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1 February 2014
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes January 2014, Vol.63, 379-380. doi:https://doi.org/10.2337/db14-ti02
Commentaries
Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs
Diabetes January 2014, Vol.63, 384-386. doi:https://doi.org/10.2337/db13-1441
GLP-1—A Candidate Humoral Mediator for Glucose Control After Roux-en-Y Gastric Bypass
Diabetes January 2014, Vol.63, 387-389. doi:https://doi.org/10.2337/db13-1660
Functional MRI Signal Fluctuations: A Preclinical Biomarker for Cognitive Impairment in Type 2 Diabetes?
Diabetes January 2014, Vol.63, 396-398. doi:https://doi.org/10.2337/db13-1685
Aldose Reductase Meets Histone Acetylation: A New Role for an Old Player
Diabetes January 2014, Vol.63, 402-404. doi:https://doi.org/10.2337/db13-1696
Toward Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect?
Diabetes January 2014, Vol.63, 405-406. doi:https://doi.org/10.2337/db13-1714
Technological Advances
Generation of L Cells in Mouse and Human Small Intestine Organoids
Natalia Petersen; Frank Reimann; Sina Bartfeld; Henner F. Farin; Femke C. Ringnalda; Robert G.J. Vries; Stieneke van den Brink; Hans Clevers; Fiona M. Gribble; Eelco J.P. de Koning
Diabetes January 2014, Vol.63, 410-420. doi:https://doi.org/10.2337/db13-0991
Metabolism
Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution
Jeb S. Orr; Arion Kennedy; Emily K. Anderson-Baucum; Corey D. Webb; Steve C. Fordahl; Keith M. Erikson; Yaofang Zhang; Anders Etzerodt; Søren K. Moestrup; Alyssa H. Hasty
Diabetes January 2014, Vol.63, 421-432. doi:https://doi.org/10.2337/db13-0213
RNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling
Yaniv Lustig; Ehud Barhod; Reut Ashwal-Fluss; Reut Gordin; Noam Shomron; Kfir Baruch-Umansky; Rina Hemi; Avraham Karasik; Hannah Kanety
Diabetes January 2014, Vol.63, 433-445. doi:https://doi.org/10.2337/db13-1032
Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes
Olli H. Laitinen; Hanna Honkanen; Outi Pakkanen; Sami Oikarinen; Minna M. Hankaniemi; Heini Huhtala; Tanja Ruokoranta; Valérie Lecouturier; Philippe André; Raimo Harju; Suvi M. Virtanen; Jussi Lehtonen; Jeffrey W. Almond; Tuula Simell; Olli Simell; Jorma Ilonen; Riitta Veijola; Mikael Knip; Heikki Hyöty
Diabetes January 2014, Vol.63, 446-455. doi:https://doi.org/10.2337/db13-0619
Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism
Louise Grant; Kirsty D. Shearer; Alicja Czopek; Emma K. Lees; Carl Owen; Abdelali Agouni; James Workman; Cristina Martin-Granados; John V. Forrester; Heather M. Wilson; Nimesh Mody; Mirela Delibegovic
Diabetes January 2014, Vol.63, 456-470. doi:https://doi.org/10.2337/db13-0885
Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway
Anh Thoai Nguyen; Stéphane Mandard; Cédric Dray; Valérie Deckert; Philippe Valet; Philippe Besnard; Daniel J. Drucker; Laurent Lagrost; Jacques Grober
Diabetes January 2014, Vol.63, 471-482. doi:https://doi.org/10.2337/db13-0903
Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass
Meera Shah; Jennie H. Law; Francesco Micheletto; Matheni Sathananthan; Chiara Dalla Man; Claudio Cobelli; Robert A. Rizza; Michael Camilleri; Alan R. Zinsmeister; Adrian Vella
Diabetes January 2014, Vol.63, 483-493. doi:https://doi.org/10.2337/db13-0954
GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats
Kirk M. Habegger; Kristy M. Heppner; Sarah E. Amburgy; Nickki Ottaway; Jenna Holland; Christine Raver; Erin Bartley; Timo D. Müller; Paul T. Pfluger; Jose Berger; Mouhamadoul Toure; Stephen C. Benoit; Richard D. DiMarchi; Diego Perez-Tilve; David A. D’Alessio; Randy J. Seeley; Matthias H. Tschöp
Diabetes January 2014, Vol.63, 505-513. doi:https://doi.org/10.2337/db13-0511
Signal Transduction
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
Yuan Zhang; Rui Li; Yan Meng; Shiwu Li; William Donelan; Yan Zhao; Lei Qi; Mingxiang Zhang; Xingli Wang; Taixing Cui; Li-Jun Yang; Dongqi Tang
Diabetes January 2014, Vol.63, 514-525. doi:https://doi.org/10.2337/db13-1106
Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice
Diabetes January 2014, Vol.63, 526-534. doi:https://doi.org/10.2337/db13-1019
Obesity Studies
Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions in a Three-Dimensional Setting: Partial Rescue by Angiopoietin-1
Diabetes January 2014, Vol.63, 535-549. doi:https://doi.org/10.2337/db13-0537
ITCH Deficiency Protects From Diet-Induced Obesity
Arianna Marino; Rossella Menghini; Marta Fabrizi; Viviana Casagrande; Maria Mavilio; Robert Stoehr; Eleonora Candi; Alessandro Mauriello; Jose M. Moreno-Navarrete; María Gómez-Serrano; Belén Peral; Gerry Melino; Renato Lauro; Jose M. Fernandez Real; Massimo Federici
Diabetes January 2014, Vol.63, 550-561. doi:https://doi.org/10.2337/db13-0802
Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue
Xudong Zhu; Guijuan Zong; Liu Zhu; Yuchen Jiang; Ke Ma; Hanwen Zhang; Yan Zhang; Hui Bai; Qing Yang; Jingjing Ben; Xiaoyu Li; Yong Xu; Qi Chen
Diabetes January 2014, Vol.63, 562-577. doi:https://doi.org/10.2337/db13-0815
Islet Studies
G0-G1 Transition and the Restriction Point in Pancreatic β-Cells In Vivo
Ayat Hija; Seth Salpeter; Agnes Klochendler; Joseph Grimsby; Michael Brandeis; Benjamin Glaser; Yuval Dor
Diabetes January 2014, Vol.63, 578-584. doi:https://doi.org/10.2337/db12-1035
SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion
Diabetes January 2014, Vol.63, 585-595. doi:https://doi.org/10.2337/db13-0666
Autoantigen-Induced Focusing of Vβ13+ T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat
Diabetes January 2014, Vol.63, 596-604. doi:https://doi.org/10.2337/db13-0462
Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice
Yoko Yagishita; Toshiaki Fukutomi; Akira Sugawara; Hiroshi Kawamura; Tetsu Takahashi; Jingbo Pi; Akira Uruno; Masayuki Yamamoto
Diabetes January 2014, Vol.63, 605-618. doi:https://doi.org/10.2337/db13-0909
Immunology and Transplantation
Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome
Aimon K. Alkanani; Naoko Hara; Egil Lien; Diana Ir; Cassandra V. Kotter; Charles E. Robertson; Brandie D. Wagner; Daniel N. Frank; Danny Zipris
Diabetes January 2014, Vol.63, 619-631. doi:https://doi.org/10.2337/db13-1007
Pathophysiology
Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments
Jun Wang; Bing Gong; Wei Zhao; Cheuk Tang; Merina Varghese; Tuyen Nguyen; Weina Bi; Amanda Bilski; Shimul Begum; Prashant Vempati; Lindsay Knable; Lap Ho; Giulio M. Pasinetti
Diabetes January 2014, Vol.63, 645-654. doi:https://doi.org/10.2337/db13-1063
Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
Sami Oikarinen; Sisko Tauriainen; Didier Hober; Bernadette Lucas; Andriani Vazeou; Amirbabak Sioofy-Khojine; Evangelos Bozas; Peter Muir; Hanna Honkanen; Jorma Ilonen; Mikael Knip; Päivi Keskinen; Marja-Terttu Saha; Heini Huhtala; Glyn Stanway; Christos Bartsocas; Johnny Ludvigsson; Keith Taylor; Heikki Hyöty; the VirDiab Study Group
Diabetes January 2014, Vol.63, 655-662. doi:https://doi.org/10.2337/db13-0620
Effects of Sitagliptin and Metformin Treatment on Incretin Hormone and Insulin Secretory Responses to Oral and “Isoglycemic” Intravenous Glucose
Diabetes January 2014, Vol.63, 663-674. doi:https://doi.org/10.2337/db13-0805
A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis
Louise L. Dunn; Philippa J.L. Simpson; Hamish C. Prosser; Laura Lecce; Gloria S.C. Yuen; Andrew Buckle; Daniel P. Sieveking; Laura Z. Vanags; Patrick R. Lim; Renee W.Y. Chow; Yuen Ting Lam; Zoe Clayton; Shisan Bao; Michael J. Davies; Nadina Stadler; David S. Celermajer; Roland Stocker; Christina A. Bursill; John P. Cooke; Martin K.C. Ng
Diabetes January 2014, Vol.63, 675-687. doi:https://doi.org/10.2337/db13-0417
Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice
Elvira Isganaitis; Melissa Woo; Huijuan Ma; Michael Chen; Wen Kong; Aristides Lytras; Vicencia Sales; Jennifer DeCoste-Lopez; Kyung-Ju Lee; Cianna Leatherwood; Deborah Lee; Connor Fitzpatrick; Walter Gall; Steven Watkins; Mary-Elizabeth Patti
Diabetes January 2014, Vol.63, 688-700. doi:https://doi.org/10.2337/db13-0558
Complications
Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy
Johanna Guzman; Alexandra N. Jauregui; Sandra Merscher-Gomez; Dony Maiguel; Cristina Muresan; Alla Mitrofanova; Ana Diez-Sampedro; Joel Szust; Tae-Hyun Yoo; Rodrigo Villarreal; Christopher Pedigo; R. Damaris Molano; Kevin Johnson; Barbara Kahn; Bjoern Hartleben; Tobias B. Huber; Jharna Saha; George W. Burke, III; E. Dale Abel; Frank C. Brosius; Alessia Fornoni
Diabetes January 2014, Vol.63, 701-714. doi:https://doi.org/10.2337/db13-0752
Genome-Wide Transcriptional Analysis of Differentially Expressed Genes in Diabetic, Healing Corneal Epithelial Cells: Hyperglycemia-Suppressed TGFβ3 Expression Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas
Diabetes January 2014, Vol.63, 715-727. doi:https://doi.org/10.2337/db13-1260
Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes
Wouter S. Hoogenboom; Thomas J. Marder; Veronica L. Flores; Susanne Huisman; Hana P. Eaton; Jason S. Schneiderman; Nicolas R. Bolo; Donald C. Simonson; Alan M. Jacobson; Marek Kubicki; Martha E. Shenton; Gail Musen
Diabetes January 2014, Vol.63, 728-738. doi:https://doi.org/10.2337/db13-1219
Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial
Diabetes January 2014, Vol.63, 739-748. doi:https://doi.org/10.2337/db13-0881
Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study
Diabetes January 2014, Vol.63, 749-760. doi:https://doi.org/10.2337/db13-0519
Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals
Srinivasan Vedantham; Devi Thiagarajan; Radha Ananthakrishnan; Lingjie Wang; Rosa Rosario; Yu Shan Zou; Ira Goldberg; Shi Fang Yan; Ann Marie Schmidt; Ravichandran Ramasamy
Diabetes January 2014, Vol.63, 761-774. doi:https://doi.org/10.2337/db13-0032
Pharmacology and Therapeutics
OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide
Henriette E. Meyer zu Schwabedissen; Kerstin Boettcher; Tobias Steiner; Ute I. Schwarz; Markus Keiser; Heyo K. Kroemer; Werner Siegmund
Diabetes January 2014, Vol.63, 775-784. doi:https://doi.org/10.2337/db13-1005
Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
Mahesh M. Umapathysivam; Michael Y. Lee; Karen L. Jones; Christopher E. Annink; Caroline E. Cousins; Laurence G. Trahair; Chris K. Rayner; Marianne J. Chapman; Michael A. Nauck; Michael Horowitz; Adam M. Deane
Diabetes January 2014, Vol.63, 785-790. doi:https://doi.org/10.2337/db13-0893
Genetics/Genomes/Proteomics/Metabolomics
BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans
Anna E. Thalacker-Mercer; Katherine H. Ingram; Fangjian Guo; Olga Ilkayeva; Christopher B. Newgard; W. Timothy Garvey
Diabetes January 2014, Vol.63, 791-800. doi:https://doi.org/10.2337/db13-0396
Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study
Bertha Hidalgo; M. Ryan Irvin; Jin Sha; Degui Zhi; Stella Aslibekyan; Devin Absher; Hemant K. Tiwari; Edmond K. Kabagambe; Jose M. Ordovas; Donna K. Arnett
Diabetes January 2014, Vol.63, 801-807. doi:https://doi.org/10.2337/db13-1100
FTO Genotype, Vitamin D Status, and Weight Gain During Childhood
Diabetes January 2014, Vol.63, 808-814. doi:https://doi.org/10.2337/db13-1290
