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In This Issue of Diabetes

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View articletitled, In This Issue of Diabetes

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Topics: animal testing , antibody therapy , cd34 antigens , cell therapy , diabetes mellitus, type 1

Diabetes November 2015, Vol.64, 3965-3966. doi:https://doi.org/10.2337/db15-ti12

Perspectives in Diabetes

American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome

Clay F. Semenkovich; Jayne Danska; Tamara Darsow; Jessica L. Dunne; Curtis Huttenhower; Richard A. Insel; Allison T. McElvaine; Robert E. Ratner; Alan R. Shuldiner; Martin J. Blaser

Abstract

View articletitled, American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome

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Topics: microbiome , microorganisms , obesity

Diabetes September 2015, Vol.64, 3967-3977. doi:https://doi.org/10.2337/db15-0597

Commentaries

ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes

Mark E. Cleasby

Abstracts

View articletitled, ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes

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Topics: natriuretic peptides , obesity , diabetes mellitus, type 2

Diabetes November 2015, Vol.64, 3978-3980. doi:https://doi.org/10.2337/dbi15-0017

RAGE Against the ABCs

Terri J. Allen; Andrew J. Murphy; Karin A. Jandeleit-Dahm

Abstracts

View articletitled, RAGE Against the ABCs

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Topics: macrophages , rage , abca1 gene , high density lipoproteins , atherosclerosis

Diabetes November 2015, Vol.64, 3981-3983. doi:https://doi.org/10.2337/dbi15-0015

Maintenance of Subcutaneous Fat Homeostasis Improves Systemic Metabolic Dysfunction in Obesity

Ippei Shimizu; Yohko Yoshida; Tohru Minamino

Abstracts

View articletitled, Maintenance of Subcutaneous Fat Homeostasis Improves Systemic Metabolic Dysfunction in Obesity

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Topics: fat, subcutaneous , homeostasis , metabolic disturbance , obesity

Diabetes November 2015, Vol.64, 3984-3986. doi:https://doi.org/10.2337/dbi15-0013

Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?

Slobodan M. Todorovic

Abstracts

View articletitled, Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?

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Topics: ion channels , neurons , neurons, afferent , pain , hyperalgesia

Diabetes November 2015, Vol.64, 3987-3989. doi:https://doi.org/10.2337/dbi15-0006

Back From the Brink: The Uses of Targeting the CXCL10:CXCR3 Axis in Type 1 Diabetes

Dirk Homann

Abstracts

View articletitled, Back From the Brink: The Uses of Targeting the CXCL10:CXCR3 Axis in Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , lymphocytic choriomeningitis virus , mice , t-lymphocytes , antibodies

Diabetes November 2015, Vol.64, 3990-3992. doi:https://doi.org/10.2337/dbi15-0019

Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population

Ewan R. Pearson

Abstracts

View articletitled, Dissecting the Etiology of Type 2 Diabetes in the Pima Indian Population

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Topics: diabetes mellitus, type 2

Diabetes November 2015, Vol.64, 3993-3995. doi:https://doi.org/10.2337/dbi15-0016

Methodology Review

Measurements of Gluconeogenesis and Glycogenolysis: A Methodological Review

Stephanie T. Chung; Shaji K. Chacko; Agneta L. Sunehag; Morey W. Haymond

Abstract

View articletitled, Measurements of Gluconeogenesis and Glycogenolysis: A Methodological Review

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Topics: deuterium , gluconeogenesis , glucose , glycerol , carbon

Diabetes November 2015, Vol.64, 3996-4010. doi:https://doi.org/10.2337/db15-0640

Metabolism

Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling

Zhi-Yong Li; Jie Song; Si-Li Zheng; Mao-Bing Fan; Yun-Feng Guan; Yi Qu; Jian Xu; Pei Wang; Chao-Yu Miao

Abstracts

View articletitled, Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling

Supplementary data

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Topics: adipocytes , insulin resistance , mice , protein overexpression , insulin

Diabetes August 2015, Vol.64, 4011-4022. doi:https://doi.org/10.2337/db15-0274

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

Mengyao Li; Sara G. Vienberg; Olivier Bezy; Brian T. O’Neill; C. Ronald Kahn

Abstracts

View articletitled, Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

Supplementary data

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Topics: insulin , insulin resistance , mice , signal transduction , insulin sensitivity

Diabetes August 2015, Vol.64, 4023-4032. doi:https://doi.org/10.2337/db14-1891

Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes

Marine Coué; Pierre-Marie Badin; Isabelle K. Vila; Claire Laurens; Katie Louche; Marie-Adeline Marquès; Virginie Bourlier; Etienne Mouisel; Geneviève Tavernier; Arild C. Rustan; Jose E. Galgani; Denis R. Joanisse; Steven R. Smith; Dominique Langin; Cedric Moro

Abstracts

View articletitled, Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes

Supplementary data

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Topics: brain natriuretic peptide , infusion procedures , insulin , lipids , mice

Diabetes August 2015, Vol.64, 4033-4045. doi:https://doi.org/10.2337/db15-0305

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes

Gurdip Daffu; Xiaoping Shen; Laura Senatus; Devi Thiagarajan; Andisheh Abedini; Carmen Hurtado del Pozo; Rosa Rosario; Fei Song; Richard A. Friedman; Ravichandran Ramasamy; Ann Marie Schmidt

Abstracts

View articletitled, RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes

Supplementary data

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Topics: cholesterol , high density lipoproteins , macrophages , mice , rage

Diabetes August 2015, Vol.64, 4046-4060. doi:https://doi.org/10.2337/db15-0575

Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue

Yang Liu; Xin Ge; Xin Dou; Liang Guo; Yuan Liu; Shui-rong Zhou; Xiang-bo Wei; Shu-wen Qian; Hai-yan Huang; Cong-jian Xu; Wei-Ping Jia; Yong-jun Dang; Xi Li; Qi-qun Tang

Abstracts

View articletitled, Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue

Supplementary data

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Topics: adipocytes , adipose tissue , fat transplantation , inflammation , insulin

Diabetes August 2015, Vol.64, 4061-4074. doi:https://doi.org/10.2337/db15-0278

Regulation of De Novo Adipocyte Differentiation Through Cross Talk Between Adipocytes and Preadipocytes

Tenagne D. Challa; Leon G. Straub; Miroslav Balaz; Elke Kiehlmann; Olivier Donze; Gottfried Rudofsky; Jozef Ukropec; Barbara Ukropcova; Christian Wolfrum

Abstract

View articletitled, Regulation of De Novo Adipocyte Differentiation Through Cross Talk Between Adipocytes and Preadipocytes

Supplementary data

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Topics: adipocytes , adipose tissue

Diabetes September 2015, Vol.64, 4075-4087. doi:https://doi.org/10.2337/db14-1932

The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

Jizheng Chen; Ning Wang; Mei Dong; Min Guo; Yang Zhao; Zhiyong Zhuo; Chao Zhang; Xiumei Chi; Yu Pan; Jing Jiang; Hong Tang; Junqi Niu; Dongliang Yang; Zhong Li; Xiao Han; Qian Wang; Xinwen Chen

Abstract

View articletitled, The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection

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Topics: forkhead box protein o1 , hdac9 gene , hepatitis c , hepatitis c virus , phosphoenolpyruvate carboxylase

Diabetes September 2015, Vol.64, 4088-4098. doi:https://doi.org/10.2337/db15-0197

Signal Transduction

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development

Mariya T. Sweetwyne; Antje Gruenwald; Thiruvur Niranjan; Ryuichi Nishinakamura; Lothar J. Strobl; Katalin Susztak

Abstract

View articletitled, Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development

Supplementary data

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Topics: notch1 gene , podocytes , mice

Diabetes August 2015, Vol.64, 4099-4111. doi:https://doi.org/10.2337/db15-0260

Islet Studies

The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Ghislaine Fontés; Julien Ghislain; Isma Benterki; Bader Zarrouki; Dominique Trudel; Yves Berthiaume; Vincent Poitout

Abstracts

View articletitled, The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Supplementary data

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Topics: insulin , mice , cystic fibrosis transmembrane conductance regulator , glucose , insulin secretion

Diabetes August 2015, Vol.64, 4112-4122. doi:https://doi.org/10.2337/db14-0810

BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion

Dagmar Klein; Silvia Álvarez-Cubela; Giacomo Lanzoni; Nancy Vargas; Kamalaveni R. Prabakar; Maria Boulina; Camillo Ricordi; Luca Inverardi; Ricardo L. Pastori; Juan Domínguez-Bendala

Abstracts

View articletitled, BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion

Supplementary data

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Topics: c-peptide , glucose , insulin , pancreas , fluorescent antibody technique

Diabetes August 2015, Vol.64, 4123-4134. doi:https://doi.org/10.2337/db15-0688

Cathelicidin Antimicrobial Peptide: A Novel Regulator of Islet Function, Islet Regeneration, and Selected Gut Bacteria

Lynley D. Pound; Christopher Patrick; Chandra E. Eberhard; Walid Mottawea; Gen-Sheng Wang; Turki Abujamel; Roxanne Vandenbeek; Alain Stintzi; Fraser W. Scott

Abstract

View articletitled, Cathelicidin Antimicrobial Peptide: A Novel Regulator of Islet Function, Islet Regeneration, and Selected Gut Bacteria

Supplementary data

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Topics: cyclic amp , ll-37 peptide , rats , calcium , peptides

Diabetes September 2015, Vol.64, 4135-4147. doi:https://doi.org/10.2337/db15-0788

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function

Honey Modi; Cecile Jacovetti; David Tarussio; Salima Metref; Ole D. Madsen; Fu-Ping Zhang; Pia Rantakari; Matti Poutanen; Serge Nef; Tracy Gorman; Romano Regazzi; Bernard Thorens

Abstract

View articletitled, Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function

Supplementary data

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Topics: glucose , insulin , insulin-like growth factor ii , mice , autocrine

Diabetes September 2015, Vol.64, 4148-4157. doi:https://doi.org/10.2337/db14-1735

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation

Pili Zhang; Anil Kumar; Liora S. Katz; Lucy Li; Martine Paulynice; Mark A. Herman; Donald K. Scott

Abstract

View articletitled, Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation

Supplementary data

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Topics: glucose , protein isoforms

Diabetes September 2015, Vol.64, 4158-4170. doi:https://doi.org/10.2337/db15-0239

Immunology and Transplantation

Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes

Lindsey E. Padgett; Brian Anderson; Chao Liu; Douglas Ganini; Ronald P. Mason; Jon D. Piganelli; Clayton E. Mathews; Hubert M. Tse

Abstract

View articletitled, Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes

Supplementary data

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Topics: cytokine , helper-inducer t-lymphocytes , ncf1 gene , superoxides , t-lymphocytes

Diabetes August 2015, Vol.64, 4171-4183. doi:https://doi.org/10.2337/db15-0546

Diabetes Inhibits Gr-1⁺ Myeloid Cell Maturation via Cebpa Deregulation

Kate Wicks; Tanja Torbica; Takahiro Umehara; Shilu Amin; Nicoletta Bobola; Kimberly A. Mace

Abstract

View articletitled, Diabetes Inhibits Gr-1+ Myeloid Cell Maturation via Cebpa Deregulation

Supplementary data

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Topics: ccaat/enhancer binding protein alpha , chemokine receptors , granulocyte colony-stimulating factor , mice , myeloid cells

Diabetes August 2015, Vol.64, 4184-4197. doi:https://doi.org/10.2337/db14-1895

Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

Stanley Lasch; Peter Müller; Monika Bayer; Josef M. Pfeilschifter; Andrew D. Luster; Edith Hintermann; Urs Christen

Abstracts

View articletitled, Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

Supplementary data

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Topics: antibodies , disease remission , lymphocytic choriomeningitis virus , mice , pancreas

Diabetes August 2015, Vol.64, 4198-4211. doi:https://doi.org/10.2337/db15-0479

βig-h3 Represses T-Cell Activation in Type 1 Diabetes

Maeva Patry; Romain Teinturier; Delphine Goehrig; Cornelia Zetu; Doriane Ripoche; In-San Kim; Philippe Bertolino; Ana Hennino

Abstracts

View articletitled, βig-h3 Represses T-Cell Activation in Type 1 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 1 , endocrine pancreas , mice , t-cell activation , t-lymphocytes

Diabetes October 2015, Vol.64, 4212-4219. doi:https://doi.org/10.2337/db15-0638

Pathophysiology

Sex Differences in the Association Between Birth Weight and Adult Type 2 Diabetes

Esther Zimmermann; Michael Gamborg; Thorkild I.A. Sørensen; Jennifer L. Baker

Abstract

View articletitled, Sex Differences in the Association Between Birth Weight and Adult Type 2 Diabetes

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Topics: birth weight , diabetes mellitus, type 2

Diabetes August 2015, Vol.64, 4220-4225. doi:https://doi.org/10.2337/db15-0494

Complications

miR-92a Corrects CD34⁺ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation

Ashay D. Bhatwadekar; Yuanqing Yan; Valerie Stepps; Sugata Hazra; Maria Korah; Stephen Bartelmez; Brahim Chaqour; Maria B. Grant

Abstract

View articletitled, miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation

Supplementary data

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Topics: cd34 antigens , micrornas , endothelium

Diabetes August 2015, Vol.64, 4226-4237. doi:https://doi.org/10.2337/db15-0521

Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease

Jennifer N. Todd; Emma H. Dahlström; Rany M. Salem; Niina Sandholm; Carol Forsblom; the FinnDiane Study Group; Amy J. McKnight; Alexander P. Maxwell; Eoin Brennan; Denise Sadlier; Catherine Godson; Per-Henrik Groop; Joel N. Hirschhorn; Jose C. Florez

Abstracts

View articletitled, Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease

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Topics: body mass index procedure , diabetic nephropathy , genetics , kidney failure, chronic , mendelian randomization analysis

Diabetes August 2015, Vol.64, 4238-4246. doi:https://doi.org/10.2337/db15-0254

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

Abstracts

View articletitled, Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy

Supplementary data

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Topics: angiotensin i , mice

Diabetes September 2015, Vol.64, 4247-4259. doi:https://doi.org/10.2337/db14-1030

Diabetic Stroke Severity: Epigenetic Remodeling and Neuronal, Glial, and Vascular Dysfunction

Anuradha Kalani; Pradip Kumar Kamat; Neetu Tyagi

Abstract

View articletitled, Diabetic Stroke Severity: Epigenetic Remodeling and Neuronal, Glial, and Vascular Dysfunction

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Topics: brain , cerebrovascular accident , epigenetics , infarction , ischemic stroke

Diabetes October 2015, Vol.64, 4260-4271. doi:https://doi.org/10.2337/db15-0422

Promoted Interaction of Nuclear Factor-κB With Demethylated Purinergic P2X3 Receptor Gene Contributes to Neuropathic Pain in Rats With Diabetes

Hong-Hong Zhang; Ji Hu; You-Lang Zhou; Xin Qin; Zhen-Yuan Song; Pan-Pan Yang; Shufen Hu; Xinghong Jiang; Guang-Yin Xu

Abstracts

View articletitled, Promoted Interaction of Nuclear Factor-κB With Demethylated Purinergic P2X3 Receptor Gene Contributes to Neuropathic Pain in Rats With Diabetes

Supplementary data

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Topics: allodynia , genes , hyperalgesia , rats , streptozocin

Diabetes June 2015, Vol.64, 4272-4284. doi:https://doi.org/10.2337/db15-0138

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1

Chaoyong He; Hongliang Li; Benoit Viollet; Ming-Hui Zou; Zhonglin Xie

Abstracts

View articletitled, AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1

Supplementary data

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Topics: ampk , stat1 gene , inflammation , phosphorylation , aorta

Diabetes April 2015, Vol.64, 4285-4297. doi:https://doi.org/10.2337/db15-0107

Pharmacology and Therapeutics

Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes

Yi Lin; Zhongjie Sun

Abstract

View articletitled, Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes

Supplementary data

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Topics: apoptosis , insulin , kl gene , mice , streptozocin

Diabetes September 2015, Vol.64, 4298-4311. doi:https://doi.org/10.2337/db15-0066

Genetics / Genomes / Proteomics / Metabolomics

Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials

Abstracts

View articletitled, Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials

Supplementary data

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Topics: body weight changes , life style , single nucleotide polymorphism , weight reduction , obesity

Diabetes August 2015, Vol.64, 4312-4321. doi:https://doi.org/10.2337/db15-0441

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes

Leslie J. Baier; Yunhua Li Muller; Maria Sara Remedi; Michael Traurig; Paolo Piaggi; Gregory Wiessner; Ke Huang; Alyssa Stacy; Sayuko Kobes; Jonathan Krakoff; Peter H. Bennett; Robert G. Nelson; William C. Knowler; Robert L. Hanson; Colin G. Nichols; Clifton Bogardus

Abstracts

View articletitled, ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes

Supplementary data

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Topics: abcc8 gene , birth weight , diabetes mellitus, type 2 , insulin , hyperinsulinism

Diabetes August 2015, Vol.64, 4322-4332. doi:https://doi.org/10.2337/db15-0459

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: clinical research , health personnel

Diabetes November 2015, Vol.64, 4333. doi:https://doi.org/10.2337/db15-ie12

E-Letters: Comments and Responses

Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522–1531

Manuel González-Ortiz; Esperanza Martínez-Abundis; Miriam Méndez-del Villar; Karina G. Pérez-Rubio

Extract

View articletitled, Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522–1531

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Topics: cyclooxygenase-2 , diet , fatty degeneration , insulin resistance , obesity

Diabetes November 2015, Vol.64, e42. doi:https://doi.org/10.2337/db15-1150

Response to Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522–1531

Ángela M. Valverde; Paloma Martín-Sanz

Extract

View articletitled, Response to Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522–1531

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Topics: cyclooxygenase-2 , diet , fatty degeneration , insulin resistance , obesity

Diabetes November 2015, Vol.64, e43-e44. doi:https://doi.org/10.2337/dbi15-0023

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In This Issue

Perspectives in Diabetes

Commentaries

Methodology Review

Metabolism

Signal Transduction

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics / Genomes / Proteomics / Metabolomics

Issues and Events

E-Letters: Comments and Responses

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