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Volume 64, Issue 1
1 January 2015
Diabetes Cover Image for Volume 64, Issue 1
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes December 2014, Vol.64, 1-2. doi:https://doi.org/10.2337/db15-ti01

Commentaries

Mineralocorticoid Receptors: An Appealing Target to Treat Coronary Microvascular Dysfunction in Diabetes
Shawn B. Bender; Guanghong Jia; James R. Sowers
View articletitled, Mineralocorticoid Receptors: An Appealing Target to Treat Coronary Microvascular Dysfunction in Diabetes
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Diabetes December 2014, Vol.64, 3-5. doi:https://doi.org/10.2337/db14-1425
Glucose-Dependent Foxo1 Switch in Healing Wounds: A Shred of Hope for Diabetic Ulcers?
Sigal Shaklai; Gabi Shefer; Naftali Stern
View articletitled, Glucose-Dependent Foxo1 Switch in Healing Wounds: A Shred of Hope for Diabetic Ulcers?
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Diabetes December 2014, Vol.64, 6-8. doi:https://doi.org/10.2337/db14-1440
Hidden Complexities in the Measurement of Fructosyl-Lysine and Advanced Glycation End Products for Risk Prediction of Vascular Complications of Diabetes
Naila Rabbani; Paul J. Thornalley
View articletitled, Hidden Complexities in the Measurement of Fructosyl-Lysine and Advanced Glycation End Products for Risk Prediction of Vascular Complications of Diabetes
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Diabetes December 2014, Vol.64, 9-11. doi:https://doi.org/10.2337/db14-1516

Metabolism

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype
Carlos Escande; Veronica Nin; Tamar Pirtskhalava; Claudia C.S. Chini; Tamar Tchkonia; James L. Kirkland; Eduardo N. Chini
View articletitled, Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype
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Diabetes July 2014, Vol.64, 12-22. doi:https://doi.org/10.2337/db14-0192
Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
Lei O. Li; Trisha J. Grevengoed; David S. Paul; Olga Ilkayeva; Timothy R. Koves; Florencia Pascual; Christopher B. Newgard; Deborah M. Muoio; Rosalind A. Coleman
View articletitled, Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
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Diabetes July 2014, Vol.64, 23-35. doi:https://doi.org/10.2337/db13-1070
Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice
Ying Liu; Rengasamy Palanivel; Esther Rai; Min Park; Tim V. Gabor; Michael P. Scheid; Aimin Xu; Gary Sweeney
View articletitled, Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice
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Diabetes July 2014, Vol.64, 36-48. doi:https://doi.org/10.2337/db14-0267
Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
Kun Lian; Chaosheng Du; Yi Liu; Di Zhu; Wenjun Yan; Haifeng Zhang; Zhibo Hong; Peilin Liu; Lijian Zhang; Haifeng Pei; Jinglong Zhang; Chao Gao; Chao Xin; Hexiang Cheng; Lize Xiong; Ling Tao
View articletitled, Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
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Diabetes July 2014, Vol.64, 49-59. doi:https://doi.org/10.2337/db14-0312
PRMT3 Regulates Hepatic Lipogenesis Through Direct Interaction With LXRα
Dong-il Kim; Min-jung Park; Seul-ki Lim; Jae-il Park; Kyung-chul Yoon; Ho-jae Han; Jan-Åke Gustafsson; Jae-hyang Lim; Soo-hyun Park
View articletitled, PRMT3 Regulates Hepatic Lipogenesis Through Direct Interaction With LXRα
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Diabetes September 2014, Vol.64, 60-71. doi:https://doi.org/10.2337/db13-1394
Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes
Mikkel Christensen; Salvatore Calanna; Alexander H. Sparre-Ulrich; Peter L. Kristensen; Mette M. Rosenkilde; Jens Faber; Francesco Purrello; Gerrit van Hall; Jens J. Holst; Tina Vilsbøll; Filip K. Knop
View articletitled, Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes
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Diabetes July 2014, Vol.64, 72-78. doi:https://doi.org/10.2337/db14-0440

Signal Transduction

GLP-1 and Exendin-4 Transiently Enhance GABAA Receptor–Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
Sergiy V. Korol; Zhe Jin; Omar Babateen; Bryndis Birnir
View articletitled, GLP-1 and Exendin-4 Transiently Enhance GABA<sub>A</sub> Receptor–Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Diabetes August 2014, Vol.64, 79-89. doi:https://doi.org/10.2337/db14-0668

Obesity Studies

Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance
Xavier S. Revelo; Sue Tsai; Helena Lei; Helen Luck; Magar Ghazarian; Hubert Tsui; Sally Y. Shi; Stephanie Schroer; Cynthia T. Luk; Gloria H.Y. Lin; Tak W. Mak; Minna Woo; Shawn Winer; Daniel A. Winer
View articletitled, Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance
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Diabetes July 2014, Vol.64, 90-103. doi:https://doi.org/10.2337/db13-1524
Pancreastatin-Dependent Inflammatory Signaling Mediates Obesity-Induced Insulin Resistance
Gautam K. Bandyopadhyay; Minh Lu; Ennio Avolio; Jawed A. Siddiqui; Jiaur R. Gayen; Joshua Wollam; Christine U. Vu; Nai-Wen Chi; Daniel T. O’Connor; Sushil K. Mahata
View articletitled, Pancreastatin-Dependent Inflammatory Signaling Mediates Obesity-Induced Insulin Resistance
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Diabetes July 2014, Vol.64, 104-116. doi:https://doi.org/10.2337/db13-1747
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity
Min Park; Ja-Woon Yi; Eun-Mi Kim; Il-Joo Yoon; Eun-Hee Lee; Hwa-Youn Lee; Kon-Young Ji; Kwang-Ho Lee; Ji-Hun Jang; Seung-Su Oh; Chul-Ho Yun; Seung-Hyung Kim; Ki-Mo Lee; Mun-Gyu Song; Dong-Hoon Kim; Hyung-Sik Kang
View articletitled, Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Promotes Adipogenesis and Diet-Induced Obesity
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Diabetes August 2014, Vol.64, 117-127. doi:https://doi.org/10.2337/db13-1869
Adiponectin Induces A20 Expression in Adipose Tissue to Confer Metabolic Benefit
Laura E. Hand; Paola Usan; Garth J.S. Cooper; Lance Y. Xu; Basil Ammori; Peter S. Cunningham; Reza Aghamohammadzadeh; Handrean Soran; Adam Greenstein; Andrew S.I. Loudon; David A. Bechtold; David W. Ray
View articletitled, Adiponectin Induces A20 Expression in Adipose Tissue to Confer Metabolic Benefit
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Diabetes September 2014, Vol.64, 128-136. doi:https://doi.org/10.2337/db13-1835
Distinct Networks of Leptin- and Insulin-Sensing Neurons Regulate Thermogenic Responses to Nutritional and Cold Challenges
Angie C.N. Chong; Richard A. Greendyk; Lori M. Zeltser
View articletitled, Distinct Networks of Leptin- and Insulin-Sensing Neurons Regulate Thermogenic Responses to Nutritional and Cold Challenges
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Diabetes August 2014, Vol.64, 137-146. doi:https://doi.org/10.2337/db14-0567

Islet Studies

PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance
Linyuan Wang; Cynthia T. Luk; Erica P. Cai; Stephanie A. Schroer; Emma M. Allister; Sally Y. Shi; Michael B. Wheeler; Herbert Y. Gaisano; Minna Woo
View articletitled, PTEN Deletion in Pancreatic α-Cells Protects Against High-Fat Diet–Induced Hyperglucagonemia and Insulin Resistance
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Diabetes August 2014, Vol.64, 147-157. doi:https://doi.org/10.2337/db13-1715

Immunology and Transplantation

Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens
Sonja Kleffel; Andrea Vergani; Sara Tezza; Moufida Ben Nasr; Monika A. Niewczas; Susan Wong; Roberto Bassi; Francesca D’Addio; Tobias Schatton; Reza Abdi; Mark Atkinson; Mohamed H. Sayegh; Li Wen; Clive H. Wasserfall; Kevin C. O’Connor; Paolo Fiorina
View articletitled, Interleukin-10<sup>+</sup> Regulatory B Cells Arise Within Antigen-Experienced CD40<sup>+</sup> B Cells to Maintain Tolerance to Islet Autoantigens
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Diabetes September 2014, Vol.64, 158-171. doi:https://doi.org/10.2337/db13-1639
Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes
Vimukthi Pathiraja; Janine P. Kuehlich; Peter D. Campbell; Balasubramanian Krishnamurthy; Thomas Loudovaris; P. Toby H. Coates; Thomas C. Brodnicki; Philip J. O’Connell; Katherine Kedzierska; Christine Rodda; Philip Bergman; Erin Hill; Anthony W. Purcell; Nadine L. Dudek; Helen E. Thomas; Thomas W.H. Kay; Stuart I. Mannering
View articletitled, Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4<sup>+</sup> T Cells Infiltrate Islets in Type 1 Diabetes
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Diabetes August 2014, Vol.64, 172-182. doi:https://doi.org/10.2337/db14-0858

Pathophysiology

Impaired Macromolecular Protein Pools in Fronto-Striato-Thalamic Circuits in Type 2 Diabetes Revealed by Magnetization Transfer Imaging
Shaolin Yang; Olusola Ajilore; Minjie Wu; Melissa Lamar; Anand Kumar
View articletitled, Impaired Macromolecular Protein Pools in Fronto-Striato-Thalamic Circuits in Type 2 Diabetes Revealed by Magnetization Transfer Imaging
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Diabetes August 2014, Vol.64, 183-192. doi:https://doi.org/10.2337/db14-0316
Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults
Michael R. Rickels; Eugen S. Goeser; Carissa Fuller; Christine Lord; Anne M. Bowler; Nicolai M. Doliba; Robert A. Hegele; Marina Cuchel
View articletitled, Loss-of-Function Mutations in <em>ABCA1</em> and Enhanced β-Cell Secretory Capacity in Young Adults
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Diabetes August 2014, Vol.64, 193-199. doi:https://doi.org/10.2337/db14-0436

Complications

Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition
Hu Huang; Jianbo He; Da’Kuawn Johnson; Yanhong Wei; Ying Liu; Shuang Wang; Gerard A. Lutty; Elia J. Duh; Peter Carmeliet; Richard D. Semba
View articletitled, Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition
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Diabetes September 2014, Vol.64, 200-212. doi:https://doi.org/10.2337/db14-0016
High Tissue Glucose Alters Intersomitic Blood Vessels in Zebrafish via Methylglyoxal Targeting the VEGF Receptor Signaling Cascade
Kristina Jörgens; Sandra J. Stoll; Jennifer Pohl; Thomas H. Fleming; Carsten Sticht; Peter P. Nawroth; Hans-Peter Hammes; Jens Kroll
View articletitled, High Tissue Glucose Alters Intersomitic Blood Vessels in Zebrafish via Methylglyoxal Targeting the VEGF Receptor Signaling Cascade
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Diabetes August 2014, Vol.64, 213-225. doi:https://doi.org/10.2337/db14-0352
Perifornical Hypothalamic Orexin and Serotonin Modulate the Counterregulatory Response to Hypoglycemic and Glucoprivic Stimuli
Oleg Otlivanchik; Christelle Le Foll; Barry E. Levin
View articletitled, Perifornical Hypothalamic Orexin and Serotonin Modulate the Counterregulatory Response to Hypoglycemic and Glucoprivic Stimuli
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Diabetes August 2014, Vol.64, 226-235. doi:https://doi.org/10.2337/db14-0671
Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes
Rajesh Garg; Ajay D. Rao; Maria Baimas-George; Shelley Hurwitz; Courtney Foster; Ravi V. Shah; Michael Jerosch-Herold; Raymond Y. Kwong; Marcelo F. Di Carli; Gail K. Adler
View articletitled, Mineralocorticoid Receptor Blockade Improves Coronary Microvascular Function in Individuals With Type 2 Diabetes
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Diabetes August 2014, Vol.64, 236-242. doi:https://doi.org/10.2337/db14-0670
Foxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds
Fanxing Xu; Badr Othman; Jason Lim; Angelika Batres; Bhaskar Ponugoti; Chenying Zhang; Leah Yi; Jian Liu; Chen Tian; Alhassan Hameedaldeen; Sarah Alsadun; Rohinton Tarapore; Dana T. Graves
View articletitled, Foxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds
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Diabetes September 2014, Vol.64, 243-256. doi:https://doi.org/10.2337/db14-0589
Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)
Nordin M.J. Hanssen; Joline W.J. Beulens; Susan van Dieren; Jean L.J.M. Scheijen; Daphne L. van der A; Annemieke M.W. Spijkerman; Yvonne T. van der Schouw; Coen D.A. Stehouwer; Casper G. Schalkwijk
View articletitled, Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL)
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Diabetes May 2014, Vol.64, 257-265. doi:https://doi.org/10.2337/db13-1864
Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression of Type 1 Diabetes
Saul Genuth; Wanjie Sun; Patricia Cleary; Xiaoyu Gao; David R. Sell; John Lachin; The DCCT/EDIC Research Group; Vincent M. Monnier
View articletitled, Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression of Type 1 Diabetes
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Diabetes September 2014, Vol.64, 266-278. doi:https://doi.org/10.2337/db14-0215
Type 2 Diabetes, Skin Autofluorescence, and Brain Atrophy
Chris Moran; Gerald Münch; Josephine M. Forbes; Richard Beare; Leigh Blizzard; Alison J. Venn; Thanh G. Phan; Jian Chen; Velandai Srikanth
View articletitled, Type 2 Diabetes, Skin Autofluorescence, and Brain Atrophy
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Diabetes July 2014, Vol.64, 279-283. doi:https://doi.org/10.2337/db14-0506

Pharmacology and Therapeutics

Metformin Supports the Antidiabetic Effect of a Sodium Glucose Cotransporter 2 Inhibitor by Suppressing Endogenous Glucose Production in Diabetic Mice
Susanne Neschen; Markus Scheerer; Anett Seelig; Peter Huypens; Jürgen Schultheiss; Moya Wu; Wolfgang Wurst; Birgit Rathkolb; Karsten Suhre; Eckhard Wolf; Johannes Beckers; Martin Hrabé de Angelis
View articletitled, Metformin Supports the Antidiabetic Effect of a Sodium Glucose Cotransporter 2 Inhibitor by Suppressing Endogenous Glucose Production in Diabetic Mice
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Diabetes July 2014, Vol.64, 284-290. doi:https://doi.org/10.2337/db14-0393

Genetics / Genomes / Proteomics / Metabolomics

Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
Joo-Yeon Hwang; Xueling Sim; Ying Wu; Jun Liang; Yasuharu Tabara; Cheng Hu; Kazuo Hara; Claudia H.T. Tam; Qiuyin Cai; Qi Zhao; Sunha Jee; Fumihiko Takeuchi; Min Jin Go; Rick Twee Hee Ong; Takayoshi Ohkubo; Young Jin Kim; Rong Zhang; Toshimasa Yamauchi; Wing Yee So; Jirong Long; Dongfeng Gu; Nanette R. Lee; Soriul Kim; Tomohiro Katsuya; Ji Hee Oh; Jianjun Liu; Satoshi Umemura; Yeon-Jung Kim; Feng Jiang; Shiro Maeda; Juliana C.N. Chan; Wei Lu; James E. Hixson; Linda S. Adair; Keum Ji Jung; Toru Nabika; Jae-Bum Bae; Mi Hee Lee; Mark Seielstad; Terri L. Young; Yik Ying Teo; Yoshikuni Kita; Naoyuki Takashima; Haruhiko Osawa; So-Hyun Lee; Min-Ho Shin; Dong Hoon Shin; Bo Youl Choi; Jiajun Shi; Yu-Tang Gao; Yong-Bing Xiang; Wei Zheng; Norihiro Kato; Miwuk Yoon; Jiang He; Xiao Ou Shu; Ronald C.W. Ma; Takashi Kadowaki; Weiping Jia; Tetsuro Miki; Lu Qi; E Shyong Tai; Karen L. Mohlke; Bok-Ghee Han; Yoon Shin Cho; Bong-Jo Kim
View articletitled, Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
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Diabetes September 2014, Vol.64, 291-298. doi:https://doi.org/10.2337/db14-0563
Clinical and Molecular Characterization of a Novel PLIN1 Frameshift Mutation Identified in Patients With Familial Partial Lipodystrophy
Kristina Kozusko; Venessa H.M. Tsang; William Bottomley; Yoon-Hi Cho; Sheetal Gandotra; Michael Mimmack; Koini Lim; Iona Isaac; Satish Patel; Vladimir Saudek; Stephen O’Rahilly; Shubha Srinivasan; Jerry R. Greenfield; Ines Barroso; Lesley V. Campbell; David B. Savage
View articletitled, Clinical and Molecular Characterization of a Novel PLIN1 Frameshift Mutation Identified in Patients With Familial Partial Lipodystrophy
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Diabetes August 2014, Vol.64, 299-310. doi:https://doi.org/10.2337/db14-0104

Statement of Principle

Statement of Principle
View articletitled, Statement of Principle
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Diabetes November 2014, Vol.64, 311. doi:https://doi.org/10.2337/db14-sp01

Erratum

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle. Diabetes 2011;60:1111–1121
Karim Bouzakri; Peter Plomgaard; Thierry Berney; Marc Y. Donath; Bente Karlund Pedersen; Philippe A. Halban
View articletitled, Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle. Diabetes 2011;60:<span class="related-article"><a href="XSLT_Related_Article_Replace_Href" data-vol="60" data-page="1111">1111–1121</a></span>
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Diabetes December 2014, Vol.64, 312. doi:https://doi.org/10.2337/db15-er01a

Issues and Events

Issues and Events
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Diabetes December 2014, Vol.64, 313. doi:https://doi.org/10.2337/db15-ie01
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities
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