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Volume 64, Issue 10
1 October 2015
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes September 2015, Vol.64, 3337-3338. doi:https://doi.org/10.2337/db15-ti10

Commentaries

Unsticking the Broken Diabetic Heart: O-GlcNAcylation and Calcium Sensitivity
Adam R. Wende
View articletitled, Unsticking the Broken Diabetic Heart: <em>O-</em>GlcNAcylation and Calcium Sensitivity
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Diabetes September 2015, Vol.64, 3339-3341. doi:https://doi.org/10.2337/dbi15-0001
Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?
Amy C. Arnold; David Robertson
View articletitled, Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?
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Diabetes September 2015, Vol.64, 3342-3344. doi:https://doi.org/10.2337/db15-0822
Paying the Toll for Glucose Regulation: A Central Role for TLR3
Matthew D. Woolard; Christopher G. Kevil
View articletitled, Paying the Toll for Glucose Regulation: A Central Role for TLR3
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Diabetes September 2015, Vol.64, 3345-3346. doi:https://doi.org/10.2337/db15-0679
Alternative Approach to Immunomodulation for Type 1 Diabetes: Antigen-Specific Immunotherapy In Utero
Parth Narendran
View articletitled, Alternative Approach to Immunomodulation for Type 1 Diabetes: Antigen-Specific Immunotherapy In Utero
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Diabetes September 2015, Vol.64, 3347-3349. doi:https://doi.org/10.2337/db15-0825
Kallikrein-Kinin System: An Emerging Competitor or Collaborator for VEGF in Diabetic Macular Edema?
Tomoaki Murakami
View articletitled, Kallikrein-Kinin System: An Emerging Competitor or Collaborator for VEGF in Diabetic Macular Edema?
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Diabetes September 2015, Vol.64, 3350-3352. doi:https://doi.org/10.2337/db15-0746
Too Much or Too Little? The Double Jeopardy of Subcutaneous Insulin Therapy in Diabetes
Mark L. Evans
View articletitled, Too Much or Too Little? The Double Jeopardy of Subcutaneous Insulin Therapy in Diabetes
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Diabetes September 2015, Vol.64, 3353-3354. doi:https://doi.org/10.2337/dbi15-0003

Metabolism

Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway
Bilun Ke; Zhiyun Zhao; Xin Ye; Zhanguo Gao; Vincent Manganiello; Bin Wu; Jianping Ye
View articletitled, Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway
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Diabetes June 2015, Vol.64, 3355-3362. doi:https://doi.org/10.2337/db15-0242
Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase
Silke Herzer; Sascha Meldner; Hermann-Josef Gröne; Viola Nordström
View articletitled, Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase
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Diabetes June 2015, Vol.64, 3363-3376. doi:https://doi.org/10.2337/db14-1726
Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion
Ele Ferrannini; Stefania Camastra; Brenno Astiarraga; Monica Nannipieri; Jose Castro-Perez; Dan Xie; Liangsu Wang; Manu Chakravarthy; Rebecca A. Haeusler
View articletitled, Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion
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Diabetes May 2015, Vol.64, 3377-3385. doi:https://doi.org/10.2337/db15-0214
Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining
Steven J. Prior; Andrew P. Goldberg; Heidi K. Ortmeyer; Eva R. Chin; Dapeng Chen; Jacob B. Blumenthal; Alice S. Ryan
View articletitled, Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining
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Diabetes June 2015, Vol.64, 3386-3395. doi:https://doi.org/10.2337/db14-1771
Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity
Lale Ozcan; Xiaoming Xu; Shi-Xian Deng; Devram S. Ghorpade; Tiffany Thomas; Serge Cremers; Brian Hubbard; Michael H. Serrano-Wu; Matthias Gaestel; Donald W. Landry; Ira Tabas
View articletitled, Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity
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Diabetes June 2015, Vol.64, 3396-3405. doi:https://doi.org/10.2337/db14-1945
Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System
Giuseppe Daniele; Patricia Iozzo; Marjorie Molina-Carrion; Jack Lancaster; Demetrio Ciociaro; Eugenio Cersosimo; Devjit Tripathy; Curtis Triplitt; Peter Fox; Nicolas Musi; Ralph DeFronzo; Amalia Gastaldelli
View articletitled, Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System
Supplementary data
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Diabetes June 2015, Vol.64, 3406-3412. doi:https://doi.org/10.2337/db14-1718
Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β–Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System
Pei-Wen Cheng; Ying-Ying Chen; Wen-Han Cheng; Pei-Jung Lu; Hsin-Hung Chen; Bo-Rong Chen; Tung-Chen Yeh; Gwo-Ching Sun; Michael Hsiao; Ching-Jiunn Tseng
View articletitled, Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β–Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System
Supplementary data
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Diabetes April 2015, Vol.64, 3413-3424. doi:https://doi.org/10.2337/db14-1439
Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion
Daniela Strodthoff; Zuheng Ma; Tina Wirström; Rona J. Strawbridge; Daniel F.J. Ketelhuth; David Engel; Robert Clarke; Sture Falkmer; Anders Hamsten; Göran K. Hansson; Anneli Björklund; Anna M. Lundberg
View articletitled, Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion
Supplementary data
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Diabetes April 2015, Vol.64, 3425-3438. doi:https://doi.org/10.2337/db14-0838
Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes
Justin M. Gregory; Guillaume Kraft; Melanie F. Scott; Doss W. Neal; Ben Farmer; Marta S. Smith; Jon R. Hastings; Eric J. Allen; E. Patrick Donahue; Noelia Rivera; Jason J. Winnick; Dale S. Edgerton; Erica Nishimura; Christian Fledelius; Christian L. Brand; Alan D. Cherrington
View articletitled, Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes
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Diabetes June 2015, Vol.64, 3439-3451. doi:https://doi.org/10.2337/db15-0071

Obesity Studies

DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity
Hedi Soussi; Sophie Reggio; Rohia Alili; Cecilia Prado; Sonia Mutel; Maria Pini; Christine Rouault; Karine Clément; Isabelle Dugail
View articletitled, DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity
Supplementary data
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Diabetes June 2015, Vol.64, 3452-3463. doi:https://doi.org/10.2337/db14-1933
Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease
Jingzhong Ding; Lindsay M. Reynolds; Tanja Zeller; Christian Müller; Kurt Lohman; Barbara J. Nicklas; Stephen B. Kritchevsky; Zhiqing Huang; Alberto de la Fuente; Nicola Soranzo; Robert E. Settlage; Chia-Chi Chuang; Timothy Howard; Ning Xu; Mark O. Goodarzi; Y.-D. Ida Chen; Jerome I. Rotter; David S. Siscovick; John S. Parks; Susan Murphy; David R. Jacobs, Jr.; Wendy Post; Russell P. Tracy; Philipp S. Wild; Stefan Blankenberg; Ina Hoeschele; David Herrington; Charles E. McCall; Yongmei Liu
View articletitled, Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease
Supplementary data
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Diabetes July 2015, Vol.64, 3464-3474. doi:https://doi.org/10.2337/db14-1314

Islet Studies

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells
Scott A. Soleimanpour; Alana M. Ferrari; Jeffrey C. Raum; David N. Groff; Juxiang Yang; Brett A. Kaufman; Doris A. Stoffers
View articletitled, Diabetes Susceptibility Genes <em>Pdx1</em> and <em>Clec16a</em> Function in a Pathway Regulating Mitophagy in β-Cells
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Diabetes June 2015, Vol.64, 3475-3484. doi:https://doi.org/10.2337/db15-0376
Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion
Shiwani Tiwari; Chris Roel; Rachel Wills; Gabriella Casinelli; Mansoor Tanwir; Karen K. Takane; Nathalie M. Fiaschi-Taesch
View articletitled, Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion
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Diabetes July 2015, Vol.64, 3485-3498. doi:https://doi.org/10.2337/db14-1885
Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration
Fabien Delaspre; Rebecca L. Beer; Meritxell Rovira; Wei Huang; Guangliang Wang; Stephen Gee; Maria del Carmen Vitery; Sarah J. Wheelan; Michael J. Parsons
View articletitled, Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration
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Diabetes July 2015, Vol.64, 3499-3509. doi:https://doi.org/10.2337/db15-0153

Immunology and Transplantation

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes
Aimon K. Alkanani; Naoko Hara; Peter A. Gottlieb; Diana Ir; Charles E. Robertson; Brandie D. Wagner; Daniel N. Frank; Danny Zipris
View articletitled, Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes
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Diabetes June 2015, Vol.64, 3510-3520. doi:https://doi.org/10.2337/db14-1847
DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes
Jeffrey D. Price; Chie Hotta-Iwamura; Yongge Zhao; Nicole M. Beauchamp; Kristin V. Tarbell
View articletitled, DCIR2<sup>+</sup> cDC2 DCs and Zbtb32 Restore CD4<sup>+</sup> T-Cell Tolerance and Inhibit Diabetes
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Diabetes June 2015, Vol.64, 3521-3531. doi:https://doi.org/10.2337/db14-1880
Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes
Slobodan Culina; Nimesh Gupta; Raphael Boisgard; Georgia Afonso; Marie-Claude Gagnerault; Jordan Dimitrov; Thomas Østerbye; Sune Justesen; Sandrine Luce; Mikhaël Attias; Bruno Kyewski; Søren Buus; F. Susan Wong; Sebastien Lacroix-Desmazes; Roberto Mallone
View articletitled, Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes
Supplementary data
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Diabetes April 2015, Vol.64, 3532-3542. doi:https://doi.org/10.2337/db15-0024

Pathophysiology

Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro
Jean-Claude Henquin; Myriam Nenquin; Yves Guiot; Jacques Rahier; Christine Sempoux
View articletitled, Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro
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Diabetes June 2015, Vol.64, 3543-3553. doi:https://doi.org/10.2337/db15-0527

Complications

Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes
Shuhua Fu; Shuqian Dong; Meili Zhu; David M. Sherry; Changyun Wang; Zhipeng You; Jody J. Haigh; Yun-Zheng Le
View articletitled, Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes
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Diabetes June 2015, Vol.64, 3554-3563. doi:https://doi.org/10.2337/db15-0180
Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats
Xiaoning Fan; Owen Chan; Yuyan Ding; Wanling Zhu; Jason Mastaitis; Robert Sherwin
View articletitled, Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats
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Diabetes June 2015, Vol.64, 3564-3572. doi:https://doi.org/10.2337/db15-0022
Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle
Genaro A. Ramirez-Correa; Junfeng Ma; Chad Slawson; Quira Zeidan; Nahyr S. Lugo-Fagundo; Mingguo Xu; Xiaoxu Shen; Wei Dong Gao; Viviane Caceres; Khalid Chakir; Lauren DeVine; Robert N. Cole; Luigi Marchionni; Nazareno Paolocci; Gerald W. Hart; Anne M. Murphy
View articletitled, Removal of Abnormal Myofilament <em>O</em>-GlcNAcylation Restores Ca<sup>2+</sup> Sensitivity in Diabetic Cardiac Muscle
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Diabetes June 2015, Vol.64, 3573-3587. doi:https://doi.org/10.2337/db14-1107
Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema
Takeshi Kita; Allen C. Clermont; Nivetha Murugesan; Qunfang Zhou; Kimihiko Fujisawa; Tatsuro Ishibashi; Lloyd Paul Aiello; Edward P. Feener
View articletitled, Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema
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Diabetes May 2015, Vol.64, 3588-3599. doi:https://doi.org/10.2337/db15-0317

Pharmacology and Therapeutics

Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice
Iolanda Lazaro; Ainhoa Oguiza; Carlota Recio; Beñat Mallavia; Julio Madrigal-Matute; Julia Blanco; Jesus Egido; Jose-Luis Martin-Ventura; Carmen Gomez-Guerrero
View articletitled, Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice
Supplementary data
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Diabetes June 2015, Vol.64, 3600-3613. doi:https://doi.org/10.2337/db14-1926
Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody
Kyle J. Bednar; Hiroki Tsukamoto; Kritika Kachapati; Shoichiro Ohta; Yuehong Wu; Jonathan D. Katz; Dana P. Ascherman; William M. Ridgway
View articletitled, Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody
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Diabetes June 2015, Vol.64, 3614-3626. doi:https://doi.org/10.2337/db14-1868

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes September 2015, Vol.64, 3627. doi:https://doi.org/10.2337/db15-ie10

E-Letters: Comments and Responses

Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
Francesco Zaccardi; David R. Webb; Kamlesh Khunti; Melanie J. Davies
View articletitled, Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
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Diabetes September 2015, Vol.64, e35-e36. doi:https://doi.org/10.2337/db15-0649
Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
Heinrich Taegtmeyer; Christophe Beauloye; Romain Harmancey; Louis Hue
View articletitled, Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
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Diabetes September 2015, Vol.64, e37. doi:https://doi.org/10.2337/db15-0655
Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
Christopher J. Nolan; Neil B. Ruderman; Steven E. Kahn; Oluf Pedersen; Marc Prentki
View articletitled, Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
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Diabetes September 2015, Vol.64, e38-e39. doi:https://doi.org/10.2337/dbi15-0002
Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510–3520
María Esther Mejía-León; Ana María Calderón de la Barca
View articletitled, Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510–3520
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Diabetes September 2015, Vol.64, e40. doi:https://doi.org/10.2337/db15-0848
Response to Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510–3520
Brandie D. Wagner; Daniel N. Frank; Danny Zipris
View articletitled, Response to Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510–3520
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Diabetes September 2015, Vol.64, e41. doi:https://doi.org/10.2337/dbi15-0009
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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