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Volume 63, Issue 12
1 December 2014
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes November 2014, Vol.63, 3977-3978. doi:https://doi.org/10.2337/db14-ti12

Editorial

Summary of the Keystone Islet Workshop (April 2014): The Increasing Demand for Human Islet Availability in Diabetes Research
Rohit N. Kulkarni; Andrew F. Stewart
View articletitled, Summary of the Keystone Islet Workshop (April 2014): The Increasing Demand for Human Islet Availability in Diabetes Research
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Diabetes November 2014, Vol.63, 3979-3981. doi:https://doi.org/10.2337/db14-1303

Perspectives in Diabetes

Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?
Tom Seijkens; Pascal Kusters; Antonios Chatzigeorgiou; Triantafyllos Chavakis; Esther Lutgens
View articletitled, Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?
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Diabetes November 2014, Vol.63, 3982-3991. doi:https://doi.org/10.2337/db14-0272
Insulin Regulates Brain Function, but How Does It Get There?
Sarah M. Gray; Rick I. Meijer; Eugene J. Barrett
View articletitled, Insulin Regulates Brain Function, but How Does It Get There?
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Diabetes November 2014, Vol.63, 3992-3997. doi:https://doi.org/10.2337/db14-0340

Commentaries

Brown Adipose Tissue and the Cold War Against Obesity
Riccardo Calvani; Christiaan Leeuwenburgh; Emanuele Marzetti
View articletitled, Brown Adipose Tissue and the Cold War Against Obesity
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Diabetes November 2014, Vol.63, 3998-4000. doi:https://doi.org/10.2337/db14-1373
Myeloperoxidase: A Therapeutic Target for Preventing Insulin Resistance and the Metabolic Sequelae of Obesity?
Jay W. Heinecke; Ira J. Goldberg
View articletitled, Myeloperoxidase: A Therapeutic Target for Preventing Insulin Resistance and the Metabolic Sequelae of Obesity?
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Diabetes November 2014, Vol.63, 4001-4003. doi:https://doi.org/10.2337/db14-1273
Integrating Publicly Available Genome-Wide Association Data to Study the Genetic Basis of Metabolically Healthy Obese and Metabolically Obese but Normal-Weight Individuals
Ruth J.F. Loos
View articletitled, Integrating Publicly Available Genome-Wide Association Data to Study the Genetic Basis of Metabolically Healthy Obese and Metabolically Obese but Normal-Weight Individuals
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Diabetes November 2014, Vol.63, 4004-4007. doi:https://doi.org/10.2337/db14-1358
Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDHH454Y Mutation
Guanghong Jia; James R. Sowers
View articletitled, Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDH<sup>H454Y</sup> Mutation
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Diabetes November 2014, Vol.63, 4008-4010. doi:https://doi.org/10.2337/db14-1243
Can the NK Family of Osteoblast Homeodomain Transcription Factors Signaling Be a Magic Bullet to Reverse Calcification-Induced Vasculopathy in Diabetes?
Souad Belmadani; Khalid Matrougui
View articletitled, Can the NK Family of Osteoblast Homeodomain Transcription Factors Signaling Be a Magic Bullet to Reverse Calcification-Induced Vasculopathy in Diabetes?
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Diabetes November 2014, Vol.63, 4011-4012. doi:https://doi.org/10.2337/db14-1366
Head Over Hepatocytes for FGF21
Matthew J. Potthoff; Brian N. Finck
View articletitled, Head Over Hepatocytes for FGF21
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Diabetes November 2014, Vol.63, 4013-4015. doi:https://doi.org/10.2337/db14-1185
Wired for Obesity?
Dinesh Selvarajah; Pratik Choudhary; I. Sadaf Farooqi
View articletitled, Wired for Obesity?
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Diabetes November 2014, Vol.63, 4016-4017. doi:https://doi.org/10.2337/db14-1311
Autoimmune Diabetes: Caught in a NET
Richard David G. Leslie; C. Bradford
View articletitled, Autoimmune Diabetes: Caught in a NET
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Diabetes November 2014, Vol.63, 4018-4020. doi:https://doi.org/10.2337/db14-1382

Metabolism

Reducing RIP140 Expression in Macrophage Alters ATM Infiltration, Facilitates White Adipose Tissue Browning, and Prevents High-Fat Diet–Induced Insulin Resistance
Pu-Ste Liu; Yi-Wei Lin; Bomi Lee; Shelly K. McCrady-Spitzer; James A. Levine; Li-Na Wei
View articletitled, Reducing RIP140 Expression in Macrophage Alters ATM Infiltration, Facilitates White Adipose Tissue Browning, and Prevents High-Fat Diet–Induced Insulin Resistance
Supplementary data
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Diabetes November 2014, Vol.63, 4021-4031. doi:https://doi.org/10.2337/db14-0619
Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation
Nolwenn Briand; Cécilia Prado; Guillaume Mabilleau; Françoise Lasnier; Xavier Le Lièpvre; Jeffrey D. Covington; Eric Ravussin; Soazig Le Lay; Isabelle Dugail
View articletitled, Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation
Supplementary data
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Diabetes November 2014, Vol.63, 4032-4044. doi:https://doi.org/10.2337/db13-1961
MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes
Hye-Jin Kim; Hyunjii Cho; Ryan Alexander; Heide Christine Patterson; Minxia Gu; Kinyui Alice Lo; Dan Xu; Vera J. Goh; Long N. Nguyen; Xiaoran Chai; Cher X. Huang; Jean-Paul Kovalik; Sujoy Ghosh; Mirko Trajkovski; David L. Silver; Harvey Lodish; Lei Sun
View articletitled, MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes
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Diabetes November 2014, Vol.63, 4045-4056. doi:https://doi.org/10.2337/db14-0466
Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
Kathleen R. Markan; Meghan C. Naber; Magdalene K. Ameka; Maxwell D. Anderegg; David J. Mangelsdorf; Steven A. Kliewer; Moosa Mohammadi; Matthew J. Potthoff
View articletitled, Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
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Diabetes November 2014, Vol.63, 4057-4063. doi:https://doi.org/10.2337/db14-0595
FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting
Qingning Liang; Ling Zhong; Jialiang Zhang; Yu Wang; Stefan R. Bornstein; Chris R. Triggle; Hong Ding; Karen S.L. Lam; Aimin Xu
View articletitled, FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting
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Diabetes November 2014, Vol.63, 4064-4075. doi:https://doi.org/10.2337/db14-0541
Hepatic ABCA1 Expression Improves β-Cell Function and Glucose Tolerance
Willeke de Haan; Joanna M. Karasinska; Piers Ruddle; Michael R. Hayden
View articletitled, Hepatic ABCA1 Expression Improves β-Cell Function and Glucose Tolerance
Supplementary data
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Diabetes November 2014, Vol.63, 4076-4082. doi:https://doi.org/10.2337/db14-0548
Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men
Martin Heni; Robert Wagner; Stephanie Kullmann; Ralf Veit; Haliza Mat Husin; Katarzyna Linder; Charlotte Benkendorff; Andreas Peter; Norbert Stefan; Hans-Ulrich Häring; Hubert Preissl; Andreas Fritsche
View articletitled, Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men
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Diabetes November 2014, Vol.63, 4083-4088. doi:https://doi.org/10.2337/db14-0477
Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
Maria Chondronikola; Elena Volpi; Elisabet Børsheim; Craig Porter; Palam Annamalai; Sven Enerbäck; Martin E. Lidell; Manish K. Saraf; Sebastien M. Labbe; Nicholas M. Hurren; Christina Yfanti; Tony Chao; Clark R. Andersen; Fernando Cesani; Hal Hawkins; Labros S. Sidossis
View articletitled, Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
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Diabetes November 2014, Vol.63, 4089-4099. doi:https://doi.org/10.2337/db14-0746

Signal Transduction

Defects in β-Cell Ca2+ Dynamics in Age-Induced Diabetes
Luosheng Li; Aleksandra Trifunovic; Martin Köhler; Yixin Wang; Jelena Petrovic Berglund; Christopher Illies; Lisa Juntti-Berggren; Nils-Göran Larsson; Per-Olof Berggren
View articletitled, Defects in β-Cell Ca<sup>2+</sup> Dynamics in Age-Induced Diabetes
Supplementary data
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Diabetes November 2014, Vol.63, 4100-4114. doi:https://doi.org/10.2337/db13-1855
Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle
Masaaki Sato; Nodi Dehvari; Anette I. Öberg; Olof S. Dallner; Anna L. Sandström; Jessica M. Olsen; Robert I. Csikasz; Roger J. Summers; Dana S. Hutchinson; Tore Bengtsson
View articletitled, Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle
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Diabetes November 2014, Vol.63, 4115-4129. doi:https://doi.org/10.2337/db13-1860
Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells
Salvatore Iovino; Alison M. Burkart; Kristina Kriauciunas; Laura Warren; Katelyn J. Hughes; Michael Molla; Youn-Kyoung Lee; Mary-Elizabeth Patti; C. Ronald Kahn
View articletitled, Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells
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Diabetes November 2014, Vol.63, 4130-4142. doi:https://doi.org/10.2337/db14-0109

Obesity Studies

Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity
Rinke Stienstra; Wieneke Dijk; Lianne van Beek; Henry Jansen; Mattijs Heemskerk; Riekelt H. Houtkooper; Simone Denis; Vanessa van Harmelen; Ko Willems van Dijk; Cees J. Tack; Sander Kersten
View articletitled, Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity
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Diabetes November 2014, Vol.63, 4143-4153. doi:https://doi.org/10.2337/db14-0256
ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity
Satoshi Nishimura; Mika Nagasaki; Shinichi Okudaira; Junken Aoki; Tsukasa Ohmori; Ryunosuke Ohkawa; Kazuhiro Nakamura; Koji Igarashi; Hiroshi Yamashita; Koji Eto; Kansei Uno; Naoto Hayashi; Takashi Kadowaki; Issei Komuro; Yutaka Yatomi; Ryozo Nagai
View articletitled, ENPP2 Contributes to Adipose Tissue Expansion and Insulin Resistance in Diet-Induced Obesity
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Diabetes November 2014, Vol.63, 4154-4164. doi:https://doi.org/10.2337/db13-1694
Negative Regulation of DsbA-L Gene Expression by the Transcription Factor Sp1
Qichen Fang; Wenjing Yang; Huating Li; Wenxiu Hu; Lihui Chen; Shan Jiang; Kun Dong; Qianqian Song; Chen Wang; Shuo Chen; Feng Liu; Weiping Jia
View articletitled, Negative Regulation of DsbA-L Gene Expression by the Transcription Factor Sp1
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Diabetes November 2014, Vol.63, 4165-4171. doi:https://doi.org/10.2337/db14-0182
Myeloperoxidase Deletion Prevents High-Fat Diet–Induced Obesity and Insulin Resistance
Qilong Wang; Zhonglin Xie; Wencheng Zhang; Jun Zhou; Yue Wu; Miao Zhang; Huaiping Zhu; Ming-Hui Zou
View articletitled, Myeloperoxidase Deletion Prevents High-Fat Diet–Induced Obesity and Insulin Resistance
Supplementary data
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Diabetes November 2014, Vol.63, 4172-4185. doi:https://doi.org/10.2337/db14-0026
GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans
Liselotte van Bloemendaal; Richard G. IJzerman; Jennifer S. ten Kulve; Frederik Barkhof; Robert J. Konrad; Madeleine L. Drent; Dick J. Veltman; Michaela Diamant
View articletitled, GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans
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Diabetes November 2014, Vol.63, 4186-4196. doi:https://doi.org/10.2337/db14-0849

Islet Studies

GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis
Indri Purwana; Juan Zheng; Xiaoming Li; Marielle Deurloo; Dong Ok Son; Zhaoyun Zhang; Christie Liang; Eddie Shen; Akshaya Tadkase; Zhong-Ping Feng; Yiming Li; Craig Hasilo; Steven Paraskevas; Rita Bortell; Dale L. Greiner; Mark Atkinson; Gerald J. Prud’homme; Qinghua Wang
View articletitled, GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis
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Diabetes November 2014, Vol.63, 4197-4205. doi:https://doi.org/10.2337/db14-0153
Islet-1 Is Essential for Pancreatic β-Cell Function
Benjamin N. Ediger; Aiping Du; Jingxuan Liu; Chad S. Hunter; Erik R. Walp; Jonathan Schug; Klaus H. Kaestner; Roland Stein; Doris A. Stoffers; Catherine L. May
View articletitled, Islet-1 Is Essential for Pancreatic β-Cell Function
Supplementary data
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Diabetes November 2014, Vol.63, 4206-4217. doi:https://doi.org/10.2337/db14-0096
Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release
Richard G. Kibbey; Cheol Soo Choi; Hui-Young Lee; Over Cabrera; Rebecca L. Pongratz; Xiaojian Zhao; Andreas L. Birkenfeld; Changhong Li; Per-Olof Berggren; Charles Stanley; Gerald I. Shulman
View articletitled, Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release
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Diabetes November 2014, Vol.63, 4218-4229. doi:https://doi.org/10.2337/db14-0783
Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes
Oliver Kluth; Daniela Matzke; Gunnar Schulze; Robert W. Schwenk; Hans-Georg Joost; Annette Schürmann
View articletitled, Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes
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Diabetes November 2014, Vol.63, 4230-4238. doi:https://doi.org/10.2337/db14-0425

Immunology and Transplantation

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes
Yudong Wang; Yang Xiao; Ling Zhong; Dewei Ye; Jialiang Zhang; Yiting Tu; Stefan R. Bornstein; Zhiguang Zhou; Karen S.L. Lam; Aimin Xu
View articletitled, Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes
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Diabetes November 2014, Vol.63, 4239-4248. doi:https://doi.org/10.2337/db14-0480

Complications

Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA
Marpadga A. Reddy; Zhuo Chen; Jung Tak Park; Mei Wang; Linda Lanting; Qiang Zhang; Kirti Bhatt; Amy Leung; Xiwei Wu; Sumanth Putta; Pål Sætrom; Sridevi Devaraj; Rama Natarajan
View articletitled, Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA
Supplementary data
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Diabetes November 2014, Vol.63, 4249-4261. doi:https://doi.org/10.2337/db14-0298
Substance P Promotes Diabetic Corneal Epithelial Wound Healing Through Molecular Mechanisms Mediated via the Neurokinin-1 Receptor
Lingling Yang; Guohu Di; Xia Qi; Mingli Qu; Yao Wang; Haoyun Duan; Patrik Danielson; Lixin Xie; Qingjun Zhou
View articletitled, Substance P Promotes Diabetic Corneal Epithelial Wound Healing Through Molecular Mechanisms Mediated via the Neurokinin-1 Receptor
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Diabetes November 2014, Vol.63, 4262-4274. doi:https://doi.org/10.2337/db14-0163
Hyperhomocysteinemia Potentiates Hyperglycemia-Induced Inflammatory Monocyte Differentiation and Atherosclerosis
Pu Fang; Daqing Zhang; Zhongjian Cheng; Chenghui Yan; Xiaohua Jiang; Warren D. Kruger; Shu Meng; Erland Arning; Teodoro Bottiglieri; Eric T. Choi; Yaling Han; Xiao-feng Yang; Hong Wang
View articletitled, Hyperhomocysteinemia Potentiates Hyperglycemia-Induced Inflammatory Monocyte Differentiation and Atherosclerosis
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Diabetes November 2014, Vol.63, 4275-4290. doi:https://doi.org/10.2337/db14-0809
Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease
Milene Vandal; Phillip J. White; Cyntia Tremblay; Isabelle St-Amour; Geneviève Chevrier; Vincent Emond; Dominique Lefrançois; Jessica Virgili; Emmanuel Planel; Yves Giguere; Andre Marette; Frederic Calon
View articletitled, Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease
Supplementary data
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Diabetes November 2014, Vol.63, 4291-4301. doi:https://doi.org/10.2337/db14-0375
Role of Heparanase-Driven Inflammatory Cascade in Pathogenesis of Diabetic Nephropathy
Rachel Goldberg; Ariel M. Rubinstein; Natali Gil; Esther Hermano; Jin-Ping Li; Johan van der Vlag; Ruth Atzmon; Amichay Meirovitz; Michael Elkin
View articletitled, Role of Heparanase-Driven Inflammatory Cascade in Pathogenesis of Diabetic Nephropathy
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Diabetes November 2014, Vol.63, 4302-4313. doi:https://doi.org/10.2337/db14-0001
IHG-1 Increases Mitochondrial Fusion and Bioenergetic Function
Fionnuala B. Hickey; James B. Corcoran; Brenda Griffin; Una Bhreathnach; Heather Mortiboys; Helen M. Reid; Darrell Andrews; Shane Byrne; Fiona Furlong; Finian Martin; Catherine Godson; Madeline Murphy
View articletitled, IHG-1 Increases Mitochondrial Fusion and Bioenergetic Function
Supplementary data
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Diabetes November 2014, Vol.63, 4314-4325. doi:https://doi.org/10.2337/db13-1256
Targeted Reduction of Vascular Msx1 and Msx2 Mitigates Arteriosclerotic Calcification and Aortic Stiffness in LDLR-Deficient Mice Fed Diabetogenic Diets
Su-Li Cheng; Abraham Behrmann; Jian-Su Shao; Bindu Ramachandran; Karen Krchma; Yoanna Bello Arredondo; Attila Kovacs; Megan Mead; Robert Maxson; Dwight A. Towler
View articletitled, Targeted Reduction of Vascular <em>Msx1</em> and <em>Msx2</em> Mitigates Arteriosclerotic Calcification and Aortic Stiffness in <em>LDLR</em>-Deficient Mice Fed Diabetogenic Diets
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Diabetes November 2014, Vol.63, 4326-4337. doi:https://doi.org/10.2337/db14-0326
Increased Intraretinal PO2 in Short-Term Diabetic Rats
Jennifer C.M. Lau; Robert A. Linsenmeier
View articletitled, Increased Intraretinal PO<sub>2</sub> in Short-Term Diabetic Rats
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Diabetes November 2014, Vol.63, 4338-4342. doi:https://doi.org/10.2337/db14-0101

Genetics/Genomes/Proteomics/Metabolomics

Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits
Christian Herder; Marja-Liisa Nuotio; Sonia Shah; Stefan Blankenberg; Eric J. Brunner; Maren Carstensen; Christian Gieger; Harald Grallert; Antti Jula; Mika Kähönen; Johannes Kettunen; Mika Kivimäki; Wolfgang Koenig; Kati Kristiansson; Claudia Langenberg; Terho Lehtimäki; Kari Luotola; Carola Marzi; Christian Müller; Annette Peters; Holger Prokisch; Olli Raitakari; Wolfgang Rathmann; Michael Roden; Marko Salmi; Katharina Schramm; Daniel Swerdlow; Adam G. Tabak; Barbara Thorand; Nick Wareham; Philipp S. Wild; Tanja Zeller; Aroon D. Hingorani; Daniel R. Witte; Meena Kumari; Markus Perola; Veikko Salomaa
View articletitled, Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits
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Diabetes November 2014, Vol.63, 4343-4359. doi:https://doi.org/10.2337/db14-0731
Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13
M. Joseph Tomlinson, IV; Achilleas Pitsillides; Rebecca Pickin; Matthew Mika; Keith L. Keene; Xuanlin Hou; Josyf Mychaleckyj; Wei-Min Chen; Patrick Concannon; Suna Onengut-Gumuscu
View articletitled, Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13
Supplementary data
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Diabetes November 2014, Vol.63, 4360-4368. doi:https://doi.org/10.2337/db13-1785
Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
Hanieh Yaghootkar; Robert A. Scott; Charles C. White; Weihua Zhang; Elizabeth Speliotes; Patricia B. Munroe; Georg B. Ehret; Joshua C. Bis; Caroline S. Fox; Mark Walker; Ingrid B. Borecki; Joshua W. Knowles; Laura Yerges-Armstrong; Claes Ohlsson; John R.B. Perry; John C. Chambers; Jaspal S. Kooner; Nora Franceschini; Claudia Langenberg; Marie-France Hivert; Zari Dastani; J. Brent Richards; Robert K. Semple; Timothy M. Frayling
View articletitled, Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
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Diabetes November 2014, Vol.63, 4369-4377. doi:https://doi.org/10.2337/db14-0318
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
Robert A. Scott; Tove Fall; Dorota Pasko; Adam Barker; Stephen J. Sharp; Larraitz Arriola; Beverley Balkau; Aurelio Barricarte; Inês Barroso; Heiner Boeing; Françoise Clavel-Chapelon; Francesca L. Crowe; Jacqueline M. Dekker; Guy Fagherazzi; Ele Ferrannini; Nita G. Forouhi; Paul W. Franks; Diana Gavrila; Vilmantas Giedraitis; Sara Grioni; Leif C. Groop; Rudolf Kaaks; Timothy J. Key; Tilman Kühn; Luca A. Lotta; Peter M. Nilsson; Kim Overvad; Domenico Palli; Salvatore Panico; J. Ramón Quirós; Olov Rolandsson; Nina Roswall; Carlotta Sacerdote; Núria Sala; María-José Sánchez; Matthias B. Schulze; Afshan Siddiq; Nadia Slimani; Ivonne Sluijs; Annemieke M.W. Spijkerman; Anne Tjonneland; Rosario Tumino; Daphne L. van der A; Hanieh Yaghootkar; The RISC Study Group; The EPIC-InterAct Consortium; Mark I. McCarthy; Robert K. Semple; Elio Riboli; Mark Walker; Erik Ingelsson; Tim M. Frayling; David B. Savage; Claudia Langenberg; Nicholas J. Wareham
View articletitled, Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
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Diabetes November 2014, Vol.63, 4378-4387. doi:https://doi.org/10.2337/db14-0319

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes November 2014, Vol.63, 4388. doi:https://doi.org/10.2337/db14-ie12

E-Letters: Comments and Responses

Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle. Diabetes 2014;63:4115–4129
Lusha Xiang; Peter N. Mittwede; Robert L. Hester
View articletitled, Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle. Diabetes 2014;63:4115–4129
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Diabetes November 2014, Vol.63, e20-e21. doi:https://doi.org/10.2337/db14-1187
Response to Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle. Diabetes 2014;63:4115–4129
Masaaki Sato; Nodi Dehvari; Anette I. Öberg; Roger J. Summers; Dana S. Hutchinson; Tore Bengtsson
View articletitled, Response to Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle. Diabetes 2014;63:4115–4129
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Diabetes November 2014, Vol.63, e22-e23. doi:https://doi.org/10.2337/db14-1283
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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