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1 March 2016
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes February 2016, Vol.65, 537-538. doi:https://doi.org/10.2337/db16-ti03
Commentaries
How Is Proteinuric Diabetic Nephropathy Caused by Disturbed Proteostasis and Autophagy in Podocytes?
Diabetes February 2016, Vol.65, 539-541. doi:https://doi.org/10.2337/dbi15-0026
The Hypothalamic Melanocortin Pathway and the Regulation of Glucose Handling in the Kidney: A Sympathetic Look at Brain-Kidney Connection
Diabetes February 2016, Vol.65, 548-550. doi:https://doi.org/10.2337/dbi15-0033
Metabolism
Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition
Sylvain Mayeur; Jean-Sébastien Wattez; Marie-Amélie Lukaszewski; Simon Lecoutre; Laura Butruille; Anne Drougard; Delphine Eberlé; Bruno Bastide; Christine Laborie; Laurent Storme; Claude Knauf; Didier Vieau; Christophe Breton; Jean Lesage
Diabetes December 2015, Vol.65, 554-560. doi:https://doi.org/10.2337/db15-0228
Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice
Piotr Zabielski; Ian R. Lanza; Srinivas Gopala; Carrie J. Holtz Heppelmann; H. Robert Bergen, III; Surendra Dasari; K. Sreekumaran Nair
Diabetes December 2015, Vol.65, 561-573. doi:https://doi.org/10.2337/db15-0823
High-Fat Diet During Mouse Pregnancy and Lactation Targets GIP-Regulated Metabolic Pathways in Adult Male Offspring
Michael Kruse; Farnaz Keyhani-Nejad; Frank Isken; Barbara Nitz; Anja Kretschmer; Eva Reischl; Tonia de las Heras Gala; Martin A. Osterhoff; Harald Grallert; Andreas F.H. Pfeiffer
Diabetes December 2015, Vol.65, 574-584. doi:https://doi.org/10.2337/db15-0478
Evidence of Extrapancreatic Glucagon Secretion in Man
Asger Lund; Jonatan I. Bagger; Nicolai J. Wewer Albrechtsen; Mikkel Christensen; Magnus Grøndahl; Bolette Hartmann; Elisabeth R. Mathiesen; Carsten P. Hansen; Jan H. Storkholm; Gerrit van Hall; Jens F. Rehfeld; Daniel Hornburg; Felix Meissner; Matthias Mann; Steen Larsen; Jens J. Holst; Tina Vilsbøll; Filip K. Knop
Diabetes December 2015, Vol.65, 585-597. doi:https://doi.org/10.2337/db15-1541
Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation
Carlos Salomon; Katherin Scholz-Romero; Suchismita Sarker; Emma Sweeney; Miharu Kobayashi; Paula Correa; Sherri Longo; Gregory Duncombe; Murray D. Mitchell; Gregory E. Rice; Sebastian E. Illanes
Diabetes December 2015, Vol.65, 598-609. doi:https://doi.org/10.2337/db15-0966
A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents
Romy Kursawe; Vishwa D. Dixit; Philipp E. Scherer; Nicola Santoro; Deepak Narayan; Ruth Gordillo; Cosimo Giannini; Ximena Lopez; Bridget Pierpont; Jessica Nouws; Gerald I. Shulman; Sonia Caprio
Diabetes December 2015, Vol.65, 610-618. doi:https://doi.org/10.2337/db15-1478
Signal Transduction
High Glucose Stimulates Tumorigenesis in Hepatocellular Carcinoma Cells Through AGER-Dependent O-GlcNAcylation of c-Jun
Diabetes January 2016, Vol.65, 619-632. doi:https://doi.org/10.2337/db15-1057
Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
Marc A. Soares; Oriana D. Cohen; Yee Cheng Low; Rita A. Sartor; Trevor Ellison; Utkarsh Anil; Lavinia Anzai; Jessica B. Chang; Pierre B. Saadeh; Piul S. Rabbani; Daniel J. Ceradini
Diabetes December 2015, Vol.65, 633-646. doi:https://doi.org/10.2337/db15-0453
Obesity Studies
Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project
Kristen E. Boyle; Zachary W. Patinkin; Allison L.B. Shapiro; Peter R. Baker, II; Dana Dabelea; Jacob E. Friedman
Diabetes December 2015, Vol.65, 647-659. doi:https://doi.org/10.2337/db15-0849
n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus
Lucas F.R. Nascimento; Gabriela F.P. Souza; Joseane Morari; Guilherme O. Barbosa; Carina Solon; Rodrigo F. Moura; Sheila C. Victório; Letícia M. Ignácio-Souza; Daniela S. Razolli; Hernandes F. Carvalho; Lício A. Velloso
Diabetes October 2015, Vol.65, 673-686. doi:https://doi.org/10.2337/db15-0008
Islet Studies
Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
Leena Paul; Emily M. Walker; Yiannis Drosos; Holly A. Cyphert; Geoffrey Neale; Roland Stein; Jack South; Gerard Grosveld; Pedro L. Herrera; Beatriz Sosa-Pineda
Diabetes December 2015, Vol.65, 687-698. doi:https://doi.org/10.2337/db15-0713
Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo
Shuaishuai Zhu; Dennis Larkin; Shusheng Lu; Candice Inouye; Leena Haataja; Arfah Anjum; Robert Kennedy; David Castle; Peter Arvan
Diabetes December 2015, Vol.65, 699-709. doi:https://doi.org/10.2337/db15-1264
Immunology and Transplantation
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes
Lue Ping Zhao; Shehab Alshiekh; Michael Zhao; Annelie Carlsson; Helena Elding Larsson; Gun Forsander; Sten A. Ivarsson; Johnny Ludvigsson; Ingrid Kockum; Claude Marcus; Martina Persson; Ulf Samuelsson; Eva Örtqvist; Chul-Woo Pyo; Wyatt C. Nelson; Daniel E. Geraghty; Åke Lernmark; for the Better Diabetes Diagnosis (BDD) Study Group
Diabetes January 2016, Vol.65, 710-718. doi:https://doi.org/10.2337/db15-1115
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
Martha Campbell-Thompson; Ann Fu; John S. Kaddis; Clive Wasserfall; Desmond A. Schatz; Alberto Pugliese; Mark A. Atkinson
Diabetes November 2015, Vol.65, 719-731. doi:https://doi.org/10.2337/db15-0779
Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule
Menno van Lummel; Peter A. van Veelen; Arnoud H. de Ru; Jos Pool; Tatjana Nikolic; Sandra Laban; Antoinette Joosten; Jan W. Drijfhout; Iria Gómez-Touriño; Sefina Arif; Henk J. Aanstoot; Mark Peakman; Bart O. Roep
Diabetes December 2015, Vol.65, 732-741. doi:https://doi.org/10.2337/db15-1031
Pathophysiology
Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice
Erin E. Mulvihill; Elodie M. Varin; John R. Ussher; Jonathan E. Campbell; K.W. Annie Bang; Tahmid Abdullah; Laurie L. Baggio; Daniel J. Drucker
Diabetes December 2015, Vol.65, 742-754. doi:https://doi.org/10.2337/db15-1224
Complications
Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy
Atsuko Tagawa; Mako Yasuda; Shinji Kume; Kosuke Yamahara; Jun Nakazawa; Masami Chin-Kanasaki; Hisazumi Araki; Shin-ichi Araki; Daisuke Koya; Katsuhiko Asanuma; Eun-Hee Kim; Masakazu Haneda; Nobuyuki Kajiwara; Kazuyuki Hayashi; Hiroshi Ohashi; Satoshi Ugi; Hiroshi Maegawa; Takashi Uzu
Diabetes September 2015, Vol.65, 755-767. doi:https://doi.org/10.2337/db15-0473
miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy
Diabetes December 2015, Vol.65, 768-779. doi:https://doi.org/10.2337/db15-1033
Pharmacology and Therapeutics
An Essential Role of NRF2 in Diabetic Wound Healing
Min Long; Montserrat Rojo de la Vega; Qing Wen; Manish Bharara; Tao Jiang; Rui Zhang; Shiwen Zhou; Pak K. Wong; Georg T. Wondrak; Hongting Zheng; Donna D. Zhang
Diabetes December 2015, Vol.65, 780-793. doi:https://doi.org/10.2337/db15-0564
Genetics / Genomes / Proteomics / Metabolomics
Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes
Yan Ge; Suna Onengut-Gumuscu; Aaron R. Quinlan; Aaron J. Mackey; Jocyndra A. Wright; Jane H. Buckner; Tania Habib; Stephen S. Rich; Patrick Concannon
Diabetes December 2015, Vol.65, 794-802. doi:https://doi.org/10.2337/db15-0322
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
Alexander Teumer; Adrienne Tin; Rossella Sorice; Mathias Gorski; Nan Cher Yeo; Audrey Y. Chu; Man Li; Yong Li; Vladan Mijatovic; Yi-An Ko; Daniel Taliun; Alessandro Luciani; Ming-Huei Chen; Qiong Yang; Meredith C. Foster; Matthias Olden; Linda T. Hiraki; Bamidele O. Tayo; Christian Fuchsberger; Aida Karina Dieffenbach; Alan R. Shuldiner; Albert V. Smith; Allison M. Zappa; Antonio Lupo; Barbara Kollerits; Belen Ponte; Bénédicte Stengel; Bernhard K. Krämer; Bernhard Paulweber; Braxton D. Mitchell; Caroline Hayward; Catherine Helmer; Christa Meisinger; Christian Gieger; Christian M. Shaffer; Christian Müller; Claudia Langenberg; Daniel Ackermann; David Siscovick; DCCT/EDIC; Eric Boerwinkle; Florian Kronenberg; Georg B. Ehret; Georg Homuth; Gerard Waeber; Gerjan Navis; Giovanni Gambaro; Giovanni Malerba; Gudny Eiriksdottir; Guo Li; H. Erich Wichmann; Harald Grallert; Henri Wallaschofski; Henry Völzke; Herrmann Brenner; Holly Kramer; I. Mateo Leach; Igor Rudan; Hans L. Hillege; Jacques S. Beckmann; Jean Charles Lambert; Jian'an Luan; Jing Hua Zhao; John Chalmers; Josef Coresh; Joshua C. Denny; Katja Butterbach; Lenore J. Launer; Luigi Ferrucci; Lyudmyla Kedenko; Margot Haun; Marie Metzger; Mark Woodward; Matthew J. Hoffman; Matthias Nauck; Melanie Waldenberger; Menno Pruijm; Murielle Bochud; Myriam Rheinberger; Niek Verweij; Nicholas J. Wareham; Nicole Endlich; Nicole Soranzo; Ozren Polasek; Pim van der Harst; Peter Paul Pramstaller; Peter Vollenweider; Philipp S. Wild; Ron T. Gansevoort; Rainer Rettig; Reiner Biffar; Robert J. Carroll; Ronit Katz; Ruth J.F. Loos; Shih-Jen Hwang; Stefan Coassin; Sven Bergmann; Sylvia E. Rosas; Sylvia Stracke; Tamara B. Harris; Tanguy Corre; Tanja Zeller; Thomas Illig; Thor Aspelund; Toshiko Tanaka; Uwe Lendeckel; Uwe Völker; Vilmundur Gudnason; Vincent Chouraki; Wolfgang Koenig; Zoltan Kutalik; Jeffrey R. O'Connell; Afshin Parsa; Iris M. Heid; Andrew D. Paterson; Ian H. de Boer; Olivier Devuyst; Jozef Lazar; Karlhans Endlich; Katalin Susztak; Johanne Tremblay; Pavel Hamet; Howard J. Jacob; Carsten A. Böger; Caroline S. Fox; Cristian Pattaro; Anna Köttgen
Diabetes December 2015, Vol.65, 803-817. doi:https://doi.org/10.2337/db15-1313
Erratum
Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055
Lucy Marzban; Alejandra Tomas; Thomas C. Becker; Lawrence Rosenberg; Jose Oberholzer; Paul E. Fraser; Philippe A. Halban; C. Bruce Verchere
Diabetes February 2016, Vol.65, 818. doi:https://doi.org/10.2337/db16-er03
Issues and Events
E-Letters: Comments and Responses
Response to Comment on Prior et al. Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining. Diabetes 2015;64:3386–3395
Steven J. Prior; Andrew P. Goldberg; Heidi K. Ortmeyer; Eva R. Chin; Dapeng Chen; Jacob B. Blumenthal; Alice S. Ryan
Diabetes February 2016, Vol.65, e13-e14. doi:https://doi.org/10.2337/dbi15-0038
Comment on Lee et al. Diabetes 2015;64:2836–2846. Comment on Roberts et al. Diabetes 2015;64:471–484
Diabetes February 2016, Vol.65, e15. doi:https://doi.org/10.2337/db15-1176
Response to Comment on Lee et al. Diabetes 2015;64:2836–2846. Comment on Roberts et al. Diabetes 2015;64:471–484
Diabetes February 2016, Vol.65, e16. doi:https://doi.org/10.2337/dbi15-0024
Response to Comment on Lee et al. Diabetes 2015;64:2836–2846. Comment on Roberts et al. Diabetes 2015;64:471–484
Diabetes February 2016, Vol.65, e17. doi:https://doi.org/10.2337/dbi15-0030
