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1 June 2014
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes May 2014, Vol.63, 1821-1822. doi:https://doi.org/10.2337/db14-ti06
Commentaries
RNA Sequencing of All Transcripts and How Islet β-Cells Fail
Diabetes May 2014, Vol.63, 1823-1825. doi:https://doi.org/10.2337/db14-0290
Timing Is Everything: Implications for Metabolic Consequences of Sleep Restriction
Diabetes May 2014, Vol.63, 1826-1828. doi:https://doi.org/10.2337/db14-0283
Stress Response Signaling Pathways May Lead to Mitochondrial Biogenesis
Diabetes May 2014, Vol.63, 1831-1832. doi:https://doi.org/10.2337/db14-0373
Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?
Diabetes May 2014, Vol.63, 1833-1835. doi:https://doi.org/10.2337/db14-0371
IL-21 and IRF4: A Complex Partnership in Immune and Metabolic Regulation
Diabetes May 2014, Vol.63, 1838-1840. doi:https://doi.org/10.2337/db14-0273
Stem Cell Senescence in Diabetes: Forgetting the Sweet Old Memories
Diabetes May 2014, Vol.63, 1841-1843. doi:https://doi.org/10.2337/db14-0275
Endogenous, Adipocyte-Derived Lipids Signal the Recruitment of Proinflammatory Immune Cells
Diabetes May 2014, Vol.63, 1844-1846. doi:https://doi.org/10.2337/db14-0303
Complexity of Impaired Parasympathetic Heart Rate Regulation in Diabetes
Diabetes May 2014, Vol.63, 1847-1849. doi:https://doi.org/10.2337/db14-0304
How Does B-Cell Tolerance Contribute to the Protective Effects of Diabetes Following Induced Mixed Chimerism in Autoimmune Diabetes?
Diabetes May 2014, Vol.63, 1855-1857. doi:https://doi.org/10.2337/db14-0327
The Extracellular Matrix Protein MAGP1 Is a Key Regulator of Adipose Tissue Remodeling During Obesity
Diabetes May 2014, Vol.63, 1858-1859. doi:https://doi.org/10.2337/db14-0331
Metabolism
Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
Diabetes May 2014, Vol.63, 1860-1869. doi:https://doi.org/10.2337/db13-1546
B-Cell Translocation Gene 2 Regulates Hepatic Glucose Homeostasis via Induction of Orphan Nuclear Receptor Nur77 in Diabetic Mouse Model
Yong Deuk Kim; Sun-Gyun Kim; Seung-Lark Hwang; Hueng-Sik Choi; Jae-Hoon Bae; Dae-Kyu Song; Seung-Soon Im
Diabetes May 2014, Vol.63, 1870-1880. doi:https://doi.org/10.2337/db13-1368
Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance
Darren C. Henstridge; Clinton R. Bruce; Brian G. Drew; Kálmán Tory; Attila Kolonics; Emma Estevez; Jason Chung; Nadine Watson; Timothy Gardner; Robert S. Lee-Young; Timothy Connor; Matthew J. Watt; Kevin Carpenter; Mark Hargreaves; Sean L. McGee; Andrea L. Hevener; Mark A. Febbraio
Diabetes May 2014, Vol.63, 1881-1894. doi:https://doi.org/10.2337/db13-0967
Orexinergic Activation of Medullary Premotor Neurons Modulates the Adrenal Sympathoexcitation to Hypothalamic Glucoprivation
Diabetes May 2014, Vol.63, 1895-1906. doi:https://doi.org/10.2337/db13-1073
High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII
Swati S. Jain; Sabina Paglialunga; Chris Vigna; Alison Ludzki; Eric A. Herbst; James S. Lally; Patrick Schrauwen; Joris Hoeks; A. Russ Tupling; Arend Bonen; Graham P. Holloway
Diabetes May 2014, Vol.63, 1907-1913. doi:https://doi.org/10.2337/db13-0816
Failure of Homeostatic Model Assessment of Insulin Resistance to Detect Marked Diet-Induced Insulin Resistance in Dogs
Marilyn Ader; Darko Stefanovski; Joyce M. Richey; Stella P. Kim; Cathryn M. Kolka; Viorica Ionut; Morvarid Kabir; Richard N. Bergman
Diabetes May 2014, Vol.63, 1914-1919. doi:https://doi.org/10.2337/db13-1215
Signal Transduction
The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
Clarissa S. Craft; Terri A. Pietka; Timothy Schappe; Trey Coleman; Michelle D. Combs; Samuel Klein; Nada A. Abumrad; Robert P. Mecham
Diabetes May 2014, Vol.63, 1920-1932. doi:https://doi.org/10.2337/db13-1604
Increased Interaction With Insulin Receptor Substrate 1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes
Michael Caruso; Danjun Ma; Zaher Msallaty; Monique Lewis; Berhane Seyoum; Wissam Al-janabi; Michael Diamond; Abdul B. Abou-Samra; Kurt Højlund; Rebecca Tagett; Sorin Draghici; Xiangmin Zhang; Jeffrey F. Horowitz; Zhengping Yi
Diabetes May 2014, Vol.63, 1933-1947. doi:https://doi.org/10.2337/db13-1872
Obesity Studies
RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice
Fei Song; Carmen Hurtado del Pozo; Rosa Rosario; Yu Shan Zou; Radha Ananthakrishnan; Xiaoyuan Xu; Payal R. Patel; Vivian M. Benoit; Shi Fang Yan; Huilin Li; Richard A. Friedman; Jason K. Kim; Ravichandran Ramasamy; Anthony W. Ferrante, Jr.; Ann Marie Schmidt
Diabetes May 2014, Vol.63, 1948-1965. doi:https://doi.org/10.2337/db13-1636
T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes
Elise Dalmas; Nicolas Venteclef; Charles Caer; Christine Poitou; Isabelle Cremer; Judith Aron-Wisnewsky; Sébastien Lacroix-Desmazes; Jagadeesh Bayry; Srinivas V. Kaveri; Karine Clément; Sébastien André; Michèle Guerre-Millo
Diabetes May 2014, Vol.63, 1966-1977. doi:https://doi.org/10.2337/db13-1511
Islet Studies
RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
Miriam Cnop; Baroj Abdulkarim; Guy Bottu; Daniel A. Cunha; Mariana Igoillo-Esteve; Matilde Masini; Jean-Valery Turatsinze; Thasso Griebel; Olatz Villate; Izortze Santin; Marco Bugliani; Laurence Ladriere; Lorella Marselli; Mark I. McCarthy; Piero Marchetti; Michael Sammeth; Décio L. Eizirik
Diabetes May 2014, Vol.63, 1978-1993. doi:https://doi.org/10.2337/db13-1383
The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
Yan Hang; Tsunehiko Yamamoto; Richard K.P. Benninger; Marcela Brissova; Min Guo; Will Bush; David W. Piston; Alvin C. Powers; Mark Magnuson; Debbie C. Thurmond; Roland Stein
Diabetes May 2014, Vol.63, 1994-2005. doi:https://doi.org/10.2337/db13-1001
Compromised Gut Microbiota Networks in Children With Anti-Islet Cell Autoimmunity
David Endesfelder; Wolfgang zu Castell; Alexandria Ardissone; Austin G. Davis-Richardson; Peter Achenbach; Michael Hagen; Maren Pflueger; Kelsey A. Gano; Jennie R. Fagen; Jennifer C. Drew; Christopher T. Brown; Bryan Kolaczkowski; Mark Atkinson; Desmond Schatz; Ezio Bonifacio; Eric W. Triplett; Anette-G. Ziegler
Diabetes May 2014, Vol.63, 2006-2014. doi:https://doi.org/10.2337/db13-1676
Immunology and Transplantation
Combination Therapy With an Anti–IL-1β Antibody and GAD65 DNA Vaccine Can Reverse Recent-Onset Diabetes in the RIP-GP Mouse Model
Philippe P. Pagni; Damien Bresson; Teresa Rodriguez-Calvo; Amira Bel Hani; Yulia Manenkova; Natalie Amirian; Alecia Blaszczak; Sina Faton; Sowbarnika Sachithanantham; Matthias G. von Herrath
Diabetes May 2014, Vol.63, 2015-2025. doi:https://doi.org/10.2337/db13-1257
Dietary Supplementation With High Doses of Regular Vitamin D3 Safely Reduces Diabetes Incidence in NOD Mice When Given Early and Long Term
Tatiana Takiishi; Lei Ding; Femke Baeke; Isabella Spagnuolo; Guido Sebastiani; Jos Laureys; Annemieke Verstuyf; Geert Carmeliet; Francesco Dotta; Tom L. Van Belle; Conny A. Gysemans; Chantal Mathieu
Diabetes May 2014, Vol.63, 2026-2036. doi:https://doi.org/10.2337/db13-1559
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation
Graham A. Tynan; Claire H. Hearnden; Ewa Oleszycka; Claire L. Lyons; Graham Coutts; Jean O’Connell; Michelle A. Corrigan; Lydia Lynch; Matthew Campbell; John J. Callanan; Kenneth H. Mok; Justin Geoghegan; Cliona O’Farrelly; Stuart M. Allan; Helen M. Roche; Donal B. O’Shea; Ed C. Lavelle
Diabetes May 2014, Vol.63, 2037-2050. doi:https://doi.org/10.2337/db13-1476
Induction of Mixed Chimerism Depletes Pre-existing and De Novo–Developed Autoreactive B Cells in Autoimmune NOD Mice
Diabetes May 2014, Vol.63, 2051-2062. doi:https://doi.org/10.2337/db13-1532
Pathophysiology
Vanin-1 Is a Key Activator for Hepatic Gluconeogenesis
Diabetes May 2014, Vol.63, 2073-2085. doi:https://doi.org/10.2337/db13-0788
IL-21 Is a Major Negative Regulator of IRF4-Dependent Lipolysis Affecting Tregs in Adipose Tissue and Systemic Insulin Sensitivity
Marta Fabrizi; Valentina Marchetti; Maria Mavilio; Arianna Marino; Viviana Casagrande; Michele Cavalera; Josè Maria Moreno-Navarrete; Teresa Mezza; Gian Pio Sorice; Loredana Fiorentino; Rossella Menghini; Renato Lauro; Giovanni Monteleone; Andrea Giaccari; José Manuel Fernandez Real; Massimo Federici
Diabetes May 2014, Vol.63, 2086-2096. doi:https://doi.org/10.2337/db13-0939
Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice
Yali Zhang; Charles M. Welzig; Kristen L. Picard; Chuang Du; Bo Wang; Jen Q. Pan; John M. Kyriakis; Mark J. Aronovitz; William C. Claycomb; Robert M. Blanton; Ho-Jin Park; Jonas B. Galper
Diabetes May 2014, Vol.63, 2097-2113. doi:https://doi.org/10.2337/db12-1459
Evidence for a Causal Relationship Between Early Exocrine Pancreatic Disease and Cystic Fibrosis–Related Diabetes: A Mendelian Randomization Study
David Soave; Melissa R. Miller; Katherine Keenan; Weili Li; Jiafen Gong; Wan Ip; Frank Accurso; Lei Sun; Johanna M. Rommens; Marci Sontag; Peter R. Durie; Lisa J. Strug
Diabetes May 2014, Vol.63, 2114-2119. doi:https://doi.org/10.2337/db13-1464
Complications
Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen
Keizo Kanasaki; Sen Shi; Megumi Kanasaki; Jianhua He; Takako Nagai; Yuka Nakamura; Yasuhito Ishigaki; Munehiro Kitada; Swayam Prakash Srivastava; Daisuke Koya
Diabetes May 2014, Vol.63, 2120-2131. doi:https://doi.org/10.2337/db13-1029
The Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in the Human Cardiac Mesenchymal Cells of Type 2 Diabetic Patients
Matteo Vecellio; Francesco Spallotta; Simona Nanni; Claudia Colussi; Chiara Cencioni; Anja Derlet; Beatrice Bassetti; Manuela Tilenni; Maria Cristina Carena; Antonella Farsetti; Gianluca Sbardella; Sabrina Castellano; Antonello Mai; Fabio Martelli; Giulio Pompilio; Maurizio C. Capogrossi; Alessandra Rossini; Stefanie Dimmeler; Andreas Zeiher; Carlo Gaetano
Diabetes May 2014, Vol.63, 2132-2147. doi:https://doi.org/10.2337/db13-0731
Genetics / Genomes / Proteomics / Metabolomics
Linking the Circadian Rhythm Gene Arntl2 to Interleukin 21 Expression in Type 1 Diabetes
Diabetes May 2014, Vol.63, 2148-2157. doi:https://doi.org/10.2337/db13-1702
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Antigone S. Dimas; Vasiliki Lagou; Adam Barker; Joshua W. Knowles; Reedik Mägi; Marie-France Hivert; Andrea Benazzo; Denis Rybin; Anne U. Jackson; Heather M. Stringham; Ci Song; Antje Fischer-Rosinsky; Trine Welløv Boesgaard; Niels Grarup; Fahim A. Abbasi; Themistocles L. Assimes; Ke Hao; Xia Yang; Cécile Lecoeur; Inês Barroso; Lori L. Bonnycastle; Yvonne Böttcher; Suzannah Bumpstead; Peter S. Chines; Michael R. Erdos; Jurgen Graessler; Peter Kovacs; Mario A. Morken; Narisu Narisu; Felicity Payne; Alena Stancakova; Amy J. Swift; Anke Tönjes; Stefan R. Bornstein; Stéphane Cauchi; Philippe Froguel; David Meyre; Peter E.H. Schwarz; Hans-Ulrich Häring; Ulf Smith; Michael Boehnke; Richard N. Bergman; Francis S. Collins; Karen L. Mohlke; Jaakko Tuomilehto; Thomas Quertemous; Lars Lind; Torben Hansen; Oluf Pedersen; Mark Walker; Andreas F.H. Pfeiffer; Joachim Spranger; Michael Stumvoll; James B. Meigs; Nicholas J. Wareham; Johanna Kuusisto; Markku Laakso; Claudia Langenberg; Josée Dupuis; Richard M. Watanabe; Jose C. Florez; Erik Ingelsson; Mark I. McCarthy; Inga Prokopenko; on behalf of the MAGIC Investigators
Diabetes May 2014, Vol.63, 2158-2171. doi:https://doi.org/10.2337/db13-0949
Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection
Jason L. Vassy; Marie-France Hivert; Bianca Porneala; Marco Dauriz; Jose C. Florez; Josée Dupuis; David S. Siscovick; Myriam Fornage; Laura J. Rasmussen-Torvik; Claude Bouchard; James B. Meigs
Diabetes May 2014, Vol.63, 2172-2182. doi:https://doi.org/10.2337/db13-1663
Errata
Body Fat Partitioning Does Not Explain the Interethnic Variation in Insulin Sensitivity Among Asian Ethnicity: The Singapore Adults Metabolism Study. Diabetes 2014;63:1093–1102
Chin Meng Khoo; Melvin Khee–Shing Leow; Suresh Anand Sadananthan; Radiance Lim; Kavita Venkataraman; Eric Yin; Hao Khoo; S. Sendhil Velan; Yu Ting Ong; Ravi Kambadur; Craig McFarlane; Peter D. Gluckman; Yun Seng Lee; Yap Seng Chong; E. Shyong Tai
Diabetes May 2014, Vol.63, 2183. doi:https://doi.org/10.2337/db14-er06