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1 March 2015
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes February 2015, Vol.64, 661-662. doi:https://doi.org/10.2337/db15-ti03
Perspectives in Diabetes
Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes
Diabetes February 2015, Vol.64, 673-686. doi:https://doi.org/10.2337/db14-0694
Commentaries
Adipose Modulation of ABCG1 Uncovers an Intimate Link Between Sphingomyelin and Triglyceride Storage
Diabetes February 2015, Vol.64, 689-692. doi:https://doi.org/10.2337/db14-1553
New Insights of µ-Calpain in the Pathogenesis of Diabetic Vascular Injury
Diabetes February 2015, Vol.64, 693-695. doi:https://doi.org/10.2337/db14-1502
Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?
Diabetes February 2015, Vol.64, 696-699. doi:https://doi.org/10.2337/db14-1666
Disruption of Insulin Receptor Signaling in Endothelial Cells Shows the Central Role of an Intact Islet Blood Flow for In Vivo β-Cell Function
Diabetes February 2015, Vol.64, 700-702. doi:https://doi.org/10.2337/db14-1523
Nonesterified Fatty Acids, Albumin, and Platelet Aggregation
Diabetes February 2015, Vol.64, 703-705. doi:https://doi.org/10.2337/db14-1481
Solving the Riddle of the Sphinx May Provide New Insights Into Diabetes and Polyneuropathy
Diabetes February 2015, Vol.64, 706-708. doi:https://doi.org/10.2337/db14-1632
Hepato-Incretin Function of GLP-1: Novel Concept and Target in Type 1 Diabetes
Diabetes February 2015, Vol.64, 715-717. doi:https://doi.org/10.2337/db14-1671
Methodology Review
Metabolomics and Diabetes: Analytical and Computational Approaches
Diabetes February 2015, Vol.64, 718-732. doi:https://doi.org/10.2337/db14-0509
Metabolism
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
Zoi Michailidou; Nicholas M. Morton; José Maria Moreno Navarrete; Christopher C. West; Kenneth J. Stewart; José Manuel Fernández-Real; Christopher J. Schofield; Jonathan R. Seckl; Peter J. Ratcliffe
Diabetes November 2014, Vol.64, 733-745. doi:https://doi.org/10.2337/db14-0233
Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport
Alexandra Chadt; Anja Immisch; Christian de Wendt; Christian Springer; Zhou Zhou; Torben Stermann; Geoffrey D. Holman; Dominique Loffing-Cueni; Johannes Loffing; Hans-Georg Joost; Hadi Al-Hasani
Diabetes September 2014, Vol.64, 746-759. doi:https://doi.org/10.2337/db14-0368
Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia
Diabetes October 2014, Vol.64, 760-765. doi:https://doi.org/10.2337/db14-0931
Ligand-Activated PPARα-Dependent DNA Demethylation Regulates the Fatty Acid β-Oxidation Genes in the Postnatal Liver
Tatsuya Ehara; Yasutomi Kamei; Xunmei Yuan; Mayumi Takahashi; Sayaka Kanai; Erina Tamura; Kazutaka Tsujimoto; Takashi Tamiya; Yoshimi Nakagawa; Hitoshi Shimano; Takako Takai-Igarashi; Izuho Hatada; Takayoshi Suganami; Koshi Hashimoto; Yoshihiro Ogawa
Diabetes October 2014, Vol.64, 775-784. doi:https://doi.org/10.2337/db14-0158
Inactivation of Corticotropin-Releasing Hormone–Induced Insulinotropic Role by High-Altitude Hypoxia
Ke Hao; Fan-Ping Kong; Yu-Qi Gao; Jia-Wei Tang; Jian Chen; A. Mark Evans; Stafford L. Lightman; Xue-Qun Chen; Ji-Zeng Du
Diabetes October 2014, Vol.64, 785-795. doi:https://doi.org/10.2337/db14-0500
Liver Glycogen Reduces Food Intake and Attenuates Obesity in a High-Fat Diet–Fed Mouse Model
Diabetes October 2014, Vol.64, 796-807. doi:https://doi.org/10.2337/db14-0728
Acute Activation of Cannabinoid Receptors by Anandamide Reduces Gastrointestinal Motility and Improves Postprandial Glycemia in Mice
Stephanie Troy-Fioramonti; Laurent Demizieux; Joseph Gresti; Tania Muller; Bruno Vergès; Pascal Degrace
Diabetes October 2014, Vol.64, 808-818. doi:https://doi.org/10.2337/db14-0721
Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production
Lucy S. Jun; Rohn L. Millican; Eric D. Hawkins; Debra L. Konkol; Aaron D. Showalter; Michael E. Christe; M. Dodson Michael; Kyle W. Sloop
Diabetes October 2014, Vol.64, 819-827. doi:https://doi.org/10.2337/db14-1052
Signal Transduction
Identification and Saturable Nature of Signaling Pathways Induced by Metreleptin in Humans: Comparative Evaluation of In Vivo, Ex Vivo, and In Vitro Administration
Hyun-Seuk Moon; Joo Young Huh; Fadime Dincer; Benjamin E. Schneider; Per-Olof Hasselgren; Christos S. Mantzoros
Diabetes September 2014, Vol.64, 828-839. doi:https://doi.org/10.2337/db14-0625
Obesity Studies
Adipocyte ATP-Binding Cassette G1 Promotes Triglyceride Storage, Fat Mass Growth, and Human Obesity
Eric Frisdal; Soazig Le Lay; Henri Hooton; Lucie Poupel; Maryline Olivier; Rohia Alili; Wanee Plengpanich; Elise F. Villard; Sophie Gilibert; Marie Lhomme; Alexandre Superville; Lobna Miftah-Alkhair; M. John Chapman; Geesje M. Dallinga-Thie; Nicolas Venteclef; Christine Poitou; Joan Tordjman; Philippe Lesnik; Anatol Kontush; Thierry Huby; Isabelle Dugail; Karine Clement; Maryse Guerin; Wilfried Le Goff
Diabetes September 2014, Vol.64, 840-855. doi:https://doi.org/10.2337/db14-0245
WISP1 Is a Novel Adipokine Linked to Inflammation in Obesity
Veronica Murahovschi; Olga Pivovarova; Iryna Ilkavets; Renata M. Dmitrieva; Stephanie Döcke; Farnaz Keyhani-Nejad; Özlem Gögebakan; Martin Osterhoff; Margrit Kemper; Silke Hornemann; Mariya Markova; Nora Klöting; Martin Stockmann; Martin O. Weickert; Valeria Lamounier-Zepter; Peter Neuhaus; Alexandra Konradi; Steven Dooley; Christian von Loeffelholz; Matthias Blüher; Andreas F.H. Pfeiffer; Natalia Rudovich
Diabetes October 2014, Vol.64, 856-866. doi:https://doi.org/10.2337/db14-0444
Islet Studies
Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion
Shinji Hashimoto; Naoto Kubota; Hiroyuki Sato; Motohiro Sasaki; Iseki Takamoto; Tetsuya Kubota; Keizo Nakaya; Mitsuhiko Noda; Kohjiro Ueki; Takashi Kadowaki
Diabetes October 2014, Vol.64, 876-886. doi:https://doi.org/10.2337/db14-0432
Cadherin Engagement Improves Insulin Secretion of Single Human β-Cells
Geraldine Parnaud; Vanessa Lavallard; Benoît Bedat; David Matthey-Doret; Philippe Morel; Thierry Berney; Domenico Bosco
Diabetes October 2014, Vol.64, 887-896. doi:https://doi.org/10.2337/db14-0257
Postnatal β-Cell Proliferation and Mass Expansion Is Dependent on the Transcription Factor Nkx6.1
Diabetes October 2014, Vol.64, 897-903. doi:https://doi.org/10.2337/db14-0684
Impaired cAMP Generation Contributes to Defective Glucose-Stimulated Insulin Secretion After Long-term Exposure to Palmitate
Diabetes October 2014, Vol.64, 904-915. doi:https://doi.org/10.2337/db14-1036
Immunology and Transplantation
β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure
Ania Skowera; Kristin Ladell; James E. McLaren; Garry Dolton; Katherine K. Matthews; Emma Gostick; Deborah Kronenberg-Versteeg; Martin Eichmann; Robin R. Knight; Susanne Heck; Jake Powrie; Polly J. Bingley; Colin M. Dayan; John J. Miles; Andrew K. Sewell; David A. Price; Mark Peakman
Diabetes September 2014, Vol.64, 916-925. doi:https://doi.org/10.2337/db14-0332
Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells
Diabetes October 2014, Vol.64, 926-936. doi:https://doi.org/10.2337/db14-1042
Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes
Diabetes October 2014, Vol.64, 937-946. doi:https://doi.org/10.2337/db14-0929
Pathophysiology
Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation
Zhongjian Cheng; Xiaohua Jiang; Meghana Pansuria; Pu Fang; Jietang Mai; Karthik Mallilankaraman; Rajesh Kumar Gandhirajan; Satoru Eguchi; Rosario Scalia; Muniswamy Madesh; Xiaofeng Yang; Hong Wang
Diabetes October 2014, Vol.64, 947-959. doi:https://doi.org/10.2337/db14-0784
Glycated Albumin With Loss of Fatty Acid Binding Capacity Contributes to Enhanced Arachidonate Oxygenation and Platelet Hyperactivity: Relevance in Patients With Type 2 Diabetes
Denis Blache; Emmanuel Bourdon; Pauline Salloignon; Géraldine Lucchi; Patrick Ducoroy; Jean-Michel Petit; Bruno Verges; Laurent Lagrost
Diabetes August 2014, Vol.64, 960-972. doi:https://doi.org/10.2337/db14-0879
Ask1 Gene Deletion Blocks Maternal Diabetes–Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome
Fang Wang; Yanqing Wu; Hui Gu; E. Albert Reece; Shengyun Fang; Rinat Gabbay-Benziv; Graham Aberdeen; Peixin Yang
Diabetes September 2014, Vol.64, 973-988. doi:https://doi.org/10.2337/db14-0409
Factors Affecting the Decline in Incidence of Diabetes in the Diabetes Prevention Program Outcomes Study (DPPOS)
Diabetes Prevention Program (DPP) Research Group; Richard F. Hamman; Edward Horton; Elizabeth Barrett-Connor; George A. Bray; Costas A. Christophi; Jill Crandall; Jose C. Florez; Sarah Fowler; Ronald Goldberg; Steven E. Kahn; William C. Knowler; John M. Lachin; Mary Beth Murphy; Elizabeth Venditti
Diabetes October 2014, Vol.64, 989-998. doi:https://doi.org/10.2337/db14-0333
Diabetic Microangiopathy: Impact of Impaired Cerebral Vasoreactivity and Delayed Angiogenesis After Permanent Middle Cerebral Artery Occlusion on Stroke Damage and Cerebral Repair in Mice
Marine Poittevin; Philippe Bonnin; Cynthia Pimpie; Léa Rivière; Catherine Sebrié; Anthony Dohan; Marc Pocard; Christiane Charriaut-Marlangue; Nathalie Kubis
Diabetes October 2014, Vol.64, 999-1010. doi:https://doi.org/10.2337/db14-0759
Ozone Exposure Triggers Insulin Resistance Through Muscle c-Jun N-Terminal Kinase Activation
Roxane E. Vella; Nicolas J. Pillon; Bader Zarrouki; Marine L. Croze; Laetitia Koppe; Michel Guichardant; Sandra Pesenti; Marie-Agnès Chauvin; Jennifer Rieusset; Alain Géloën; Christophe O. Soulage
Diabetes October 2014, Vol.64, 1011-1024. doi:https://doi.org/10.2337/db13-1181
Complications
Intranasal Insulin Enhanced Resting-State Functional Connectivity of Hippocampal Regions in Type 2 Diabetes
Diabetes September 2014, Vol.64, 1025-1034. doi:https://doi.org/10.2337/db14-1000
Pharmacology and Therapeutics
Lowering Plasma 1-Deoxysphingolipids Improves Neuropathy in Diabetic Rats
Alaa Othman; Roberto Bianchi; Irina Alecu; Yu Wei; Carla Porretta-Serapiglia; Raffaella Lombardi; Alessia Chiorazzi; Cristina Meregalli; Norberto Oggioni; Guido Cavaletti; Giuseppe Lauria; Arnold von Eckardstein; Thorsten Hornemann
Diabetes October 2014, Vol.64, 1035-1045. doi:https://doi.org/10.2337/db14-1325
Glucagon-Like Peptide-1 Receptor Agonists Increase Pancreatic Mass by Induction of Protein Synthesis
Jacqueline A. Koehler; Laurie L. Baggio; Xiemin Cao; Tahmid Abdulla; Jonathan E. Campbell; Thomas Secher; Jacob Jelsing; Brett Larsen; Daniel J. Drucker
Diabetes October 2014, Vol.64, 1046-1056. doi:https://doi.org/10.2337/db14-0883
Treatment of Diabetic Rats With Insulin or a Synthetic Insulin Receptor Agonist Peptide Leads to Divergent Metabolic Responses
Henriette Frikke-Schmidt; Thomas Å. Pedersen; Christian Fledelius; Grith S. Olsen; Stephan D. Bouman; Mark Fitch; Marc Hellerstein
Diabetes October 2014, Vol.64, 1057-1066. doi:https://doi.org/10.2337/db14-0914
Erratum
Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition. Diabetes 2015;64:200–212
Hu Huang; Jianbo He; Da’Kuawn Johnson; Yanhong Wei; Ying Liu; Shuang Wang; Gerard A. Lutty; Elia J. Duh; Richard D. Semba
Diabetes February 2015, Vol.64, 1067. doi:https://doi.org/10.2337/db15-er03
Expression of Concern
Expression of Concern
Diabetes February 2015, Vol.64, 1068-1070. doi:https://doi.org/10.2337/db15-ec03
Issues and Events
E-Letters: Comments and Responses
Comment on Rondas et al. Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes. Diabetes 2015;64:573–586
Diabetes February 2015, Vol.64, e4. doi:https://doi.org/10.2337/db14-1463