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1 January 2015
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Topics:
exenatide
,
forkhead box protein o1
,
glucagon-like peptide 1
,
hippocampus
,
wound healing
Diabetes December 2014, Vol.64, 1-2. doi:https://doi.org/10.2337/db15-ti01
Commentaries
Mineralocorticoid Receptors: An Appealing Target to Treat Coronary Microvascular Dysfunction in Diabetes
Topics:
microvascular angina
,
mineralocorticoid receptor
,
angiotensin-converting enzyme inhibitors
,
obesity
Diabetes December 2014, Vol.64, 3-5. doi:https://doi.org/10.2337/db14-1425
Glucose-Dependent Foxo1 Switch in Healing Wounds: A Shred of Hope for Diabetic Ulcers?
Topics:
diabetic ulcer
,
forkhead box protein o1
,
glucose
,
insulin
Diabetes December 2014, Vol.64, 6-8. doi:https://doi.org/10.2337/db14-1440
Metabolism
Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype
Carlos Escande; Veronica Nin; Tamar Pirtskhalava; Claudia C.S. Chini; Tamar Tchkonia; James L. Kirkland; Eduardo N. Chini
Topics:
adipocytes
,
adipose tissue
,
diet, high-fat
,
mice
,
obesity
Diabetes July 2014, Vol.64, 12-22. doi:https://doi.org/10.2337/db14-0192
Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
Lei O. Li; Trisha J. Grevengoed; David S. Paul; Olga Ilkayeva; Timothy R. Koves; Florencia Pascual; Christopher B. Newgard; Deborah M. Muoio; Rosalind A. Coleman
Topics:
acyl coenzyme a
,
glucose
,
metabolites
,
mice
,
oxidation
Diabetes July 2014, Vol.64, 23-35. doi:https://doi.org/10.2337/db13-1070
Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice
Ying Liu; Rengasamy Palanivel; Esther Rai; Min Park; Tim V. Gabor; Michael P. Scheid; Aimin Xu; Gary Sweeney
Topics:
adiponectin
,
autophagy
,
mice
,
oxidative stress
,
skeletal muscles
Diabetes July 2014, Vol.64, 36-48. doi:https://doi.org/10.2337/db14-0267
Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
Kun Lian; Chaosheng Du; Yi Liu; Di Zhu; Wenjun Yan; Haifeng Zhang; Zhibo Hong; Peilin Liu; Lijian Zhang; Haifeng Pei; Jinglong Zhang; Chao Gao; Chao Xin; Hexiang Cheng; Lize Xiong; Ling Tao
Topics:
amino acids, branched-chain
,
mice
,
catabolism
,
ampk
,
plasma
Diabetes July 2014, Vol.64, 49-59. doi:https://doi.org/10.2337/db14-0312
PRMT3 Regulates Hepatic Lipogenesis Through Direct Interaction With LXRα
Dong-il Kim; Min-jung Park; Seul-ki Lim; Jae-il Park; Kyung-chul Yoon; Ho-jae Han; Jan-Åke Gustafsson; Jae-hyang Lim; Soo-hyun Park
Topics:
antibodies
,
arginine
,
cell nucleus
,
diet, high-fat
,
lipogenesis
Diabetes September 2014, Vol.64, 60-71. doi:https://doi.org/10.2337/db13-1394
Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes
Mikkel Christensen; Salvatore Calanna; Alexander H. Sparre-Ulrich; Peter L. Kristensen; Mette M. Rosenkilde; Jens Faber; Francesco Purrello; Gerrit van Hall; Jens J. Holst; Tina Vilsbøll; Filip K. Knop
Topics:
glucagon
,
glucagon-like peptide 1
,
glucose
,
hypoglycemia
,
insulin
Diabetes July 2014, Vol.64, 72-78. doi:https://doi.org/10.2337/db14-0440
Signal Transduction
GLP-1 and Exendin-4 Transiently Enhance GABAA Receptor–Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
Topics:
exenatide
,
gamma-aminobutyric acid
,
glucagon-like peptide 1
,
hippocampus
,
neurons
Diabetes August 2014, Vol.64, 79-89. doi:https://doi.org/10.2337/db14-0668
Obesity Studies
Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance
Xavier S. Revelo; Sue Tsai; Helena Lei; Helen Luck; Magar Ghazarian; Hubert Tsui; Sally Y. Shi; Stephanie Schroer; Cynthia T. Luk; Gloria H.Y. Lin; Tak W. Mak; Minna Woo; Shawn Winer; Daniel A. Winer
Topics:
cytokine
,
insulin
,
insulin resistance
,
mice
,
mice, knockout
Diabetes July 2014, Vol.64, 90-103. doi:https://doi.org/10.2337/db13-1524
Pancreastatin-Dependent Inflammatory Signaling Mediates Obesity-Induced Insulin Resistance
Gautam K. Bandyopadhyay; Minh Lu; Ennio Avolio; Jawed A. Siddiqui; Jiaur R. Gayen; Joshua Wollam; Christine U. Vu; Nai-Wen Chi; Daniel T. O’Connor; Sushil K. Mahata
Topics:
chromogranin a
,
inflammation
,
insulin
,
insulin resistance
,
mice
Diabetes July 2014, Vol.64, 104-116. doi:https://doi.org/10.2337/db13-1747
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity
Min Park; Ja-Woon Yi; Eun-Mi Kim; Il-Joo Yoon; Eun-Hee Lee; Hwa-Youn Lee; Kon-Young Ji; Kwang-Ho Lee; Ji-Hun Jang; Seung-Su Oh; Chul-Ho Yun; Seung-Hyung Kim; Ki-Mo Lee; Mun-Gyu Song; Dong-Hoon Kim; Hyung-Sik Kang
Topics:
mice
,
obesity
,
trem2 gene
,
adipocytes
Diabetes August 2014, Vol.64, 117-127. doi:https://doi.org/10.2337/db13-1869
Adiponectin Induces A20 Expression in Adipose Tissue to Confer Metabolic Benefit
Laura E. Hand; Paola Usan; Garth J.S. Cooper; Lance Y. Xu; Basil Ammori; Peter S. Cunningham; Reza Aghamohammadzadeh; Handrean Soran; Adam Greenstein; Andrew S.I. Loudon; David A. Bechtold; David W. Ray
Topics:
adiponectin
,
adipose tissue
,
inflammation
,
mice
,
obesity
Diabetes September 2014, Vol.64, 128-136. doi:https://doi.org/10.2337/db13-1835
Distinct Networks of Leptin- and Insulin-Sensing Neurons Regulate Thermogenic Responses to Nutritional and Cold Challenges
Topics:
cold temperature
,
common cold
,
insulin
,
insulin receptor
,
leptin
Diabetes August 2014, Vol.64, 137-146. doi:https://doi.org/10.2337/db14-0567
Islet Studies
PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance
Linyuan Wang; Cynthia T. Luk; Erica P. Cai; Stephanie A. Schroer; Emma M. Allister; Sally Y. Shi; Michael B. Wheeler; Herbert Y. Gaisano; Minna Woo
Topics:
glucagon
,
mice
,
pten gene
,
glucagon secretion
,
arginine
Diabetes August 2014, Vol.64, 147-157. doi:https://doi.org/10.2337/db13-1715
Immunology and Transplantation
Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens
Sonja Kleffel; Andrea Vergani; Sara Tezza; Moufida Ben Nasr; Monika A. Niewczas; Susan Wong; Roberto Bassi; Francesca D’Addio; Tobias Schatton; Reza Abdi; Mark Atkinson; Mohamed H. Sayegh; Li Wen; Clive H. Wasserfall; Kevin C. O’Connor; Paolo Fiorina
Topics:
b-lymphocytes
,
interleukin-10
,
mice, inbred nod
,
cd40 antigens
Diabetes September 2014, Vol.64, 158-171. doi:https://doi.org/10.2337/db13-1639
Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes
Vimukthi Pathiraja; Janine P. Kuehlich; Peter D. Campbell; Balasubramanian Krishnamurthy; Thomas Loudovaris; P. Toby H. Coates; Thomas C. Brodnicki; Philip J. O’Connell; Katherine Kedzierska; Christine Rodda; Philip Bergman; Erin Hill; Anthony W. Purcell; Nadine L. Dudek; Helen E. Thomas; Thomas W.H. Kay; Stuart I. Mannering
Topics:
clone cells
,
human leukocyte antigens
,
peptides
,
proinsulin
,
t-lymphocytes
Diabetes August 2014, Vol.64, 172-182. doi:https://doi.org/10.2337/db14-0858
Pathophysiology
Impaired Macromolecular Protein Pools in Fronto-Striato-Thalamic Circuits in Type 2 Diabetes Revealed by Magnetization Transfer Imaging
Diabetes August 2014, Vol.64, 183-192. doi:https://doi.org/10.2337/db14-0316
Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults
Michael R. Rickels; Eugen S. Goeser; Carissa Fuller; Christine Lord; Anne M. Bowler; Nicolai M. Doliba; Robert A. Hegele; Marina Cuchel
Topics:
abca1 gene
,
glucose
,
heterozygote
,
high density lipoprotein decreased
,
homozygote
Diabetes August 2014, Vol.64, 193-199. doi:https://doi.org/10.2337/db14-0436
Complications
Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition
Hu Huang; Jianbo He; Da’Kuawn Johnson; Yanhong Wei; Ying Liu; Shuang Wang; Gerard A. Lutty; Elia J. Duh; Peter Carmeliet; Richard D. Semba
Topics:
mice
,
placenta growth factor
,
retina
,
vascular endothelial growth factor a
Diabetes September 2014, Vol.64, 200-212. doi:https://doi.org/10.2337/db14-0016
High Tissue Glucose Alters Intersomitic Blood Vessels in Zebrafish via Methylglyoxal Targeting the VEGF Receptor Signaling Cascade
Kristina Jörgens; Sandra J. Stoll; Jennifer Pohl; Thomas H. Fleming; Carsten Sticht; Peter P. Nawroth; Hans-Peter Hammes; Jens Kroll
Topics:
embryo
,
glucose
,
zebrafish
,
vascular endothelial growth factor receptor-2
,
vascular endothelial growth factor receptors
Diabetes August 2014, Vol.64, 213-225. doi:https://doi.org/10.2337/db14-0352
Perifornical Hypothalamic Orexin and Serotonin Modulate the Counterregulatory Response to Hypoglycemic and Glucoprivic Stimuli
Topics:
glucose
,
orexins
,
serotonin
,
hypoglycemia
,
neurons
Diabetes August 2014, Vol.64, 226-235. doi:https://doi.org/10.2337/db14-0671
Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes
Rajesh Garg; Ajay D. Rao; Maria Baimas-George; Shelley Hurwitz; Courtney Foster; Ravi V. Shah; Michael Jerosch-Herold; Raymond Y. Kwong; Marcelo F. Di Carli; Gail K. Adler
Topics:
diabetes mellitus, type 2
,
hydrochlorothiazide
,
mineralocorticoid receptor
,
spironolactone
,
statins
Diabetes August 2014, Vol.64, 236-242. doi:https://doi.org/10.2337/db14-0670
Foxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds
Fanxing Xu; Badr Othman; Jason Lim; Angelika Batres; Bhaskar Ponugoti; Chenying Zhang; Leah Yi; Jian Liu; Chen Tian; Alhassan Hameedaldeen; Sarah Alsadun; Rohinton Tarapore; Dana T. Graves
Topics:
blood glucose normal
,
forkhead box protein o1
,
glucose
,
mice
,
mucous membrane
Diabetes September 2014, Vol.64, 243-256. doi:https://doi.org/10.2337/db14-0589
Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)
Nordin M.J. Hanssen; Joline W.J. Beulens; Susan van Dieren; Jean L.J.M. Scheijen; Daphne L. van der A; Annemieke M.W. Spijkerman; Yvonne T. van der Schouw; Coen D.A. Stehouwer; Casper G. Schalkwijk
Topics:
cardiovascular event
,
diabetes mellitus, type 2
,
plasma
,
cardiovascular diseases
,
glycosylation end products, advanced
Diabetes May 2014, Vol.64, 257-265. doi:https://doi.org/10.2337/db13-1864
Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression of Type 1 Diabetes
Saul Genuth; Wanjie Sun; Patricia Cleary; Xiaoyu Gao; David R. Sell; John Lachin; The DCCT/EDIC Research Group; Vincent M. Monnier
Topics:
collagen
,
dcct trial
,
edic trial
,
kidney diseases
,
neuropathy
Diabetes September 2014, Vol.64, 266-278. doi:https://doi.org/10.2337/db14-0215
Type 2 Diabetes, Skin Autofluorescence, and Brain Atrophy
Chris Moran; Gerald Münch; Josephine M. Forbes; Richard Beare; Leigh Blizzard; Alison J. Venn; Thanh G. Phan; Jian Chen; Velandai Srikanth
Topics:
autofluorescence
,
cerebral atrophy
,
diabetes mellitus, type 2
,
skin
Diabetes July 2014, Vol.64, 279-283. doi:https://doi.org/10.2337/db14-0506
Pharmacology and Therapeutics
Metformin Supports the Antidiabetic Effect of a Sodium Glucose Cotransporter 2 Inhibitor by Suppressing Endogenous Glucose Production in Diabetic Mice
Susanne Neschen; Markus Scheerer; Anett Seelig; Peter Huypens; Jürgen Schultheiss; Moya Wu; Wolfgang Wurst; Birgit Rathkolb; Karsten Suhre; Eckhard Wolf; Johannes Beckers; Martin Hrabé de Angelis
Topics:
glucose
,
metformin
,
mice
,
combined modality therapy
,
blood glucose
Diabetes July 2014, Vol.64, 284-290. doi:https://doi.org/10.2337/db14-0393
Genetics / Genomes / Proteomics / Metabolomics
Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
Joo-Yeon Hwang; Xueling Sim; Ying Wu; Jun Liang; Yasuharu Tabara; Cheng Hu; Kazuo Hara; Claudia H.T. Tam; Qiuyin Cai; Qi Zhao; Sunha Jee; Fumihiko Takeuchi; Min Jin Go; Rick Twee Hee Ong; Takayoshi Ohkubo; Young Jin Kim; Rong Zhang; Toshimasa Yamauchi; Wing Yee So; Jirong Long; Dongfeng Gu; Nanette R. Lee; Soriul Kim; Tomohiro Katsuya; Ji Hee Oh; Jianjun Liu; Satoshi Umemura; Yeon-Jung Kim; Feng Jiang; Shiro Maeda; Juliana C.N. Chan; Wei Lu; James E. Hixson; Linda S. Adair; Keum Ji Jung; Toru Nabika; Jae-Bum Bae; Mi Hee Lee; Mark Seielstad; Terri L. Young; Yik Ying Teo; Yoshikuni Kita; Naoyuki Takashima; Haruhiko Osawa; So-Hyun Lee; Min-Ho Shin; Dong Hoon Shin; Bo Youl Choi; Jiajun Shi; Yu-Tang Gao; Yong-Bing Xiang; Wei Zheng; Norihiro Kato; Miwuk Yoon; Jiang He; Xiao Ou Shu; Ronald C.W. Ma; Takashi Kadowaki; Weiping Jia; Tetsuro Miki; Lu Qi; E Shyong Tai; Karen L. Mohlke; Bok-Ghee Han; Yoon Shin Cho; Bong-Jo Kim
Topics:
fasting
,
fasting blood glucose measurement
,
genetics
,
genome
,
genotype determination
Diabetes September 2014, Vol.64, 291-298. doi:https://doi.org/10.2337/db14-0563
Clinical and Molecular Characterization of a Novel PLIN1 Frameshift Mutation Identified in Patients With Familial Partial Lipodystrophy
Kristina Kozusko; Venessa H.M. Tsang; William Bottomley; Yoon-Hi Cho; Sheetal Gandotra; Michael Mimmack; Koini Lim; Iona Isaac; Satish Patel; Vladimir Saudek; Stephen O’Rahilly; Shubha Srinivasan; Jerry R. Greenfield; Ines Barroso; Lesley V. Campbell; David B. Savage
Topics:
lipid droplet
,
mutation
,
perilipin
,
proband
,
frameshift mutation function
Diabetes August 2014, Vol.64, 299-310. doi:https://doi.org/10.2337/db14-0104
Statement of Principle
Statement of Principle
Topics:
cancer
,
endocrinologists
,
endocrinology
,
hormones
,
delivery of health care
Diabetes November 2014, Vol.64, 311. doi:https://doi.org/10.2337/db14-sp01
Erratum
Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle. Diabetes 2011;60:1111–1121
Karim Bouzakri; Peter Plomgaard; Thierry Berney; Marc Y. Donath; Bente Karlund Pedersen; Philippe A. Halban
Topics:
insulin
,
pancreas
,
skeletal muscles
Diabetes December 2014, Vol.64, 312. doi:https://doi.org/10.2337/db15-er01a
