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In This Issue of Diabetes

Extract

View articletitled, In This Issue of Diabetes

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Topics: diabetes mellitus, type 2 , diet , endostatins , exenatide , glucagon-like peptide 1

Diabetes June 2015, Vol.64, 2287-2288. doi:https://doi.org/10.2337/db15-ti07

Perspectives in Diabetes

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Allyson K. Palmer; Tamara Tchkonia; Nathan K. LeBrasseur; Eduardo N. Chini; Ming Xu; James L. Kirkland

Abstract

View articletitled, Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

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Topics: aging , cellular senescence , diabetes mellitus, type 2 , older adult , obesity

Diabetes June 2015, Vol.64, 2289-2298. doi:https://doi.org/10.2337/db14-1820

Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium

Rudolph L. Leibel; Randy J. Seeley; Tamara Darsow; Erika Gebel Berg; Steven R. Smith; Robert Ratner

Extract

View articletitled, Biologic Responses to Weight Loss and Weight Regain: Report From an American Diabetes Association Research Symposium

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Topics: weight reduction , obesity

Diabetes June 2015, Vol.64, 2299-2309. doi:https://doi.org/10.2337/db15-0004

Gut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism

Changting Xiao; Satya Dash; Cecilia Morgantini; Khosrow Adeli; Gary F. Lewis

Abstracts

View articletitled, Gut Peptides Are Novel Regulators of Intestinal Lipoprotein Secretion: Experimental and Pharmacological Manipulation of Lipoprotein Metabolism

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Topics: agonists , apolipoproteins b , bodily secretions , diabetes mellitus, type 2 , dipeptidyl-peptidase iv inhibitors

Diabetes June 2015, Vol.64, 2310-2318. doi:https://doi.org/10.2337/db14-1706

Commentaries

GLP-1R Agonists and Endothelial Dysfunction: More Than Just Glucose Lowering?

Julie Lovshin; David Cherney

Abstracts

View articletitled, GLP-1R Agonists and Endothelial Dysfunction: More Than Just Glucose Lowering?

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Topics: agonists , endothelial dysfunction , glucose , endothelium , exenatide

Diabetes June 2015, Vol.64, 2319-2321. doi:https://doi.org/10.2337/db15-0366

Hypoglycemia-Associated Autonomic Failure in Diabetes: Maladaptive, Adaptive, or Both?

Philip E. Cryer

Abstracts

View articletitled, Hypoglycemia-Associated Autonomic Failure in Diabetes: Maladaptive, Adaptive, or Both?

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Topics: hypoglycemia , pure autonomic failure , hypoglycemic agents

Diabetes June 2015, Vol.64, 2322-2323. doi:https://doi.org/10.2337/db15-0331

Defective Glucagon-Like Peptide 1 Secretion in Prediabetes and Type 2 Diabetes Is Influenced by Weight and Sex. Chicken, Egg, or None of the Above?

Adrian Vella; Claudio Cobelli

Abstracts

View articletitled, Defective Glucagon-Like Peptide 1 Secretion in Prediabetes and Type 2 Diabetes Is Influenced by Weight and Sex. Chicken, Egg, or None of the Above?

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Topics: bodily secretions , diabetes mellitus, type 2 , glucagon-like peptide 1 , prediabetes , chickens

Diabetes June 2015, Vol.64, 2324-2325. doi:https://doi.org/10.2337/db15-0292

Interaction of Adipogenesis and Angiogenesis in Dietary-Induced Obesity

Guanghong Jia; Luis A. Martinez-Lemus; James R. Sowers

Abstracts

View articletitled, Interaction of Adipogenesis and Angiogenesis in Dietary-Induced Obesity

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Topics: angiogenesis , diet , obesity , mtor serine-threonine kinases

Diabetes June 2015, Vol.64, 2326-2328. doi:https://doi.org/10.2337/db15-0202

An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes

Wilfredo Rosario; David D’Alessio

Abstracts

View articletitled, An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes

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Topics: epithelium , glucagon-like peptide 1 , inflammation , intestines , lymphocytes

Diabetes June 2015, Vol.64, 2329-2331. doi:https://doi.org/10.2337/db15-0436

PET Measurements of Organ Metabolism: The Devil Is in the Details

Kooresh I. Shoghi; Robert J. Gropler

Abstracts

View articletitled, PET Measurements of Organ Metabolism: The Devil Is in the Details

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Topics: metabolism , positron-emission tomography , radiolabel , lipoproteins, vldl , diagnostic imaging

Diabetes June 2015, Vol.64, 2332-2334. doi:https://doi.org/10.2337/db15-0226

Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes

Leslie S. Satin; Santiago Schnell

Abstracts

View articletitled, Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , gene expression , insulin , glucose

Diabetes June 2015, Vol.64, 2335-2337. doi:https://doi.org/10.2337/db15-0434

Intestinal Lipoprotein Secretion: Incretin-Based Physiology and Pharmacology Beyond Glucose

Robert H. Eckel

Abstracts

View articletitled, Intestinal Lipoprotein Secretion: Incretin-Based Physiology and Pharmacology Beyond Glucose

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Topics: agonists , bodily secretions , glucose , incretin , intestines

Diabetes June 2015, Vol.64, 2338-2340. doi:https://doi.org/10.2337/db15-0470

New Piece in the Jigsaw Puzzle: Adipose Tissue–Derived Stem Cells From Obese Subjects Drive Th17 Polarization

Balázs Csóka; Pál Pacher; Péter Bai; György Haskó

Abstracts

View articletitled, New Piece in the Jigsaw Puzzle: Adipose Tissue–Derived Stem Cells From Obese Subjects Drive Th17 Polarization

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Topics: adipose tissue , obesity , stem cells , interleukin-17

Diabetes June 2015, Vol.64, 2341-2343. doi:https://doi.org/10.2337/db15-0437

Blood Lipids and Type 2 Diabetes Risk: Can Genetics Help Untangle the Web?

Daniel I. Swerdlow; Naveed Sattar

Abstracts

View articletitled, Blood Lipids and Type 2 Diabetes Risk: Can Genetics Help Untangle the Web?

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Topics: diabetes mellitus, type 2 , genetics , lipids

Diabetes June 2015, Vol.64, 2344-2345. doi:https://doi.org/10.2337/db15-0458

Diabetes Symposium: Browning of Adipose Tissue—What’s New?

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

Paul Cohen; Bruce M. Spiegelman

Abstract

View articletitled, Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

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Topics: adipose tissue, beige , brown fat , adipocytes , thermogenesis , common cold

Diabetes June 2015, Vol.64, 2346-2351. doi:https://doi.org/10.2337/db15-0318

Human Brown Adipose Tissue: What We Have Learned So Far

Matthias J. Betz; Sven Enerbäck

Abstract

View articletitled, Human Brown Adipose Tissue: What We Have Learned So Far

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Topics: common cold , obesity , insulin resistance , cold sensation , cold temperature

Diabetes June 2015, Vol.64, 2352-2360. doi:https://doi.org/10.2337/db15-0146

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

Kristin I. Stanford; Roeland J.W. Middelbeek; Laurie J. Goodyear

Abstract

View articletitled, Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

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Topics: adipocytes , adipokines , adipose tissue , genes , mice

Diabetes June 2015, Vol.64, 2361-2368. doi:https://doi.org/10.2337/db15-0227

Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation

Patrick Seale

Abstract

View articletitled, Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation

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Topics: brown fat , genes , adipocytes , common cold , transcription, genetic

Diabetes June 2015, Vol.64, 2369-2375. doi:https://doi.org/10.2337/db15-0203

Metabolism

Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia

Thomas H. Meek; Mauricio D. Dorfman; Miles E. Matsen; Jonathan D. Fischer; Alexis Cubelo; Monica R. Kumar; Gerald J. Taborsky, Jr.; Gregory J. Morton

Abstract

View articletitled, Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia

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Topics: glucagon , glucose , hyperglycemia , insulin , ketosis

Diabetes January 2015, Vol.64, 2376-2387. doi:https://doi.org/10.2337/db14-1562

Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes

Denis P. Blondin; Sébastien M. Labbé; Christophe Noll; Margaret Kunach; Serge Phoenix; Brigitte Guérin; Éric E. Turcotte; François Haman; Denis Richard; André C. Carpentier

Abstract

View articletitled, Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes

Supplementary data

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Topics: cell respiration , cold sensation , cold temperature , common cold , diabetes mellitus, type 2

Diabetes February 2015, Vol.64, 2388-2397. doi:https://doi.org/10.2337/db14-1651

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

Gijs den Besten; Aycha Bleeker; Albert Gerding; Karen van Eunen; Rick Havinga; Theo H. van Dijk; Maaike H. Oosterveer; Johan W. Jonker; Albert K. Groen; Dirk-Jan Reijngoud; Barbara M. Bakker

Abstract

View articletitled, Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

Supplementary data

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Topics: ampk , insulin resistance , lipogenesis , liver , mice

Diabetes February 2015, Vol.64, 2398-2408. doi:https://doi.org/10.2337/db14-1213

GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice

Eva Tomas; Violeta Stanojevic; Karen McManus; Ashok Khatri; Paul Everill; William W. Bachovchin; Joel F. Habener

Abstracts

View articletitled, GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice

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Topics: amides , glucagon-like peptide 1 , mice , peptides

Diabetes April 2015, Vol.64, 2409-2419. doi:https://doi.org/10.2337/db14-1708

SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle

Young Do Koo; Jin Woo Choi; Myungjin Kim; Sehyun Chae; Byung Yong Ahn; Min Kim; Byung Chul Oh; Daehee Hwang; Jae Hong Seol; Young-Bum Kim; Young Joo Park; Sung Soo Chung; Kyong Soo Park

Abstract

View articletitled, SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle

Supplementary data

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Topics: enzymes , obesity , palmitates , polymerase chain reaction , protein overexpression

Diabetes March 2015, Vol.64, 2420-2431. doi:https://doi.org/10.2337/db15-0115

Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans

Margaret Kunach; Christophe Noll; Serge Phoenix; Brigitte Guérin; Jean-Patrice Baillargeon; Eric E. Turcotte; André C. Carpentier

Abstracts

View articletitled, Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans

Supplementary data

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Topics: chylomicrons , diet , glucose intolerance , liver , myocardium

Diabetes December 2014, Vol.64, 2432-2441. doi:https://doi.org/10.2337/db14-1166

Obesity Studies

Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis

Hui Wang; Yang Chen; Xin-an Lu; Guanghua Liu; Yan Fu; Yongzhang Luo

Abstracts

View articletitled, Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis

Supplementary data

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Topics: endostatins , obesity , diet

Diabetes January 2015, Vol.64, 2442-2456. doi:https://doi.org/10.2337/db14-0528

Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

Denovan P. Begg; Aaron A. May; Joram D. Mul; Min Liu; David A. D’Alessio; Randy J. Seeley; Stephen C. Woods

Abstract

View articletitled, Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

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Topics: cerebrospinal fluid , insulin , isophane insulin , plasma , mice

Diabetes February 2015, Vol.64, 2457-2466. doi:https://doi.org/10.2337/db14-1364

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Abstract

View articletitled, Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Supplementary data

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Topics: body mass index procedure , child , diet , fto gene , obesity

Diabetes February 2015, Vol.64, 2467-2476. doi:https://doi.org/10.2337/db14-1629

Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

Assia Eljaafari; Maud Robert; Marwa Chehimi; Stephanie Chanon; Christine Durand; Guillaume Vial; Nadia Bendridi; Anne-Marie Madec; Emmanuel Disse; Martine Laville; Jennifer Rieusset; Etienne Lefai; Hubert Vidal; Luciano Pirola

Abstracts

View articletitled, Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

Supplementary data

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Topics: ambulatory surgery center , bodily secretions , coculture techniques , interleukin-17 , obesity

Diabetes March 2015, Vol.64, 2477-2488. doi:https://doi.org/10.2337/db15-0162

Islet Studies

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

William J. Stanley; Sara A. Litwak; Hong Sheng Quah; Sih Min Tan; Thomas W.H. Kay; Tony Tiganis; Judy B. de Haan; Helen E. Thomas; Esteban N. Gurzov

Abstract

View articletitled, Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

Supplementary data

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Topics: interferons , mice , protein tyrosine phosphatase , signal transduction , endocrine pancreas

Diabetes March 2015, Vol.64, 2489-2496. doi:https://doi.org/10.2337/db14-1575

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

Patrick S. McGrath; Carey L. Watson; Cameron Ingram; Michael A. Helmrath; James M. Wells

Abstract

View articletitled, The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

Supplementary data

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Topics: endocrine cells , endocrine pancreas , mice , pancreas , transcription factor

Diabetes January 2015, Vol.64, 2497-2505. doi:https://doi.org/10.2337/db14-1412

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study

Lars Krogvold; Oskar Skog; Görel Sundström; Bjørn Edwin; Trond Buanes; Kristian F. Hanssen; Johnny Ludvigsson; Manfred Grabherr; Olle Korsgren; Knut Dahl-Jørgensen

Abstracts

View articletitled, Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD Study

Supplementary data

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Topics: diabetes mellitus, type 1 , endocrine pancreas , genes , glucose , insulin

Diabetes February 2015, Vol.64, 2506-2512. doi:https://doi.org/10.2337/db14-1911

Pathophysiology

GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

Kristine Færch; Signe S. Torekov; Dorte Vistisen; Nanna B. Johansen; Daniel R. Witte; Anna Jonsson; Oluf Pedersen; Torben Hansen; Torsten Lauritzen; Annelli Sandbæk; Jens Juul Holst; Marit E. Jørgensen

Abstracts

View articletitled, GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

Supplementary data

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Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose , obesity , prediabetes

Diabetes February 2015, Vol.64, 2513-2525. doi:https://doi.org/10.2337/db14-1751

Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

Yanqing Wu; Fang Wang; Mao Fu; Cheng Wang; Michael J. Quon; Peixin Yang

Abstract

View articletitled, Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy

Supplementary data

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Topics: diabetes mellitus, type 2 , embryo , insulin , metformin , mice

Diabetes February 2015, Vol.64, 2526-2536. doi:https://doi.org/10.2337/db14-1683

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Bernardo Yusta; Laurie L. Baggio; Jacqueline Koehler; Dianne Holland; Xiemin Cao; Lee J. Pinnell; Kathene C. Johnson-Henry; William Yeung; Michael G. Surette; K.W. Annie Bang; Philip M. Sherman; Daniel J. Drucker

Abstracts

View articletitled, GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Supplementary data

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Topics: agonists , intestines , mice , signal transduction , rna, messenger

Diabetes March 2015, Vol.64, 2537-2549. doi:https://doi.org/10.2337/db14-1577

Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance

Barry E. Hurwitz; Neil Schneiderman; Jennifer B. Marks; Armando J. Mendez; Alex Gonzalez; Maria M. Llabre; Steven R. Smith; Roberto Bizzotto; Eleonora Santini; Maria Laura Manca; Jay S. Skyler; Andrea Mari; Ele Ferrannini

Abstract

View articletitled, Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance

Supplementary data

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Topics: carbohydrates , diet, carbohydrate loading , endothelium , glucose , insulin

Diabetes March 2015, Vol.64, 2550-2559. doi:https://doi.org/10.2337/db15-0106

Complications

Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema

Jennifer K. Sun; Salma H. Radwan; Ahmed Z. Soliman; Jan Lammer; Michael M. Lin; Sonja G. Prager; Paolo S. Silva; Lloyd Bryce Aiello; Lloyd Paul Aiello

Abstracts

View articletitled, Neural Retinal Disorganization as a Robust Marker of Visual Acuity in Current and Resolved Diabetic Macular Edema

Supplementary data

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Topics: cysts , edema , eye , spectral domain-optical coherence tomography , diabetic macular edema

Diabetes January 2015, Vol.64, 2560-2570. doi:https://doi.org/10.2337/db14-0782

Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Humans

Nino G. Joy; Donna B. Tate; Lisa M. Younk; Stephen N. Davis

Abstracts

View articletitled, Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Humans

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Topics: blood glucose normal , endothelium , hypoglycemia , hypoglycemic agents , insulin

Diabetes February 2015, Vol.64, 2571-2580. doi:https://doi.org/10.2337/db14-1729

Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy

Sara Rezzola; Massimo Dal Monte; Mirella Belleri; Antonella Bugatti; Paola Chiodelli; Michela Corsini; Maurizio Cammalleri; Anna Cancarini; Lucia Morbidelli; Pasqua Oreste; Paola Bagnoli; Francesco Semeraro; Marco Presta

Abstracts

View articletitled, Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy

Supplementary data

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Topics: angiogenesis , heparin , mice , vascular endothelial growth factor a , vascular endothelial growth factor receptor-2

Diabetes February 2015, Vol.64, 2581-2592. doi:https://doi.org/10.2337/db14-1378

Inhibition of PAI-1 Via PAI-039 Improves Dermal Wound Closure in Diabetes

Irena A. Rebalka; Matthew J. Raleigh; Donna M. D’Souza; Samantha K. Coleman; Alexandra N. Rebalka; Thomas J. Hawke

Abstract

View articletitled, Inhibition of PAI-1 Via PAI-039 Improves Dermal Wound Closure in Diabetes

Supplementary data

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Topics: epidermis , mice , plasminogen activator inhibitor 1 , streptozocin , symptom aggravating factors

Diabetes March 2015, Vol.64, 2593-2602. doi:https://doi.org/10.2337/db14-1174

Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy

Argyrios Chronopoulos; Sumon Roy; Ekaterina Beglova; Keith Mansfield; Lynn Wachtman; Sayon Roy

Abstracts

View articletitled, Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy

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Topics: blood capillaries , callithrix , retina , primates , diabetic retinopathy

Diabetes March 2015, Vol.64, 2603-2608. doi:https://doi.org/10.2337/db14-0866

Pharmacology and Therapeutics

Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia

Abstracts

View articletitled, Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia

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Topics: mice , osteoblasts , osteopenia , glucose , skeletal muscles

Diabetes January 2015, Vol.64, 2609-2623. doi:https://doi.org/10.2337/db14-1611

Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans

Juraj Koska; Michelle Sands; Camelia Burciu; Karen M. D’Souza; Kalyani Raravikar; James Liu; Seth Truran; Daniel A. Franco; Eric A. Schwartz; Dawn C. Schwenke; David D’Alessio; Raymond Q. Migrino; Peter D. Reaven

Abstracts

View articletitled, Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans

Supplementary data

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Topics: exenatide , glucose , lipids , endothelial dysfunction , vasodilation

Diabetes February 2015, Vol.64, 2624-2635. doi:https://doi.org/10.2337/db14-0976

Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance

David Ho; Xin Zhao; Lin Yan; Chujun Yuan; Haihong Zong; Dorothy E. Vatner; Jeffery E. Pessin; Stephen F. Vatner

Abstracts

View articletitled, Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance

Supplementary data

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Topics: insulin , insulin resistance , mice , obesity , diet

Diabetes March 2015, Vol.64, 2636-2645. doi:https://doi.org/10.2337/db14-0494

Genetics / Genomes / Proteomics / Metabolomics

Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population

Robert L. Hanson; Rong Rong; Sayuko Kobes; Yunhua Li Muller; E. Jennifer Weil; Jeffrey M. Curtis; Robert G. Nelson; Leslie J. Baier

Abstract

View articletitled, Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population

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Topics: diabetes mellitus, type 2 , gene frequency

Diabetes February 2015, Vol.64, 2646-2657. doi:https://doi.org/10.2337/db14-1715

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes

Sabrina Prudente; Hetal Shah; Diego Bailetti; Marcus Pezzolesi; Patinut Buranasupkajorn; Luana Mercuri; Christine Mendonca; Salvatore De Cosmo; Monika Niewczas; Vincenzo Trischitta; Alessandro Doria

Abstract

View articletitled, Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , genetics , glul gene , cardiovascular death

Diabetes February 2015, Vol.64, 2658-2663. doi:https://doi.org/10.2337/db14-1653

Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus

Emily K. Blue; BreAnn M. Sheehan; Zia V. Nuss; Frances A. Boyle; Caleb M. Hocutt; Cassandra R. Gohn; Kaela M. Varberg; Jeanette N. McClintick; Laura S. Haneline

Abstracts

View articletitled, Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus

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Topics: aging , dna , endothelium , epigenetics , genes

Diabetes February 2015, Vol.64, 2664-2675. doi:https://doi.org/10.2337/db14-1709

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

Tove Fall; Weijia Xie; Wenny Poon; Hanieh Yaghootkar; Reedik Mägi; the GENESIS Consortium; Joshua W. Knowles; Valeriya Lyssenko; Michael Weedon; Timothy M. Frayling; Erik Ingelsson

Abstracts

View articletitled, Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

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Topics: lipids , single nucleotide polymorphism , diabetes mellitus, type 2 , high density lipoprotein cholesterol

Diabetes May 2015, Vol.64, 2676-2684. doi:https://doi.org/10.2337/db14-1710

Erratum

Erratum. PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes 2015;64:529—540

Rongying Li; Jeongkyung Lee; Mi-sun Kim; Victoria Liu; Mousumi Moulik; Haiyan Li; Qing Yi; Aini Xie; Wenhao Chen; Lina Yang; Yimin Li; Tsung Huang Tsai; Kazuhiro Oka; Lawrence Chan; Vijay Yechoor

Extract

View articletitled, Erratum. PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice. Diabetes 2015;64:<a href="XSLT_Related_Article_Replace_Href" data-vol="64" data-page="529">529—540</a>

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Topics: diabetes mellitus, type 1 , mice, inbred nod , programmed cell death 1 ligand 1

Diabetes June 2015, Vol.64, 2685. doi:https://doi.org/10.2337/db15-er07

Issues and Events

Extract

View articletitled, Issues and Events

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Topics: databases , hawaii , louisiana , podcasts

Diabetes June 2015, Vol.64, 2686. doi:https://doi.org/10.2337/db15-ie07

E-Letters: Comments and Responses

Comment on Vandal et al. Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291–4301

Husam Ghanim; Paresh Dandona

Extract

View articletitled, Comment on Vandal et al. Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291–4301

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Topics: alzheimer's disease , animal model , brain , diet, high-fat , insulin

Diabetes June 2015, Vol.64, e17. doi:https://doi.org/10.2337/db15-0267

Response to Comment on Vandal et al. Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291–4301

Milene Vandal; Frederic Calon

Extract

View articletitled, Response to Comment on Vandal et al. Insulin Reverses the High-Fat Diet–Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291–4301

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Topics: alzheimer's disease , animal model , brain , diet, high-fat , insulin

Diabetes June 2015, Vol.64, e18. doi:https://doi.org/10.2337/db15-0386

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