Issues

Topics: adipose tissue , bilirubin , generalized anxiety disorder , glucose uptake , kidney diseases

Diabetes July 2014, Vol.63, 2565-2566. doi:https://doi.org/10.2337/db14-ti08

Perspectives in Diabetes

Partial Duct Ligation: β-Cell Proliferation and Beyond

Mark Van de Casteele; Gunter Leuckx; Ying Cai; Yixing Yuchi; Violette Coppens; Sofie De Groef; Naomi Van Gassen; Luc Baeyens; Yves Heremans; Christopher V.E. Wright; Harry Heimberg

Extract

Topics: mice , pancreas , ligation

Diabetes July 2014, Vol.63, 2567-2577. doi:https://doi.org/10.2337/db13-0831

Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions

Jeffrey B. Halter; Nicolas Musi; Frances McFarland Horne; Jill P. Crandall; Andrew Goldberg; Lawrence Harkless; William R. Hazzard; Elbert S. Huang; M. Sue Kirkman; Jorge Plutzky; Kenneth E. Schmader; Susan Zieman; Kevin P. High

Abstracts

Topics: aging , cardiovascular diseases , older adult , heterogeneity , diabetes mellitus, type 2

Diabetes July 2014, Vol.63, 2578-2589. doi:https://doi.org/10.2337/db14-0020

Metformin Pharmacogenomics: Current Status and Future Directions

Aaron C. Pawlyk; Kathleen M. Giacomini; Catherine McKeon; Alan R. Shuldiner; Jose C. Florez

Abstracts

Topics: metformin , pharmacogenomics

Diabetes July 2014, Vol.63, 2590-2599. doi:https://doi.org/10.2337/db13-1367

Commentaries

Heparanase Shakes Hands With Lipoprotein Lipase: A Tale of Two Cells

Subrata Chakrabarti

Abstracts

Topics: hand , lipoprotein lipase , tremor , cardiac myocytes , endothelium

Diabetes July 2014, Vol.63, 2600-2602. doi:https://doi.org/10.2337/db14-0503

Of Bugs and Men: Antigen-Fortified Lactoccoccus lactis for Type 1 Diabetes Immunotherapy

Roberto Mallone; Slobodan Culina

Abstracts

Topics: antigens , diabetes mellitus, type 1 , immunotherapy , bone nails , pins - internal fixators

Diabetes July 2014, Vol.63, 2603-2605. doi:https://doi.org/10.2337/db14-0587

Exercise and Mitochondrial Function in Adipose Biology: All Roads Lead to NO

David A. Bernlohr

Abstracts

Topics: mitochondria , nitric oxide synthase , origin of life , adipocytes

Diabetes July 2014, Vol.63, 2606-2608. doi:https://doi.org/10.2337/db14-0638

Metformin Pharmacogenomics: Biomarkers to Mechanisms

Liewei Wang; Richard Weinshilboum

Abstracts

Topics: biological markers , metformin , pharmacogenomics

Diabetes July 2014, Vol.63, 2609-2610. doi:https://doi.org/10.2337/db14-0609

Improved Mitochondrial Function Is Linked With Improved Insulin Sensitivity Through Reductions in FFA

Bret H. Goodpaster; Paul M. Coen

Abstracts

Topics: insulin sensitivity , mitochondria

Diabetes July 2014, Vol.63, 2611-2612. doi:https://doi.org/10.2337/db14-0277

Bilirubin: A Potential Biomarker and Therapeutic Target for Diabetic Nephropathy

Travis D. Hull; Anupam Agarwal

Abstracts

Topics: bilirubin , biological markers , diabetic nephropathy

Diabetes July 2014, Vol.63, 2613-2616. doi:https://doi.org/10.2337/db14-0691

Is There Cross Talk Between Portal and Hypothalamic Glucose-Sensing Circuits?

Owen Chan; Robert S. Sherwin

Abstracts

Topics: glucose , hypothalamus , hypoglycemia , sensor

Diabetes July 2014, Vol.63, 2617-2619. doi:https://doi.org/10.2337/db14-0755

Metabolism

The Concentration of Phosphatidylethanolamine in Mitochondria Can Modulate ATP Production and Glucose Metabolism in Mice

Jelske N. van der Veen; Susanne Lingrell; Robin P. da Silva; René L. Jacobs; Dennis E. Vance

Abstract

Topics: glucose , mice , mitochondria , phospholipids , pyruvates

Diabetes July 2014, Vol.63, 2620-2630. doi:https://doi.org/10.2337/db13-0993

A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis

Fei Xiao; Junjie Yu; Bin Liu; Yajie Guo; Kai Li; Jiali Deng; Jin Zhang; Chunxia Wang; Shanghai Chen; Ying Du; Yingli Lu; Yuzhong Xiao; Zhou Zhang; Feifan Guo

Abstracts

Topics: fatty liver , insulin , insulin sensitivity , liver , mice

Diabetes July 2014, Vol.63, 2631-2642. doi:https://doi.org/10.2337/db13-1689

Endothelial Cell Heparanase Taken Up by Cardiomyocytes Regulates Lipoprotein Lipase Transfer to the Coronary Lumen After Diabetes

Ying Wang; Amy Pei-Ling Chiu; Katharina Neumaier; Fulong Wang; Dahai Zhang; Bahira Hussein; Nathaniel Lal; Andrea Wan; George Liu; Israel Vlodavsky; Brian Rodrigues

Abstracts

Topics: cardiac myocytes , gelatinase b , muscle cells , lysosomes , western blotting

Diabetes July 2014, Vol.63, 2643-2655. doi:https://doi.org/10.2337/db13-1842

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

Abstracts

Topics: diet , neutralization , vascular endothelial growth factor a , mice , insulin

Diabetes July 2014, Vol.63, 2656-2667. doi:https://doi.org/10.2337/db13-1665

Small Intestinal Glucose Exposure Determines the Magnitude of the Incretin Effect in Health and Type 2 Diabetes

Chinmay S. Marathe; Christopher K. Rayner; Michelle Bound; Helen Checklin; Scott Standfield; Judith Wishart; Kylie Lange; Karen L. Jones; Michael Horowitz

Abstract

Topics: blood glucose , diabetes mellitus, type 2 , glucagon , glucagon-like peptide 1 , glucose

Diabetes July 2014, Vol.63, 2668-2675. doi:https://doi.org/10.2337/db13-1757

Signal Transduction

Insulin Inhibits Cardiac Contractility by Inducing a G_i-Biased β₂-Adrenergic Signaling in Hearts

Qin Fu; Bing Xu; Yongming Liu; Dippal Parikh; Jing Li; Ying Li; Yuan Zhang; Christian Riehle; Yi Zhu; Tenley Rawlings; Qian Shi; Richard B. Clark; Xiongwen Chen; E. Dale Abel; Yang K. Xiang

Abstract

Topics: heart , insulin , signal transduction , mice , cardiac myocytes

Diabetes July 2014, Vol.63, 2676-2689. doi:https://doi.org/10.2337/db13-1763

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

Mini P. Sajan; Mildred E. Acevedo-Duncan; Mary L. Standaert; Robert A. Ivey; Mackenzie Lee; Robert V. Farese

Abstracts

Topics: diet , forkhead box protein o1 , insulin , liver , mice

Diabetes July 2014, Vol.63, 2690-2701. doi:https://doi.org/10.2337/db13-1863

Obesity Studies

Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates

Stephanie R. Thorn; Karalee C. Baquero; Sean A. Newsom; Karim C. El Kasmi; Bryan C. Bergman; Gerald I. Shulman; Kevin L. Grove; Jacob E. Friedman

Abstract

Topics: child , diet , gene expression , heart failure , inflammation

Diabetes July 2014, Vol.63, 2702-2713. doi:https://doi.org/10.2337/db14-0276

Islet Studies

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet

Judith Molina; Rayner Rodriguez-Diaz; Alberto Fachado; M. Caroline Jacques-Silva; Per-Olof Berggren; Alejandro Caicedo

Abstract

Topics: acetylcholine , bodily secretions , cholinergic agents , endocrine pancreas , insulin

Diabetes July 2014, Vol.63, 2714-2726. doi:https://doi.org/10.2337/db13-1371

Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis

Marika Bogdani; Pamela Y. Johnson; Susan Potter-Perigo; Nadine Nagy; Anthony J. Day; Paul L. Bollyky; Thomas N. Wight

Abstract

Topics: donors , endocrine pancreas , hyaluronan , inflammatory cells , insulin

Diabetes July 2014, Vol.63, 2727-2743. doi:https://doi.org/10.2337/db13-1658

Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency

Decheng Ren; Juan Sun; Changzheng Wang; Honggang Ye; Liqun Mao; Emily H. Cheng; Graeme I. Bell; Kenneth S. Polonsky

Abstract

Topics: ablation , apoptosis , mice , molecule , psychological suppression

Diabetes July 2014, Vol.63, 2744-2750. doi:https://doi.org/10.2337/db13-1513

Immunology and Transplantation

CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment

Zuoan Yi; Laura L. Stunz; Gail A. Bishop

Abstract

Topics: cd40 antigens , insulin resistance , mice , obesity , adipose tissue

Diabetes July 2014, Vol.63, 2751-2760. doi:https://doi.org/10.2337/db13-1657

IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice

Qiyuan Tan; Monika Majewska-Szczepanik; Xiaojun Zhang; Marian Szczepanik; Zhiguang Zhou; F. Susan Wong; Li Wen

Abstract

Topics: cytokine , mice , mice, inbred nod , t-lymphocytes , atrial premature complexes

Diabetes July 2014, Vol.63, 2761-2775. doi:https://doi.org/10.2337/db13-1504

Pathophysiology

Effects of Sitagliptin on Glycemia, Incretin Hormones, and Antropyloroduodenal Motility in Response to Intraduodenal Glucose Infusion in Healthy Lean and Obese Humans and Patients With Type 2 Diabetes Treated With or Without Metformin

Tongzhi Wu; Jing Ma; Michelle J. Bound; Helen Checklin; Carolyn F. Deacon; Karen L. Jones; Michael Horowitz; Christopher K. Rayner

Abstracts

Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose , incretin , infusion procedures

Diabetes July 2014, Vol.63, 2776-2787. doi:https://doi.org/10.2337/db13-1627

Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin’s Metabolic Action in the Presence of Insulin Resistance

Weidong Chai; Xingxing Zhang; Eugene J. Barrett; Zhenqi Liu

Abstract

Topics: glucagon-like peptide 1 , infusion procedures , insulin , microvascular network , insulin resistance

Diabetes July 2014, Vol.63, 2788-2799. doi:https://doi.org/10.2337/db13-1597

Exercise Training Induces Mitochondrial Biogenesis and Glucose Uptake in Subcutaneous Adipose Tissue Through eNOS-Dependent Mechanisms

Elisabetta Trevellin; Michele Scorzeto; Massimiliano Olivieri; Marnie Granzotto; Alessandra Valerio; Laura Tedesco; Roberto Fabris; Roberto Serra; Marco Quarta; Carlo Reggiani; Enzo Nisoli; Roberto Vettor

Abstracts

Topics: adipocytes , fat, subcutaneous , glucose uptake , mice , mitochondria

Diabetes July 2014, Vol.63, 2800-2811. doi:https://doi.org/10.2337/db13-1234

Chronic Reduction of Plasma Free Fatty Acid Improves Mitochondrial Function and Whole-Body Insulin Sensitivity in Obese and Type 2 Diabetic Individuals

Giuseppe Daniele; Roy Eldor; Aurora Merovci; Geoffrey D. Clarke; Juan Xiong; Devjit Tripathy; Anna Taranova; Muhammad Abdul-Ghani; Ralph A. DeFronzo

Abstracts

Topics: diabetes mellitus, type 2 , insulin , insulin sensitivity , mitochondria , obesity

Diabetes July 2014, Vol.63, 2812-2820. doi:https://doi.org/10.2337/db13-1130

A Maternal Gluten-Free Diet Reduces Inflammation and Diabetes Incidence in the Offspring of NOD Mice

Camilla Hartmann Friis Hansen; Łukasz Krych; Karsten Buschard; Stine B. Metzdorff; Christine Nellemann; Lars H. Hansen; Dennis S. Nielsen; Hanne Frøkiær; Søren Skov; Axel K. Hansen

Abstract

Topics: diet , mice , mice, inbred nod , microbiome , intestines

Diabetes July 2014, Vol.63, 2821-2832. doi:https://doi.org/10.2337/db13-1612

Limited Acute Influences of Electrical Baroreceptor Activation on Insulin Sensitivity and Glucose Delivery: A Randomized, Double-Blind, Crossover Clinical Study

Marcus May; Jelka Ahrens; Jan Menne; Hermann Haller; Joachim Beige; Siegfried Eckert; Jens Jordan; Stefan Engeli

Abstracts

Topics: baroreflex , glucose , insulin , insulin sensitivity , pressoreceptors

Diabetes July 2014, Vol.63, 2833-2837. doi:https://doi.org/10.2337/db13-1651

Incretin Effect and Glucagon Responses to Oral and Intravenous Glucose in Patients With Maturity-Onset Diabetes of the Young—Type 2 and Type 3

Signe H. Østoft; Jonatan I. Bagger; Torben Hansen; Oluf Pedersen; Jens J. Holst; Filip K. Knop; Tina Vilsbøll

Abstracts

Topics: glucagon , glucose , glucose, parenteral form , hnf1a gene , incretin

Diabetes July 2014, Vol.63, 2838-2844. doi:https://doi.org/10.2337/db13-1878

Complications

Bilirubin and Progression of Nephropathy in Type 2 Diabetes: A Post Hoc Analysis of RENAAL With Independent Replication in IDNT

Ineke J. Riphagen; Petronella E. Deetman; Stephan J.L. Bakker; Gerjan Navis; Mark E. Cooper; Julia B. Lewis; Dick de Zeeuw; Hiddo J. Lambers Heerspink

Abstracts

Topics: bilirubin , diabetes mellitus, type 2 , kidney diseases

Diabetes July 2014, Vol.63, 2845-2853. doi:https://doi.org/10.2337/db13-1652

The Rate of Fall of Blood Glucose Determines the Necessity of Forebrain-Projecting Catecholaminergic Neurons for Male Rat Sympathoadrenal Responses

Anne J. Jokiaho; Casey M. Donovan; Alan G. Watts

Abstracts

Topics: hypoglycemia , hypoglycemic agents , neurons , porokeratosis, disseminated superficial actinic , glucose

Diabetes July 2014, Vol.63, 2854-2865. doi:https://doi.org/10.2337/db13-1753

Activation of Hindbrain Neurons Is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia

MaryAnn Bohland; Aleksey V. Matveyenko; Maziyar Saberi; Arshad M. Khan; Alan G. Watts; Casey M. Donovan

Abstracts

Topics: glucose , hindbrain , hypoglycemia , hypoglycemic agents , neurons

Diabetes July 2014, Vol.63, 2866-2875. doi:https://doi.org/10.2337/db13-1600

Pharmacology and Therapeutics

Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

Sofie Robert; Conny Gysemans; Tatiana Takiishi; Hannelie Korf; Isabella Spagnuolo; Guido Sebastiani; Karolien Van Huynegem; Lothar Steidler; Silvia Caluwaerts; Pieter Demetter; Clive H. Wasserfall; Mark A. Atkinson; Francesco Dotta; Pieter Rottiers; Tom L. Van Belle; Chantal Mathieu

Abstracts

Topics: generalized anxiety disorder , mice , mice, inbred nod , antigens , t-lymphocytes

Diabetes July 2014, Vol.63, 2876-2887. doi:https://doi.org/10.2337/db13-1236

Genetics / Genomes / Proteomics / Metabolomics

GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes

Charles Shaw-Smith; Elisa De Franco; Hana Lango Allen; Marta Batlle; Sarah E. Flanagan; Maciej Borowiec; Craig E. Taplin; Janiëlle van Alfen-van der Velden; Jaime Cruz-Rojo; Guiomar Perez de Nanclares; Zosia Miedzybrodzka; Grazyna Deja; Iwona Wlodarska; Wojciech Mlynarski; Jorge Ferrer; Andrew T. Hattersley; Sian Ellard

Abstracts

Topics: child , congenital heart defects , mutation , newborn , pancreas

Diabetes July 2014, Vol.63, 2888-2894. doi:https://doi.org/10.2337/db14-0061

Erratum

Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes 2014;63:1594–1604

Tatiana L. Fonseca; Joao Pedro Werneck-De-Castro; Melany Castillo; Barbara M.L.C. Bocco; Gustavo W. Fernandes; Elizabeth A. McAninch; Daniele L. Ignacio; Caio C.S. Moises; Alexandre Ferreira; Balázs Gereben; Antonio C. Bianco

Extract

Topics: fatty acid oxidation , iodide peroxidase , mice , thyroid hormones

Diabetes July 2014, Vol.63, 2895. doi:https://doi.org/10.2337/db14-er08

Statement of Retraction

Activation of Aldose Reductase by Interaction With Tubulin and Involvement of This Mechanism in Diabetic Cataract Formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265

Juan F. Rivelli; Verónica S. Santander; Sofía O. Peretti; Noelia E. Monesterolo; Ayelen D. Nigra; Gabriela Previtali; Marina R. Amaiden; Carlos A. Arce; Emiliano Primo; Angela T. Lisa; Juan Pie; César H. Casale

Extract

Topics: aldehyde reductase , diabetic cataract , tubulin

Diabetes July 2014, Vol.63, 2896. doi:https://doi.org/10.2337/db13-1265

Issues and Events

Extract

Topics: diffuse mesangial sclerosis , dimethyl sulfide , florida , hawaii , india

Diabetes July 2014, Vol.63, 2897. doi:https://doi.org/10.2337/db14-ie08

E-Letters: Comments and Responses

Comment on Ye et al. The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal? Diabetes 2014;63:332–342

Altan Onat; Servet Altay; Hüsniye Yüksel

Extract

Topics: diabetes mellitus, type 2 , lipoproteins

Diabetes July 2014, Vol.63, e14. doi:https://doi.org/10.2337/db14-0521

Response to Comment on Ye et al. The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal? Diabetes 2014;63:332–342

Zheng Ye; Manjinder S. Sandhu; Nita G. Forouhi

Extract