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In This Issue of Diabetes

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View articletitled, In This Issue of Diabetes

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Topics: diabetes mellitus, type 1 , gastric bypass , glucagon-like peptide 1 , potable water , rats

Diabetes January 2014, Vol.63, 379-380. doi:https://doi.org/10.2337/db14-ti02

Commentaries

Irisin ERKs the Fat

Jun Wu; Bruce M. Spiegelman

Abstracts

View articletitled, Irisin ERKs the Fat

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Topics: irisin

Diabetes January 2014, Vol.63, 381-383. doi:https://doi.org/10.2337/db13-1586

Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs

Francesco Dotta; Guido Sebastiani

Abstracts

View articletitled, Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs

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Topics: diabetes mellitus, type 1 , enterovirus infections , infections , enterovirus , autoimmunity

Diabetes January 2014, Vol.63, 384-386. doi:https://doi.org/10.2337/db13-1441

GLP-1—A Candidate Humoral Mediator for Glucose Control After Roux-en-Y Gastric Bypass

Jörg Schirra; Burkhard Göke

Abstracts

View articletitled, GLP-1—A Candidate Humoral Mediator for Glucose Control After Roux-en-Y Gastric Bypass

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Topics: gastric bypass, roux-en-y , glucagon-like peptide 1 , glycemic control , diabetes mellitus, type 2 , surgical procedures, operative

Diabetes January 2014, Vol.63, 387-389. doi:https://doi.org/10.2337/db13-1660

LY2605541—A Preferential Hepato-Specific Insulin Analogue

Sten Madsbad

Abstracts

View articletitled, LY2605541—A Preferential Hepato-Specific Insulin Analogue

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Topics: insulin , insulin analogs , insulin glargine , basal insulin , hypoglycemia

Diabetes January 2014, Vol.63, 390-392. doi:https://doi.org/10.2337/db13-1646

Turning Off a Viral/Lipid Sensor Improves Type 2 Diabetes

Licio A. Velloso

Abstracts

View articletitled, Turning Off a Viral/Lipid Sensor Improves Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , lipids , sensor , insulin , obesity

Diabetes January 2014, Vol.63, 393-395. doi:https://doi.org/10.2337/db13-1704

Functional MRI Signal Fluctuations: A Preclinical Biomarker for Cognitive Impairment in Type 2 Diabetes?

Renata Belfort-DeAguiar; R. Todd Constable; Robert S. Sherwin

Abstracts

View articletitled, Functional MRI Signal Fluctuations: A Preclinical Biomarker for Cognitive Impairment in Type 2 Diabetes?

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Topics: biological markers , cognitive impairment , diabetes mellitus, type 2 , functional magnetic resonance imaging

Diabetes January 2014, Vol.63, 396-398. doi:https://doi.org/10.2337/db13-1685

GLP-1: The Oracle for Gastric Bypass?

Gema Frühbeck; Ruben Nogueiras

Abstracts

View articletitled, GLP-1: The Oracle for Gastric Bypass?

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Topics: gastric bypass , glucagon-like peptide 1 , surgical procedures, operative , weight reduction , obesity

Diabetes January 2014, Vol.63, 399-401. doi:https://doi.org/10.2337/db13-1708

Aldose Reductase Meets Histone Acetylation: A New Role for an Old Player

Julia V. Busik; Maria B. Grant

Abstracts

View articletitled, Aldose Reductase Meets Histone Acetylation: A New Role for an Old Player

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Topics: aldehyde reductase , diabetes mellitus complications , histone acetylation

Diabetes January 2014, Vol.63, 402-404. doi:https://doi.org/10.2337/db13-1696

Toward Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect?

Corinne D. Engelman

Abstracts

View articletitled, Toward Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect?

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Topics: fto gene , overweight and obesity prevention , vitamin d , obesity

Diabetes January 2014, Vol.63, 405-406. doi:https://doi.org/10.2337/db13-1714

Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1

Jenny Tong; David D’Alessio

Abstracts

View articletitled, Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1

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Topics: glucagon-like peptide 1 , gastric emptying

Diabetes January 2014, Vol.63, 407-409. doi:https://doi.org/10.2337/db13-1764

Technological Advances

Generation of L Cells in Mouse and Human Small Intestine Organoids

Natalia Petersen; Frank Reimann; Sina Bartfeld; Henner F. Farin; Femke C. Ringnalda; Robert G.J. Vries; Stieneke van den Brink; Hans Clevers; Fiona M. Gribble; Eelco J.P. de Koning

Abstract

View articletitled, Generation of L Cells in Mouse and Human Small Intestine Organoids

Supplementary data

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Topics: glucagon-like peptide 1 , l cells (cell line) , mice , organoids , intestines

Diabetes January 2014, Vol.63, 410-420. doi:https://doi.org/10.2337/db13-0991

Metabolism

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

Jeb S. Orr; Arion Kennedy; Emily K. Anderson-Baucum; Corey D. Webb; Steve C. Fordahl; Keith M. Erikson; Yaofang Zhang; Anders Etzerodt; Søren K. Moestrup; Alyssa H. Hasty

Abstract

View articletitled, Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

Supplementary data

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Topics: iron , obesity , macrophages , mice

Diabetes January 2014, Vol.63, 421-432. doi:https://doi.org/10.2337/db13-0213

RNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling

Yaniv Lustig; Ehud Barhod; Reut Ashwal-Fluss; Reut Gordin; Noam Shomron; Kfir Baruch-Umansky; Rina Hemi; Avraham Karasik; Hannah Kanety

Abstract

View articletitled, RNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling

Supplementary data

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Topics: adiponectin , luciferases , mice , micrornas , myoblasts

Diabetes January 2014, Vol.63, 433-445. doi:https://doi.org/10.2337/db13-1032

Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Olli H. Laitinen; Hanna Honkanen; Outi Pakkanen; Sami Oikarinen; Minna M. Hankaniemi; Heini Huhtala; Tanja Ruokoranta; Valérie Lecouturier; Philippe André; Raimo Harju; Suvi M. Virtanen; Jussi Lehtonen; Jeffrey W. Almond; Tuula Simell; Olli Simell; Jorma Ilonen; Riitta Veijola; Mikael Knip; Heikki Hyöty

Abstracts

View articletitled, Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Supplementary data

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Topics: autoantibodies , autoimmunity , child , diabetes mellitus, type 1 , enterovirus

Diabetes January 2014, Vol.63, 446-455. doi:https://doi.org/10.2337/db13-0619

Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism

Louise Grant; Kirsty D. Shearer; Alicja Czopek; Emma K. Lees; Carl Owen; Abdelali Agouni; James Workman; Cristina Martin-Granados; John V. Forrester; Heather M. Wilson; Nimesh Mody; Mirela Delibegovic

Abstract

View articletitled, Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism

Supplementary data

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Topics: inflammation , interleukin-10 , macrophages , mice , stat3 protein

Diabetes January 2014, Vol.63, 456-470. doi:https://doi.org/10.2337/db13-0885

Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway

Anh Thoai Nguyen; Stéphane Mandard; Cédric Dray; Valérie Deckert; Philippe Valet; Philippe Besnard; Daniel J. Drucker; Laurent Lagrost; Jacques Grober

Abstract

View articletitled, Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway

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Topics: glucagon-like peptide 1 , glucose , insulin , mice , intraperitoneal injections

Diabetes January 2014, Vol.63, 471-482. doi:https://doi.org/10.2337/db13-0903

Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass

Meera Shah; Jennie H. Law; Francesco Micheletto; Matheni Sathananthan; Chiara Dalla Man; Claudio Cobelli; Robert A. Rizza; Michael Camilleri; Alan R. Zinsmeister; Adrian Vella

Abstracts

View articletitled, Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass

Supplementary data

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Topics: glucagon-like peptide 1 , glucose , infusion procedures , insulin , postprandial period

Diabetes January 2014, Vol.63, 483-493. doi:https://doi.org/10.2337/db13-0954

Novel PEGylated Basal Insulin LY2605541 Has a Preferential Hepatic Effect on Glucose Metabolism

Mary Courtney Moore; Marta S. Smith; Vikram P. Sinha; John M. Beals; M. Dodson Michael; Scott J. Jacober; Alan D. Cherrington

Abstracts

View articletitled, Novel PEGylated Basal Insulin LY2605541 Has a Preferential Hepatic Effect on Glucose Metabolism

Supplementary data

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Topics: basal insulin , glucose , glucose metabolism , infusion procedures , insulin

Diabetes January 2014, Vol.63, 494-504. doi:https://doi.org/10.2337/db13-0826

GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats

Kirk M. Habegger; Kristy M. Heppner; Sarah E. Amburgy; Nickki Ottaway; Jenna Holland; Christine Raver; Erin Bartley; Timo D. Müller; Paul T. Pfluger; Jose Berger; Mouhamadoul Toure; Stephen C. Benoit; Richard D. DiMarchi; Diego Perez-Tilve; David A. D’Alessio; Randy J. Seeley; Matthias H. Tschöp

Abstracts

View articletitled, GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats

Supplementary data

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Topics: eating , glucagon-like peptide 1 , glucose tolerance , obesity , rats

Diabetes January 2014, Vol.63, 505-513. doi:https://doi.org/10.2337/db13-0511

Signal Transduction

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Yuan Zhang; Rui Li; Yan Meng; Shiwu Li; William Donelan; Yan Zhao; Lei Qi; Mingxiang Zhang; Xingli Wang; Taixing Cui; Li-Jun Yang; Dongqi Tang

Abstracts

View articletitled, Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Supplementary data

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Topics: adipocytes , irisin

Diabetes January 2014, Vol.63, 514-525. doi:https://doi.org/10.2337/db13-1106

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

Takahisa Nakamura; Alessandro Arduini; Brenna Baccaro; Masato Furuhashi; Gökhan S. Hotamisligil

Abstracts

View articletitled, Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

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Topics: insulin , mice , obesity , phosphotransferases , glucose homeostasis

Diabetes January 2014, Vol.63, 526-534. doi:https://doi.org/10.2337/db13-1019

Obesity Studies

Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions in a Three-Dimensional Setting: Partial Rescue by Angiopoietin-1

Vanessa Pellegrinelli; Christine Rouault; Nicolas Veyrie; Karine Clément; Danièle Lacasa

Abstract

View articletitled, Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions in a Three-Dimensional Setting: Partial Rescue by Angiopoietin-1

Supplementary data

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Topics: adipocytes , coculture techniques , electroconvulsive therapy , epidural cortical stimulation , obesity

Diabetes January 2014, Vol.63, 535-549. doi:https://doi.org/10.2337/db13-0537

ITCH Deficiency Protects From Diet-Induced Obesity

Arianna Marino; Rossella Menghini; Marta Fabrizi; Viviana Casagrande; Maria Mavilio; Robert Stoehr; Eleonora Candi; Alessandro Mauriello; Jose M. Moreno-Navarrete; María Gómez-Serrano; Belén Peral; Gerry Melino; Renato Lauro; Jose M. Fernandez Real; Massimo Federici

Abstract

View articletitled, ITCH Deficiency Protects From Diet-Induced Obesity

Supplementary data

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Topics: mice , obesity , pruritus , diet , adipose tissue

Diabetes January 2014, Vol.63, 550-561. doi:https://doi.org/10.2337/db13-0802

Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue

Xudong Zhu; Guijuan Zong; Liu Zhu; Yuchen Jiang; Ke Ma; Hanwen Zhang; Yan Zhang; Hui Bai; Qing Yang; Jingjing Ben; Xiaoyu Li; Yong Xu; Qi Chen

Abstract

View articletitled, Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue

Supplementary data

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Topics: adipose tissue , insulin resistance , macrophages , mice , obesity

Diabetes January 2014, Vol.63, 562-577. doi:https://doi.org/10.2337/db13-0815

Islet Studies

G₀-G₁ Transition and the Restriction Point in Pancreatic β-Cells In Vivo

Ayat Hija; Seth Salpeter; Agnes Klochendler; Joseph Grimsby; Michael Brandeis; Benjamin Glaser; Yuval Dor

Abstract

View articletitled, G0-G1 Transition and the Restriction Point in Pancreatic β-Cells In Vivo

Supplementary data

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Topics: cell cycle , g1-s restriction point , ki-67 antigen , mice , pancreas

Diabetes January 2014, Vol.63, 578-584. doi:https://doi.org/10.2337/db12-1035

SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion

Zheng Chen; David L. Morris; Lin Jiang; Yong Liu; Liangyou Rui

Abstracts

View articletitled, SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion

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Topics: 1-phosphatidylinositol 3-kinase , insulin , mice , pancreas , streptozocin

Diabetes January 2014, Vol.63, 585-595. doi:https://doi.org/10.2337/db13-0666

Autoantigen-Induced Focusing of Vβ13⁺ T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat

Ryan A. Eberwine; Laura Cort; Michael Habib; John P. Mordes; Elizabeth P. Blankenhorn

Abstracts

View articletitled, Autoantigen-Induced Focusing of Vβ13+ T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat

Supplementary data

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Topics: autoantigens , prediabetes , rats , t-lymphocytes , insulin

Diabetes January 2014, Vol.63, 596-604. doi:https://doi.org/10.2337/db13-0462

Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

Yoko Yagishita; Toshiaki Fukutomi; Akira Sugawara; Hiroshi Kawamura; Tetsu Takahashi; Jingbo Pi; Akira Uruno; Masayuki Yamamoto

Abstract

View articletitled, Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

Supplementary data

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Topics: kelch-like ech-associated protein 1 , mice , nitric oxide synthase , pancreas , insulin

Diabetes January 2014, Vol.63, 605-618. doi:https://doi.org/10.2337/db13-0909

Immunology and Transplantation

Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome

Aimon K. Alkanani; Naoko Hara; Egil Lien; Diana Ir; Cassandra V. Kotter; Charles E. Robertson; Brandie D. Wagner; Daniel N. Frank; Danny Zipris

Abstract

View articletitled, Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome

Supplementary data

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Topics: mice , poly i-c , toll-like receptor 9 , trimethoprim-sulfamethoxazole combination , myd88 gene

Diabetes January 2014, Vol.63, 619-631. doi:https://doi.org/10.2337/db13-1007

pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence

M. Hanief Sofi; Radhika Gudi; Subha Karumuthil-Melethil; Nicolas Perez; Benjamin M. Johnson; Chenthamarakshan Vasu

Abstract

View articletitled, pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence

Supplementary data

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Topics: intestinal bacteria , mice , mice, inbred nod , potable water , cytokine

Diabetes January 2014, Vol.63, 632-644. doi:https://doi.org/10.2337/db13-0981

Pathophysiology

Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

Jun Wang; Bing Gong; Wei Zhao; Cheuk Tang; Merina Varghese; Tuyen Nguyen; Weina Bi; Amanda Bilski; Shimul Begum; Prashant Vempati; Lindsay Knable; Lap Ho; Giulio M. Pasinetti

Abstract

View articletitled, Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

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Topics: brain , diabetes mellitus, type 2 , histone deacetylase , mice , epigenetics

Diabetes January 2014, Vol.63, 645-654. doi:https://doi.org/10.2337/db13-1063

Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

Abstracts

View articletitled, Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

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Topics: antibodies , diabetes mellitus, type 1 , neutralizing antibodies , viruses , infections

Diabetes January 2014, Vol.63, 655-662. doi:https://doi.org/10.2337/db13-0620

Effects of Sitagliptin and Metformin Treatment on Incretin Hormone and Insulin Secretory Responses to Oral and “Isoglycemic” Intravenous Glucose

Irfan Vardarli; Elisabeth Arndt; Carolyn F. Deacon; Jens J. Holst; Michael A. Nauck

Abstracts

View articletitled, Effects of Sitagliptin and Metformin Treatment on Incretin Hormone and Insulin Secretory Responses to Oral and “Isoglycemic” Intravenous Glucose

Supplementary data

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Topics: glucagon-like peptide 1 , glucose , glucose, parenteral form , hormones , incretin

Diabetes January 2014, Vol.63, 663-674. doi:https://doi.org/10.2337/db13-0805

A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

Abstract

View articletitled, A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

Supplementary data

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Topics: angiogenesis , gene silencing , glucose , hindlimb , hyperglycemia

Diabetes January 2014, Vol.63, 675-687. doi:https://doi.org/10.2337/db13-0417

Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

Elvira Isganaitis; Melissa Woo; Huijuan Ma; Michael Chen; Wen Kong; Aristides Lytras; Vicencia Sales; Jennifer DeCoste-Lopez; Kyung-Ju Lee; Cianna Leatherwood; Deborah Lee; Connor Fitzpatrick; Walter Gall; Steven Watkins; Mary-Elizabeth Patti

Abstract

View articletitled, Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice

Supplementary data

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Topics: insulin , insulin resistance , mice , diet , glucose intolerance

Diabetes January 2014, Vol.63, 688-700. doi:https://doi.org/10.2337/db13-0558

Complications

Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy

Abstract

View articletitled, Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy

Supplementary data

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Topics: kidney glomerulus , mice , podocytes , albuminuria

Diabetes January 2014, Vol.63, 701-714. doi:https://doi.org/10.2337/db13-0752

Genome-Wide Transcriptional Analysis of Differentially Expressed Genes in Diabetic, Healing Corneal Epithelial Cells: Hyperglycemia-Suppressed TGFβ3 Expression Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas

Ilham Bettahi; Haijing Sun; Nan Gao; Feng Wang; Xiaofan Mi; Weiping Chen; Zuguo Liu; Fu-Shin X. Yu

Abstracts

View articletitled, Genome-Wide Transcriptional Analysis of Differentially Expressed Genes in Diabetic, Healing Corneal Epithelial Cells: Hyperglycemia-Suppressed TGFβ3 Expression Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas

Supplementary data

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Topics: chronic exertional compartment syndrome , cornea , epithelium , hyperglycemia , genes

Diabetes January 2014, Vol.63, 715-727. doi:https://doi.org/10.2337/db13-1260

Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

Wouter S. Hoogenboom; Thomas J. Marder; Veronica L. Flores; Susanne Huisman; Hana P. Eaton; Jason S. Schneiderman; Nicolas R. Bolo; Donald C. Simonson; Alan M. Jacobson; Marek Kubicki; Martha E. Shenton; Gail Musen

Abstract

View articletitled, Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes

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Topics: brain , diabetes mellitus, type 2 , diffusion tractography , functional magnetic resonance imaging , middle-aged adult

Diabetes January 2014, Vol.63, 728-738. doi:https://doi.org/10.2337/db13-1219

Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial

John M. Lachin; Paula McGee; Jerry P. Palmer; for the DCCT/EDIC Research Group

Abstracts

View articletitled, Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial

Supplementary data

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Topics: c-peptide , hemoglobin a, glycosylated , insulin , dcct trial , retinal diseases

Diabetes January 2014, Vol.63, 739-748. doi:https://doi.org/10.2337/db13-0881

Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

Ying Cui; Yun Jiao; Yu-Chen Chen; Kun Wang; Bo Gao; Song Wen; Shenghong Ju; Gao-Jun Teng

Abstracts

View articletitled, Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study

Supplementary data

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Topics: correlation studies , diabetes mellitus, type 2 , functional magnetic resonance imaging , brain , occipital lobe

Diabetes January 2014, Vol.63, 749-760. doi:https://doi.org/10.2337/db13-0519

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Srinivasan Vedantham; Devi Thiagarajan; Radha Ananthakrishnan; Lingjie Wang; Rosa Rosario; Yu Shan Zou; Ira Goldberg; Shi Fang Yan; Ann Marie Schmidt; Ravichandran Ramasamy

Abstracts

View articletitled, Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

Supplementary data

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Topics: acetylation , aorta , apolipoprotein e , glucose , mice

Diabetes January 2014, Vol.63, 761-774. doi:https://doi.org/10.2337/db13-0032

Pharmacology and Therapeutics

OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide

Henriette E. Meyer zu Schwabedissen; Kerstin Boettcher; Tobias Steiner; Ute I. Schwarz; Markus Keiser; Heyo K. Kroemer; Werner Siegmund

Abstract

View articletitled, OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide

Supplementary data

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Topics: glyburide , solute carrier organic anion transporter family member 1b3 , sulfonylurea compounds , pancreas

Diabetes January 2014, Vol.63, 775-784. doi:https://doi.org/10.2337/db13-1005

Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia

Mahesh M. Umapathysivam; Michael Y. Lee; Karen L. Jones; Christopher E. Annink; Caroline E. Cousins; Laurence G. Trahair; Chris K. Rayner; Marianne J. Chapman; Michael A. Nauck; Michael Horowitz; Adam M. Deane

Abstracts

View articletitled, Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia

Supplementary data

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Topics: gastric emptying , glucagon-like peptide 1 , insulin , postprandial period , blood glucose

Diabetes January 2014, Vol.63, 785-790. doi:https://doi.org/10.2337/db13-0893

Genetics/Genomes/Proteomics/Metabolomics

BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans

Anna E. Thalacker-Mercer; Katherine H. Ingram; Fangjian Guo; Olga Ilkayeva; Christopher B. Newgard; W. Timothy Garvey

Abstracts

View articletitled, BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans

Supplementary data

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Topics: amino acids , body mass index procedure , diabetes mellitus, type 2 , insulin , obesity

Diabetes January 2014, Vol.63, 791-800. doi:https://doi.org/10.2337/db13-0396

Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study

Bertha Hidalgo; M. Ryan Irvin; Jin Sha; Degui Zhi; Stella Aslibekyan; Devin Absher; Hemant K. Tiwari; Edmond K. Kabagambe; Jose M. Ordovas; Donna K. Arnett

Abstract

View articletitled, Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study

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Topics: antilipemic agents , diabetes mellitus, type 2 , diet , epigenome-wide association study , fasting

Diabetes January 2014, Vol.63, 801-807. doi:https://doi.org/10.2337/db13-1100

FTO Genotype, Vitamin D Status, and Weight Gain During Childhood

Barbara H. Lourenço; Lu Qi; Walter C. Willett; Marly A. Cardoso; for the ACTION Study Team

Abstracts

View articletitled, FTO Genotype, Vitamin D Status, and Weight Gain During Childhood

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Topics: body mass index procedure , child , fto gene , genotype , vitamin d

Diabetes January 2014, Vol.63, 808-814. doi:https://doi.org/10.2337/db13-1290

Errata

Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55:2153–2156

Helen C. Freeman; Alison Hugill; Neil T. Dear; Frances M. Ashcroft; Roger D. Cox

Extract

View articletitled, Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55:<a href="XSLT_Related_Article_Replace_Href" data-vol="55" data-page="2153">2153–2156</a>

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Topics: glucose intolerance , mice , mice, inbred c57bl , nad(p)+ transhydrogenase

Diabetes January 2014, Vol.63, 815. doi:https://doi.org/10.2337/db14-er02

Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol. Diabetes 2013;62:4063–4069

Fariba Shojaee-Moradie; Yuying Ma; Shaoying Lou; Roman Hovorka; A. Margot Umpleby

Extract

View articletitled, Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol. Diabetes 2013;62:<a href="XSLT_Related_Article_Replace_Href" data-vol="62" data-page="4063">4063–4069</a>

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Topics: chylomicrons , hypertriglyceridemia , lipoproteins, vldl , metabolic syndrome x , triglycerides

Diabetes January 2014, Vol.63, 815. doi:https://doi.org/10.2337/db14-er02a

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: atherosclerosis , chief complaint , colorado , diabetic foot ulcer , florida

Diabetes January 2014, Vol.63, 816. doi:https://doi.org/10.2337/db14-ie02

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