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1 October 2016
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes September 2016, Vol.65, 2819-2820. doi:https://doi.org/10.2337/db16-ti10
Editorial
Eulogy for the Metabolic Clinical Investigator?
Diabetes September 2016, Vol.65, 2821-2823. doi:https://doi.org/10.2337/db16-0923
Commentaries
Exosomes in Diabetic Cardiomyopathy: The Next-Generation Therapeutic Targets?
Diabetes September 2016, Vol.65, 2829-2831. doi:https://doi.org/10.2337/dbi16-0041
Hydrogen Sulfide Therapy in Diabetes-Accelerated Atherosclerosis: A Whiff of Success
Diabetes September 2016, Vol.65, 2832-2834. doi:https://doi.org/10.2337/dbi16-0042
Metabolism
O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis
Jagannath Misra; Don-Kyu Kim; Yoon Seok Jung; Han Byeol Kim; Yong-Hoon Kim; Eun-Kyung Yoo; Byung Gyu Kim; Sunghoon Kim; In-Kyu Lee; Robert A. Harris; Jeong-Sun Kim; Chul-Ho Lee; Jin Won Cho; Hueng-Sik Choi
Diabetes June 2016, Vol.65, 2835-2848. doi:https://doi.org/10.2337/db15-1523
TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle
Anja Böhm; Christoph Hoffmann; Martin Irmler; Patrick Schneeweiss; Günter Schnauder; Corinna Sailer; Vera Schmid; Jens Hudemann; Jürgen Machann; Fritz Schick; Johannes Beckers; Martin Hrabě de Angelis; Harald Staiger; Andreas Fritsche; Norbert Stefan; Andreas M. Nieß; Hans-Ulrich Häring; Cora Weigert
Diabetes June 2016, Vol.65, 2849-2861. doi:https://doi.org/10.2337/db15-1723
One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation
Marlou L. Dirks; Benjamin T. Wall; Bas van de Valk; Tanya M. Holloway; Graham P. Holloway; Adrian Chabowski; Gijs H. Goossens; Luc J.C. van Loon
Diabetes June 2016, Vol.65, 2862-2875. doi:https://doi.org/10.2337/db15-1661
Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis
Younghoon Go; Ji Yun Jeong; Nam Ho Jeoung; Jae-Han Jeon; Bo-Yoon Park; Hyeon-Ji Kang; Chae-Myeong Ha; Young-Keun Choi; Sun Joo Lee; Hye Jin Ham; Byung-Gyu Kim; Keun-Gyu Park; So Young Park; Chul-Ho Lee; Cheol Soo Choi; Tae-Sik Park; W.N. Paul Lee; Robert A. Harris; In-Kyu Lee
Diabetes July 2016, Vol.65, 2876-2887. doi:https://doi.org/10.2337/db16-0223
Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness
Rona J. Strawbridge; Agneta Hilding; Angela Silveira; Cecilia Österholm; Bengt Sennblad; Olga McLeod; Panagiota Tsikrika; Fariba Foroogh; Elena Tremoli; Damiano Baldassarre; Fabrizio Veglia; Rainer Rauramaa; Andries J. Smit; Phillipe Giral; Sudhir Kurl; Elmo Mannarino; Enzo Grossi; Ann-Christine Syvänen; Steve E. Humphries; Ulf de Faire; Claes-Göran Östenson; Lars Maegdefessel; Anders Hamsten; Alexandra Bäcklund; on behalf of the IMPROVE Study Group
Diabetes September 2016, Vol.65, 2888-2899. doi:https://doi.org/10.2337/db15-1333
Gene Expression and DNA Methylation of PPARGC1A in Muscle and Adipose Tissue From Adult Offspring of Women With Diabetes in Pregnancy
Louise Kelstrup; Line Hjort; Azadeh Houshmand-Oeregaard; Tine D. Clausen; Ninna S. Hansen; Christa Broholm; Liv Borch-Johnsen; Elisabeth R. Mathiesen; Allan A. Vaag; Peter Damm
Diabetes July 2016, Vol.65, 2900-2910. doi:https://doi.org/10.2337/db16-0227
Increased Skeletal Muscle GLUT4 Expression in Obese Mice After Voluntary Wheel Running Exercise Is Posttranscriptional
Diabetes July 2016, Vol.65, 2911-2919. doi:https://doi.org/10.2337/db16-0305
Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase
Laura K.M. Steinbusch; Alexandre Picard; Marion S. Bonnet; Davide Basco; Gwenaël Labouèbe; Bernard Thorens
Diabetes July 2016, Vol.65, 2920-2931. doi:https://doi.org/10.2337/db15-1514
Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG
Annette Karen Serup; Thomas Junker Alsted; Andreas Børsting Jordy; Peter Schjerling; Cecilia Holm; Bente Kiens
Diabetes August 2016, Vol.65, 2932-2942. doi:https://doi.org/10.2337/db16-0655
Obesity Studies
Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial
Olivia M. Farr; Jagriti Upadhyay; Anna Gavrieli; Michelle Camp; Nikolaos Spyrou; Harper Kaye; Hannah Mathew; Maria Vamvini; Anastasia Koniaris; Holly Kilim; Alexandra Srnka; Alexandra Migdal; Christos S. Mantzoros
Diabetes July 2016, Vol.65, 2943-2953. doi:https://doi.org/10.2337/db16-0635
Fat Mass Reduction With Adipocyte Hypertrophy and Insulin Resistance in Heterozygous PPARγ Mutant Rats
Valentino Gumbilai; Ken Ebihara; Megumi Aizawa-Abe; Chihiro Ebihara; Mingming Zhao; Yuji Yamamoto; Tomoji Mashimo; Kiminori Hosoda; Tadao Serikawa; Kazuwa Nakao
Diabetes July 2016, Vol.65, 2954-2965. doi:https://doi.org/10.2337/db15-1422
DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization
Fen Zhuge; Yinhua Ni; Mayumi Nagashimada; Naoto Nagata; Liang Xu; Naofumi Mukaida; Shuichi Kaneko; Tsuguhito Ota
Diabetes July 2016, Vol.65, 2966-2979. doi:https://doi.org/10.2337/db16-0317
Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity
Hong Jiao; Agné Kulyté; Erik Näslund; Anders Thorell; Paul Gerdhem; Juha Kere; Peter Arner; Ingrid Dahlman
Diabetes July 2016, Vol.65, 2980-2989. doi:https://doi.org/10.2337/db16-0522
Insulin Resistance, Microbiota, and Fat Distribution Changes by a New Model of Vertical Sleeve Gastrectomy in Obese Rats
Nicola Basso; Emanuele Soricelli; Lidia Castagneto-Gissey; Giovanni Casella; Davide Albanese; Francesca Fava; Claudio Donati; Kieran Tuohy; Giulia Angelini; Federica La Neve; Anna Severino; Virginia Kamvissi-Lorenz; Andrea L. Birkenfeld; Stefan Bornstein; Melania Manco; Geltrude Mingrone
Diabetes July 2016, Vol.65, 2990-3001. doi:https://doi.org/10.2337/db16-0039
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization
Laura J. Corbin; Rebecca C. Richmond; Kaitlin H. Wade; Stephen Burgess; Jack Bowden; George Davey Smith; Nicholas J. Timpson
Diabetes July 2016, Vol.65, 3002-3007. doi:https://doi.org/10.2337/db16-0418
Islet Studies
Islet Pericytes Are Required for β-Cell Maturity
Adi Sasson; Eleonor Rachi; Lina Sakhneny; Daria Baer; Michal Lisnyansky; Alona Epshtein; Limor Landsman
Diabetes July 2016, Vol.65, 3008-3014. doi:https://doi.org/10.2337/db16-0365
Nardilysin Is Required for Maintaining Pancreatic β-Cell Function
Kiyoto Nishi; Yuichi Sato; Mikiko Ohno; Yoshinori Hiraoka; Sayaka Saijo; Jiro Sakamoto; Po-Min Chen; Yusuke Morita; Shintaro Matsuda; Kanako Iwasaki; Kazu Sugizaki; Norio Harada; Yoshiko Mukumoto; Hiroshi Kiyonari; Kenichiro Furuyama; Yoshiya Kawaguchi; Shinji Uemoto; Toru Kita; Nobuya Inagaki; Takeshi Kimura; Eiichiro Nishi
Diabetes July 2016, Vol.65, 3015-3027. doi:https://doi.org/10.2337/db16-0178
Single-Cell Transcriptomics of the Human Endocrine Pancreas
Yue J. Wang; Jonathan Schug; Kyoung-Jae Won; Chengyang Liu; Ali Naji; Dana Avrahami; Maria L. Golson; Klaus H. Kaestner
Diabetes June 2016, Vol.65, 3028-3038. doi:https://doi.org/10.2337/db16-0405
SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity
Xin Tong; Tatsuyoshi Kono; Emily K. Anderson-Baucum; Wataru Yamamoto; Patrick Gilon; Djamel Lebeche; Richard N. Day; Gary E. Shull; Carmella Evans-Molina
Diabetes August 2016, Vol.65, 3039-3052. doi:https://doi.org/10.2337/db16-0084
Pathophysiology
Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling
Donna M. D’Souza; Sarah Zhou; Irena A. Rebalka; Blair MacDonald; Jasmin Moradi; Matthew P. Krause; Dhuha Al-Sajee; Zubin Punthakee; Mark A. Tarnopolsky; Thomas J. Hawke
Diabetes June 2016, Vol.65, 3053-3061. doi:https://doi.org/10.2337/db15-1577
DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes
Bastien Vergoni; Pierre-Jean Cornejo; Jérôme Gilleron; Mansour Djedaini; Franck Ceppo; Arnaud Jacquel; Gwennaelle Bouget; Clémence Ginet; Teresa Gonzalez; Julie Maillet; Véronique Dhennin; Marie Verbanck; Patrick Auberger; Philippe Froguel; Jean-François Tanti; Mireille Cormont
Diabetes July 2016, Vol.65, 3062-3074. doi:https://doi.org/10.2337/db16-0014
Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase
Shyam Sundar Nandi; Hong Zheng; Neeru M. Sharma; Hamid R. Shahshahan; Kaushik P. Patel; Paras K. Mishra
Diabetes July 2016, Vol.65, 3075-3090. doi:https://doi.org/10.2337/db16-0023
High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I
Joanne T.M. Tan; Hamish C.G. Prosser; Louise L. Dunn; Laura Z. Vanags; Anisyah Ridiandries; Tania Tsatralis; Laura Leece; Zoë E. Clayton; Sui Ching G. Yuen; Stacy Robertson; Yuen Ting Lam; David S. Celermajer; Martin K.C. Ng; Christina A. Bursill
Diabetes June 2016, Vol.65, 3091-3103. doi:https://doi.org/10.2337/db15-1668
Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes
Diabetes July 2016, Vol.65, 3104-3110. doi:https://doi.org/10.2337/db16-0616
Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice
Xiaohong Wang; Haitao Gu; Wei Huang; Jiangtong Peng; Yutian Li; Liwang Yang; Dongze Qin; Kobina Essandoh; Yigang Wang; Tianqing Peng; Guo-Chang Fan
Diabetes June 2016, Vol.65, 3111-3128. doi:https://doi.org/10.2337/db15-1563
Complications
Cardiac Autonomic Function Is Associated With the Coronary Microcirculatory Function in Patients With Type 2 Diabetes
Bernt Johan von Scholten; Christian Stevns Hansen; Philip Hasbak; Andreas Kjaer; Peter Rossing; Tine Willum Hansen
Diabetes June 2016, Vol.65, 3129-3138. doi:https://doi.org/10.2337/db16-0437
Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes
Alison D. McNeilly; Jennifer R. Gallagher; Albena T. Dinkova-Kostova; John D. Hayes; John Sharkey; Michael L.J. Ashford; Rory J. McCrimmon
Diabetes July 2016, Vol.65, 3151-3160. doi:https://doi.org/10.2337/db15-1653
Acute Effects of Oral Dehydroepiandrosterone on Counterregulatory Responses During Repeated Hypoglycemia in Healthy Humans
Maia Mikeladze; Maka S. Hedrington; Nino Joy; Donna B. Tate; Lisa M. Younk; Ian Davis; Stephen N. Davis
Diabetes August 2016, Vol.65, 3161-3170. doi:https://doi.org/10.2337/db16-0406
Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation
Liping Xie; Yue Gu; Mingliang Wen; Shuang Zhao; Wan Wang; Yan Ma; Guoliang Meng; Yi Han; Yuhui Wang; George Liu; Philip K. Moore; Xin Wang; Hong Wang; Zhiren Zhang; Ying Yu; Albert Ferro; Zhengrong Huang; Yong Ji
Diabetes June 2016, Vol.65, 3171-3184. doi:https://doi.org/10.2337/db16-0020
Pharmacology and Therapeutics
Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency
Mohammad Zarei; Emma Barroso; Rosana Leiva; Marta Barniol-Xicota; Eugènia Pujol; Carmen Escolano; Santiago Vázquez; Xavier Palomer; Virginia Pardo; Águeda González-Rodríguez; Ángela M. Valverde; Tania Quesada-López; Francesc Villarroya; Walter Wahli; Manuel Vázquez-Carrera
Diabetes August 2016, Vol.65, 3185-3199. doi:https://doi.org/10.2337/db16-0155
Genetics / Genomes / Proteomics / Metabolomics
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Geoffrey A. Walford; Stefan Gustafsson; Denis Rybin; Alena Stančáková; Han Chen; Ching-Ti Liu; Jaeyoung Hong; Richard A. Jensen; Ken Rice; Andrew P. Morris; Reedik Mägi; Anke Tönjes; Inga Prokopenko; Marcus E. Kleber; Graciela Delgado; Günther Silbernagel; Anne U. Jackson; Emil V. Appel; Niels Grarup; Joshua P. Lewis; May E. Montasser; Claes Landenvall; Harald Staiger; Jian’an Luan; Timothy M. Frayling; Michael N. Weedon; Weijia Xie; Sonsoles Morcillo; María Teresa Martínez-Larrad; Mary L. Biggs; Yii-Der Ida Chen; Arturo Corbaton-Anchuelo; Kristine Færch; Juan Miguel Gómez-Zumaquero; Mark O. Goodarzi; Jorge R. Kizer; Heikki A. Koistinen; Aaron Leong; Lars Lind; Cecilia Lindgren; Fausto Machicao; Alisa K. Manning; Gracia María Martín-Núñez; Gemma Rojo-Martínez; Jerome I. Rotter; David S. Siscovick; Joseph M. Zmuda; Zhongyang Zhang; Manuel Serrano-Rios; Ulf Smith; Federico Soriguer; Torben Hansen; Torben J. Jørgensen; Allan Linnenberg; Oluf Pedersen; Mark Walker; Claudia Langenberg; Robert A. Scott; Nicholas J. Wareham; Andreas Fritsche; Hans-Ulrich Häring; Norbert Stefan; Leif Groop; Jeff R. O’Connell; Michael Boehnke; Richard N. Bergman; Francis S. Collins; Karen L. Mohlke; Jaakko Tuomilehto; Winfried März; Peter Kovacs; Michael Stumvoll; Bruce M. Psaty; Johanna Kuusisto; Markku Laakso; James B. Meigs; Josée Dupuis; Erik Ingelsson; Jose C. Florez
Diabetes July 2016, Vol.65, 3200-3211. doi:https://doi.org/10.2337/db16-0199
The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes
Thomas W. Laver; Kevin Colclough; Maggie Shepherd; Kashyap Patel; Jayne A.L. Houghton; Petra Dusatkova; Stepanka Pruhova; Andrew D. Morris; Colin N. Palmer; Mark I. McCarthy; Sian Ellard; Andrew T. Hattersley; Michael N. Weedon
Diabetes August 2016, Vol.65, 3212-3217. doi:https://doi.org/10.2337/db16-0628
Errata
Erratum. Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells. Diabetes 2007;56:1387–1394
Kenneth K.Y. Cheng; Karen S.L. Lam; Yu Wang; Yu Huang; David Carling; Donghai Wu; Chiwai Wong; Aimin Xu
Diabetes September 2016, Vol.65, 3218. doi:https://doi.org/10.2337/db16-er10a
Erratum. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4A Signaling Pathway. Diabetes 2010;59:2949–2959
Junlei Chang; Yiming Li; Yu Huang; Karen S.L. Lam; Ruby L.C. Hoo; Wing Tak Wong; Kenneth K.Y. Cheng; Yiqun Wang; Paul M. Vanhoutte; Aimin Xu
Diabetes September 2016, Vol.65, 3219. doi:https://doi.org/10.2337/db16-er10b
Erratum. APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. Diabetes 2011;60:3044–3054
Yi Wang; Kenneth K.Y. Cheng; Karen S.L. Lam; Donghai Wu; Yu Wang; Yu Huang; Paul M. Vanhoutte; Gary Sweeney; Yiming Li; Aimin Xu
Diabetes September 2016, Vol.65, 3219. doi:https://doi.org/10.2337/db16-er10c
