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1 September 2015
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Topics:
diabetes mellitus, type 1
,
diabetes mellitus, type 2
,
high density lipoprotein cholesterol
,
mendelian randomization analysis
,
micrornas
Diabetes August 2015, Vol.64, 3053-3054. doi:https://doi.org/10.2337/db15-ti09
Commentaries
Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions
Topics:
adipocytes
,
adipose tissue
,
bodily secretions
,
muscle cells
,
obesity
Diabetes August 2015, Vol.64, 3055-3057. doi:https://doi.org/10.2337/db15-0403
SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control
Topics:
carbon
,
glycemic control
,
mice
,
glucose intolerance
,
glucose
Diabetes August 2015, Vol.64, 3058-3060. doi:https://doi.org/10.2337/db15-0709
A Dash of Salt-Inducible Kinase 1 Keeps Insulin Levels in Check
Topics:
cyclic amp
,
dietary sodium chloride
,
insulin
,
insulin secretion
,
phosphotransferases
Diabetes August 2015, Vol.64, 3061-3062. doi:https://doi.org/10.2337/db15-0692
Diabetic Nephropathy: Emerging Biomarkers for Risk Assessment
Topics:
biological markers
,
diabetic nephropathy
,
micrornas
Diabetes August 2015, Vol.64, 3063-3065. doi:https://doi.org/10.2337/db15-0738
New Insights on the Role of SERCA During Vessel Remodeling in Metabolic Syndrome
Diabetes August 2015, Vol.64, 3066-3068. doi:https://doi.org/10.2337/db15-0761
Metabolism
DLK1 Regulates Whole-Body Glucose Metabolism: A Negative Feedback Regulation of the Osteocalcin-Insulin Loop
Topics:
insulin
,
mice
,
insulin secretion
Diabetes April 2015, Vol.64, 3069-3080. doi:https://doi.org/10.2337/db14-1642
SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice
Louise Lantier; Ashley S. Williams; Ian M. Williams; Karen K. Yang; Deanna P. Bracy; Mickael Goelzer; Freyja D. James; David Gius; David H. Wasserman
Topics:
heart failure
,
insulin
,
mice
,
skeletal muscles
,
insulin resistance
Diabetes May 2015, Vol.64, 3081-3092. doi:https://doi.org/10.2337/db14-1810
Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice
Jose Cordoba-Chacon; Neena Majumdar; Edward O. List; Alberto Diaz-Ruiz; Stuart J. Frank; Anna Manzano; Ramon Bartrons; Michelle Puchowicz; John J. Kopchick; Rhonda D. Kineman
Topics:
liver
,
mice
,
insulin
,
somatotropin
,
somatropin
Diabetes May 2015, Vol.64, 3093-3103. doi:https://doi.org/10.2337/db15-0370
Obesity Studies
Preserved Insulin Secretory Capacity and Weight Loss Are the Predominant Predictors of Glycemic Control in Patients With Type 2 Diabetes Randomized to Roux-en-Y Gastric Bypass
Kim T. Nguyen; Charles J. Billington; Adrian Vella; Qi Wang; Leaque Ahmed; John P. Bantle; Marc Bessler; John E. Connett; William B. Inabnet; Avis Thomas; Sayeed Ikramuddin; Judith Korner
Topics:
c-peptide
,
diabetes mellitus, type 2
,
gastric bypass, roux-en-y
,
hemoglobin a, glycosylated
,
insulin
Diabetes April 2015, Vol.64, 3104-3110. doi:https://doi.org/10.2337/db14-1870
Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice
Liping Qiao; Zhuyu Guo; Chris Bosco; Stefano Guidotti; Yunfeng Wang; Mingyong Wang; Mana Parast; Jerome Schaack; William W. Hay, Jr.; Thomas R. Moore; Jianhua Shao
Topics:
fetus
,
heart failure
,
placenta
,
trophoblasts
,
mice
Diabetes May 2015, Vol.64, 3111-3120. doi:https://doi.org/10.2337/db14-1627
Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity
Vanessa Pellegrinelli; Christine Rouault; Sergio Rodriguez-Cuenca; Victorine Albert; Frédérique Edom-Vovard; Antonio Vidal-Puig; Karine Clément; Gillian S. Butler-Browne; Danièle Lacasa
Topics:
adipocytes
,
muscle cells
,
obesity
,
skeletal myocytes
,
atrophy
Diabetes February 2015, Vol.64, 3121-3134. doi:https://doi.org/10.2337/db14-0796
Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity
Sini Heinonen; Jana Buzkova; Maheswary Muniandy; Risto Kaksonen; Miina Ollikainen; Khadeeja Ismail; Antti Hakkarainen; Jesse Lundbom; Nina Lundbom; Katriina Vuolteenaho; Eeva Moilanen; Jaakko Kaprio; Aila Rissanen; Anu Suomalainen; Kirsi H. Pietiläinen
Topics:
mitochondria
,
obesity
,
twins
,
dna, mitochondrial
Diabetes May 2015, Vol.64, 3135-3145. doi:https://doi.org/10.2337/db14-1937
DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts
Tao Huang; Yan Zheng; Qibin Qi; Min Xu; Sylvia H. Ley; Yanping Li; Jae H. Kang; Janey Wiggs; Louis R. Pasquale; Andrew T. Chan; Eric B. Rimm; David J. Hunter; JoAnn E. Manson; Walter C. Willett; Frank B. Hu; Lu Qi
Topics:
body mass index procedure
,
diet
,
dna methylation
,
genetics
,
obesity
Diabetes May 2015, Vol.64, 3146-3154. doi:https://doi.org/10.2337/db15-0264
Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress
Topics:
ampk
,
fat, subcutaneous
,
insulin sensitivity
,
malonyl coenzyme a
,
oxidative stress
Diabetes May 2015, Vol.64, 3155-3159. doi:https://doi.org/10.2337/db14-1765
Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function
Andrew J. Murton; Kanagaraj Marimuthu; Joanne E. Mallinson; Anna L. Selby; Kenneth Smith; Michael J. Rennie; Paul L. Greenhaff
Topics:
muscle proteins
,
obesity
,
older adult
,
leg
,
insulin
Diabetes May 2015, Vol.64, 3160-3171. doi:https://doi.org/10.2337/db15-0021
Islet Studies
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
David M. Blodgett; Anetta Nowosielska; Shaked Afik; Susanne Pechhold; Anthony J. Cura; Norman J. Kennedy; Soyoung Kim; Alper Kucukural; Roger J. Davis; Sally C. Kent; Dale L. Greiner; Manuel G. Garber; David M. Harlan; Philip diIorio
Topics:
endocrine pancreas
,
fetus
,
genes
,
hormones
,
rna
Diabetes April 2015, Vol.64, 3172-3181. doi:https://doi.org/10.2337/db15-0039
Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel
Rachel J. Salisbury; Bing Han; Rachel E. Jennings; Andrew A. Berry; Adam Stevens; Zainab Mohamed; Sarah A. Sugden; Ronald De Krijger; Sarah E. Cross; Paul P.V. Johnson; Melanie Newbould; Karen E. Cosgrove; Karen Piper Hanley; Indraneel Banerjee; Mark J. Dunne; Neil A. Hanley
Topics:
congenital hyperinsulinism
,
fetus
,
infant
,
insulin
,
mutation
Diabetes April 2015, Vol.64, 3182-3188. doi:https://doi.org/10.2337/db14-1202
Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells
Min-Jung Kim; Su-Kyung Park; Ji-Hyun Lee; Chang-Yun Jung; Dong Jun Sung; Jae-Hyung Park; Young-Sil Yoon; Jinyoung Park; Keun-Gyu Park; Dae-Kyu Song; Hana Cho; Seong-Tae Kim; Seung-Hoi Koo
Topics:
cyclic amp
,
insulin secretion
,
phosphotransferases
,
glucose
,
phosphorylation
Diabetes April 2015, Vol.64, 3189-3202. doi:https://doi.org/10.2337/db14-1240
GPR43 Potentiates β-Cell Function in Obesity
Joanne C. McNelis; Yun Sok Lee; Rafael Mayoral; Rik van der Kant; Andrew M.F. Johnson; Joshua Wollam; Jerrold M. Olefsky
Topics:
acetates
,
agonists
,
insulin
,
insulin secretion
,
mice
Diabetes May 2015, Vol.64, 3203-3217. doi:https://doi.org/10.2337/db14-1938
Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury
Yixing Yuchi; Ying Cai; Bart Legein; Sofie De Groef; Gunter Leuckx; Violette Coppens; Eva Van Overmeire; Willem Staels; Nico De Leu; Geert Martens; Jo A. Van Ginderachter; Harry Heimberg; Mark Van de Casteele
Topics:
mice
,
pancreas
,
embryo
,
gene expression
,
estrogen
Diabetes May 2015, Vol.64, 3218-3228. doi:https://doi.org/10.2337/db14-1798
Immunology and Transplantation
BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
Balasubramanian Krishnamurthy; Jonathan Chee; Gaurang Jhala; Prerak Trivedi; Tara Catterall; Claudia Selck; Esteban N. Gurzov; Thomas C. Brodnicki; Kate L. Graham; Jibran A. Wali; Yifan Zhan; Daniel Gray; Andreas Strasser; Janette Allison; Helen E. Thomas; Thomas W.H. Kay
Topics:
mice
,
mice, inbred nod
,
regulatory t-lymphocytes
,
thymocytes
,
t-lymphocytes
Diabetes May 2015, Vol.64, 3229-3238. doi:https://doi.org/10.2337/db14-1851
Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes
Alistair J.K. Williams; Vito Lampasona; Michael Schlosser; Patricia W. Mueller; David L. Pittman; William E. Winter; Beena Akolkar; Rebecca Wyatt; Cristina Brigatti; Stephanie Krause; Peter Achenbach; Participating Laboratories
Topics:
antibodies
,
autoantibodies
,
generalized anxiety disorder
,
diabetes mellitus, type 1
,
serum
Diabetes May 2015, Vol.64, 3239-3246. doi:https://doi.org/10.2337/db14-1693
Reactivity to N-Terminally Truncated GAD65(96–585) Identifies GAD Autoantibodies That Are More Closely Associated With Diabetes Progression in Relatives of Patients With Type 1 Diabetes
Alistair J.K. Williams; Vito Lampasona; Rebecca Wyatt; Cristina Brigatti; Kathleen M. Gillespie; Polly J. Bingley; Peter Achenbach
Diabetes May 2015, Vol.64, 3247-3252. doi:https://doi.org/10.2337/db14-1694
Complications
Effects of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Healthy Man
Topics:
alprazolam
,
blood glucose normal
,
gaba-a receptor
,
glucagon
,
glucose
Diabetes April 2015, Vol.64, 3253-3261. doi:https://doi.org/10.2337/db15-0212
Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes
Gilberto Velho; Stéphanie Ragot; Kamel Mohammedi; Elise Gand; Mathilde Fraty; Frédéric Fumeron; Pierre-Jean Saulnier; Naima Bellili-Munoz; Nadine Bouby; Louis Potier; François Alhenc-Gelas; Michel Marre; Samy Hadjadj; Ronan Roussel
Topics:
follow-up
,
mid-regional pro-adrenomedullin
,
plasma
,
kidney
,
diabetes mellitus, type 2
Diabetes May 2015, Vol.64, 3262-3272. doi:https://doi.org/10.2337/db14-1852
GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop
Ferdinando Giacco; Xueliang Du; Anna Carratú; Gary J. Gerfen; Maria D’Apolito; Ida Giardino; Andrea Rasola; Oriano Marin; Ajit S. Divakaruni; Anne N. Murphy; Manasi S. Shah; Michael Brownlee
Topics:
glucose
,
glucagon-like peptide 1
,
hyperglycemia
Diabetes August 2015, Vol.64, 3273-3284. doi:https://doi.org/10.2337/db15-0084
Circulating TGF-β1–Regulated miRNAs and the Risk of Rapid Progression to ESRD in Type 1 Diabetes
Marcus G. Pezzolesi; Eiichiro Satake; Kevin P. McDonnell; Melissa Major; Adam M. Smiles; Andrzej S. Krolewski
Topics:
kidney failure, chronic
,
micrornas
,
plasma
Diabetes April 2015, Vol.64, 3285-3293. doi:https://doi.org/10.2337/db15-0116
The Metabolic Syndrome and Microvascular Complications in a Murine Model of Type 2 Diabetes
Junguk Hur; Jacqueline R. Dauch; Lucy M. Hinder; John M. Hayes; Carey Backus; Subramaniam Pennathur; Matthias Kretzler; Frank C. Brosius, III; Eva L. Feldman
Topics:
diabetes mellitus, type 2
,
metabolic syndrome x
,
mice
,
phenotype determination
,
pioglitazone
Diabetes May 2015, Vol.64, 3294-3304. doi:https://doi.org/10.2337/db15-0133
Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis
John D. Clarke; Anika L. Dzierlenga; Nicholas R. Nelson; Hui Li; Samantha Werts; Michael J. Goedken; Nathan J. Cherrington
Topics:
diet
,
kidney
,
membrane transport proteins
,
metformin
,
mice
Diabetes May 2015, Vol.64, 3305-3313. doi:https://doi.org/10.2337/db14-1947
Pharmacology and Therapeutics
Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)–Deficient Mice
Topics:
ghrelin
,
insulin
,
mice
,
hepatocytes
,
glucose homeostasis
Diabetes May 2015, Vol.64, 3314-3320. doi:https://doi.org/10.2337/db15-0124
Metabolic Syndrome Abolishes Glucagon-Like Peptide 1 Receptor Agonist Stimulation of SERCA in Coronary Smooth Muscle
Stacey L. Dineen; Mikaela L. McKenney; Lauren N. Bell; Allison M. Fullenkamp; Kyle A. Schultz; Mouhamad Alloosh; Naga Chalasani; Michael Sturek
Topics:
exenatide
,
glucagon-like peptide-1 agonists
,
intravascular ultrasonography
,
metabolic syndrome x
,
sarcoplasmic reticulum calcium-transporting atpases
Diabetes April 2015, Vol.64, 3321-3327. doi:https://doi.org/10.2337/db14-1790
Genetics / Genomes / Proteomics / Metabolomics
HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Diabetes May 2015, Vol.64, 3328-3333. doi:https://doi.org/10.2337/db14-1603
Errata
Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835–3845
Sefina Arif; Pia Leete; Vy Nguyen; Katherine Marks; Nurhanani Mohamed Nor; Megan Estorninho; Deborah Kronenberg-Versteeg; Polly J. Bingley; John A. Todd; Catherine Guy; David B. Dunger; Jake Powrie; Abby Willcox; Alan K. Foulis; Sarah J. Richardson; Emanuele de Rinaldis; Noel G. Morgan; Anna Lorenc; Mark Peakman
Topics:
diabetes mellitus, type 1
,
heterogeneity
,
phenotype
Diabetes August 2015, Vol.64, 3334. doi:https://doi.org/10.2337/db15-er09a
Issues and Events
Issues and Events
Topics:
health personnel
Diabetes August 2015, Vol.64, 3335. doi:https://doi.org/10.2337/db15-ie09
E-Letters: Comments and Responses
Comment on Pellegrinelli et al. Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity. Diabetes 2015;64:3121–3134
Topics:
adipocytes
,
atrophy
,
inflammation
,
muscle cells
,
obesity
Diabetes August 2015, Vol.64, e22. doi:https://doi.org/10.2337/db15-0296
Response to Comment on Pellegrinelli et al. Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity. Diabetes 2015;64:3121–3134
Topics:
adipocytes
,
atrophy
,
inflammation
,
muscle cells
,
obesity
Diabetes August 2015, Vol.64, e23-e24. doi:https://doi.org/10.2337/db15-0440
Comment on Rickels et al. Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults. Diabetes 2015;64:193–199
Topics:
abca1 gene
,
loss of function mutation
,
young adult
,
cholesterol
Diabetes August 2015, Vol.64, e25-e26. doi:https://doi.org/10.2337/db15-0518
Comment on Færch et al. GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes 2015;64:2513–2525
Topics:
diabetes mellitus, type 2
,
glucagon-like peptide 1
,
glucose
,
obesity
,
prediabetes
Diabetes August 2015, Vol.64, e28-e29. doi:https://doi.org/10.2337/db15-0614
Response to Comment on Færch et al. GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes 2015;64:2513–2525
Kristine Færch; Signe S. Torekov; Dorte Vistisen; Nanna B. Johansen; Daniel R. Witte; Anna Jonsson; Oluf Pedersen; Torben Hansen; Torsten Lauritzen; Annelli Sandbæk; Jens Juul Holst; Marit E. Jørgensen
Topics:
diabetes mellitus, type 2
,
glucagon-like peptide 1
,
glucose
,
obesity
,
prediabetes
Diabetes August 2015, Vol.64, e30-e31. doi:https://doi.org/10.2337/db15-0743
Comment on Sharma. Mitochondrial Hormesis and Diabetic Complications. Diabetes 2015;64:663–672
Topics:
diabetes mellitus complications
,
mitochondria
Diabetes August 2015, Vol.64, e32-e33. doi:https://doi.org/10.2337/db15-0589
Response to Comment on Sharma. Mitochondrial Hormesis and Diabetic Complications. Diabetes 2015;64:663–672
Topics:
diabetes mellitus complications
,
mitochondria
Diabetes August 2015, Vol.64, e34. doi:https://doi.org/10.2337/db15-0800
