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1 April 2014
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes March 2014, Vol.63, 1167-1168. doi:https://doi.org/10.2337/db14-ti04
Editors’ Commentary
Time to Look Back and to Look Forward
K. Sreekumaran Nair; E. Dale Abel; Sharon G. Adler; Peter J. Dyck; Thomas W. Gardner; Kathryn M. Haskins; Gökhan Hotamisligil; Michael D. Jensen; Anna Krook; Lawrence J. Mandarino; Braxton D. Mitchell; Jeffrey E. Pessin; James R. Sowers; Lori Sussel; Nick Wareham; Adrian Vella
Diabetes March 2014, Vol.63, 1169-1170. doi:https://doi.org/10.2337/db14-0067
Commentaries
Incretin Therapy and Pancreatic Pathologies: Background Pathology Versus Drug-Induced Pathology in Rats
Diabetes March 2014, Vol.63, 1174-1178. doi:https://doi.org/10.2337/db13-1909
Tipping the Balance in Metabolic Regulation: Regulating Regulatory T Cells by Costimulation
Diabetes March 2014, Vol.63, 1179-1181. doi:https://doi.org/10.2337/db13-1915
Tissue-Specific Expression of GLP1R in Mice: Is the Problem of Antibody Nonspecificity Solved?
Diabetes March 2014, Vol.63, 1182-1184. doi:https://doi.org/10.2337/db13-1937
Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling
Diabetes March 2014, Vol.63, 1188-1190. doi:https://doi.org/10.2337/db13-1839
Glycogen Synthase Kinase-3β and Cathepsin B in Diabetic Endothelial Progenitor Cell Dysfunction: An Old Player Finds a New Partner
Diabetes March 2014, Vol.63, 1194-1197. doi:https://doi.org/10.2337/db14-0004
Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in β-Cell Regeneration Research
Diabetes March 2014, Vol.63, 1198-1199. doi:https://doi.org/10.2337/db14-0009
A Radical Concept on Caveolae and Endothelial Dysfunction in Coronary Microvascular Disease in Diabetes
Diabetes March 2014, Vol.63, 1200-1202. doi:https://doi.org/10.2337/db14-0057
Methodology Review
The Oral Minimal Model Method
Diabetes March 2014, Vol.63, 1203-1213. doi:https://doi.org/10.2337/db13-1198
Metabolism
Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission
Roxanne Dutia; Katrina Brakoniecki; Phoebe Bunker; Furcy Paultre; Peter Homel; André C. Carpentier; James McGinty; Blandine Laferrère
Diabetes March 2014, Vol.63, 1214-1223. doi:https://doi.org/10.2337/db13-1176
Identification and Characterization of GLP-1 Receptor–Expressing Cells Using a New Transgenic Mouse Model
Paul Richards; Helen E. Parker; Alice E. Adriaenssens; Joshua M. Hodgson; Simon C. Cork; Stefan Trapp; Fiona M. Gribble; Frank Reimann
Diabetes March 2014, Vol.63, 1224-1233. doi:https://doi.org/10.2337/db13-1440
Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats
Dandong Wu; Mengliu Yang; Yang Chen; Yanjun Jia; Zhongmin Alex Ma; Guenther Boden; Ling Li; Gangyi Yang
Diabetes March 2014, Vol.63, 1234-1247. doi:https://doi.org/10.2337/db13-0899
Additive Effects of MicroRNAs and Transcription Factors on CCL2 Production in Human White Adipose Tissue
Agné Kulyté; Yasmina Belarbi; Silvia Lorente-Cebrián; Clara Bambace; Erik Arner; Carsten O. Daub; Per Hedén; Mikael Rydén; Niklas Mejhert; Peter Arner
Diabetes March 2014, Vol.63, 1248-1258. doi:https://doi.org/10.2337/db13-0702
Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids
Diabetes March 2014, Vol.63, 1259-1269. doi:https://doi.org/10.2337/db13-1090
Obesity Studies
Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell
Sheng Wu; Sara Divall; Amanda Nwaopara; Sally Radovick; Fredric Wondisford; CheMyong Ko; Andrew Wolfe
Diabetes March 2014, Vol.63, 1270-1282. doi:https://doi.org/10.2337/db13-1514
Islet Studies
Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting
Diabetes March 2014, Vol.63, 1283-1288. doi:https://doi.org/10.2337/db13-1435
Immunology and Transplantation
T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance
Jixin Zhong; Xiaoquan Rao; Zachary Braunstein; Anne Taylor; Vimal Narula; Jeffrey Hazey; Dean Mikami; Bradley Needleman; Jessica Rutsky; Qinghua Sun; Jeffrey A. Deiuliis; Abhay R. Satoskar; Sanjay Rajagopalan
Diabetes March 2014, Vol.63, 1289-1302. doi:https://doi.org/10.2337/db13-1094
Pathophysiology
Occurrence of Spontaneous Pancreatic Lesions in Normal and Diabetic Rats: A Potential Confounding Factor in the Nonclinical Assessment of GLP-1–Based Therapies
Kristina D. Chadwick; Anthony M. Fletcher; M. Cecilia Parrula; Susan Bonner-Weir; Raja S. Mangipudy; Evan Janovitz; Michael J. Graziano; Denis Roy; Timothy P. Reilly
Diabetes March 2014, Vol.63, 1303-1314. doi:https://doi.org/10.2337/db13-1268
KCNQ1 Long QT Syndrome Patients Have Hyperinsulinemia and Symptomatic Hypoglycemia
Signe S. Torekov; Eva Iepsen; Michael Christiansen; Allan Linneberg; Oluf Pedersen; Jens J. Holst; Jørgen K. Kanters; Torben Hansen
Diabetes March 2014, Vol.63, 1315-1325. doi:https://doi.org/10.2337/db13-1454
Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells
Richard A. Zuellig; Thorsten Hornemann; Alaa Othman; Adrian B. Hehl; Heiko Bode; Tanja Güntert; Omolara O. Ogunshola; Enrica Saponara; Kamile Grabliauskaite; Jae-Hwi Jang; Udo Ungethuem; Yu Wei; Arnold von Eckardstein; Rolf Graf; Sabrina Sonda
Diabetes March 2014, Vol.63, 1326-1339. doi:https://doi.org/10.2337/db13-1042
Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation
Guo-Xiao Wang; Kae Won Cho; Maeran Uhm; Chun-Rui Hu; Siming Li; Zoharit Cozacov; Acer E. Xu; Ji-Xin Cheng; Alan R. Saltiel; Carey N. Lumeng; Jiandie D. Lin
Diabetes March 2014, Vol.63, 1340-1352. doi:https://doi.org/10.2337/db13-1139
Complications
Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1
Mattia Albiero; Nicol Poncina; Marc Tjwa; Stefano Ciciliot; Lisa Menegazzo; Giulio Ceolotto; Saula Vigili de Kreutzenberg; Rute Moura; Marco Giorgio; Piergiuseppe Pelicci; Angelo Avogaro; Gian Paolo Fadini
Diabetes March 2014, Vol.63, 1353-1365. doi:https://doi.org/10.2337/db13-0894
Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy
Li Xiao; Xuejing Zhu; Shikun Yang; Fuyou Liu; Zhiguang Zhou; Ming Zhan; Ping Xie; Dongshan Zhang; Jun Li; Panai Song; Yashpal S. Kanwar; Lin Sun
Diabetes March 2014, Vol.63, 1366-1380. doi:https://doi.org/10.2337/db13-1412
Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients
James Cassuto; Huijuan Dou; Istvan Czikora; Andras Szabo; Vijay S. Patel; Vinayak Kamath; Eric Belin de Chantemele; Attila Feher; Maritza J. Romero; Zsolt Bagi
Diabetes March 2014, Vol.63, 1381-1393. doi:https://doi.org/10.2337/db13-0577
Pharmacology and Therapeutics
Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity
Guifen Qiang; Shenghui Xue; Jenny J. Yang; Guanhua Du; Xiaobin Pang; Xiaoting Li; Devrishi Goswami; Patrick R. Griffin; Eric A. Ortlund; Chi Bun Chan; Keqiang Ye
Diabetes March 2014, Vol.63, 1394-1409. doi:https://doi.org/10.2337/db13-0334
Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair
Benjamin Hibbert; Jessie R. Lavoie; Xiaoli Ma; Tara Seibert; Joshua E. Raizman; Trevor Simard; Yong-Xiang Chen; Duncan Stewart; Edward R. O’Brien
Diabetes March 2014, Vol.63, 1410-1421. doi:https://doi.org/10.2337/db13-0941
GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet
Christoffer Clemmensen; Joseph Chabenne; Brian Finan; Lorraine Sullivan; Katrin Fischer; Daniela Küchler; Laura Sehrer; Teja Ograjsek; Susanna M. Hofmann; Sonja C. Schriever; Paul T. Pfluger; Jason Pinkstaff; Matthias H. Tschöp; Richard DiMarchi; Timo D. Müller
Diabetes March 2014, Vol.63, 1422-1427. doi:https://doi.org/10.2337/db13-1609
Erratum
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:1084–1093
Carlos Escande; Veronica Nin; Nathan L. Price; Verena Capellini; Ana P. Gomes; Maria Thereza Barbosa; Luke O’Neil; Thomas A. White; David A. Sinclair; Eduardo N. Chini
Diabetes March 2014, Vol.63, 1428. doi:https://doi.org/10.2337/db14-er04
Issues and Events
Online Letters: Comments and Responses
Response to Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922
Guenther Boden; Peter Cheung; Sajad Salehi; Carol Homko; Catherine Loveland-Jones; Senthil Jayarajan; T. Peter Stein; Carlos A. Barrero; Salim Merali; Kevin Jon Williams; Ming-Lin Liu
Diabetes March 2014, Vol.63, e2. doi:https://doi.org/10.2337/db13-1906
Response to Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223
Roxanne Dutia; Katrina Brakoniecki; Phoebe Bunker; Furcy Paultre; Peter Homel; André C. Carpentier; James McGinty; Blandine Laferrère
Diabetes March 2014, Vol.63, e4. doi:https://doi.org/10.2337/db14-0112
