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1 July 2015
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes June 2015, Vol.64, 2287-2288. doi:https://doi.org/10.2337/db15-ti07
Perspectives in Diabetes
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Allyson K. Palmer; Tamara Tchkonia; Nathan K. LeBrasseur; Eduardo N. Chini; Ming Xu; James L. Kirkland
Diabetes June 2015, Vol.64, 2289-2298. doi:https://doi.org/10.2337/db14-1820
Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium
Diabetes June 2015, Vol.64, 2299-2309. doi:https://doi.org/10.2337/db15-0004
Gut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism
Diabetes June 2015, Vol.64, 2310-2318. doi:https://doi.org/10.2337/db14-1706
Commentaries
GLP-1R Agonists and Endothelial Dysfunction: More Than Just Glucose Lowering?
Diabetes June 2015, Vol.64, 2319-2321. doi:https://doi.org/10.2337/db15-0366
Hypoglycemia-Associated Autonomic Failure in Diabetes: Maladaptive, Adaptive, or Both?
Diabetes June 2015, Vol.64, 2322-2323. doi:https://doi.org/10.2337/db15-0331
Interaction of Adipogenesis and Angiogenesis in Dietary-Induced Obesity
Diabetes June 2015, Vol.64, 2326-2328. doi:https://doi.org/10.2337/db15-0202
An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes
Diabetes June 2015, Vol.64, 2329-2331. doi:https://doi.org/10.2337/db15-0436
PET Measurements of Organ Metabolism: The Devil Is in the Details
Diabetes June 2015, Vol.64, 2332-2334. doi:https://doi.org/10.2337/db15-0226
Intestinal Lipoprotein Secretion: Incretin-Based Physiology and Pharmacology Beyond Glucose
Diabetes June 2015, Vol.64, 2338-2340. doi:https://doi.org/10.2337/db15-0470
New Piece in the Jigsaw Puzzle: Adipose Tissue–Derived Stem Cells From Obese Subjects Drive Th17 Polarization
Diabetes June 2015, Vol.64, 2341-2343. doi:https://doi.org/10.2337/db15-0437
Blood Lipids and Type 2 Diabetes Risk: Can Genetics Help Untangle the Web?
Diabetes June 2015, Vol.64, 2344-2345. doi:https://doi.org/10.2337/db15-0458
Diabetes Symposium: Browning of Adipose Tissue—What’s New?
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations
Diabetes June 2015, Vol.64, 2361-2368. doi:https://doi.org/10.2337/db15-0227
Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation
Diabetes June 2015, Vol.64, 2369-2375. doi:https://doi.org/10.2337/db15-0203
Metabolism
Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia
Thomas H. Meek; Mauricio D. Dorfman; Miles E. Matsen; Jonathan D. Fischer; Alexis Cubelo; Monica R. Kumar; Gerald J. Taborsky, Jr.; Gregory J. Morton
Diabetes January 2015, Vol.64, 2376-2387. doi:https://doi.org/10.2337/db14-1562
Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes
Denis P. Blondin; Sébastien M. Labbé; Christophe Noll; Margaret Kunach; Serge Phoenix; Brigitte Guérin; Éric E. Turcotte; François Haman; Denis Richard; André C. Carpentier
Diabetes February 2015, Vol.64, 2388-2397. doi:https://doi.org/10.2337/db14-1651
Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation
Gijs den Besten; Aycha Bleeker; Albert Gerding; Karen van Eunen; Rick Havinga; Theo H. van Dijk; Maaike H. Oosterveer; Johan W. Jonker; Albert K. Groen; Dirk-Jan Reijngoud; Barbara M. Bakker
Diabetes February 2015, Vol.64, 2398-2408. doi:https://doi.org/10.2337/db14-1213
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle
Young Do Koo; Jin Woo Choi; Myungjin Kim; Sehyun Chae; Byung Yong Ahn; Min Kim; Byung Chul Oh; Daehee Hwang; Jae Hong Seol; Young-Bum Kim; Young Joo Park; Sung Soo Chung; Kyong Soo Park
Diabetes March 2015, Vol.64, 2420-2431. doi:https://doi.org/10.2337/db15-0115
Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans
Margaret Kunach; Christophe Noll; Serge Phoenix; Brigitte Guérin; Jean-Patrice Baillargeon; Eric E. Turcotte; André C. Carpentier
Diabetes December 2014, Vol.64, 2432-2441. doi:https://doi.org/10.2337/db14-1166
Obesity Studies
Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis
Diabetes January 2015, Vol.64, 2442-2456. doi:https://doi.org/10.2337/db14-0528
Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin
Denovan P. Begg; Aaron A. May; Joram D. Mul; Min Liu; David A. D’Alessio; Randy J. Seeley; Stephen C. Woods
Diabetes February 2015, Vol.64, 2457-2466. doi:https://doi.org/10.2337/db14-1364
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents
Qibin Qi; Mary K. Downer; Tuomas O. Kilpeläinen; H. Rob Taal; Sheila J. Barton; Ioanna Ntalla; Marie Standl; Vesna Boraska; Ville Huikari; Jessica C. Kiefte-de Jong; Antje Körner; Timo A. Lakka; Gaifen Liu; Jessica Magnusson; Masayuki Okuda; Olli Raitakari; Rebecca Richmond; Robert A. Scott; Mark E.S. Bailey; Kathrin Scheuermann; John W. Holloway; Hazel Inskip; Carmen R. Isasi; Yasmin Mossavar-Rahmani; Vincent W.V. Jaddoe; Jaana Laitinen; Virpi Lindi; Erik Melén; Yannis Pitsiladis; Niina Pitkänen; Harold Snieder; Joachim Heinrich; Nicholas J. Timpson; Tao Wang; Hinoda Yuji; Eleftheria Zeggini; George V. Dedoussis; Robert C. Kaplan; Judith Wylie-Rosett; Ruth J.F. Loos; Frank B. Hu; Lu Qi
Diabetes February 2015, Vol.64, 2467-2476. doi:https://doi.org/10.2337/db14-1629
Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation
Assia Eljaafari; Maud Robert; Marwa Chehimi; Stephanie Chanon; Christine Durand; Guillaume Vial; Nadia Bendridi; Anne-Marie Madec; Emmanuel Disse; Martine Laville; Jennifer Rieusset; Etienne Lefai; Hubert Vidal; Luciano Pirola
Diabetes March 2015, Vol.64, 2477-2488. doi:https://doi.org/10.2337/db15-0162
Islet Studies
Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets
William J. Stanley; Sara A. Litwak; Hong Sheng Quah; Sih Min Tan; Thomas W.H. Kay; Tony Tiganis; Judy B. de Haan; Helen E. Thomas; Esteban N. Gurzov
Diabetes March 2015, Vol.64, 2489-2496. doi:https://doi.org/10.2337/db14-1575
The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas
Diabetes January 2015, Vol.64, 2497-2505. doi:https://doi.org/10.2337/db14-1412
Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study
Lars Krogvold; Oskar Skog; Görel Sundström; Bjørn Edwin; Trond Buanes; Kristian F. Hanssen; Johnny Ludvigsson; Manfred Grabherr; Olle Korsgren; Knut Dahl-Jørgensen
Diabetes February 2015, Vol.64, 2506-2512. doi:https://doi.org/10.2337/db14-1911
Pathophysiology
GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study
Kristine Færch; Signe S. Torekov; Dorte Vistisen; Nanna B. Johansen; Daniel R. Witte; Anna Jonsson; Oluf Pedersen; Torben Hansen; Torsten Lauritzen; Annelli Sandbæk; Jens Juul Holst; Marit E. Jørgensen
Diabetes February 2015, Vol.64, 2513-2525. doi:https://doi.org/10.2337/db14-1751
Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy
Diabetes February 2015, Vol.64, 2526-2536. doi:https://doi.org/10.2337/db14-1683
GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R
Bernardo Yusta; Laurie L. Baggio; Jacqueline Koehler; Dianne Holland; Xiemin Cao; Lee J. Pinnell; Kathene C. Johnson-Henry; William Yeung; Michael G. Surette; K.W. Annie Bang; Philip M. Sherman; Daniel J. Drucker
Diabetes March 2015, Vol.64, 2537-2549. doi:https://doi.org/10.2337/db14-1577
Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance
Barry E. Hurwitz; Neil Schneiderman; Jennifer B. Marks; Armando J. Mendez; Alex Gonzalez; Maria M. Llabre; Steven R. Smith; Roberto Bizzotto; Eleonora Santini; Maria Laura Manca; Jay S. Skyler; Andrea Mari; Ele Ferrannini
Diabetes March 2015, Vol.64, 2550-2559. doi:https://doi.org/10.2337/db15-0106
Complications
Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema
Jennifer K. Sun; Salma H. Radwan; Ahmed Z. Soliman; Jan Lammer; Michael M. Lin; Sonja G. Prager; Paolo S. Silva; Lloyd Bryce Aiello; Lloyd Paul Aiello
Diabetes January 2015, Vol.64, 2560-2570. doi:https://doi.org/10.2337/db14-0782
Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Humans
Diabetes February 2015, Vol.64, 2571-2580. doi:https://doi.org/10.2337/db14-1729
Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy
Sara Rezzola; Massimo Dal Monte; Mirella Belleri; Antonella Bugatti; Paola Chiodelli; Michela Corsini; Maurizio Cammalleri; Anna Cancarini; Lucia Morbidelli; Pasqua Oreste; Paola Bagnoli; Francesco Semeraro; Marco Presta
Diabetes February 2015, Vol.64, 2581-2592. doi:https://doi.org/10.2337/db14-1378
Inhibition of PAI-1 Via PAI-039 Improves Dermal Wound Closure in Diabetes
Irena A. Rebalka; Matthew J. Raleigh; Donna M. D’Souza; Samantha K. Coleman; Alexandra N. Rebalka; Thomas J. Hawke
Diabetes March 2015, Vol.64, 2593-2602. doi:https://doi.org/10.2337/db14-1174
Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy
Diabetes March 2015, Vol.64, 2603-2608. doi:https://doi.org/10.2337/db14-0866
Pharmacology and Therapeutics
Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia
Mohd. Parvez Khan; Abhishek Kumar Singh; Amit Arvind Joharapurkar; Manisha Yadav; Sonal Shree; Harish Kumar; Anagha Gurjar; Jay Sharan Mishra; Mahesh Chandra Tiwari; Geet Kumar Nagar; Sudhir Kumar; Ravishankar Ramachandran; Anupam Sharan; Mukul Rameshchandra Jain; Arun Kumar Trivedi; Rakesh Maurya; Madan Madhav Godbole; Jiaur Rahaman Gayen; Sabyasachi Sanyal; Naibedya Chattopadhyay
Diabetes January 2015, Vol.64, 2609-2623. doi:https://doi.org/10.2337/db14-1611
Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans
Juraj Koska; Michelle Sands; Camelia Burciu; Karen M. D’Souza; Kalyani Raravikar; James Liu; Seth Truran; Daniel A. Franco; Eric A. Schwartz; Dawn C. Schwenke; David D’Alessio; Raymond Q. Migrino; Peter D. Reaven
Diabetes February 2015, Vol.64, 2624-2635. doi:https://doi.org/10.2337/db14-0976
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance
David Ho; Xin Zhao; Lin Yan; Chujun Yuan; Haihong Zong; Dorothy E. Vatner; Jeffery E. Pessin; Stephen F. Vatner
Diabetes March 2015, Vol.64, 2636-2645. doi:https://doi.org/10.2337/db14-0494
Genetics / Genomes / Proteomics / Metabolomics
Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population
Robert L. Hanson; Rong Rong; Sayuko Kobes; Yunhua Li Muller; E. Jennifer Weil; Jeffrey M. Curtis; Robert G. Nelson; Leslie J. Baier
Diabetes February 2015, Vol.64, 2646-2657. doi:https://doi.org/10.2337/db14-1715
Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes
Sabrina Prudente; Hetal Shah; Diego Bailetti; Marcus Pezzolesi; Patinut Buranasupkajorn; Luana Mercuri; Christine Mendonca; Salvatore De Cosmo; Monika Niewczas; Vincenzo Trischitta; Alessandro Doria
Diabetes February 2015, Vol.64, 2658-2663. doi:https://doi.org/10.2337/db14-1653
Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus
Emily K. Blue; BreAnn M. Sheehan; Zia V. Nuss; Frances A. Boyle; Caleb M. Hocutt; Cassandra R. Gohn; Kaela M. Varberg; Jeanette N. McClintick; Laura S. Haneline
Diabetes February 2015, Vol.64, 2664-2675. doi:https://doi.org/10.2337/db14-1709
Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes
Tove Fall; Weijia Xie; Wenny Poon; Hanieh Yaghootkar; Reedik Mägi; the GENESIS Consortium; Joshua W. Knowles; Valeriya Lyssenko; Michael Weedon; Timothy M. Frayling; Erik Ingelsson
Diabetes May 2015, Vol.64, 2676-2684. doi:https://doi.org/10.2337/db14-1710
Erratum
Erratum. PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes 2015;64:529—540
Rongying Li; Jeongkyung Lee; Mi-sun Kim; Victoria Liu; Mousumi Moulik; Haiyan Li; Qing Yi; Aini Xie; Wenhao Chen; Lina Yang; Yimin Li; Tsung Huang Tsai; Kazuhiro Oka; Lawrence Chan; Vijay Yechoor
Diabetes June 2015, Vol.64, 2685. doi:https://doi.org/10.2337/db15-er07