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1 February 2016
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Topics:
aspirin
,
burnout
,
diabetes mellitus, type 1
,
diabetes mellitus, type 2
,
diabetic foot ulcer
Diabetes January 2016, Vol.65, 305-306. doi:https://doi.org/10.2337/db16-ti02
Perspectives in Diabetes
Type 1 Diabetes—Reaping the Rewards of a Targeted Research Investment
Topics:
diabetes mellitus, type 1
Diabetes January 2016, Vol.65, 307-313. doi:https://doi.org/10.2337/db15-1030
Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology
Jimmy Masjkur; Steven W. Poser; Polyxeni Nikolakopoulou; George Chrousos; Ronald D. McKay; Stefan R. Bornstein; Peter M. Jones; Andreas Androutsellis-Theotokis
Topics:
neural stem cells
,
pancreas
,
signal transduction
,
signal transduction pathways
,
endocrine pancreas
Diabetes January 2016, Vol.65, 314-330. doi:https://doi.org/10.2337/db15-1099
Gasotransmitters in Vascular Complications of Diabetes
Joost C. van den Born; Hans-Peter Hammes; Wolfgang Greffrath; Harry van Goor; Jan-Luuk Hillebrands; on behalf of the DFG GRK International Research Training Group 1874 Diabetic Microvascular Complications (DIAMICOM)
Topics:
diabetes mellitus complications
,
kidney diseases
,
mice
,
neuropathy
,
retinal diseases
Diabetes January 2016, Vol.65, 331-345. doi:https://doi.org/10.2337/db15-1003
Commentaries
A New Road for Treating the Vascular Complications of Diabetes: So Let's Step on the Gas
Diabetes January 2016, Vol.65, 346-348. doi:https://doi.org/10.2337/dbi15-0029
Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes
Topics:
blood platelet disorders
,
blood platelets
,
diabetes mellitus, type 1
,
platelet disorder, functional
,
thromboxane
Diabetes January 2016, Vol.65, 349-351. doi:https://doi.org/10.2337/dbi15-0032
Reversibility of Defects in Proinsulin Processing and Islet β-Cell Failure in Obesity-Related Type 2 Diabetes
Topics:
diabetes mellitus, type 2
,
insulin
,
obesity
,
proinsulin
,
granules
Diabetes January 2016, Vol.65, 352-354. doi:https://doi.org/10.2337/dbi15-0020
Diabetic Central Neuropathy: CNS Damage Related to Hyperglycemia
Topics:
hyperglycemia
,
neuropathy
,
glucose
,
brain
Diabetes January 2016, Vol.65, 355-357. doi:https://doi.org/10.2337/dbi15-0034
Metabolism
Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function
Katsuhiko Funai; Irfan J. Lodhi; Larry D. Spears; Li Yin; Haowei Song; Samuel Klein; Clay F. Semenkovich
Topics:
calcium
,
insulin sensitivity
,
mice
,
phospholipids
,
skeletal muscles
Diabetes October 2015, Vol.65, 358-370. doi:https://doi.org/10.2337/db15-0659
TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes
Meera Shah; Ron T. Varghese; John M. Miles; Francesca Piccinini; Chiara Dalla Man; Claudio Cobelli; Kent R. Bailey; Robert A. Rizza; Adrian Vella
Topics:
chief complaint
,
genotype
,
glucagon
,
glucose
,
infusion procedures
Diabetes November 2015, Vol.65, 371-380. doi:https://doi.org/10.2337/db15-1233
MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction
Matthieu Ruiz; Lise Coderre; Dominic Lachance; Valérie Houde; Cécile Martel; Julie Thompson Legault; Marc-Antoine Gillis; Bertrand Bouchard; Caroline Daneault; André C. Carpentier; Matthias Gaestel; Bruce G. Allen; Christine Des Rosiers
Topics:
cardiac function, impaired
,
heart
,
insulin
,
mice
,
streptozocin
Diabetes November 2015, Vol.65, 381-392. doi:https://doi.org/10.2337/db15-0238
Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor–Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy
Yuzhong Xiao; Hao Liu; Junjie Yu; Zilong Zhao; Fei Xiao; Tingting Xia; Chunxia Wang; Kai Li; Jiali Deng; Yajie Guo; Shanghai Chen; Yan Chen; Feifan Guo
Topics:
autophagy
,
fatty liver
,
liver
,
mice
,
hepatocytes
Diabetes November 2015, Vol.65, 393-405. doi:https://doi.org/10.2337/db15-1024
Obesity Studies
Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity
Diabetes October 2015, Vol.65, 406-420. doi:https://doi.org/10.2337/db15-0374
Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways
Cintia Folgueira; Daniel Beiroa; Aurelie Callon; Omar Al-Massadi; Silvia Barja-Fernandez; Ana Senra; Johan Fernø; Miguel López; Carlos Dieguez; Felipe F. Casanueva; Françoise Rohner-Jeanrenaud; Luisa M. Seoane; Ruben Nogueiras
Topics:
mice
,
uroguanylin
,
infusion procedures
Diabetes November 2015, Vol.65, 421-432. doi:https://doi.org/10.2337/db15-0889
Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function
Topics:
adipocytes
,
body fat distribution
,
genes
,
insulin
,
lipogenesis
Diabetes January 2016, Vol.65, 433-437. doi:https://doi.org/10.2337/db15-0828
Islet Studies
Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function
Cristina Alarcon; Brandon B. Boland; Yuji Uchizono; Patrick C. Moore; Bryan Peterson; Suryalekha Rajan; Olivia S. Rhodes; Andrew B. Noske; Leena Haataja; Peter Arvan; Bradly J. Marsh; Jotham Austin; Christopher J. Rhodes
Topics:
glucose
,
insulin
,
mice
,
obesity
,
proinsulin
Diabetes August 2015, Vol.65, 438-450. doi:https://doi.org/10.2337/db15-0792
Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice
Boris L. Gala-Lopez; Andrew R. Pepper; Rena L. Pawlick; Doug O’Gorman; Tatsuya Kin; Antonio Bruni; Nasser Abualhassan; Mariusz Bral; Austin Bautista; Jocelyn E. Manning Fox; Lachlan G. Young; Patrick E. MacDonald; A.M. James Shapiro
Topics:
teller acuity cards
,
total arterial compliance
,
trigeminal autonomic cephalalgias
,
mice
,
transplantation
Diabetes November 2015, Vol.65, 451-462. doi:https://doi.org/10.2337/db15-0764
Metabolism Regulates Exposure of Pancreatic Islets to Circulating Molecules In Vivo
Aurélien Michau; David J. Hodson; Pierre Fontanaud; Anne Guillou; Gabriel Espinosa-Carrasco; François Molino; Catherine J. Peters; Iain C. Robinson; Paul Le Tissier; Patrice Mollard; Marie Schaeffer
Topics:
extravasation of diagnostic and therapeutic materials
,
mice
,
molecule
,
permeability
,
endocrine pancreas
Diabetes November 2015, Vol.65, 463-475. doi:https://doi.org/10.2337/db15-1168
Pathophysiology
Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes
Paul K. Mazaika; Stuart A. Weinzimer; Nelly Mauras; Bruce Buckingham; Neil H. White; Eva Tsalikian; Tamara Hershey; Allison Cato; Tandy Aye; Larry Fox; Darrell M. Wilson; Michael J. Tansey; William Tamborlane; Daniel Peng; Mira Raman; Matthew Marzelli; Allan L. Reiss; for the Diabetes Research in Children Network (DirecNet)
Topics:
blood glucose
,
brain
,
brain volume
,
child
,
diabetes mellitus, type 1
Diabetes October 2015, Vol.65, 476-485. doi:https://doi.org/10.2337/db15-1242
Complications
Measurements of CD34+/CD45-dim Stem Cells Predict Healing of Diabetic Neuropathic Wounds
Stephen R. Thom; Michelle Hampton; Michael A. Troiano; Ziad Mirza; D. Scot Malay; Steven Shannon; Nathan B. Jennato; Cornelius M. Donohue; Ole Hoffstad; Diana Woltereck; Ming Yang; Kevin Yu; Veena M. Bhopale; Svitlana Kovtun; David J. Margolis
Topics:
cd45 antigens
,
flow cytometry
,
rna, messenger
,
statistical process control
,
stem cells
Diabetes October 2015, Vol.65, 486-497. doi:https://doi.org/10.2337/db15-0517
Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes
Miran A. Jaffa; Deirdre Luttrell; Alvin H. Schmaier; Richard L. Klein; Maria Lopes-Virella; Louis M. Luttrell; Ayad A. Jaffa; the DCCT/EDIC Research Group
Topics:
carotid intima-media thickness
,
dcct trial
,
diabetes mellitus, type 1
,
edic trial
,
plasma
Diabetes November 2015, Vol.65, 498-502. doi:https://doi.org/10.2337/db15-0930
Pharmacology and Therapeutics
In Vivo Platelet Activation and Aspirin Responsiveness in Type 1 Diabetes
Francesco Zaccardi; Alessandro Rizzi; Giovanna Petrucci; Flavia Ciaffardini; Luigi Tanese; Francesca Pagliaccia; Viviana Cavalca; Angela Ciminello; Aida Habib; Isabella Squellerio; Paola Rizzo; Elena Tremoli; Bianca Rocca; Dario Pitocco; Carlo Patrono
Topics:
aspirin
,
blood platelets
,
platelet activation
,
diabetes mellitus, type 1
,
urinary tract
Diabetes October 2015, Vol.65, 503-509. doi:https://doi.org/10.2337/db15-0936
Genetics / Genomes / Proteomics / Metabolomics
Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression
Michael Traurig; Robert L. Hanson; Alejandra Marinelarena; Sayuko Kobes; Paolo Piaggi; Shelley Cole; Joanne E. Curran; John Blangero; Harald Göring; Satish Kumar; Robert G. Nelson; Barbara V. Howard; William C. Knowler; Leslie J. Baier; Clifton Bogardus
Diabetes October 2015, Vol.65, 510-519. doi:https://doi.org/10.2337/db15-0571
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants
Marie-France Hivert; Costas A. Christophi; Paul W. Franks; Kathleen A. Jablonski; David A. Ehrmann; Steven E. Kahn; Edward S. Horton; Toni I. Pollin; Kieren J. Mather; Leigh Perreault; Elizabeth Barrett-Connor; William C. Knowler; Jose C. Florez; for the Diabetes Prevention Program Research Group
Topics:
diabetes prevention
,
genetics
,
insulin resistance
,
insulin sensitivity
,
life style
Diabetes November 2015, Vol.65, 520-526. doi:https://doi.org/10.2337/db15-0950
Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans
Aparna Pal; Thomas P. Potjer; Soren K. Thomsen; Hui Jin Ng; Amy Barrett; Raphael Scharfmann; Tim J. James; D. Timothy Bishop; Fredrik Karpe; Ian F. Godsland; Hans F.A. Vasen; Julia Newton-Bishop; Hanno Pijl; Mark I. McCarthy; Anna L. Gloyn
Topics:
cell cycle
,
genes, p16
,
glucose
,
glucose homeostasis
,
insulin
Diabetes November 2015, Vol.65, 527-533. doi:https://doi.org/10.2337/db15-0602
Erratum
Erratum. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes 2012;61:1180–1191
Shounan Yi; Ming Ji; Jingjing Wu; Xiaoqian Ma; Peta Phillips; Wayne J. Hawthorne; Philip J. O’Connell
Topics:
adoptive transfer
,
interleukin-10
,
mice
,
regulatory t-lymphocytes
,
rejection (psychology)
Diabetes January 2016, Vol.65, 534. doi:https://doi.org/10.2337/db16-er02
Issues and Events
E-Letters: Comments and Responses
Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85–95
Topics:
cardiac function, impaired
,
diet
,
epicardial adipose tissue
,
inflammation
,
obesity
Diabetes January 2016, Vol.65, e1-e2. doi:https://doi.org/10.2337/db15-1425
Response to Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85–95
Topics:
cardiac function, impaired
,
diet
,
epicardial adipose tissue
,
inflammation
,
obesity
Diabetes January 2016, Vol.65, e3-e4. doi:https://doi.org/10.2337/dbi15-0037
Comment on Giacco et al. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes 2015;64:3273–3284
Topics:
cytokinesis
,
glucagon-like peptide 1
,
hyperglycemia
,
superoxides
Diabetes January 2016, Vol.65, e5. doi:https://doi.org/10.2337/db15-1344
Response to Comment on Giacco et al. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes 2015;64:3273–3284
Topics:
cytokinesis
,
glucagon-like peptide 1
,
hyperglycemia
Diabetes January 2016, Vol.65, e6-e7. doi:https://doi.org/10.2337/dbi15-0031
Comment on Yi et al. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes 2012;61:1180–1191
Topics:
adoptive transfer
,
interleukin-10
,
mice
,
regulatory t-lymphocytes
,
rejection (psychology)
Diabetes January 2016, Vol.65, e8. doi:https://doi.org/10.2337/db15-1201
Response to Comment on Yi et al. Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes 2012;61:1180–1191
Topics:
adoptive transfer
,
interleukin-10
,
mice
,
regulatory t-lymphocytes
,
rejection (psychology)
Diabetes January 2016, Vol.65, e9-e10. doi:https://doi.org/10.2337/dbi15-0042
