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In This Issue of Diabetes

Extract

View articletitled, In This Issue of Diabetes

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Topics: emergency service, hospital , insulin , insulin resistance , stress , wolfram syndrome

Diabetes February 2014, Vol.63, 817-818. doi:https://doi.org/10.2337/db14-ti03

Perspectives in Diabetes

Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

Ernesto Bernal-Mizrachi; Rohit N. Kulkarni; Donald K. Scott; Franck Mauvais-Jarvis; Andrew F. Stewart; Adolfo Garcia-Ocaña

Abstract

View articletitled, Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

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Topics: 1-phosphatidylinositol 3-kinase , ampk , calcium , cell cycle , estrogen

Diabetes February 2014, Vol.63, 819-831. doi:https://doi.org/10.2337/db13-1146

Commentaries

Insulin Resistance Compensation: Not Just a Matter of β-Cells?

Eduard Montanya

Abstracts

View articletitled, Insulin Resistance Compensation: Not Just a Matter of β-Cells?

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Topics: insulin , insulin resistance

Diabetes February 2014, Vol.63, 832-834. doi:https://doi.org/10.2337/db13-1843

Commentary

New Insight Into Early Events in Type 1 Diabetes: Role for Islet Stem Cell Exosomes

Miodrag L. Lukic; Nada Pejnovic; Ana Lukic

Abstracts

View articletitled, New Insight Into Early Events in Type 1 Diabetes: Role for Islet Stem Cell Exosomes

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Topics: antigens , diabetes mellitus, type 1 , exosomes , stem cells , t-lymphocytes

Diabetes February 2014, Vol.63, 835-837. doi:https://doi.org/10.2337/db13-1786

When the Skeleton Is Controlling Pancreatic β-Cell Mass During Development and After

Thomas Bouckenooghe; Bruno Lefebvre

Abstracts

View articletitled, When the Skeleton Is Controlling Pancreatic β-Cell Mass During Development and After

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Topics: insulin , osteocalcin , pancreas

Diabetes February 2014, Vol.63, 838-840. doi:https://doi.org/10.2337/db13-1781

Remodeling of Nutrient Homeostasis by Unfolded Protein Response

Toshinari Takamura

Abstracts

View articletitled, Remodeling of Nutrient Homeostasis by Unfolded Protein Response

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Topics: emergency service, hospital , homeostasis , hyperinsulinism , insulin , nutrients

Diabetes February 2014, Vol.63, 841-843. doi:https://doi.org/10.2337/db13-1721

Wolfram Syndrome iPS Cells: The First Human Cell Model of Endoplasmic Reticulum Disease

Fumihiko Urano

Abstracts

View articletitled, Wolfram Syndrome iPS Cells: The First Human Cell Model of Endoplasmic Reticulum Disease

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Topics: endoplasmic reticulum , idiopathic pneumonia syndrome , wolfram syndrome

Diabetes February 2014, Vol.63, 844-846. doi:https://doi.org/10.2337/db13-1809

Adipose Triglyceride Lipase and G₀/G₁ Switch Gene 2: Approaching Proof of Concept

Thomas S. Nielsen; Niels Møller

Abstracts

View articletitled, Adipose Triglyceride Lipase and G0/G1 Switch Gene 2: Approaching Proof of Concept

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Topics: genes, switch , lipase , proof of concept studies , lipolysis , diabetes mellitus, type 2

Diabetes February 2014, Vol.63, 847-849. doi:https://doi.org/10.2337/db13-1838

Metabolism

A_2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation

Balázs Csóka; Balázs Koscsó; Gábor Törő; Endre Kókai; László Virág; Zoltán H. Németh; Pál Pacher; Péter Bai; György Haskó

Abstract

View articletitled, A2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation

Supplementary data

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Topics: adipose tissue , inflammation , insulin , macrophages , mice

Diabetes February 2014, Vol.63, 850-866. doi:https://doi.org/10.2337/db13-0573

Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis

Haibo Sha; Liu Yang; Meilian Liu; Sheng Xia; Yong Liu; Feng Liu; Sander Kersten; Ling Qi

Abstracts

View articletitled, Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis

Supplementary data

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Topics: adipocytes , adiponectin , mice , glucose homeostasis

Diabetes February 2014, Vol.63, 867-879. doi:https://doi.org/10.2337/db13-1067

Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

Janine J. Geerling; Mariëtte R. Boon; Gerard C. van der Zon; Sjoerd A.A. van den Berg; Anita M. van den Hoek; Marc Lombès; Hans M.G. Princen; Louis M. Havekes; Patrick C.N. Rensen; Bruno Guigas

Abstracts

View articletitled, Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

Supplementary data

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Topics: lipoproteins, vldl , metformin , lipids , mice , drug clearance

Diabetes February 2014, Vol.63, 880-891. doi:https://doi.org/10.2337/db13-0194

Insulin Signals Through the Dorsal Vagal Complex to Regulate Energy Balance

Beatrice M. Filippi; Aria Bassiri; Mona A. Abraham; Frank A. Duca; Jessica T.Y. Yue; Tony K.T. Lam

Abstract

View articletitled, Insulin Signals Through the Dorsal Vagal Complex to Regulate Energy Balance

Supplementary data

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Topics: insulin , rats , infusion procedures , eating

Diabetes February 2014, Vol.63, 892-899. doi:https://doi.org/10.2337/db13-1044

FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues

Tali Garin-Shkolnik; Assaf Rudich; Gökhan S. Hotamisligil; Menachem Rubinstein

Abstract

View articletitled, FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues

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Topics: adipocytes , adipose tissue , antibodies , catabolism , fat, subcutaneous

Diabetes February 2014, Vol.63, 900-911. doi:https://doi.org/10.2337/db13-0436

Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue

Guenther Boden; Peter Cheung; Sajad Salehi; Carol Homko; Catherine Loveland-Jones; Senthil Jayarajan; T. Peter Stein; Kevin Jon Williams; Ming-Lin Liu; Carlos A. Barrero; Salim Merali

Abstracts

View articletitled, Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue

Supplementary data

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Topics: insulin , rna, messenger , hyperinsulinism

Diabetes February 2014, Vol.63, 912-922. doi:https://doi.org/10.2337/db13-0906

β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

Linshan Shang; Haiqing Hua; Kylie Foo; Hector Martinez; Kazuhisa Watanabe; Matthew Zimmer; David J. Kahler; Matthew Freeby; Wendy Chung; Charles LeDuc; Robin Goland; Rudolph L. Leibel; Dieter Egli

Abstracts

View articletitled, β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

Supplementary data

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Topics: emergency service, hospital , glucose , insulin , stress , tungsten

Diabetes February 2014, Vol.63, 923-933. doi:https://doi.org/10.2337/db13-0717

Targeted Disruption of G₀/G₁ Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet–Induced Liver Steatosis

Xiaodong Zhang; Xitao Xie; Bradlee L. Heckmann; Alicia M. Saarinen; Traci A. Czyzyk; Jun Liu

Abstracts

View articletitled, Targeted Disruption of G0/G1 Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet–Induced Liver Steatosis

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Topics: fasting , fatty liver , lipolysis , liver , mice

Diabetes February 2014, Vol.63, 934-946. doi:https://doi.org/10.2337/db13-1422

Hepatic Overexpression of ATP Synthase β Subunit Activates PI3K/Akt Pathway to Ameliorate Hyperglycemia of Diabetic Mice

Chunjiong Wang; Zhenzhen Chen; Sha Li; Yuan Zhang; Shi Jia; Jing Li; Yujing Chi; Yifei Miao; Youfei Guan; Jichun Yang

Abstracts

View articletitled, Hepatic Overexpression of ATP Synthase β Subunit Activates PI3K/Akt Pathway to Ameliorate Hyperglycemia of Diabetic Mice

Supplementary data

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Topics: hyperglycemia , liver , mice , protein overexpression , insulin

Diabetes February 2014, Vol.63, 947-959. doi:https://doi.org/10.2337/db13-1096

Signal Transduction

Long-Term IKK2/NF-κB Signaling in Pancreatic β-Cells Induces Immune-Mediated Diabetes

Heba H. Salem; Bernadette Trojanowski; Katja Fiedler; Harald J. Maier; Reinhold Schirmbeck; Martin Wagner; Bernhard O. Boehm; Thomas Wirth; Bernd Baumann

Abstract

View articletitled, Long-Term IKK2/NF-κB Signaling in Pancreatic β-Cells Induces Immune-Mediated Diabetes

Supplementary data

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Topics: mice , pancreas , signal transduction , diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction , inflammation

Diabetes February 2014, Vol.63, 960-975. doi:https://doi.org/10.2337/db13-1037

Obesity Studies

Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects

Elisa Fabbrini; Mauro Serafini; Irena Colic Baric; Stanley L. Hazen; Samuel Klein

Abstract

View articletitled, Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects

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Topics: antioxidants , insulin , insulin sensitivity , obesity , oxidative stress

Diabetes February 2014, Vol.63, 976-981. doi:https://doi.org/10.2337/db13-1396

Islet Studies

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Bader Zarrouki; Isma Benterki; Ghislaine Fontés; Marie-Line Peyot; Ondrej Seda; Marc Prentki; Vincent Poitout

Abstract

View articletitled, Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Supplementary data

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Topics: epidermal growth factor receptors , forkhead box protein m1 , heparin-binding egf-like growth factor , infusion procedures , insulin

Diabetes February 2014, Vol.63, 982-993. doi:https://doi.org/10.2337/db13-0425

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

Teresa Mezza; Giovanna Muscogiuri; Gian Pio Sorice; Gennaro Clemente; Jiang Hu; Alfredo Pontecorvi; Jens J. Holst; Andrea Giaccari; Rohit N. Kulkarni

Abstracts

View articletitled, Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

Supplementary data

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Topics: insulin , insulin resistance , pancreas , surgical procedures, operative

Diabetes February 2014, Vol.63, 994-1007. doi:https://doi.org/10.2337/db13-1013

Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice

Muhammad Jubayer Rahman; Danielle Regn; Roman Bashratyan; Yang D. Dai

Abstracts

View articletitled, Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice

Supplementary data

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Topics: flow cytometry , mice , mice, inbred nod , autoimmunity , prediabetes

Diabetes February 2014, Vol.63, 1008-1020. doi:https://doi.org/10.2337/db13-0859

Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a

Jianwen Wei; Timothy Hanna; Nina Suda; Gerard Karsenty; Patricia Ducy

Abstracts

View articletitled, Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a

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Topics: osteocalcin , insulin , signal transduction , mice

Diabetes February 2014, Vol.63, 1021-1031. doi:https://doi.org/10.2337/db13-0887

Immunology and Transplantation

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Hong Sheng Quah; Socorro Miranda-Hernandez; Aimee Khoo; Ashley Harding; Stacey Fynch; Lorraine Elkerbout; Thomas C. Brodnicki; Alan G. Baxter; Thomas W.H. Kay; Helen E. Thomas; Kate L. Graham

Abstracts

View articletitled, Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Supplementary data

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Topics: diabetes mellitus, type 1 , gene expression profiling , interferons , mice , mice, inbred nod

Diabetes February 2014, Vol.63, 1032-1040. doi:https://doi.org/10.2337/db13-1210

Pathophysiology

Early Onset of Diabetes in the Proband Is the Major Determinant of Risk in HLA DR3-DQ2/DR4-DQ8 Siblings

Kathleen M. Gillespie; Rachel J. Aitken; Isabel Wilson; Alistair J.K. Williams; Polly J. Bingley

Abstract

View articletitled, Early Onset of Diabetes in the Proband Is the Major Determinant of Risk in HLA DR3-DQ2/DR4-DQ8 Siblings

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Topics: human leukocyte antigens , proband , diabetes mellitus, type 1 , autoimmunity , autoantibodies

Diabetes February 2014, Vol.63, 1041-1047. doi:https://doi.org/10.2337/db13-0994

The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes

Frank Neuschäfer-Rube; Stefanie Lieske; Manuela Kuna; Janin Henkel; Rachel J. Perry; Derek M. Erion; Dominik Pesta; Diana M. Willmes; Sebastian Brachs; Christian von Loeffelholz; Alexander Tolkachov; Michael Schupp; Andrea Pathe-Neuschäfer-Rube; Andreas F.H. Pfeiffer; Gerald I. Shulman; Gerhard P. Püschel; Andreas L. Birkenfeld

Abstract

View articletitled, The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes

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Topics: cyclic amp-responsive dna-binding protein , diabetes mellitus, type 2 , glucagon , hepatocytes , rna, messenger

Diabetes February 2014, Vol.63, 1048-1057. doi:https://doi.org/10.2337/db13-0749

Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging

Bret H. Goodpaster; Alessandra Bertoldo; Jason M. Ng; Koichiro Azuma; R. Richard Pencek; Carol Kelley; Julie C. Price; Claudio Cobelli; David E. Kelley

Abstract

View articletitled, Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging

Supplementary data

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Topics: diabetes mellitus, type 2 , fluorodeoxyglucose f18 , glucose , insulin , obesity

Diabetes February 2014, Vol.63, 1058-1068. doi:https://doi.org/10.2337/db13-1249

Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion

Serenella Salinari; Carel W. le Roux; Alessandro Bertuzzi; Francesco Rubino; Geltrude Mingrone

Abstract

View articletitled, Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion

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Topics: bypass , duodenum , glucagon-like peptide 1 , glucose , ileectomy

Diabetes February 2014, Vol.63, 1069-1078. doi:https://doi.org/10.2337/db13-0856

Defining the Role of GLP-1 in the Enteroinsulinar Axis in Type 2 Diabetes Using DPP-4 Inhibition and GLP-1 Receptor Blockade

Benedikt A. Aulinger; Anne Bedorf; Gabriele Kutscherauer; Jocelyn de Heer; Jens J. Holst; Burkhard Göke; Jörg Schirra

Abstracts

View articletitled, Defining the Role of GLP-1 in the Enteroinsulinar Axis in Type 2 Diabetes Using DPP-4 Inhibition and GLP-1 Receptor Blockade

Supplementary data

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Topics: diabetes mellitus, type 2 , dipeptidyl-peptidase iv , glucagon-like peptide 1 , glucose , oral glucose tolerance test

Diabetes February 2014, Vol.63, 1079-1092. doi:https://doi.org/10.2337/db13-1455

Body Fat Partitioning Does Not Explain the Interethnic Variation in Insulin Sensitivity Among Asian Ethnicity: The Singapore Adults Metabolism Study

Chin Meng Khoo; Melvin Khee-Shing Leow; Suresh Anand Sadananthan; Radiance Lim; Kavita Venkataraman; Eric Yin Hao Khoo; S. Sendhil Velan; Yu Ting Ong; Ravi Kambadur; Craig McFarlane; Peter D. Gluckman; Yung Seng Lee; Yap Seng Chong; E. Shyong Tai

Abstracts

View articletitled, Body Fat Partitioning Does Not Explain the Interethnic Variation in Insulin Sensitivity Among Asian Ethnicity: The Singapore Adults Metabolism Study

Supplementary data

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Topics: body fat , insulin , insulin resistance , insulin sensitivity , liver

Diabetes February 2014, Vol.63, 1093-1102. doi:https://doi.org/10.2337/db13-1483

Complications

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

Rita E. Mirza; Milie M. Fang; Eileen M. Weinheimer-Haus; William J. Ennis; Timothy J. Koh

Abstract

View articletitled, Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

Supplementary data

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Topics: caspase-1 , inflammasomes , interleukin-18 , mice , bone marrow

Diabetes February 2014, Vol.63, 1103-1114. doi:https://doi.org/10.2337/db13-0927

Circulating Inflammatory Markers and the Risk of Vascular Complications and Mortality in People With Type 2 Diabetes and Cardiovascular Disease or Risk Factors: The ADVANCE Study

Gordon Lowe; Mark Woodward; Graham Hillis; Ann Rumley; Qiang Li; Stephen Harrap; Michel Marre; Pavel Hamet; Anushka Patel; Neil Poulter; John Chalmers

Abstracts

View articletitled, Circulating Inflammatory Markers and the Risk of Vascular Complications and Mortality in People With Type 2 Diabetes and Cardiovascular Disease or Risk Factors: The ADVANCE Study

Supplementary data

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Topics: cardiovascular diseases , c-reactive protein , diabetes mellitus, type 2 , fibrinogen , inflammatory markers

Diabetes February 2014, Vol.63, 1115-1123. doi:https://doi.org/10.2337/db12-1625

Heat Shock Prevents Insulin Resistance–Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling

Pinakin Arun Karpe; Kulbhushan Tikoo

Abstract

View articletitled, Heat Shock Prevents Insulin Resistance–Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling

Supplementary data

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Topics: aorta , dna (cytosine-5-)-methyltransferase 1 , endothelial dysfunction , insulin resistance , nitric oxide synthase

Diabetes February 2014, Vol.63, 1124-1139. doi:https://doi.org/10.2337/db13-1267

Role of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia

Barbara Szepietowska; Tamas L. Horvath; Robert S. Sherwin

Abstract

View articletitled, Role of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia

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Topics: hypoglycemia , rats , microinjections

Diabetes February 2014, Vol.63, 1140-1147. doi:https://doi.org/10.2337/db13-1259

Pronounced Reduction of Cutaneous Langerhans Cell Density in Recently Diagnosed Type 2 Diabetes

Alexander Strom; Jutta Brüggemann; Iris Ziegler; Kay Jeruschke; Juergen Weiss; Hadi Al-Hasani; Michael Roden; Dan Ziegler; for the GDS Group

Abstracts

View articletitled, Pronounced Reduction of Cutaneous Langerhans Cell Density in Recently Diagnosed Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , langerhans cell , skin biopsies , peripheral nerves , immunohistochemistry

Diabetes February 2014, Vol.63, 1148-1153. doi:https://doi.org/10.2337/db13-1444

Genetics / Genomes / Proteomics / Metabolomics

Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity

Abstracts

View articletitled, Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity

Supplementary data

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Topics: diabetes mellitus, type 2 , gene expression , genes , genetics , insulin

Diabetes February 2014, Vol.63, 1154-1165. doi:https://doi.org/10.2337/db13-1301

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: atherosclerosis , chief complaint , diabetic foot ulcer , florida , microbiome

Diabetes February 2014, Vol.63, 1166. doi:https://doi.org/10.2337/db14-ie03

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In This Issue

Perspectives in Diabetes

Commentaries

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Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

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