
β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes
Sara F. Michaliszyn; Andrea Mari; SoJung Lee; Fida Bacha; Hala Tfayli; Lama Farchoukh; Ele Ferrannini; Silva Arslanian
Topics:
diabetes mellitus, type 2
,
glucose
,
hormones
,
incretin
,
oral glucose tolerance test
Diabetes October 2014, Vol.63, 3846-3855. doi:https://doi.org/10.2337/db13-1951
Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes
Tomas Jelenik; Gilles Séquaris; Kirti Kaul; D. Margriet Ouwens; Esther Phielix; Jörg Kotzka; Birgit Knebel; Jürgen Weiß; Anna Lena Reinbeck; Linda Janke; Peter Nowotny; Hans-Joachim Partke; Dongyan Zhang; Gerald I. Shulman; Julia Szendroedi; Michael Roden
Topics:
insulin
,
insulin resistance
,
lipids
,
liver
,
mice
Diabetes October 2014, Vol.63, 3856-3867. doi:https://doi.org/10.2337/db13-1794
Prospective Associations of Vitamin D Status With β-Cell Function, Insulin Sensitivity, and Glycemia: The Impact of Parathyroid Hormone Status
Caroline K. Kramer; Balakumar Swaminathan; Anthony J. Hanley; Philip W. Connelly; Mathew Sermer; Bernard Zinman; Ravi Retnakaran
Topics:
vitamin d
,
postpartum period
,
insulin sensitivity
,
vitamin d deficiency
,
glucose
Diabetes October 2014, Vol.63, 3868-3879. doi:https://doi.org/10.2337/db14-0489
Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes
Teresa Rodriguez-Calvo; Olov Ekwall; Natalie Amirian; Jose Zapardiel-Gonzalo; Matthias G. von Herrath
Topics:
diabetes mellitus, type 2
,
donors
,
exocrine pancreas
,
insulin
,
pancreas
Diabetes October 2014, Vol.63, 3880-3890. doi:https://doi.org/10.2337/db14-0549
Complications
Exendin-4, a GLP-1 Receptor Agonist, Attenuates Prostate Cancer Growth
Takashi Nomiyama; Takako Kawanami; Shinichiro Irie; Yuriko Hamaguchi; Yuichi Terawaki; Kunitaka Murase; Yoko Tsutsumi; Ryoko Nagaishi; Makito Tanabe; Hidetaka Morinaga; Tomoko Tanaka; Makio Mizoguchi; Kazuki Nabeshima; Masatoshi Tanaka; Toshihiko Yanase
Diabetes October 2014, Vol.63, 3891-3905. doi:https://doi.org/10.2337/db13-1169
Retinal Vessel Calibers Predict Long-term Microvascular Complications in Type 1 Diabetes: The Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)
Rebecca Broe; Malin L. Rasmussen; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Lauren Hodgson; Tien Y. Wong; Tunde Peto; Jakob Grauslund
Diabetes October 2014, Vol.63, 3906-3914. doi:https://doi.org/10.2337/db14-0227
Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes
Chris Tikellis; Raelene J. Pickering; Despina Tsorotes; Olivier Huet; Mark E. Cooper; Karin Jandeleit-Dahm; Merlin C. Thomas
Topics:
adhesions
,
aorta
,
apolipoprotein e
,
atherogenesis
,
endothelium
Diabetes October 2014, Vol.63, 3915-3925. doi:https://doi.org/10.2337/db13-0932
Neuroretinal Dysfunction With Intact Blood-Retinal Barrier and Absent Vasculopathy in Type 1 Diabetes
Topics:
color
,
contrast sensitivity
,
diabetes mellitus, type 1
,
fundus photography
,
neurophysiology-biologic function
Diabetes October 2014, Vol.63, 3926-3937. doi:https://doi.org/10.2337/db13-1673
Trends in Incidence of Type 1 Diabetes Among Non-Hispanic White Youth in the U.S., 2002–2009
Jean M. Lawrence; Giuseppina Imperatore; Dana Dabelea; Elizabeth J. Mayer-Davis; Barbara Linder; Sharon Saydah; Georgeanna J. Klingensmith; Lawrence Dolan; Debra A. Standiford; Catherine Pihoker; David J. Pettitt; Jennifer W. Talton; Joan Thomas; Ronny A. Bell; Ralph B. D’Agostino, Jr.; for the SEARCH for Diabetes in Youth Study Group
Topics:
adolescent
,
diabetes mellitus, type 1
Diabetes October 2014, Vol.63, 3938-3945. doi:https://doi.org/10.2337/db13-1891
Pharmacology and Therapeutics
Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog
Dale S. Edgerton; Mary C. Moore; Jason J. Winnick; Melanie Scott; Ben Farmer; Helle Naver; Claus B. Jeppesen; Peter Madsen; Thomas B. Kjeldsen; Erica Nishimura; Christian L. Brand; Alan D. Cherrington
Topics:
glucose
,
infusion procedures
,
insulin
,
insulin analogs
,
portal vein
Diabetes October 2014, Vol.63, 3946-3954. doi:https://doi.org/10.2337/db14-0266
Genetics / Genomes / Proteomics / Metabolomics
Fat Mass and Obesity-Associated Gene (FTO) Is Linked to Higher Plasma Levels of the Hunger Hormone Ghrelin and Lower Serum Levels of the Satiety Hormone Leptin in Older Adults
Christian Benedict; Tomas Axelsson; Stefan Söderberg; Anders Larsson; Erik Ingelsson; Lars Lind; Helgi B. Schiöth
Diabetes October 2014, Vol.63, 3955-3959. doi:https://doi.org/10.2337/db14-0470
Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families
Yi-Guang Chen; Susanne M. Cabrera; Shuang Jia; Mary L. Kaldunski; Joanna Kramer; Sami Cheong; Rhonda Geoffrey; Mark F. Roethle; Jeffrey E. Woodliff; Carla J. Greenbaum; Xujing Wang; Martin J. Hessner
Topics:
plasma
,
human leukocyte antigens
,
regulatory t-lymphocytes
,
cytokine
Diabetes October 2014, Vol.63, 3960-3973. doi:https://doi.org/10.2337/db14-0214
Erratum
Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653
Luan Shu; Nadine S. Sauter; Fabienne T. Schulthess; Aleksey V. Matveyenko; José Oberholzer; Kathrin Maedler
Topics:
endocrine pancreas
,
tcf7l2 gene
Diabetes October 2014, Vol.63, 3974. doi:https://doi.org/10.2337/db14-er11
