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Volume 64, Issue 2
1 February 2015
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes January 2015, Vol.64, 315-316. doi:https://doi.org/10.2337/db15-ti02

Banting Lecture

Deciphering Metabolic Messages From the Gut Drives Therapeutic Innovation: The 2014 Banting Lecture
Daniel J. Drucker
View articletitled, Deciphering Metabolic Messages From the Gut Drives Therapeutic Innovation: The 2014 Banting Lecture
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Diabetes January 2015, Vol.64, 317-326. doi:https://doi.org/10.2337/db14-1514

Perspectives in Diabetes

New Insights Into Gestational Glucose Metabolism: Lessons Learned From 21st Century Approaches
Anthony R. Angueira; Anton E. Ludvik; Timothy E. Reddy; Barton Wicksteed; William L. Lowe, Jr.; Brian T. Layden
View articletitled, New Insights Into Gestational Glucose Metabolism: Lessons Learned From 21st Century Approaches
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Diabetes January 2015, Vol.64, 327-334. doi:https://doi.org/10.2337/db14-0877

Commentaries

Why Do Exercise and Dietary Restriction During Pregnancy Affect Glucose Tolerance in Opposite Ways?
Katarina T. Borer
View articletitled, Why Do Exercise and Dietary Restriction During Pregnancy Affect Glucose Tolerance in Opposite Ways?
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Diabetes January 2015, Vol.64, 335-337. doi:https://doi.org/10.2337/db14-1476
An Absorbing Sense of Sweetness
Fiona M. Gribble
View articletitled, An Absorbing Sense of Sweetness
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Diabetes January 2015, Vol.64, 338-340. doi:https://doi.org/10.2337/db14-1477
Further Insight on the Limits of Success of Glycemic Control in Type 1 Diabetes
Barbara E.K. Klein; Ronald Klein
View articletitled, Further Insight on the Limits of Success of Glycemic Control in Type 1 Diabetes
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Diabetes January 2015, Vol.64, 341-343. doi:https://doi.org/10.2337/db14-1447

Technological Advances

Noninvasive In Vivo Imaging of Diabetes-Induced Renal Oxidative Stress and Response to Therapy Using Hyperpolarized 13C Dehydroascorbate Magnetic Resonance
Kayvan R. Keshari; David M. Wilson; Victor Sai; Robert Bok; Kuang-Yu Jen; Peder Larson; Mark Van Criekinge; John Kurhanewicz; Zhen J. Wang
View articletitled, Noninvasive In Vivo Imaging of Diabetes-Induced Renal Oxidative Stress and Response to Therapy Using Hyperpolarized <sup>13</sup>C Dehydroascorbate Magnetic Resonance
Supplementary data
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Diabetes September 2014, Vol.64, 344-352. doi:https://doi.org/10.2337/db13-1829

Metabolism

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation
Dmitri Samovski; Jingyu Sun; Terri Pietka; Richard W. Gross; Robert H. Eckel; Xiong Su; Philip D. Stahl; Nada A. Abumrad
View articletitled, Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation
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Diabetes August 2014, Vol.64, 353-359. doi:https://doi.org/10.2337/db14-0582
Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation
Sergej Pirkmajer; Sameer S. Kulkarni; Robby Z. Tom; Fiona A. Ross; Simon A. Hawley; D. Grahame Hardie; Juleen R. Zierath; Alexander V. Chibalin
View articletitled, Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation
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Diabetes October 2014, Vol.64, 360-369. doi:https://doi.org/10.2337/db14-0508
Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine
Rune E. Kuhre; Charlotte R. Frost; Berit Svendsen; Jens J. Holst
View articletitled, Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine
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Diabetes August 2014, Vol.64, 370-382. doi:https://doi.org/10.2337/db14-0807
Delayed Skeletal Muscle Mitochondrial ADP Recovery in Youth With Type 1 Diabetes Relates to Muscle Insulin Resistance
Melanie Cree-Green; Bradley R. Newcomer; Mark S. Brown; Amy D. Baumgartner; Bryan Bergman; Brendan Drew; Judith G. Regensteiner; Laura Pyle; Jane E.B. Reusch; Kristen J. Nadeau
View articletitled, Delayed Skeletal Muscle Mitochondrial ADP Recovery in Youth With Type 1 Diabetes Relates to Muscle Insulin Resistance
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Diabetes August 2014, Vol.64, 383-392. doi:https://doi.org/10.2337/db14-0765
Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
Xiaocen Kong; Jing Yu; Jianhua Bi; Hanmei Qi; Wenjuan Di; Lin Wu; Long Wang; Juanmin Zha; Shan Lv; Feng Zhang; Yan Li; Fang Hu; Feng Liu; Hong Zhou; Juan Liu; Guoxian Ding
View articletitled, Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
Supplementary data
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Diabetes September 2014, Vol.64, 393-404. doi:https://doi.org/10.2337/db14-0395
Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
Hongxia Ren; Taylor Y. Lu; Timothy E. McGraw; Domenico Accili
View articletitled, Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
Supplementary data
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Diabetes September 2014, Vol.64, 405-417. doi:https://doi.org/10.2337/db14-0752
ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
Salmaan Ahmed Khan; Aishwarya Sathyanarayan; Mara T. Mashek; Kuok Teong Ong; Edith E. Wollaston-Hayden; Douglas G. Mashek
View articletitled, ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
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Diabetes January 2015, Vol.64, 418-426. doi:https://doi.org/10.2337/db14-0325
Exercise Before and During Pregnancy Prevents the Deleterious Effects of Maternal High-Fat Feeding on Metabolic Health of Male Offspring
Kristin I. Stanford; Min-Young Lee; Kristen M. Getchell; Kawai So; Michael F. Hirshman; Laurie J. Goodyear
View articletitled, Exercise Before and During Pregnancy Prevents the Deleterious Effects of Maternal High-Fat Feeding on Metabolic Health of Male Offspring
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Diabetes September 2014, Vol.64, 427-433. doi:https://doi.org/10.2337/db13-1848
GLP-1 Plays a Limited Role in Improved Glycemia Shortly After Roux-en-Y Gastric Bypass: A Comparison With Intensive Lifestyle Modification
Marion L. Vetter; Thomas A. Wadden; Karen L. Teff; Zahra F. Khan; Raymond Carvajal; Scott Ritter; Reneé H. Moore; Jesse L. Chittams; Alex Iagnocco; Kenric Murayama; Gary Korus; Noel N. Williams; Michael R. Rickels
View articletitled, GLP-1 Plays a Limited Role in Improved Glycemia Shortly After Roux-en-Y Gastric Bypass: A Comparison With Intensive Lifestyle Modification
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Diabetes September 2014, Vol.64, 434-446. doi:https://doi.org/10.2337/db14-0558
5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents
Dawn E.W. Livingstone; Pascal Barat; Emma M. Di Rollo; Georgina A. Rees; Benjamin A. Weldin; Eva A. Rog-Zielinska; David P. MacFarlane; Brian R. Walker; Ruth Andrew
View articletitled, 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents
Supplementary data
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Diabetes September 2014, Vol.64, 447-458. doi:https://doi.org/10.2337/db14-0249
Hypothalamic Orexin Prevents Hepatic Insulin Resistance via Daily Bidirectional Regulation of Autonomic Nervous System in Mice
Hiroshi Tsuneki; Emi Tokai; Yuya Nakamura; Keisuke Takahashi; Mikio Fujita; Takehiro Asaoka; Kanta Kon; Yuuki Anzawa; Tsutomu Wada; Ichiro Takasaki; Kumi Kimura; Hiroshi Inoue; Masashi Yanagisawa; Takeshi Sakurai; Toshiyasu Sasaoka
View articletitled, Hypothalamic Orexin Prevents Hepatic Insulin Resistance via Daily Bidirectional Regulation of Autonomic Nervous System in Mice
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Diabetes September 2014, Vol.64, 459-470. doi:https://doi.org/10.2337/db14-0695
Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway
Lee D. Roberts; Tom Ashmore; Aleksandra O. Kotwica; Steven A. Murfitt; Bernadette O. Fernandez; Martin Feelisch; Andrew J. Murray; Julian L. Griffin
View articletitled, Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide Pathway
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Diabetes September 2014, Vol.64, 471-484. doi:https://doi.org/10.2337/db14-0496

Signal Transduction

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes
Peter H. Albers; Andreas J.T. Pedersen; Jesper B. Birk; Dorte E. Kristensen; Birgitte F. Vind; Otto Baba; Jane Nøhr; Kurt Højlund; Jørgen F.P. Wojtaszewski
View articletitled, Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes
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Diabetes September 2014, Vol.64, 485-497. doi:https://doi.org/10.2337/db14-0590

Obesity Studies

Vertical Sleeve Gastrectomy Restores Glucose Homeostasis in Apolipoprotein A-IV KO Mice
Josh W. Pressler; April Haller; Joyce Sorrell; Fei Wang; Randy J. Seeley; Patrick Tso; Darleen A. Sandoval
View articletitled, Vertical Sleeve Gastrectomy Restores Glucose Homeostasis in Apolipoprotein A-IV KO Mice
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Diabetes August 2014, Vol.64, 498-507. doi:https://doi.org/10.2337/db14-0825
Adiponectin Resistance and Proinflammatory Changes in the Visceral Adipose Tissue Induced by Fructose Consumption via Ketohexokinase-Dependent Pathway
George Marek; Varinderpal Pannu; Prashanth Shanmugham; Brianna Pancione; Dominic Mascia; Sean Crosson; Takuji Ishimoto; Yuri Y. Sautin
View articletitled, Adiponectin Resistance and Proinflammatory Changes in the Visceral Adipose Tissue Induced by Fructose Consumption via Ketohexokinase-Dependent Pathway
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Diabetes September 2014, Vol.64, 508-518. doi:https://doi.org/10.2337/db14-0411
Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch
Xinxin Xiang; He Lan; Hong Tang; Fang Yuan; Yanhui Xu; Jing Zhao; Yin Li; Weizhen Zhang
View articletitled, Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch
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Diabetes September 2014, Vol.64, 519-528. doi:https://doi.org/10.2337/db14-0427

Islet Studies

PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice
Rongying Li; Jeongkyung Lee; Mi-sun Kim; Victoria Liu; Mousumi Moulik; Haiyan Li; Qing Yi; Aini Xie; Wenhao Chen; Lina Yang; Yimin Li; Tsung Huang Tsai; Kazuhiro Oka; Lawrence Chan; Vijay Yechoor
View articletitled, PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice
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Diabetes October 2014, Vol.64, 529-540. doi:https://doi.org/10.2337/db13-1737
Inhibition of Ca2+-Independent Phospholipase A2β (iPLA2β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
Robert N. Bone; Ying Gai; Victoria Magrioti; Maroula G. Kokotou; Tomader Ali; Xiaoyong Lei; Hubert M. Tse; George Kokotos; Sasanka Ramanadham
View articletitled, Inhibition of Ca<sup>2+</sup>-Independent Phospholipase A<sub>2</sub>β (iPLA<sub>2</sub>β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
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Diabetes September 2014, Vol.64, 541-554. doi:https://doi.org/10.2337/db14-0097
Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep
Paul J. Rozance; Miranda Anderson; Marina Martinez; Anna Fahy; Antoni R. Macko; Jenai Kailey; Gregory J. Seedorf; Steven H. Abman; William W. Hay, Jr.; Sean W. Limesand
View articletitled, Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep
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Diabetes September 2014, Vol.64, 555-564. doi:https://doi.org/10.2337/db14-0462

Immunology and Transplantation

Assessment of β-Cell Mass and α- and β-Cell Survival and Function by Arginine Stimulation in Human Autologous Islet Recipients
R. Paul Robertson; Lindsey D. Bogachus; Elizabeth Oseid; Susan Parazzoli; Mary Elizabeth Patti; Michael R. Rickels; Christian Schuetz; Ty Dunn; Timothy Pruett; A.N. Balamurugan; David E.R. Sutherland; Gregory Beilman; Melena D. Bellin
View articletitled, Assessment of β-Cell Mass and α- and β-Cell Survival and Function by Arginine Stimulation in Human Autologous Islet Recipients
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Diabetes September 2014, Vol.64, 565-572. doi:https://doi.org/10.2337/db14-0690
Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes
Dieter Rondas; Inne Crèvecoeur; Wannes D’Hertog; Gabriela Bomfim Ferreira; An Staes; Abhishek D. Garg; Decio L. Eizirik; Patrizia Agostinis; Kris Gevaert; Lut Overbergh; Chantal Mathieu
View articletitled, Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes
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Diabetes September 2014, Vol.64, 573-586. doi:https://doi.org/10.2337/db14-0621
Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells
Per-Ola Carlsson; Erik Schwarcz; Olle Korsgren; Katarina Le Blanc
View articletitled, Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells
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Diabetes September 2014, Vol.64, 587-592. doi:https://doi.org/10.2337/db14-0656
B-1a Lymphocytes Attenuate Insulin Resistance
Lei Shen; Melissa Hui Yen Chng; Michael N. Alonso; Robert Yuan; Daniel A. Winer; Edgar G. Engleman
View articletitled, B-1a Lymphocytes Attenuate Insulin Resistance
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Diabetes September 2014, Vol.64, 593-603. doi:https://doi.org/10.2337/db14-0554

Pathophysiology

Inflammation and Hyperglycemia Mediate Deaf1 Splicing in the Pancreatic Lymph Nodes via Distinct Pathways During Type 1 Diabetes
Linda Yip; Rebecca Fuhlbrigge; Cariel Taylor; Remi J. Creusot; Teppei Nishikawa-Matsumura; Chan C. Whiting; Jill M. Schartner; Rahima Akter; Matthias von Herrath; C. Garrison Fathman
View articletitled, Inflammation and Hyperglycemia Mediate <em>Deaf1</em> Splicing in the Pancreatic Lymph Nodes via Distinct Pathways During Type 1 Diabetes
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Diabetes September 2014, Vol.64, 604-617. doi:https://doi.org/10.2337/db14-0803

Complications

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy
Hirofumi Suzuki; Yosuke Kayama; Masaya Sakamoto; Hiroyuki Iuchi; Ippei Shimizu; Takuya Yoshino; Daisuke Katoh; Tomohisa Nagoshi; Katsuyoshi Tojo; Tohru Minamino; Michihiro Yoshimura; Kazunori Utsunomiya
View articletitled, Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy
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Diabetes September 2014, Vol.64, 618-630. doi:https://doi.org/10.2337/db13-1896
Effect of Intensive Diabetes Therapy on the Progression of Diabetic Retinopathy in Patients With Type 1 Diabetes: 18 Years of Follow-up in the DCCT/EDIC
The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
View articletitled, Effect of Intensive Diabetes Therapy on the Progression of Diabetic Retinopathy in Patients With Type 1 Diabetes: 18 Years of Follow-up in the DCCT/EDIC
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Diabetes September 2014, Vol.64, 631-642. doi:https://doi.org/10.2337/db14-0930
Combination Therapies Prevent the Neuropathic, Proinflammatory Characteristics of Bone Marrow in Streptozotocin-Induced Diabetic Rats
James M. Dominguez, II; Mark A. Yorek; Maria B. Grant
View articletitled, Combination Therapies Prevent the Neuropathic, Proinflammatory Characteristics of Bone Marrow in Streptozotocin-Induced Diabetic Rats
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Diabetes September 2014, Vol.64, 643-653. doi:https://doi.org/10.2337/db14-0433
The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes
Tina Costacou; Caterina Rosano; Howard Aizenstein; Joseph M. Mettenburg; Karen Nunley; Robert E. Ferrell; Trevor J. Orchard
View articletitled, The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes
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Diabetes September 2014, Vol.64, 654-659. doi:https://doi.org/10.2337/db14-0723

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes January 2015, Vol.64, 660. doi:https://doi.org/10.2337/db15-ie02

E-Letters: Comments and Responses

Comment on Malik. Which Test for Diagnosing Early Human Diabetic Neuropathy? Diabetes 2014;63:2206–2208
Josine C. van der Heyden; Erwin Birnie; Dick Mul; Henk J. Veeze; Joleen H. Blok; Henk-Jan Aanstoot
View articletitled, Comment on Malik. Which Test for Diagnosing Early Human Diabetic Neuropathy? Diabetes 2014;63:2206–2208
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Diabetes January 2015, Vol.64, e1. doi:https://doi.org/10.2337/db14-1472
Response to Comment on Malik. Which Test for Diagnosing Early Human Diabetic Neuropathy? Diabetes 2014;63:2206–2208
Ioannis N. Petropoulos; Mitra Tavakoli; Andrew Marshall; Rayaz A. Malik
View articletitled, Response to Comment on Malik. Which Test for Diagnosing Early Human Diabetic Neuropathy? Diabetes 2014;63:2206–2208
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Diabetes January 2015, Vol.64, e2-e3. doi:https://doi.org/10.2337/db14-1608
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
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