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Commentaries
Advances in Risk Prediction of Type 2 Diabetes: Integrating Genetic Scores With Framingham Risk Models
Diabetes April 2015, Vol.64, 1495-1497. doi:https://doi.org/10.2337/db15-0033
Brain IL-6—Where Amylin and GLP-1 Antiobesity Signaling Congregate
Diabetes April 2015, Vol.64, 1498-1499. doi:https://doi.org/10.2337/db14-1910
Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?
Diabetes April 2015, Vol.64, 1503-1505. doi:https://doi.org/10.2337/db14-1931
To Lose Weight or Not to Lose Weight, That Is the Big Question—in Obesity-Related Heart Failure
Diabetes April 2015, Vol.64, 1509-1510. doi:https://doi.org/10.2337/db15-0003
Puzzling About Partial Glucagon Responses to Hypoglycemia in Intrahepatic Islet Recipients: Missing Pieces
Diabetes April 2015, Vol.64, 1511-1512. doi:https://doi.org/10.2337/db15-0040
Metabolism
Ghrelin Is a Novel Regulator of GLP-1 Secretion
Diabetes November 2014, Vol.64, 1513-1521. doi:https://doi.org/10.2337/db14-1176
Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance
Daniel E. Francés; Omar Motiño; Noelia Agrá; Águeda González-Rodríguez; Ana Fernández-Álvarez; Carme Cucarella; Rafael Mayoral; Luis Castro-Sánchez; Ester García-Casarrubios; Lisardo Boscá; Cristina E. Carnovale; Marta Casado; Ángela M. Valverde; Paloma Martín-Sanz
Diabetes November 2014, Vol.64, 1522-1531. doi:https://doi.org/10.2337/db14-0979
Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction
Kari E. Wong; Catherine R. Mikus; Dorothy H. Slentz; Sarah E. Seiler; Karen L. DeBalsi; Olga R. Ilkayeva; Karen I. Crain; Michael T. Kinter; C. Lawrence Kien; Robert D. Stevens; Deborah M. Muoio
Diabetes November 2014, Vol.64, 1532-1543. doi:https://doi.org/10.2337/db14-0827
Salsalate Activates Brown Adipose Tissue in Mice
Andrea D. van Dam; Kimberly J. Nahon; Sander Kooijman; Susan M. van den Berg; Anish A. Kanhai; Takuya Kikuchi; Mattijs M. Heemskerk; Vanessa van Harmelen; Marc Lombès; Anita M. van den Hoek; Menno P.J. de Winther; Esther Lutgens; Bruno Guigas; Patrick C.N. Rensen; Mariëtte R. Boon
Diabetes December 2014, Vol.64, 1544-1554. doi:https://doi.org/10.2337/db14-1125
Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation
Gordon I. Smith; Jun Yoshino; Kelly L. Stromsdorfer; Seth J. Klein; Faidon Magkos; Dominic N. Reeds; Samuel Klein; Bettina Mittendorfer
Diabetes December 2014, Vol.64, 1555-1563. doi:https://doi.org/10.2337/db14-1279
Unconjugated Bilirubin Mediates Heme Oxygenase-1–Induced Vascular Benefits in Diabetic Mice
Jian Liu; Li Wang; Xiao Yu Tian; Limei Liu; Wing Tak Wong; Yang Zhang; Quan-Bin Han; Hing-Man Ho; Nanping Wang; Siu Ling Wong; Zhen-Yu Chen; Jun Yu; Chi-Fai Ng; Xiaoqiang Yao; Yu Huang
Diabetes December 2014, Vol.64, 1564-1575. doi:https://doi.org/10.2337/db14-1391
Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues
Cheng Xu; Yu Cai; Pengcheng Fan; Bo Bai; Jie Chen; Han-Bing Deng; Chi-Ming Che; Aimin Xu; Paul M. Vanhoutte; Yu Wang
Diabetes December 2014, Vol.64, 1576-1590. doi:https://doi.org/10.2337/db14-1180
Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3
Junjie Yu; Fei Xiao; Yajie Guo; Jiali Deng; Bin Liu; Qian Zhang; Kai Li; Chunxia Wang; Shanghai Chen; Feifan Guo
Diabetes December 2014, Vol.64, 1591-1602. doi:https://doi.org/10.2337/db14-1368
Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice
Laura Zemany; Sanjay Bhanot; Odile D. Peroni; Susan F. Murray; Pedro M. Moraes-Vieira; Angela Castoldi; Prasad Manchem; Shuling Guo; Brett P. Monia; Barbara B. Kahn
Diabetes December 2014, Vol.64, 1603-1614. doi:https://doi.org/10.2337/db14-0970
Lipid-Induced Insulin Resistance Is Associated With an Impaired Skeletal Muscle Protein Synthetic Response to Amino Acid Ingestion in Healthy Young Men
Francis B. Stephens; Carolyn Chee; Benjamin T. Wall; Andrew J. Murton; Chris E. Shannon; Luc J.C. van Loon; Kostas Tsintzas
Diabetes December 2014, Vol.64, 1615-1620. doi:https://doi.org/10.2337/db14-0961
Obesity Studies
Amylin-Induced Central IL-6 Production Enhances Ventromedial Hypothalamic Leptin Signaling
Christelle Le Foll; Miranda D. Johnson; Ambrose A. Dunn-Meynell; Christina N. Boyle; Thomas A. Lutz; Barry E. Levin
Diabetes November 2014, Vol.64, 1621-1631. doi:https://doi.org/10.2337/db14-0645
Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms
Vincenza Cifarelli; Laura M. Lashinger; Kaylyn L. Devlin; Sarah M. Dunlap; Jennifer Huang; Rudolf Kaaks; Michael N. Pollak; Stephen D. Hursting
Diabetes January 2015, Vol.64, 1632-1642. doi:https://doi.org/10.2337/db14-1132
Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox
Sowndramalingam Sankaralingam; Osama Abo Alrob; Liyan Zhang; Jagdip S. Jaswal; Cory S. Wagg; Arata Fukushima; Raj S. Padwal; David E. Johnstone; Arya M. Sharma; Gary D. Lopaschuk
Diabetes December 2014, Vol.64, 1643-1657. doi:https://doi.org/10.2337/db14-1050
Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity
Diabetes December 2014, Vol.64, 1658-1669. doi:https://doi.org/10.2337/db14-0631
BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis
Birgit Gustafson; Ann Hammarstedt; Shahram Hedjazifar; Jenny M. Hoffmann; Per-Arne Svensson; Joseph Grimsby; Cristina Rondinone; Ulf Smith
Diabetes January 2015, Vol.64, 1670-1681. doi:https://doi.org/10.2337/db14-1127
Islet Studies
Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes
Lars Krogvold; Bjørn Edwin; Trond Buanes; Gun Frisk; Oskar Skog; Mahesh Anagandula; Olle Korsgren; Dag Undlien; Morten C. Eike; Sarah J. Richardson; Pia Leete; Noel G. Morgan; Sami Oikarinen; Maarit Oikarinen; Jutta E. Laiho; Heikki Hyöty; Johnny Ludvigsson; Kristian F. Hanssen; Knut Dahl-Jørgensen
Diabetes November 2014, Vol.64, 1682-1687. doi:https://doi.org/10.2337/db14-1370
PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control
Kelly A. Kaihara; Lorna M. Dickson; Johanne H. Ellenbroek; Caitlin M.D. Orr; Brian T. Layden; Barton Wicksteed
Diabetes December 2014, Vol.64, 1688-1697. doi:https://doi.org/10.2337/db14-1051
Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells
Diabetes December 2014, Vol.64, 1698-1702. doi:https://doi.org/10.2337/db14-1675
Immunology and Transplantation
Loss of Anergic B Cells in Prediabetic and New-Onset Type 1 Diabetic Patients
Mia J. Smith; Thomas A. Packard; Shannon K. O’Neill; Carole J. Henry Dunand; Min Huang; Lisa Fitzgerald-Miller; Daniel Stowell; Rochelle M. Hinman; Patrick C. Wilson; Peter A. Gottlieb; John C. Cambier
Diabetes December 2014, Vol.64, 1703-1712. doi:https://doi.org/10.2337/db13-1798
Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes
Michael R. Rickels; Carissa Fuller; Cornelia Dalton-Bakes; Eileen Markmann; Maral Palanjian; Kevin Cullison; Janice Tiao; Shiv Kapoor; Chengyang Liu; Ali Naji; Karen L. Teff
Diabetes December 2014, Vol.64, 1713-1718. doi:https://doi.org/10.2337/db14-1620
Pathophysiology
HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk
Olli Helminen; Susanna Aspholm; Tytti Pokka; Milla-Riikka Hautakangas; Nora Haatanen; Johanna Lempainen; Jorma Ilonen; Olli Simell; Mikael Knip; Riitta Veijola
Diabetes December 2014, Vol.64, 1719-1727. doi:https://doi.org/10.2337/db14-0497
Complications
Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model
Shengbin Huang; Yongfu Wang; Xueqi Gan; Du Fang; Changjia Zhong; Long Wu; Gang Hu; Alexander A. Sosunov; Guy M. McKhann; Haiyang Yu; Shirley ShiDu Yan
Diabetes November 2014, Vol.64, 1728-1742. doi:https://doi.org/10.2337/db14-0758
Semaphorin3a Promotes Advanced Diabetic Nephropathy
Pardeep K. Aggarwal; Delma Veron; David B. Thomas; Dionicio Siegel; Gilbert Moeckel; Michael Kashgarian; Alda Tufro
Diabetes December 2014, Vol.64, 1743-1759. doi:https://doi.org/10.2337/db14-0719
Hypoglycemia-Associated Changes in the Electroencephalogram in Patients With Type 1 Diabetes and Normal Hypoglycemia Awareness or Unawareness
Anne-Sophie Sejling; Troels W. Kjær; Ulrik Pedersen-Bjergaard; Sarah S. Diemar; Christian S.S. Frandsen; Linda Hilsted; Jens Faber; Jens J. Holst; Lise Tarnow; Martin N. Nielsen; Line S. Remvig; Birger Thorsteinsson; Claus B. Juhl
Diabetes December 2014, Vol.64, 1760-1769. doi:https://doi.org/10.2337/db14-1359
Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
Nelly Mauras; Paul Mazaika; Bruce Buckingham; Stuart Weinzimer; Neil H. White; Eva Tsalikian; Tamara Hershey; Allison Cato; Peiyao Cheng; Craig Kollman; Roy W. Beck; Katrina Ruedy; Tandy Aye; Larry Fox; Ana Maria Arbelaez; Darrell Wilson; Michael Tansey; William Tamborlane; Daniel Peng; Matthew Marzelli; Karen K. Winer; Allan L. Reiss; for the Diabetes Research in Children Network (DirecNet)
Diabetes December 2014, Vol.64, 1770-1779. doi:https://doi.org/10.2337/db14-1445
Pharmacology and Therapeutics
Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat
Diabetes December 2014, Vol.64, 1780-1785. doi:https://doi.org/10.2337/db14-1018
Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study
Diabetes December 2014, Vol.64, 1786-1793. doi:https://doi.org/10.2337/db14-1388
Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes
Diabetes January 2015, Vol.64, 1794-1803. doi:https://doi.org/10.2337/db14-0635
Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes
Mohammed Abdelsaid; Roshini Prakash; Weiguo Li; Maha Coucha; Sherif Hafez; Maribeth H. Johnson; Susan C. Fagan; Adviye Ergul
Diabetes December 2014, Vol.64, 1804-1817. doi:https://doi.org/10.2337/db14-1423
Genetics / Genomes / Proteomics / Metabolomics
Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study
Carina Törn; David Hadley; Hye-Seung Lee; William Hagopian; Åke Lernmark; Olli Simell; Marian Rewers; Anette Ziegler; Desmond Schatz; Beena Akolkar; Suna Onengut-Gumuscu; Wei-Min Chen; Jorma Toppari; Juha Mykkänen; Jorma Ilonen; Stephen S. Rich; Jin-Xiong She; Andrea K. Steck; Jeffrey Krischer; the TEDDY Study Group
Diabetes November 2014, Vol.64, 1818-1829. doi:https://doi.org/10.2337/db14-1497
Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes
Philippa J. Talmud; on behalf of the UCLEB Consortium; Jackie A. Cooper; on behalf of the UCLEB Consortium; Richard W. Morris; on behalf of the UCLEB Consortium; Frank Dudbridge; on behalf of the UCLEB Consortium; Tina Shah; on behalf of the UCLEB Consortium; Jorgen Engmann; on behalf of the UCLEB Consortium; Caroline Dale; on behalf of the UCLEB Consortium; Jon White; on behalf of the UCLEB Consortium; Stela McLachlan; on behalf of the UCLEB Consortium; Delilah Zabaneh; on behalf of the UCLEB Consortium; Andrew Wong; on behalf of the UCLEB Consortium; Ken K. Ong; on behalf of the UCLEB Consortium; Tom Gaunt; on behalf of the UCLEB Consortium; Michael V. Holmes; on behalf of the UCLEB Consortium; Debbie A. Lawlor; on behalf of the UCLEB Consortium; Marcus Richards; on behalf of the UCLEB Consortium; Rebecca Hardy; on behalf of the UCLEB Consortium; Diana Kuh; on behalf of the UCLEB Consortium; Nicholas Wareham; on behalf of the UCLEB Consortium; Claudia Langenberg; on behalf of the UCLEB Consortium; Yoav Ben-Shlomo; on behalf of the UCLEB Consortium; S. Goya Wannamethee; on behalf of the UCLEB Consortium; Mark W.J. Strachan; on behalf of the UCLEB Consortium; Meena Kumari; on behalf of the UCLEB Consortium; John C. Whittaker; on behalf of the UCLEB Consortium; Fotios Drenos; on behalf of the UCLEB Consortium; Mika Kivimaki; on behalf of the UCLEB Consortium; Aroon D. Hingorani; on behalf of the UCLEB Consortium; Jacqueline F. Price; on behalf of the UCLEB Consortium; Steve E. Humphries; on behalf of the UCLEB Consortium
Diabetes December 2014, Vol.64, 1830-1840. doi:https://doi.org/10.2337/db14-1504
Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
Tove Fall; on behalf of the ENGAGE Consortium; Sara Hägg; on behalf of the ENGAGE Consortium; Alexander Ploner; on behalf of the ENGAGE Consortium; Reedik Mägi; on behalf of the ENGAGE Consortium; Krista Fischer; on behalf of the ENGAGE Consortium; Harmen H.M. Draisma; on behalf of the ENGAGE Consortium; Antti-Pekka Sarin; on behalf of the ENGAGE Consortium; Beben Benyamin; on behalf of the ENGAGE Consortium; Claes Ladenvall; on behalf of the ENGAGE Consortium; Mikael Åkerlund; on behalf of the ENGAGE Consortium; Mart Kals; on behalf of the ENGAGE Consortium; Tõnu Esko; on behalf of the ENGAGE Consortium; Christopher P. Nelson; on behalf of the ENGAGE Consortium; Marika Kaakinen; on behalf of the ENGAGE Consortium; Ville Huikari; on behalf of the ENGAGE Consortium; Massimo Mangino; on behalf of the ENGAGE Consortium; Aline Meirhaeghe; on behalf of the ENGAGE Consortium; Kati Kristiansson; on behalf of the ENGAGE Consortium; Marja-Liisa Nuotio; on behalf of the ENGAGE Consortium; Michael Kobl; on behalf of the ENGAGE Consortium; Harald Grallert; on behalf of the ENGAGE Consortium; Abbas Dehghan; on behalf of the ENGAGE Consortium; Maris Kuningas; on behalf of the ENGAGE Consortium; Paul S. de Vries; on behalf of the ENGAGE Consortium; Renée F.A.G. de Bruijn; on behalf of the ENGAGE Consortium; Sara M. Willems; on behalf of the ENGAGE Consortium; Kauko Heikkilä; on behalf of the ENGAGE Consortium; Karri Silventoinen; on behalf of the ENGAGE Consortium; Kirsi H. Pietiläinen; on behalf of the ENGAGE Consortium; Vanessa Legry; on behalf of the ENGAGE Consortium; Vilmantas Giedraitis; on behalf of the ENGAGE Consortium; Louisa Goumidi; on behalf of the ENGAGE Consortium; Ann-Christine Syvänen; on behalf of the ENGAGE Consortium; Konstantin Strauch; on behalf of the ENGAGE Consortium; Wolfgang Koenig; on behalf of the ENGAGE Consortium; Peter Lichtner; on behalf of the ENGAGE Consortium; Christian Herder; on behalf of the ENGAGE Consortium; Aarno Palotie; on behalf of the ENGAGE Consortium; Cristina Menni; on behalf of the ENGAGE Consortium; André G. Uitterlinden; on behalf of the ENGAGE Consortium; Kari Kuulasmaa; on behalf of the ENGAGE Consortium; Aki S. Havulinna; on behalf of the ENGAGE Consortium; Luis A. Moreno; on behalf of the ENGAGE Consortium; Marcela Gonzalez-Gross; on behalf of the ENGAGE Consortium; Alun Evans; on behalf of the ENGAGE Consortium; David-Alexandre Tregouet; on behalf of the ENGAGE Consortium; John W.G. Yarnell; on behalf of the ENGAGE Consortium; Jarmo Virtamo; on behalf of the ENGAGE Consortium; Jean Ferrières; on behalf of the ENGAGE Consortium; Giovanni Veronesi; on behalf of the ENGAGE Consortium; Markus Perola; on behalf of the ENGAGE Consortium; Dominique Arveiler; on behalf of the ENGAGE Consortium; Paolo Brambilla; on behalf of the ENGAGE Consortium; Lars Lind; on behalf of the ENGAGE Consortium; Jaakko Kaprio; on behalf of the ENGAGE Consortium; Albert Hofman; on behalf of the ENGAGE Consortium; Bruno H. Stricker; on behalf of the ENGAGE Consortium; Cornelia M. van Duijn; on behalf of the ENGAGE Consortium; M. Arfan Ikram; on behalf of the ENGAGE Consortium; Oscar H. Franco; on behalf of the ENGAGE Consortium; Dominique Cottel; on behalf of the ENGAGE Consortium; Jean Dallongeville; on behalf of the ENGAGE Consortium; Alistair S. Hall; on behalf of the ENGAGE Consortium; Antti Jula; on behalf of the ENGAGE Consortium; Martin D. Tobin; on behalf of the ENGAGE Consortium; Brenda W. Penninx; on behalf of the ENGAGE Consortium; Annette Peters; on behalf of the ENGAGE Consortium; Christian Gieger; on behalf of the ENGAGE Consortium; Nilesh J. Samani; on behalf of the ENGAGE Consortium; Grant W. Montgomery; on behalf of the ENGAGE Consortium; John B. Whitfield; on behalf of the ENGAGE Consortium; Nicholas G. Martin; on behalf of the ENGAGE Consortium; Leif Groop; on behalf of the ENGAGE Consortium; Tim D. Spector; on behalf of the ENGAGE Consortium; Patrik K. Magnusson; on behalf of the ENGAGE Consortium; Philippe Amouyel; on behalf of the ENGAGE Consortium; Dorret I. Boomsma; on behalf of the ENGAGE Consortium; Peter M. Nilsson; on behalf of the ENGAGE Consortium; Marjo-Riitta Järvelin; on behalf of the ENGAGE Consortium; Valeriya Lyssenko; on behalf of the ENGAGE Consortium; Andres Metspalu; on behalf of the ENGAGE Consortium; David P. Strachan; on behalf of the ENGAGE Consortium; Veikko Salomaa; on behalf of the ENGAGE Consortium; Samuli Ripatti; on behalf of the ENGAGE Consortium; Nancy L. Pedersen; on behalf of the ENGAGE Consortium; Inga Prokopenko; on behalf of the ENGAGE Consortium; Mark I. McCarthy; on behalf of the ENGAGE Consortium; Erik Ingelsson; on behalf of the ENGAGE Consortium
Diabetes February 2015, Vol.64, 1841-1852. doi:https://doi.org/10.2337/db14-0988
Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
Nicholette D. Palmer; Mark O. Goodarzi; Carl D. Langefeld; Nan Wang; Xiuqing Guo; Kent D. Taylor; Tasha E. Fingerlin; Jill M. Norris; Thomas A. Buchanan; Anny H. Xiang; Talin Haritunians; Julie T. Ziegler; Adrienne H. Williams; Darko Stefanovski; Jinrui Cui; Adrienne W. Mackay; Leora F. Henkin; Richard N. Bergman; Xiaoyi Gao; James Gauderman; Rohit Varma; Craig L. Hanis; Nancy J. Cox; Heather M. Highland; Jennifer E. Below; Amy L. Williams; Noel P. Burtt; Carlos A. Aguilar-Salinas; Alicia Huerta-Chagoya; Clicerio Gonzalez-Villalpando; Lorena Orozco; Christopher A. Haiman; Michael Y. Tsai; W. Craig Johnson; Jie Yao; Laura Rasmussen-Torvik; James Pankow; Beverly Snively; Rebecca D. Jackson; Simin Liu; Jerry L. Nadler; Fouad Kandeel; Yii-Der I. Chen; Donald W. Bowden; Stephen S. Rich; Leslie J. Raffel; Jerome I. Rotter; Richard M. Watanabe; Lynne E. Wagenknecht
Diabetes December 2014, Vol.64, 1853-1866. doi:https://doi.org/10.2337/db14-0732
Issues and Events
E-Letters: Comments and Responses
Response to Comment on Balestrieri et al. Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment. Diabetes 2015;64:1395–1406
Maria Luisa Balestrieri; Maria Rosaria Rizzo; Michelangela Barbieri; Pasquale Paolisso; Nunzia D’Onofrio; Alfonso Giovane; Luigi Servillo; Giuseppe Paolisso; Raffaele Marfella
Diabetes April 2015, Vol.64, e6. doi:https://doi.org/10.2337/db14-1676
