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1 September 2014
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes August 2014, Vol.63, 2899-2900. doi:https://doi.org/10.2337/db14-ti09
Commentaries
Integrating Transcriptome and Epigenome: Putting Together the Pieces of the Type 2 Diabetes Pathogenesis Puzzle
Diabetes August 2014, Vol.63, 2901-2903. doi:https://doi.org/10.2337/db14-0757
Is There a Sweet Spot for Nrf2 Activation in the Treatment of Diabetic Kidney Disease?
Diabetes August 2014, Vol.63, 2904-2905. doi:https://doi.org/10.2337/db14-0829
Role for Tet in Hyperglycemia-Induced Demethylation: A Novel Mechanism of Diabetic Metabolic Memory
Diabetes August 2014, Vol.63, 2906-2908. doi:https://doi.org/10.2337/db14-0675
Visual Fields Refine Understanding of Diabetic Retinopathy Progression
Diabetes August 2014, Vol.63, 2909-2910. doi:https://doi.org/10.2337/db14-0741
Metabolism
I Prostanoid Receptor–Mediated Inflammatory Pathway Promotes Hepatic Gluconeogenesis Through Activation of PKA and Inhibition of AKT
Shuai Yan; Qianqian Zhang; Xiaojing Zhong; Juan Tang; Yuanyang Wang; Junjie Yu; Yi Zhou; Jian Zhang; Feifan Guo; Yi Liu; Garret A. FitzGerald; Ying Yu
Diabetes August 2014, Vol.63, 2911-2923. doi:https://doi.org/10.2337/db13-1893
Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)–Deficient Mice Are Resistant to Diet-Induced Obesity
Diabetes August 2014, Vol.63, 2924-2934. doi:https://doi.org/10.2337/db14-0066
Metabolic Crosstalk: Molecular Links Between Glycogen and Lipid Metabolism in Obesity
Binbin Lu; Dave Bridges; Yemen Yang; Kaleigh Fisher; Alan Cheng; Louise Chang; Zhuo-Xian Meng; Jiandie D. Lin; Michael Downes; Ruth T. Yu; Christopher Liddle; Ronald M. Evans; Alan R. Saltiel
Diabetes August 2014, Vol.63, 2935-2948. doi:https://doi.org/10.2337/db13-1531
KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression
Chu-Fang Chou; Yi-Yu Lin; Hsu-Kun Wang; Xiaolin Zhu; Matteo Giovarelli; Paola Briata; Roberto Gherzi; W. Timothy Garvey; Ching-Yi Chen
Diabetes August 2014, Vol.63, 2949-2961. doi:https://doi.org/10.2337/db13-1901
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
Emma Nilsson; Per Anders Jansson; Alexander Perfilyev; Petr Volkov; Maria Pedersen; Maria K. Svensson; Pernille Poulsen; Rasmus Ribel-Madsen; Nancy L. Pedersen; Peter Almgren; João Fadista; Tina Rönn; Bente Klarlund Pedersen; Camilla Scheele; Allan Vaag; Charlotte Ling
Diabetes August 2014, Vol.63, 2962-2976. doi:https://doi.org/10.2337/db13-1459
Insulin Resistance Is Associated With Diminished Endoplasmic Reticulum Stress Responses in Adipose Tissue of Healthy and Diabetic Subjects
Diabetes August 2014, Vol.63, 2977-2983. doi:https://doi.org/10.2337/db14-0055
Islet Studies
Glycoprotein 130 Receptor Signaling Mediates α-Cell Dysfunction in a Rodent Model of Type 2 Diabetes
Samuel Z. Chow; Madeleine Speck; Piriya Yoganathan; Dominika Nackiewicz; Ann Maria Hansen; Mette Ladefoged; Björn Rabe; Stefan Rose-John; Peter J. Voshol; Francis C. Lynn; Pedro L. Herrera; Werner Müller; Helga Ellingsgaard; Jan A. Ehses
Diabetes August 2014, Vol.63, 2984-2995. doi:https://doi.org/10.2337/db13-1121
Pancreatic β-Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
Alberto Bartolomé; Maki Kimura-Koyanagi; Shun-Ichiro Asahara; Carlos Guillén; Hiroyuki Inoue; Kyoko Teruyama; Shinobu Shimizu; Ayumi Kanno; Ana García-Aguilar; Masato Koike; Yasuo Uchiyama; Manuel Benito; Tetsuo Noda; Yoshiaki Kido
Diabetes August 2014, Vol.63, 2996-3008. doi:https://doi.org/10.2337/db13-0970
ADCY5 Couples Glucose to Insulin Secretion in Human Islets
David J. Hodson; Ryan K. Mitchell; Lorella Marselli; Timothy J. Pullen; Silvia Gimeno Brias; Francesca Semplici; Katy L. Everett; Dermot M.F. Cooper; Marco Bugliani; Piero Marchetti; Vanessa Lavallard; Domenico Bosco; Lorenzo Piemonti; Paul R. Johnson; Stephen J. Hughes; Daliang Li; Wen-Hong Li; A.M. James Shapiro; Guy A. Rutter
Diabetes August 2014, Vol.63, 3009-3021. doi:https://doi.org/10.2337/db13-1607
Immunology and Transplantation
Identification of Novel Autoantibodies in Type 1 Diabetic Patients Using a High-Density Protein Microarray
Bo Kyung Koo; Sehyun Chae; Kristine M. Kim; Min Jueng Kang; Eunhee G. Kim; Soo Heon Kwak; Hye Seung Jung; Young Min Cho; Sung Hee Choi; Young Joo Park; Choong Ho Shin; Hak C. Jang; Chan Soo Shin; Daehee Hwang; Eugene C. Yi; Kyong Soo Park
Diabetes August 2014, Vol.63, 3022-3032. doi:https://doi.org/10.2337/db13-1566
Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
Diabetes August 2014, Vol.63, 3033-3040. doi:https://doi.org/10.2337/db13-1952
Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis
Francesca D’Addio; Alessandro Valderrama Vasquez; Moufida Ben Nasr; Edward Franek; Dalong Zhu; Lirong Li; Guang Ning; Emilian Snarski; Paolo Fiorina
Diabetes August 2014, Vol.63, 3041-3046. doi:https://doi.org/10.2337/db14-0295
Pathophysiology
Diabetes Irreversibly Depletes Bone Marrow–Derived Mesenchymal Progenitor Cell Subpopulations
Michael Januszyk; Michael Sorkin; Jason P. Glotzbach; Ivan N. Vial; Zeshaan N. Maan; Robert C. Rennert; Dominik Duscher; Hariharan Thangarajah; Michael T. Longaker; Atul J. Butte; Geoffrey C. Gurtner
Diabetes August 2014, Vol.63, 3047-3056. doi:https://doi.org/10.2337/db13-1366
Complications
Angiopoietin 2 Induces Pericyte Apoptosis via α3β1 Integrin Signaling in Diabetic Retinopathy
Diabetes August 2014, Vol.63, 3057-3068. doi:https://doi.org/10.2337/db13-1942
Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation
Diabetes August 2014, Vol.63, 3069-3076. doi:https://doi.org/10.2337/db13-1916
mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes
Patrice E. Fort; Mandy K. Losiewicz; Subramaniam Pennathur; Leonard S. Jefferson; Scot R. Kimball; Steven F. Abcouwer; Thomas W. Gardner
Diabetes August 2014, Vol.63, 3077-3090. doi:https://doi.org/10.2337/db14-0235
Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease
Sih Min Tan; Arpeeta Sharma; Nada Stefanovic; Derek Y.C. Yuen; Tom C. Karagiannis; Colin Meyer; Keith W. Ward; Mark E. Cooper; Judy B. de Haan
Diabetes August 2014, Vol.63, 3091-3103. doi:https://doi.org/10.2337/db13-1743
Progression of Early Retinal Dysfunction in Diabetes Over Time: Results of a Long-term Prospective Clinical Study
Diabetes August 2014, Vol.63, 3104-3111. doi:https://doi.org/10.2337/db13-1628
Task-Induced Brain Activity Patterns in Type 2 Diabetes: A Potential Biomarker for Cognitive Decline
Thomas J. Marder; Veronica L. Flores; Nicolas R. Bolo; Wouter S. Hoogenboom; Donald C. Simonson; Alan M. Jacobson; Sarah E. Foote; Martha E. Shenton; Reisa A. Sperling; Gail Musen
Diabetes August 2014, Vol.63, 3112-3119. doi:https://doi.org/10.2337/db13-1783
Pharmacology and Therapeutics
Recommendations for the Definition of Clinical Responder in Insulin Preservation Studies
Diabetes August 2014, Vol.63, 3120-3127. doi:https://doi.org/10.2337/db14-0095
Genetics / Genomes / Proteomics / Metabolomics
IRS1 G972R Missense Polymorphism Is Associated With Failure to Oral Antidiabetes Drugs in White Patients With Type 2 Diabetes From Italy
Sabrina Prudente; Eleonora Morini; Daniela Lucchesi; Olga Lamacchia; Diego Bailetti; Luana Mercuri; Federica Alberico; Massimiliano Copetti; Laura Pucci; Stefania Fariello; Laura Giusti; Mauro Cignarelli; Giuseppe Penno; Salvatore De Cosmo; Vincenzo Trischitta
Diabetes August 2014, Vol.63, 3135-3140. doi:https://doi.org/10.2337/db13-1966
MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
C. Lisa Kurtz; Bailey C.E. Peck; Emily E. Fannin; Carine Beysen; Ji Miao; Stuart R. Landstreet; Shengli Ding; Vandana Turaga; P. Kay Lund; Scott Turner; Sudha B. Biddinger; Kasey C. Vickers; Praveen Sethupathy
Diabetes August 2014, Vol.63, 3141-3148. doi:https://doi.org/10.2337/db13-1015
Pleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels
Naishi Li; Marijke R. van der Sijde; LifeLines Cohort Study Group; Stephan J.L. Bakker; Robin P.F. Dullaart; Pim van der Harst; Ron T. Gansevoort; Clara C. Elbers; Cisca Wijmenga; Harold Snieder; Marten H. Hofker; Jingyuan Fu
Diabetes August 2014, Vol.63, 3149-3158. doi:https://doi.org/10.2337/db13-1800
Addendum
GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance. Diabetes 2012;61:1090—1099
Rasmus S. Biensø; Stine Ringholm; Kristian Kiilerich; Niels-Jacob Aachmann-Andersen; Rikke Krogh-Madsen; Borja Guerra; Peter Plomgaard; Gerrit van Hall; Jonas T. Treebak; Bengt Saltin; Carsten Lundby; Jose A.L. Calbet; Henriette Pilegaard; Jørgen F.P. Wojtaszewski
Diabetes August 2014, Vol.63, 3159. doi:https://doi.org/10.2337/db14-ad09
Issues and Events
E-Letters: Comments and Responses
Comment on Wu and Spiegelman. Irisin ERKs the Fat. Diabetes 2014;63:381−383
Diabetes August 2014, Vol.63, e16. doi:https://doi.org/10.2337/db14-0776
Response to Comment on Wu and Spiegelman. Irisin ERKs the Fat. Diabetes 2014;63:381−383
Diabetes August 2014, Vol.63, e17. doi:https://doi.org/10.2337/db14-0898