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1 November 2015
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes October 2015, Vol.64, 3629-3630. doi:https://doi.org/10.2337/db15-ti11
Perspectives in Diabetes
Commentaries
Sweet and Low on Leptin: Hormonal Regulation of Sweet Taste Buds
Diabetes October 2015, Vol.64, 3651-3652. doi:https://doi.org/10.2337/dbi15-0004
Enhancing the Metabolic Benefits of Bariatric Surgery: Tipping the Scales With Exercise
Diabetes October 2015, Vol.64, 3656-3658. doi:https://doi.org/10.2337/dbi15-0018
Metabolism
Elevated Hepatic miR-22-3p Expression Impairs Gluconeogenesis by Silencing the Wnt-Responsive Transcription Factor Tcf7
Kirandeep Kaur; Saurabh Vig; Rohit Srivastava; Akansha Mishra; Vijay Pal Singh; Arvind K. Srivastava; Malabika Datta
Diabetes July 2015, Vol.64, 3659-3669. doi:https://doi.org/10.2337/db14-1924
Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin
Diabetes July 2015, Vol.64, 3670-3679. doi:https://doi.org/10.2337/db15-0390
Seven-Day Caloric and Saturated Fat Restriction Increases Myocardial Dietary Fatty Acid Partitioning in Impaired Glucose-Tolerant Subjects
Christophe Noll; Margaret Kunach; Frédérique Frisch; Lucie Bouffard; Stéphanie Dubreuil; Farrah Jean-Denis; Serge Phoenix; Stephen C. Cunnane; Brigitte Guérin; Eric E. Turcotte; André C. Carpentier
Diabetes July 2015, Vol.64, 3690-3699. doi:https://doi.org/10.2337/db15-0337
Ectopic UCP1 Overexpression in White Adipose Tissue Improves Insulin Sensitivity in Lou/C Rats, a Model of Obesity Resistance
Anne-Laure Poher; Christelle Veyrat-Durebex; Jordi Altirriba; Xavier Montet; Didier J. Colin; Aurélie Caillon; Jacqueline Lyautey; Françoise Rohner-Jeanrenaud
Diabetes July 2015, Vol.64, 3700-3712. doi:https://doi.org/10.2337/db15-0210
Matrix-Assisted Transplantation of Functional Beige Adipose Tissue
Kevin M. Tharp; Amit K. Jha; Judith Kraiczy; Alexandra Yesian; Grigory Karateev; Riccardo Sinisi; Elena A. Dubikovskaya; Kevin E. Healy; Andreas Stahl
Diabetes August 2015, Vol.64, 3713-3724. doi:https://doi.org/10.2337/db15-0728
Hypothalamic Nesfatin-1 Stimulates Sympathetic Nerve Activity via Hypothalamic ERK Signaling
Mamoru Tanida; Hitoshi Gotoh; Naoki Yamamoto; Mofei Wang; Yuhichi Kuda; Yasutaka Kurata; Masatomo Mori; Toshishige Shibamoto
Diabetes August 2015, Vol.64, 3725-3736. doi:https://doi.org/10.2337/db15-0282
Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery
Paul M. Coen; Elizabeth V. Menshikova; Giovanna Distefano; Donghai Zheng; Charles J. Tanner; Robert A. Standley; Nicole L. Helbling; Gabriel S. Dubis; Vladimir B. Ritov; Hui Xie; Marisa E. Desimone; Steven R. Smith; Maja Stefanovic-Racic; Frederico G.S. Toledo; Joseph A. Houmard; Bret H. Goodpaster
Diabetes August 2015, Vol.64, 3737-3750. doi:https://doi.org/10.2337/db15-0809
Signal Transduction
Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds
Ryusuke Yoshida; Kenshi Noguchi; Noriatsu Shigemura; Masafumi Jyotaki; Ichiro Takahashi; Robert F. Margolskee; Yuzo Ninomiya
Diabetes June 2015, Vol.64, 3751-3762. doi:https://doi.org/10.2337/db14-1462
Obesity Studies
Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models
Sarah Forbes; Stuart Stafford; Gareth Coope; Helen Heffron; Katia Real; Robert Newman; Richard Davenport; Matt Barnes; Johannes Grosse; Helen Cox
Diabetes August 2015, Vol.64, 3763-3771. doi:https://doi.org/10.2337/db15-0481
Islet Studies
MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
Diabetes July 2015, Vol.64, 3772-3783. doi:https://doi.org/10.2337/db15-0281
Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
Hainan Chen; Jeffrey W. Kleinberger; Karen K. Takane; Fatimah Salim; Nathalie Fiaschi-Taesch; Kyrie Pappas; Ramon Parsons; Jing Jiang; Yue Zhang; Hongtao Liu; Peng Wang; Aaron S. Bender; Stuart J. Frank; Andrew F. Stewart
Diabetes July 2015, Vol.64, 3784-3797. doi:https://doi.org/10.2337/db15-0083
Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone
Daniel Oropeza; Nathalie Jouvet; Lionel Budry; Jonathan E. Campbell; Khalil Bouyakdan; Julie Lacombe; Gabrielle Perron; Valerie Bergeron; Joshua C. Neuman; Harpreet K. Brar; Rachel J. Fenske; Clemence Meunier; Sarah Sczelecki; Michelle E. Kimple; Daniel J. Drucker; Robert A. Screaton; Vincent Poitout; Mathieu Ferron; Thierry Alquier; Jennifer L. Estall
Diabetes July 2015, Vol.64, 3798-3807. doi:https://doi.org/10.2337/db15-0272
TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells
Laura Marroqui; Reinaldo Sousa Dos Santos; Tina Fløyel; Fabio A. Grieco; Izortze Santin; Anne Op de beeck; Lorella Marselli; Piero Marchetti; Flemming Pociot; Decio L. Eizirik
Diabetes August 2015, Vol.64, 3808-3817. doi:https://doi.org/10.2337/db15-0362
Type 2 Diabetes–Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis
Nicholas C. Vierra; Prasanna K. Dadi; Imju Jeong; Matthew Dickerson; David R. Powell; David A. Jacobson
Diabetes August 2015, Vol.64, 3818-3828. doi:https://doi.org/10.2337/db15-0280
Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
Maria L. Golson; Jennifer C. Dunn; Matthew F. Maulis; Prasanna K. Dadi; Anna B. Osipovich; Mark A. Magnuson; David A. Jacobson; Maureen Gannon
Diabetes August 2015, Vol.64, 3829-3838. doi:https://doi.org/10.2337/db15-0465
EphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From α-Cells
Diabetes August 2015, Vol.64, 3839-3851. doi:https://doi.org/10.2337/db15-0488
c-Kit Receptor Signaling Regulates Islet Vasculature, β-Cell Survival, and Function In Vivo
Diabetes August 2015, Vol.64, 3852-3866. doi:https://doi.org/10.2337/db15-0054
Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
Marisa M. Fisher; Renecia A. Watkins; Janice Blum; Carmella Evans-Molina; Naga Chalasani; Linda A. DiMeglio; Kieren J. Mather; Sarah A. Tersey; Raghavendra G. Mirmira
Diabetes July 2015, Vol.64, 3867-3872. doi:https://doi.org/10.2337/db15-0430
Immunology and Transplantation
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
Song Xue; Amanda Posgai; Clive Wasserfall; Courtney Myhr; Martha Campbell-Thompson; Clayton E. Mathews; Todd Brusko; Alex Rabinovitch; Alexei Savinov; Manuela Battaglia; Desmond Schatz; Michael Haller; Mark A. Atkinson
Diabetes July 2015, Vol.64, 3873-3884. doi:https://doi.org/10.2337/db15-0164
Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes
Clayton E. Mathews; Song Xue; Amanda Posgai; Yaima L. Lightfoot; Xia Li; Andrea Lin; Clive Wasserfall; Michael J. Haller; Desmond Schatz; Mark A. Atkinson
Diabetes July 2015, Vol.64, 3885-3890. doi:https://doi.org/10.2337/db15-0449
Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes
Jennie H.M. Yang; Antony J. Cutler; Ricardo C. Ferreira; James L. Reading; Nicholas J. Cooper; Chris Wallace; Pamela Clarke; Deborah J. Smyth; Christopher S. Boyce; Guo-Jian Gao; John A. Todd; Linda S. Wicker; Timothy I.M. Tree
Diabetes July 2015, Vol.64, 3891-3902. doi:https://doi.org/10.2337/db15-0516
Complications
ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice
Greg H. Tesch; Frank Y. Ma; Yingjie Han; John T. Liles; David G. Breckenridge; David J. Nikolic-Paterson
Diabetes July 2015, Vol.64, 3903-3913. doi:https://doi.org/10.2337/db15-0384
Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo
Leena P. Bharath; Ting Ruan; Youyou Li; Anindita Ravindran; Xin Wan; Jennifer Kim Nhan; Matthew Lewis Walker; Lance Deeter; Rebekah Goodrich; Elizabeth Johnson; Derek Munday; Robert Mueller; David Kunz; Deborah Jones; Van Reese; Scott A. Summers; Pon Velayutham Anandh Babu; William L. Holland; Quan-Jiang Zhang; E. Dale Abel; J. David Symons
Diabetes August 2015, Vol.64, 3914-3926. doi:https://doi.org/10.2337/db15-0244
Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
Claudia A. Grillo; Gerardo G. Piroli; Robert C. Lawrence; Shayna A. Wrighten; Adrienne J. Green; Steven P. Wilson; Randall R. Sakai; Sandra J. Kelly; Marlene A. Wilson; David D. Mott; Lawrence P. Reagan
Diabetes July 2015, Vol.64, 3927-3936. doi:https://doi.org/10.2337/db15-0596
Pharmacology and Therapeutics
Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis
Arpeeta Sharma; Stephanie Sellers; Nada Stefanovic; Cleo Leung; Sih Min Tan; Olivier Huet; David J. Granville; Mark E. Cooper; Judy B. de Haan; Pascal Bernatchez
Diabetes June 2015, Vol.64, 3937-3950. doi:https://doi.org/10.2337/db15-0472
Genetics / Genomes / Proteomics / Metabolomics
A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly
Baroj Abdulkarim; Marc Nicolino; Mariana Igoillo-Esteve; Mathilde Daures; Sophie Romero; Anne Philippi; Valérie Senée; Miguel Lopes; Daniel A. Cunha; Heather P. Harding; Céline Derbois; Nathalie Bendelac; Andrew T. Hattersley; Décio L. Eizirik; David Ron; Miriam Cnop; Cécile Julier
Diabetes July 2015, Vol.64, 3951-3962. doi:https://doi.org/10.2337/db15-0477
