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In This Issue of Diabetes

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View articletitled, In This Issue of Diabetes

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Topics: astrocytes , caveolae , endothelium , gastric bypass , gastrointestinal tract

Diabetes March 2014, Vol.63, 1167-1168. doi:https://doi.org/10.2337/db14-ti04

Editors’ Commentary

Time to Look Back and to Look Forward

K. Sreekumaran Nair; E. Dale Abel; Sharon G. Adler; Peter J. Dyck; Thomas W. Gardner; Kathryn M. Haskins; Gökhan Hotamisligil; Michael D. Jensen; Anna Krook; Lawrence J. Mandarino; Braxton D. Mitchell; Jeffrey E. Pessin; James R. Sowers; Lori Sussel; Nick Wareham; Adrian Vella

Extract

View articletitled, Time to Look Back and to Look Forward

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Topics: altruism , cell lines , chinese (other dialects) , decision making , editorial board

Diabetes March 2014, Vol.63, 1169-1170. doi:https://doi.org/10.2337/db14-0067

Commentaries

Effects of Roux-en-Y Gastric Bypass on β-Cell Function

Ram Weiss

Abstracts

View articletitled, Effects of Roux-en-Y Gastric Bypass on β-Cell Function

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Topics: diabetes mellitus, type 2 , gastric bypass, roux-en-y , obesity , disease remission , insulin sensitivity

Diabetes March 2014, Vol.63, 1171-1173. doi:https://doi.org/10.2337/db13-1897

Incretin Therapy and Pancreatic Pathologies: Background Pathology Versus Drug-Induced Pathology in Rats

Josephine M. Egan; Chee W. Chia

Abstracts

View articletitled, Incretin Therapy and Pancreatic Pathologies: Background Pathology Versus Drug-Induced Pathology in Rats

Supplementary data

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Topics: exenatide , incretin , pancreas , rats , glucagon-like peptide 1

Diabetes March 2014, Vol.63, 1174-1178. doi:https://doi.org/10.2337/db13-1909

Tipping the Balance in Metabolic Regulation: Regulating Regulatory T Cells by Costimulation

Ling Qi

Abstracts

View articletitled, Tipping the Balance in Metabolic Regulation: Regulating Regulatory T Cells by Costimulation

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Topics: inflammation , lymphocyte costimulation , metabolic regulation , obesity , regulatory t-lymphocytes

Diabetes March 2014, Vol.63, 1179-1181. doi:https://doi.org/10.2337/db13-1915

Tissue-Specific Expression of GLP1R in Mice: Is the Problem of Antibody Nonspecificity Solved?

Annayya Aroor; Ravi Nistala

Abstracts

View articletitled, Tissue-Specific Expression of GLP1R in Mice: Is the Problem of Antibody Nonspecificity Solved?

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Topics: antibodies , mice , glucagon-like peptide 1

Diabetes March 2014, Vol.63, 1182-1184. doi:https://doi.org/10.2337/db13-1937

Diabetes Gets on the Nerves of the Bone Marrow Niche

Annarosa Leri; Marcello Rota

Abstracts

View articletitled, Diabetes Gets on the Nerves of the Bone Marrow Niche

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Topics: bone marrow , nervousness , stem cells , mice , nerve supply

Diabetes March 2014, Vol.63, 1185-1187. doi:https://doi.org/10.2337/db13-1931

Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling

Myrlene A. Staten; David E. Kelley

Abstracts

View articletitled, Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling

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Topics: bodily secretions , challenge tests , insulin , mathematics

Diabetes March 2014, Vol.63, 1188-1190. doi:https://doi.org/10.2337/db13-1839

Deoxysphingolipids: β-Cell, Beware of These New Kids on the Block

Anjaneyulu Kowluru

Abstracts

View articletitled, Deoxysphingolipids: β-Cell, Beware of These New Kids on the Block

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Topics: ceramides , child , glucose , metabolic disturbance , sphingolipids

Diabetes March 2014, Vol.63, 1191-1193. doi:https://doi.org/10.2337/db14-0022

Glycogen Synthase Kinase-3β and Cathepsin B in Diabetic Endothelial Progenitor Cell Dysfunction: An Old Player Finds a New Partner

Ranganath Muniyappa; James R. Sowers

Abstracts

View articletitled, Glycogen Synthase Kinase-3β and Cathepsin B in Diabetic Endothelial Progenitor Cell Dysfunction: An Old Player Finds a New Partner

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Topics: cathepsin b , endothelial progenitor cells , glycogen (starch) synthase , phosphotransferases

Diabetes March 2014, Vol.63, 1194-1197. doi:https://doi.org/10.2337/db14-0004

Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in β-Cell Regeneration Research

Andrew F. Stewart

Abstracts

View articletitled, Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in β-Cell Regeneration Research

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Topics: angiopoietin-like protein 8 , elephants , growth factor , mice , molecule

Diabetes March 2014, Vol.63, 1198-1199. doi:https://doi.org/10.2337/db14-0009

A Radical Concept on Caveolae and Endothelial Dysfunction in Coronary Microvascular Disease in Diabetes

Erik J. Henriksen

Abstracts

View articletitled, A Radical Concept on Caveolae and Endothelial Dysfunction in Coronary Microvascular Disease in Diabetes

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Topics: caveolae , endothelial dysfunction , microvascular angina , arteriole , endothelium

Diabetes March 2014, Vol.63, 1200-1202. doi:https://doi.org/10.2337/db14-0057

Methodology Review

The Oral Minimal Model Method

Claudio Cobelli; Chiara Dalla Man; Gianna Toffolo; Rita Basu; Adrian Vella; Robert Rizza

Abstracts

View articletitled, The Oral Minimal Model Method

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Topics: c-peptide , glucose , insulin , oral glucose tolerance test

Diabetes March 2014, Vol.63, 1203-1213. doi:https://doi.org/10.2337/db13-1198

Metabolism

Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission

Roxanne Dutia; Katrina Brakoniecki; Phoebe Bunker; Furcy Paultre; Peter Homel; André C. Carpentier; James McGinty; Blandine Laferrère

Abstracts

View articletitled, Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission

Supplementary data

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Topics: disease remission , gastric bypass, roux-en-y , glucose , incretin , oral glucose tolerance test

Diabetes March 2014, Vol.63, 1214-1223. doi:https://doi.org/10.2337/db13-1176

Identification and Characterization of GLP-1 Receptor–Expressing Cells Using a New Transgenic Mouse Model

Paul Richards; Helen E. Parker; Alice E. Adriaenssens; Joshua M. Hodgson; Simon C. Cork; Stefan Trapp; Fiona M. Gribble; Frank Reimann

Abstracts

View articletitled, Identification and Characterization of GLP-1 Receptor–Expressing Cells Using a New Transgenic Mouse Model

Supplementary data

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Topics: fluorescence , ganglia , glucagon-like peptide 1 , glucagon-like peptide-1 receptor , mice

Diabetes March 2014, Vol.63, 1224-1233. doi:https://doi.org/10.2337/db13-1440

Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats

Dandong Wu; Mengliu Yang; Yang Chen; Yanjun Jia; Zhongmin Alex Ma; Guenther Boden; Ling Li; Gangyi Yang

Abstracts

View articletitled, Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats

Supplementary data

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Topics: glucose , hypothalamus , insulin , liver , mtor serine-threonine kinases

Diabetes March 2014, Vol.63, 1234-1247. doi:https://doi.org/10.2337/db13-0899

Additive Effects of MicroRNAs and Transcription Factors on CCL2 Production in Human White Adipose Tissue

Agné Kulyté; Yasmina Belarbi; Silvia Lorente-Cebrián; Clara Bambace; Erik Arner; Carsten O. Daub; Per Hedén; Mikael Rydén; Niklas Mejhert; Peter Arner

Abstract

View articletitled, Additive Effects of MicroRNAs and Transcription Factors on CCL2 Production in Human White Adipose Tissue

Supplementary data

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Topics: adipocytes , micrornas , monocyte chemoattractant protein-1

Diabetes March 2014, Vol.63, 1248-1258. doi:https://doi.org/10.2337/db13-0702

Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids

Christelle Le Foll; Ambrose A. Dunn-Meynell; Henri M. Miziorko; Barry E. Levin

Abstract

View articletitled, Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids

Supplementary data

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Topics: astrocytes , diet , eating , glucose , ketone bodies

Diabetes March 2014, Vol.63, 1259-1269. doi:https://doi.org/10.2337/db13-1090

Obesity Studies

Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell

Sheng Wu; Sara Divall; Amanda Nwaopara; Sally Radovick; Fredric Wondisford; CheMyong Ko; Andrew Wolfe

Abstract

View articletitled, Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell

Supplementary data

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Topics: insulin , mice , obesity , ovary , infertility

Diabetes March 2014, Vol.63, 1270-1282. doi:https://doi.org/10.2337/db13-1514

Islet Studies

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

Yang Jiao; John Le Lay; Ming Yu; Ali Naji; Klaus H. Kaestner

Abstracts

View articletitled, Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

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Topics: angiopoietin-like protein 8 , insulin , mice , transplantation , kidney

Diabetes March 2014, Vol.63, 1283-1288. doi:https://doi.org/10.2337/db13-1435

Immunology and Transplantation

T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance

Jixin Zhong; Xiaoquan Rao; Zachary Braunstein; Anne Taylor; Vimal Narula; Jeffrey Hazey; Dean Mikami; Bradley Needleman; Jessica Rutsky; Qinghua Sun; Jeffrey A. Deiuliis; Abhay R. Satoskar; Sanjay Rajagopalan

Abstracts

View articletitled, T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance

Supplementary data

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Topics: cd80 antigens , diet , inflammation , lymphocyte costimulation , macrophages

Diabetes March 2014, Vol.63, 1289-1302. doi:https://doi.org/10.2337/db13-1094

Pathophysiology

Occurrence of Spontaneous Pancreatic Lesions in Normal and Diabetic Rats: A Potential Confounding Factor in the Nonclinical Assessment of GLP-1–Based Therapies

Kristina D. Chadwick; Anthony M. Fletcher; M. Cecilia Parrula; Susan Bonner-Weir; Raja S. Mangipudy; Evan Janovitz; Michael J. Graziano; Denis Roy; Timothy P. Reilly

Abstracts

View articletitled, Occurrence of Spontaneous Pancreatic Lesions in Normal and Diabetic Rats: A Potential Confounding Factor in the Nonclinical Assessment of GLP-1–Based Therapies

Supplementary data

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Topics: glucagon-like peptide 1 , hip joint , hip region , pancreas , rats

Diabetes March 2014, Vol.63, 1303-1314. doi:https://doi.org/10.2337/db13-1268

KCNQ1 Long QT Syndrome Patients Have Hyperinsulinemia and Symptomatic Hypoglycemia

Signe S. Torekov; Eva Iepsen; Michael Christiansen; Allan Linneberg; Oluf Pedersen; Jens J. Holst; Jørgen K. Kanters; Torben Hansen

Abstract

View articletitled, KCNQ1 Long QT Syndrome Patients Have Hyperinsulinemia and Symptomatic Hypoglycemia

Supplementary data

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Topics: glucose , hyperinsulinism , hypoglycemia , insulin , kvlqt1

Diabetes March 2014, Vol.63, 1315-1325. doi:https://doi.org/10.2337/db13-1454

Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

Richard A. Zuellig; Thorsten Hornemann; Alaa Othman; Adrian B. Hehl; Heiko Bode; Tanja Güntert; Omolara O. Ogunshola; Enrica Saponara; Kamile Grabliauskaite; Jae-Hwi Jang; Udo Ungethuem; Yu Wei; Arnold von Eckardstein; Rolf Graf; Sabrina Sonda

Abstracts

View articletitled, Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

Supplementary data

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Topics: actins , biological markers , ceramides , cytoskeleton , cytotoxicity

Diabetes March 2014, Vol.63, 1326-1339. doi:https://doi.org/10.2337/db13-1042

Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation

Guo-Xiao Wang; Kae Won Cho; Maeran Uhm; Chun-Rui Hu; Siming Li; Zoharit Cozacov; Acer E. Xu; Ji-Xin Cheng; Alan R. Saltiel; Carey N. Lumeng; Jiandie D. Lin

Abstract

View articletitled, Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation

Supplementary data

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Topics: adipocytes , adipose tissue , inflammation , mice , obesity

Diabetes March 2014, Vol.63, 1340-1352. doi:https://doi.org/10.2337/db13-1139

Complications

Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1

Mattia Albiero; Nicol Poncina; Marc Tjwa; Stefano Ciciliot; Lisa Menegazzo; Giulio Ceolotto; Saula Vigili de Kreutzenberg; Rute Moura; Marco Giorgio; Piergiuseppe Pelicci; Angelo Avogaro; Gian Paolo Fadini

Abstracts

View articletitled, Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1

Supplementary data

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Topics: autonomic neuropathy , hematopoietic stem cell mobilization , ischemia , mice , neuropathy

Diabetes March 2014, Vol.63, 1353-1365. doi:https://doi.org/10.2337/db13-0894

Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

Li Xiao; Xuejing Zhu; Shikun Yang; Fuyou Liu; Zhiguang Zhou; Ming Zhan; Ping Xie; Dongshan Zhang; Jun Li; Panai Song; Yashpal S. Kanwar; Lin Sun

Abstracts

View articletitled, Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

Supplementary data

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Topics: evidence-based practice , kidney , mitochondria , streptozocin , rats

Diabetes March 2014, Vol.63, 1366-1380. doi:https://doi.org/10.2337/db13-1412

Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients

James Cassuto; Huijuan Dou; Istvan Czikora; Andras Szabo; Vijay S. Patel; Vinayak Kamath; Eric Belin de Chantemele; Attila Feher; Maritza J. Romero; Zsolt Bagi

Abstracts

View articletitled, Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients

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Topics: arteriole , caveolae , dilatation, pathologic , endothelium , nitric oxide synthase

Diabetes March 2014, Vol.63, 1381-1393. doi:https://doi.org/10.2337/db13-0577

Pharmacology and Therapeutics

Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

Guifen Qiang; Shenghui Xue; Jenny J. Yang; Guanhua Du; Xiaobin Pang; Xiaoting Li; Devrishi Goswami; Patrick R. Griffin; Eric A. Ortlund; Chi Bun Chan; Keqiang Ye

Abstracts

View articletitled, Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity

Supplementary data

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Topics: insulin , mice , hypoglycemic agents , blood glucose , insulin receptor

Diabetes March 2014, Vol.63, 1394-1409. doi:https://doi.org/10.2337/db13-0334

Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair

Benjamin Hibbert; Jessie R. Lavoie; Xiaoli Ma; Tara Seibert; Joshua E. Raizman; Trevor Simard; Yong-Xiang Chen; Duncan Stewart; Edward R. O’Brien

Abstracts

View articletitled, Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair

Supplementary data

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Topics: apoptosis , arterial repair , bone wires , cathepsin b , endothelial progenitor cells

Diabetes March 2014, Vol.63, 1410-1421. doi:https://doi.org/10.2337/db13-0941

GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

Christoffer Clemmensen; Joseph Chabenne; Brian Finan; Lorraine Sullivan; Katrin Fischer; Daniela Küchler; Laura Sehrer; Teja Ograjsek; Susanna M. Hofmann; Sonja C. Schriever; Paul T. Pfluger; Jason Pinkstaff; Matthias H. Tschöp; Richard DiMarchi; Timo D. Müller

Abstract

View articletitled, GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

Supplementary data

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Topics: glucagon , glucagon-like peptide 1 , leptin , diet , mice

Diabetes March 2014, Vol.63, 1422-1427. doi:https://doi.org/10.2337/db13-1609

Erratum

Flavonoid Apigenin Is an Inhibitor of the NAD⁺ase CD38: Implications for Cellular NAD⁺ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:1084–1093

Carlos Escande; Veronica Nin; Nathan L. Price; Verena Capellini; Ana P. Gomes; Maria Thereza Barbosa; Luke O’Neil; Thomas A. White; David A. Sinclair; Eduardo N. Chini

Extract

View articletitled, Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:<a href="XSLT_Related_Article_Replace_Href" data-vol="62" data-page="1084">1084–1093</a>

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Topics: acetylation , cd38 , flavonoids , metabolic syndrome x , metabolism

Diabetes March 2014, Vol.63, 1428. doi:https://doi.org/10.2337/db14-er04

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: atherosclerosis , chief complaint , diabetic foot ulcer , florida , microbiome

Diabetes March 2014, Vol.63, 1429. doi:https://doi.org/10.2337/db14-ie04

Online Letters: Comments and Responses

Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922

Stefanie Lieske; Andreas L. Birkenfeld

Extract

View articletitled, Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922

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Topics: adipose tissue , insulin , unfolded protein response

Diabetes March 2014, Vol.63, e1. doi:https://doi.org/10.2337/db13-1844

Response to Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922

Guenther Boden; Peter Cheung; Sajad Salehi; Carol Homko; Catherine Loveland-Jones; Senthil Jayarajan; T. Peter Stein; Carlos A. Barrero; Salim Merali; Kevin Jon Williams; Ming-Lin Liu

Extract

View articletitled, Response to Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922

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Topics: adipose tissue , insulin , unfolded protein response

Diabetes March 2014, Vol.63, e2. doi:https://doi.org/10.2337/db13-1906

Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223

Antonio E. Pontiroli

Extract

View articletitled, Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223

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Topics: disease remission , gastric bypass

Diabetes March 2014, Vol.63, e3. doi:https://doi.org/10.2337/db13-1924

Response to Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223

Roxanne Dutia; Katrina Brakoniecki; Phoebe Bunker; Furcy Paultre; Peter Homel; André C. Carpentier; James McGinty; Blandine Laferrère

Extract

View articletitled, Response to Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223

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Topics: disease remission , gastric bypass

Diabetes March 2014, Vol.63, e4. doi:https://doi.org/10.2337/db14-0112

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In This Issue

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Methodology Review

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Obesity Studies

Islet Studies

Immunology and Transplantation

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Online Letters: Comments and Responses

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