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1 May 2014
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes April 2014, Vol.63, 1431-1432. doi:https://doi.org/10.2337/db14-ti05
Perspectives in Diabetes
Commentaries
The Importance of the Liver in Insulin Replacement Therapy in Insulin-Deficient Diabetes
Diabetes April 2014, Vol.63, 1445-1447. doi:https://doi.org/10.2337/db14-0056
Amyloid and the Macrophage: It’s All About Local Production of IL-1β
Diabetes April 2014, Vol.63, 1448-1450. doi:https://doi.org/10.2337/db14-0003
MicroRNAs Emerge as Modulators of NAD+-Dependent Energy Metabolism in Skeletal Muscle
Diabetes April 2014, Vol.63, 1451-1453. doi:https://doi.org/10.2337/db14-0166
Diabetes Improvement Following Roux-en-Y Gastric Bypass: Understanding Dynamic Changes in Insulin Secretion and Action
Diabetes April 2014, Vol.63, 1454-1456. doi:https://doi.org/10.2337/db13-1918
Zinc–rs13266634 and the Arrival of Diabetes Pharmacogenetics: The “Zinc Mystique”
Diabetes April 2014, Vol.63, 1463-1464. doi:https://doi.org/10.2337/db14-0151
Technological Advances
GLP-1R–Targeting Magnetic Nanoparticles for Pancreatic Islet Imaging
Ping Wang; Byunghee Yoo; Jingsheng Yang; Xueli Zhang; Alana Ross; Pamela Pantazopoulos; Guangping Dai; Anna Moore
Diabetes April 2014, Vol.63, 1465-1474. doi:https://doi.org/10.2337/db13-1543
Original Research
Metabolism
Hypermethylation of Sp1 Binding Site Suppresses Hypothalamic POMC in Neonates and May Contribute to Metabolic Disorders in Adults: Impact of Maternal Dietary CLAs
Xiaomei Zhang; Ran Yang; Yan Jia; Demin Cai; Bo Zhou; Xiaoli Qu; Huihua Han; Liang Xu; Linfeng Wang; Yanan Yao; Guoqing Yang
Diabetes April 2014, Vol.63, 1475-1487. doi:https://doi.org/10.2337/db13-1221
Metabolism
HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle
Brian G. Drew; Vicente Ribas; Jamie A. Le; Darren C. Henstridge; Jennifer Phun; Zhenqi Zhou; Teo Soleymani; Pedram Daraei; Daniel Sitz; Laurent Vergnes; Jonathan Wanagat; Karen Reue; Mark A. Febbraio; Andrea L. Hevener
Diabetes April 2014, Vol.63, 1488-1505. doi:https://doi.org/10.2337/db13-0665
Hepcidin Is Directly Regulated by Insulin and Plays an Important Role in Iron Overload in Streptozotocin-Induced Diabetic Rats
Diabetes April 2014, Vol.63, 1506-1518. doi:https://doi.org/10.2337/db13-1195
Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex
Mitsuhisa Tabata; Joseph T. Rodgers; Jessica A. Hall; Yoonjin Lee; Mark P. Jedrychowski; Steven P. Gygi; Pere Puigserver
Diabetes April 2014, Vol.63, 1519-1532. doi:https://doi.org/10.2337/db13-1304
The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity
Diabetes April 2014, Vol.63, 1533-1545. doi:https://doi.org/10.2337/db13-1061
MicroRNA-149 Inhibits PARP-2 and Promotes Mitochondrial Biogenesis via SIRT-1/PGC-1α Network in Skeletal Muscle
Diabetes April 2014, Vol.63, 1546-1559. doi:https://doi.org/10.2337/db13-1364
Effects of AMPK Activation on Insulin Sensitivity and Metabolism in Leptin-Deficient ob/ob Mice
Robby Zachariah Tom; Pablo M. Garcia-Roves; Rasmus J.O. Sjögren; Lake Q. Jiang; Maria H. Holmström; Atul S. Deshmukh; Elaine Vieira; Alexander V. Chibalin; Marie Björnholm; Juleen R. Zierath
Diabetes April 2014, Vol.63, 1560-1571. doi:https://doi.org/10.2337/db13-0670
Reduced Incorporation of Fatty Acids Into Triacylglycerol in Myotubes From Obese Individuals With Type 2 Diabetes
Lauren M. Sparks; Madeleen Bosma; Bram Brouwers; Tineke van de Weijer; Lena Bilet; Gert Schaart; Esther Moonen-Kornips; Thomas O. Eichmann; Achim Lass; Matthijs K.C. Hesselink; Patrick Schrauwen
Diabetes April 2014, Vol.63, 1583-1593. doi:https://doi.org/10.2337/db13-1123
Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse
Tatiana L. Fonseca; Joao Pedro Werneck-De-Castro; Melany Castillo; Barbara M.L.C. Bocco; Gustavo W. Fernandes; Elizabeth A. McAninch; Daniele L. Ignacio; Caio C.S. Moises; Alexander R. Ferreira; Balázs Gereben; Antonio C. Bianco
Diabetes April 2014, Vol.63, 1594-1604. doi:https://doi.org/10.2337/db13-1768
Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring
Rhianna C. Laker; Travis S. Lillard; Mitsuharu Okutsu; Mei Zhang; Kyle L. Hoehn; Jessica J. Connelly; Zhen Yan
Diabetes April 2014, Vol.63, 1605-1611. doi:https://doi.org/10.2337/db13-1614
Signal Transduction
IG20/MADD Plays a Critical Role in Glucose-Induced Insulin Secretion
Liang-cheng Li; Yong Wang; Ryan Carr; Christine Samir Haddad; Ze Li; Lixia Qian; Jose Oberholzer; Ajay V. Maker; Qian Wang; Bellur S. Prabhakar
Diabetes April 2014, Vol.63, 1612-1623. doi:https://doi.org/10.2337/db13-0707
Obesity Studies
Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release
Yoko Suzuki; Hiroyuki Shimizu; Noriko Ishizuka; Naoto Kubota; Tetsuya Kubota; Akira Senoo; Haruaki Kageyama; Toshimasa Osaka; Satoshi Hirako; Hyoun-Ju Kim; Akiyo Matsumoto; Seiji Shioda; Masatomo Mori; Takashi Kadowaki; Shuji Inoue
Diabetes April 2014, Vol.63, 1637-1648. doi:https://doi.org/10.2337/db13-0636
LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance
Fei Lan; Hirofumi Misu; Keita Chikamoto; Hiroaki Takayama; Akihiro Kikuchi; Kensuke Mohri; Noboru Takata; Hiroto Hayashi; Naoto Matsuzawa-Nagata; Yumie Takeshita; Hiroyo Noda; Yukako Matsumoto; Tsuguhito Ota; Toru Nagano; Masatoshi Nakagen; Ken-ichi Miyamoto; Kanako Takatsuki; Toru Seo; Kaito Iwayama; Kunpei Tokuyama; Seiichi Matsugo; Hong Tang; Yoshiro Saito; Satoshi Yamagoe; Shuichi Kaneko; Toshinari Takamura
Diabetes April 2014, Vol.63, 1649-1664. doi:https://doi.org/10.2337/db13-0728
Gastric Bypass Improves β-Cell Function and Increases β-Cell Mass in a Porcine Model
Andreas Lindqvist; Peter Spégel; Mikael Ekelund; Eliana Garcia Vaz; Stefan Pierzynowski; Maria F. Gomez; Hindrik Mulder; Jan Hedenbro; Leif Groop; Nils Wierup
Diabetes April 2014, Vol.63, 1665-1671. doi:https://doi.org/10.2337/db13-0969
Islet Studies
Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction
Diabetes April 2014, Vol.63, 1698-1711. doi:https://doi.org/10.2337/db13-0863
Immunology and Transplantation
A Humanized Mouse Model of Autoimmune Insulitis
Ashley A. Viehmann Milam; Stephen E. Maher; Joanna A. Gibson; Jasmin Lebastchi; Li Wen; Nancy H. Ruddle; Kevan C. Herold; Alfred L.M. Bothwell
Diabetes April 2014, Vol.63, 1712-1724. doi:https://doi.org/10.2337/db13-1141
Pathophysiology
Early Enhancements of Hepatic and Later of Peripheral Insulin Sensitivity Combined With Increased Postprandial Insulin Secretion Contribute to Improved Glycemic Control After Roux-en-Y Gastric Bypass
Kirstine N. Bojsen-Møller; Carsten Dirksen; Nils B. Jørgensen; Siv H. Jacobsen; Annette K. Serup; Peter H. Albers; Dorte L. Hansen; Dorte Worm; Lars Naver; Viggo B. Kristiansen; Jørgen F.P. Wojtaszewski; Bente Kiens; Jens J. Holst; Erik A. Richter; Sten Madsbad
Diabetes April 2014, Vol.63, 1725-1737. doi:https://doi.org/10.2337/db13-1307
Risk of Cardiac Arrhythmias During Hypoglycemia in Patients With Type 2 Diabetes and Cardiovascular Risk
Elaine Chow; Alan Bernjak; Scott Williams; Robert A. Fawdry; Steve Hibbert; Jenny Freeman; Paul J. Sheridan; Simon R. Heller
Diabetes April 2014, Vol.63, 1738-1747. doi:https://doi.org/10.2337/db13-0468
Complications
Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes
Feng Miao; Zhuo Chen; Saul Genuth; Andrew Paterson; Lingxiao Zhang; Xiwei Wu; Sierra Min Li; Patricia Cleary; Arthur Riggs; David M. Harlan; Gayle Lorenzi; Orville Kolterman; Wanjie Sun; John M. Lachin; Rama Natarajan; the DCCT/EDIC Research Group
Diabetes April 2014, Vol.63, 1748-1762. doi:https://doi.org/10.2337/db13-1251
Pharmacology and Therapeutics
Proinsulin-Transferrin Fusion Protein as a Novel Long-Acting Insulin Analog for the Inhibition of Hepatic Glucose Production
Diabetes April 2014, Vol.63, 1779-1788. doi:https://doi.org/10.2337/db13-0973
Genetics / Genomes / Proteomics / Metabolomics
Low HERV-K(C4) Copy Number Is Associated With Type 1 Diabetes
Mike J. Mason; Cate Speake; Vivian H. Gersuk; Quynh-Anh Nguyen; Kimberly K. O’Brien; Jared M. Odegard; Jane H. Buckner; Carla J. Greenbaum; Damien Chaussabel; Gerald T. Nepom
Diabetes April 2014, Vol.63, 1789-1795. doi:https://doi.org/10.2337/db13-1382
Interactions Between Zinc Transporter-8 Gene (SLC30A8) and Plasma Zinc Concentrations for Impaired Glucose Regulation and Type 2 Diabetes
Zhilei Shan; Wei Bao; Yan Zhang; Ying Rong; Xia Wang; Yilin Jin; Yadong Song; Ping Yao; Changhao Sun; Frank B. Hu; Liegang Liu
Diabetes April 2014, Vol.63, 1796-1803. doi:https://doi.org/10.2337/db13-0606
Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions
Diabetes April 2014, Vol.63, 1804-1816. doi:https://doi.org/10.2337/db13-0867
Statement of Retraction
Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy. Diabetes 2008;57:1002–1017. DOI: 10.2337/db07-0339
Cory Toth; Ling Ling Rong; Christina Yang; Jose Martinez; Fei Song; Noor Ramji; Valentine Brussee; Wei Liu; Jeff Durand; Minh Dang Nguyen; Ann Marie Schmidt; Douglas W. Zochodne
Diabetes April 2014, Vol.63, 1817. doi:https://doi.org/10.2337/db14-rt05
Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy. Diabetes 2009;58:934–945. DOI: 10.2337/db08-1287
George Francis; Jose Martinez; Wei Liu; Thuhien Nguyen; Amit Ayer; Jared Fine; Douglas Zochodne; Leah R. Hanson; William H. Frey, II; Cory Toth
Diabetes April 2014, Vol.63, 1817. doi:https://doi.org/10.2337/db14-rt05a
Update of Retraction—Blockade of Receptor for Advanced Glycation End Products in a Model of Type 1 Diabetic Leukoencephalopathy. Diabetes. 19 November 2012 [Epub ahead of print]. DOI: 10.2337/db12-0317
Natalia Rincon; Kevin Xu; Jemma Li; Jose A. Martinez; Geeta S. Singh; David Han; Paul Lalli; Amit Ayer; Kevin Tse; LingLing Rong; Ann Marie Schmidt; Cory C. Toth
Diabetes April 2014, Vol.63, 1817. doi:https://doi.org/10.2337/db14-rt05b
Issues and Events
Online Letters: Comments and Responses
Response to Comment on Sprouse et al. SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength. Diabetes 2014;63:363–368
Courtney Sprouse; Heather Gordish-Dressman; E. Funda Orkunoglu-Suer; Jason S. Lipof; Stephanie Moeckel-Cole; Ronak R. Patel; Kasra Adham; Justin S. Larkin; Monica J. Hubal; Amy K. Kearns; Priscilla M. Clarkson; Paul D. Thompson; Theodore J. Angelopoulos; Paul M. Gordon; Niall M. Moyna; Linda S. Pescatello; Paul S. Visich; Robert F. Zoeller; Eric P. Hoffman; Laura L. Tosi; Joseph M. Devaney
Diabetes April 2014, Vol.63, e9-e10. doi:https://doi.org/10.2337/db14-0222