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Volume 63, Issue 3
1 March 2014
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes February 2014, Vol.63, 817-818. doi:https://doi.org/10.2337/db14-ti03

Perspectives in Diabetes

Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map
Ernesto Bernal-Mizrachi; Rohit N. Kulkarni; Donald K. Scott; Franck Mauvais-Jarvis; Andrew F. Stewart; Adolfo Garcia-Ocaña
View articletitled, Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map
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Diabetes February 2014, Vol.63, 819-831. doi:https://doi.org/10.2337/db13-1146

Commentaries

Insulin Resistance Compensation: Not Just a Matter of β-Cells?
Eduard Montanya
View articletitled, Insulin Resistance Compensation: Not Just a Matter of β-Cells?
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Diabetes February 2014, Vol.63, 832-834. doi:https://doi.org/10.2337/db13-1843

Commentary

New Insight Into Early Events in Type 1 Diabetes: Role for Islet Stem Cell Exosomes
Miodrag L. Lukic; Nada Pejnovic; Ana Lukic
View articletitled, New Insight Into Early Events in Type 1 Diabetes: Role for Islet Stem Cell Exosomes
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Diabetes February 2014, Vol.63, 835-837. doi:https://doi.org/10.2337/db13-1786
When the Skeleton Is Controlling Pancreatic β-Cell Mass During Development and After
Thomas Bouckenooghe; Bruno Lefebvre
View articletitled, When the Skeleton Is Controlling Pancreatic β-Cell Mass During Development and After
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Diabetes February 2014, Vol.63, 838-840. doi:https://doi.org/10.2337/db13-1781
Remodeling of Nutrient Homeostasis by Unfolded Protein Response
Toshinari Takamura
View articletitled, Remodeling of Nutrient Homeostasis by Unfolded Protein Response
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Diabetes February 2014, Vol.63, 841-843. doi:https://doi.org/10.2337/db13-1721
Wolfram Syndrome iPS Cells: The First Human Cell Model of Endoplasmic Reticulum Disease
Fumihiko Urano
View articletitled, Wolfram Syndrome iPS Cells: The First Human Cell Model of Endoplasmic Reticulum Disease
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Diabetes February 2014, Vol.63, 844-846. doi:https://doi.org/10.2337/db13-1809
Adipose Triglyceride Lipase and G0/G1 Switch Gene 2: Approaching Proof of Concept
Thomas S. Nielsen; Niels Møller
View articletitled, Adipose Triglyceride Lipase and G<sub>0</sub>/G<sub>1</sub> Switch Gene 2: Approaching Proof of Concept
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Diabetes February 2014, Vol.63, 847-849. doi:https://doi.org/10.2337/db13-1838

Metabolism

A2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation
Balázs Csóka; Balázs Koscsó; Gábor Törő; Endre Kókai; László Virág; Zoltán H. Németh; Pál Pacher; Péter Bai; György Haskó
View articletitled, A<sub>2B</sub> Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation
Supplementary data
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Diabetes February 2014, Vol.63, 850-866. doi:https://doi.org/10.2337/db13-0573
Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis
Haibo Sha; Liu Yang; Meilian Liu; Sheng Xia; Yong Liu; Feng Liu; Sander Kersten; Ling Qi
View articletitled, Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis
Supplementary data
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Diabetes February 2014, Vol.63, 867-879. doi:https://doi.org/10.2337/db13-1067
Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice
Janine J. Geerling; Mariëtte R. Boon; Gerard C. van der Zon; Sjoerd A.A. van den Berg; Anita M. van den Hoek; Marc Lombès; Hans M.G. Princen; Louis M. Havekes; Patrick C.N. Rensen; Bruno Guigas
View articletitled, Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice
Supplementary data
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Diabetes February 2014, Vol.63, 880-891. doi:https://doi.org/10.2337/db13-0194
Insulin Signals Through the Dorsal Vagal Complex to Regulate Energy Balance
Beatrice M. Filippi; Aria Bassiri; Mona A. Abraham; Frank A. Duca; Jessica T.Y. Yue; Tony K.T. Lam
View articletitled, Insulin Signals Through the Dorsal Vagal Complex to Regulate Energy Balance
Supplementary data
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Diabetes February 2014, Vol.63, 892-899. doi:https://doi.org/10.2337/db13-1044
FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues
Tali Garin-Shkolnik; Assaf Rudich; Gökhan S. Hotamisligil; Menachem Rubinstein
View articletitled, FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues
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Diabetes February 2014, Vol.63, 900-911. doi:https://doi.org/10.2337/db13-0436
Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue
Guenther Boden; Peter Cheung; Sajad Salehi; Carol Homko; Catherine Loveland-Jones; Senthil Jayarajan; T. Peter Stein; Kevin Jon Williams; Ming-Lin Liu; Carlos A. Barrero; Salim Merali
View articletitled, Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue
Supplementary data
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Diabetes February 2014, Vol.63, 912-922. doi:https://doi.org/10.2337/db13-0906
β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome
Linshan Shang; Haiqing Hua; Kylie Foo; Hector Martinez; Kazuhisa Watanabe; Matthew Zimmer; David J. Kahler; Matthew Freeby; Wendy Chung; Charles LeDuc; Robin Goland; Rudolph L. Leibel; Dieter Egli
View articletitled, β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome
Supplementary data
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Diabetes February 2014, Vol.63, 923-933. doi:https://doi.org/10.2337/db13-0717
Targeted Disruption of G0/G1 Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet–Induced Liver Steatosis
Xiaodong Zhang; Xitao Xie; Bradlee L. Heckmann; Alicia M. Saarinen; Traci A. Czyzyk; Jun Liu
View articletitled, Targeted Disruption of G<sub>0</sub>/G<sub>1</sub> Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet–Induced Liver Steatosis
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Diabetes February 2014, Vol.63, 934-946. doi:https://doi.org/10.2337/db13-1422
Hepatic Overexpression of ATP Synthase β Subunit Activates PI3K/Akt Pathway to Ameliorate Hyperglycemia of Diabetic Mice
Chunjiong Wang; Zhenzhen Chen; Sha Li; Yuan Zhang; Shi Jia; Jing Li; Yujing Chi; Yifei Miao; Youfei Guan; Jichun Yang
View articletitled, Hepatic Overexpression of ATP Synthase β Subunit Activates PI3K/Akt Pathway to Ameliorate Hyperglycemia of Diabetic Mice
Supplementary data
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Diabetes February 2014, Vol.63, 947-959. doi:https://doi.org/10.2337/db13-1096

Signal Transduction

Long-Term IKK2/NF-κB Signaling in Pancreatic β-Cells Induces Immune-Mediated Diabetes
Heba H. Salem; Bernadette Trojanowski; Katja Fiedler; Harald J. Maier; Reinhold Schirmbeck; Martin Wagner; Bernhard O. Boehm; Thomas Wirth; Bernd Baumann
View articletitled, Long-Term IKK2/NF-κB Signaling in Pancreatic β-Cells Induces Immune-Mediated Diabetes
Supplementary data
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Diabetes February 2014, Vol.63, 960-975. doi:https://doi.org/10.2337/db13-1037

Obesity Studies

Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects
Elisa Fabbrini; Mauro Serafini; Irena Colic Baric; Stanley L. Hazen; Samuel Klein
View articletitled, Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects
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Diabetes February 2014, Vol.63, 976-981. doi:https://doi.org/10.2337/db13-1396

Islet Studies

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1
Bader Zarrouki; Isma Benterki; Ghislaine Fontés; Marie-Line Peyot; Ondrej Seda; Marc Prentki; Vincent Poitout
View articletitled, Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1
Supplementary data
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Diabetes February 2014, Vol.63, 982-993. doi:https://doi.org/10.2337/db13-0425
Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
Teresa Mezza; Giovanna Muscogiuri; Gian Pio Sorice; Gennaro Clemente; Jiang Hu; Alfredo Pontecorvi; Jens J. Holst; Andrea Giaccari; Rohit N. Kulkarni
View articletitled, Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
Supplementary data
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Diabetes February 2014, Vol.63, 994-1007. doi:https://doi.org/10.2337/db13-1013
Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice
Muhammad Jubayer Rahman; Danielle Regn; Roman Bashratyan; Yang D. Dai
View articletitled, Exosomes Released by Islet-Derived Mesenchymal Stem Cells Trigger Autoimmune Responses in NOD Mice
Supplementary data
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Diabetes February 2014, Vol.63, 1008-1020. doi:https://doi.org/10.2337/db13-0859
Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
Jianwen Wei; Timothy Hanna; Nina Suda; Gerard Karsenty; Patricia Ducy
View articletitled, Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
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Diabetes February 2014, Vol.63, 1021-1031. doi:https://doi.org/10.2337/db13-0887

Immunology and Transplantation

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Hong Sheng Quah; Socorro Miranda-Hernandez; Aimee Khoo; Ashley Harding; Stacey Fynch; Lorraine Elkerbout; Thomas C. Brodnicki; Alan G. Baxter; Thomas W.H. Kay; Helen E. Thomas; Kate L. Graham
View articletitled, Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
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Diabetes February 2014, Vol.63, 1032-1040. doi:https://doi.org/10.2337/db13-1210

Pathophysiology

Early Onset of Diabetes in the Proband Is the Major Determinant of Risk in HLA DR3-DQ2/DR4-DQ8 Siblings
Kathleen M. Gillespie; Rachel J. Aitken; Isabel Wilson; Alistair J.K. Williams; Polly J. Bingley
View articletitled, Early Onset of Diabetes in the Proband Is the Major Determinant of Risk in HLA DR3-DQ2/DR4-DQ8 Siblings
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Diabetes February 2014, Vol.63, 1041-1047. doi:https://doi.org/10.2337/db13-0994
The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes
Frank Neuschäfer-Rube; Stefanie Lieske; Manuela Kuna; Janin Henkel; Rachel J. Perry; Derek M. Erion; Dominik Pesta; Diana M. Willmes; Sebastian Brachs; Christian von Loeffelholz; Alexander Tolkachov; Michael Schupp; Andrea Pathe-Neuschäfer-Rube; Andreas F.H. Pfeiffer; Gerald I. Shulman; Gerhard P. Püschel; Andreas L. Birkenfeld
View articletitled, The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes
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Diabetes February 2014, Vol.63, 1048-1057. doi:https://doi.org/10.2337/db13-0749
Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging
Bret H. Goodpaster; Alessandra Bertoldo; Jason M. Ng; Koichiro Azuma; R. Richard Pencek; Carol Kelley; Julie C. Price; Claudio Cobelli; David E. Kelley
View articletitled, Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging
Supplementary data
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Diabetes February 2014, Vol.63, 1058-1068. doi:https://doi.org/10.2337/db13-1249
Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion
Serenella Salinari; Carel W. le Roux; Alessandro Bertuzzi; Francesco Rubino; Geltrude Mingrone
View articletitled, Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion
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Diabetes February 2014, Vol.63, 1069-1078. doi:https://doi.org/10.2337/db13-0856
Defining the Role of GLP-1 in the Enteroinsulinar Axis in Type 2 Diabetes Using DPP-4 Inhibition and GLP-1 Receptor Blockade
Benedikt A. Aulinger; Anne Bedorf; Gabriele Kutscherauer; Jocelyn de Heer; Jens J. Holst; Burkhard Göke; Jörg Schirra
View articletitled, Defining the Role of GLP-1 in the Enteroinsulinar Axis in Type 2 Diabetes Using DPP-4 Inhibition and GLP-1 Receptor Blockade
Supplementary data
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Diabetes February 2014, Vol.63, 1079-1092. doi:https://doi.org/10.2337/db13-1455
Body Fat Partitioning Does Not Explain the Interethnic Variation in Insulin Sensitivity Among Asian Ethnicity: The Singapore Adults Metabolism Study
Chin Meng Khoo; Melvin Khee-Shing Leow; Suresh Anand Sadananthan; Radiance Lim; Kavita Venkataraman; Eric Yin Hao Khoo; S. Sendhil Velan; Yu Ting Ong; Ravi Kambadur; Craig McFarlane; Peter D. Gluckman; Yung Seng Lee; Yap Seng Chong; E. Shyong Tai
View articletitled, Body Fat Partitioning Does Not Explain the Interethnic Variation in Insulin Sensitivity Among Asian Ethnicity: The Singapore Adults Metabolism Study
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Diabetes February 2014, Vol.63, 1093-1102. doi:https://doi.org/10.2337/db13-1483

Complications

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice
Rita E. Mirza; Milie M. Fang; Eileen M. Weinheimer-Haus; William J. Ennis; Timothy J. Koh
View articletitled, Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice
Supplementary data
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Diabetes February 2014, Vol.63, 1103-1114. doi:https://doi.org/10.2337/db13-0927
Circulating Inflammatory Markers and the Risk of Vascular Complications and Mortality in People With Type 2 Diabetes and Cardiovascular Disease or Risk Factors: The ADVANCE Study
Gordon Lowe; Mark Woodward; Graham Hillis; Ann Rumley; Qiang Li; Stephen Harrap; Michel Marre; Pavel Hamet; Anushka Patel; Neil Poulter; John Chalmers
View articletitled, Circulating Inflammatory Markers and the Risk of Vascular Complications and Mortality in People With Type 2 Diabetes and Cardiovascular Disease or Risk Factors: The ADVANCE Study
Supplementary data
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Diabetes February 2014, Vol.63, 1115-1123. doi:https://doi.org/10.2337/db12-1625
Heat Shock Prevents Insulin Resistance–Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling
Pinakin Arun Karpe; Kulbhushan Tikoo
View articletitled, Heat Shock Prevents Insulin Resistance–Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling
Supplementary data
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Diabetes February 2014, Vol.63, 1124-1139. doi:https://doi.org/10.2337/db13-1267
Role of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia
Barbara Szepietowska; Tamas L. Horvath; Robert S. Sherwin
View articletitled, Role of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia
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Diabetes February 2014, Vol.63, 1140-1147. doi:https://doi.org/10.2337/db13-1259
Pronounced Reduction of Cutaneous Langerhans Cell Density in Recently Diagnosed Type 2 Diabetes
Alexander Strom; Jutta Brüggemann; Iris Ziegler; Kay Jeruschke; Juergen Weiss; Hadi Al-Hasani; Michael Roden; Dan Ziegler; for the GDS Group
View articletitled, Pronounced Reduction of Cutaneous Langerhans Cell Density in Recently Diagnosed Type 2 Diabetes
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Diabetes February 2014, Vol.63, 1148-1153. doi:https://doi.org/10.2337/db13-1444

Genetics / Genomes / Proteomics / Metabolomics

Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
Sarah Keildson; Joao Fadista; Claes Ladenvall; Åsa K. Hedman; Targ Elgzyri; Kerrin S. Small; Elin Grundberg; Alexandra C. Nica; Daniel Glass; J. Brent Richards; Amy Barrett; James Nisbet; Hou-Feng Zheng; Tina Rönn; Kristoffer Ström; Karl-Fredrik Eriksson; Inga Prokopenko; MAGIC Consortium; DIAGRAM Consortium; MuTHER Consortium; Timothy D. Spector; Emmanouil T. Dermitzakis; Panos Deloukas; Mark I. McCarthy; Johan Rung; Leif Groop; Paul W. Franks; Cecilia M. Lindgren; Ola Hansson
View articletitled, Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity
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Diabetes February 2014, Vol.63, 1154-1165. doi:https://doi.org/10.2337/db13-1301

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes February 2014, Vol.63, 1166. doi:https://doi.org/10.2337/db14-ie03
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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