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April 2016
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Topics:
biological markers
,
diabetes mellitus, type 1
,
gene expression profiling
,
kidney failure, chronic
,
obesity
Diabetes March 2016, Vol.65, 821-822. doi:https://doi.org/10.2337/db16-ti04
Commentaries
miR, miR in the Cell, Does the Virus Control Them All?
Topics:
cells
,
diabetes mellitus, type 1
,
infections
,
micrornas
,
viruses
Diabetes March 2016, Vol.65, 823-825. doi:https://doi.org/10.2337/dbi15-0039
The Importance of Restoring the Adiponectin Signaling Pathway to Reduce Myocardial Reperfusion Injury in Diabetes
Topics:
adiponectin
,
myocardial reperfusion injury
,
signal pathway
,
signal transduction pathways
,
stat3 protein
Diabetes March 2016, Vol.65, 826-828. doi:https://doi.org/10.2337/dbi15-0044
Metabolism
PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue
Sun-Sil Choi; Eun-Sun Kim; Ji-Eun Jung; David P. Marciano; Ala Jo; Ja Young Koo; Soo Youn Choi; Yong Ryoul Yang; Hyun-Jun Jang; Eung-Kyun Kim; Jiyoung Park; Hyug Moo Kwon; In Hee Lee; Seung Bum Park; Kyung-Jae Myung; Pann-Ghill Suh; Patrick R. Griffin; Jang Hyun Choi
Topics:
imatinib mesylate
,
glucose
Diabetes January 2016, Vol.65, 829-839. doi:https://doi.org/10.2337/db15-1382
Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals
Carolyn Chee; Chris E. Shannon; Aisling Burns; Anna L. Selby; Daniel Wilkinson; Kenneth Smith; Paul L. Greenhaff; Francis B. Stephens
Topics:
insulin resistance
,
insulin sensitivity
,
lipids
,
overweight
,
oxidation
Diabetes January 2016, Vol.65, 840-850. doi:https://doi.org/10.2337/db15-1383
Proximity to Delivery Alters Insulin Sensitivity and Glucose Metabolism in Pregnant Mice
Barbara Musial; Denise S. Fernandez-Twinn; Owen R. Vaughan; Susan E. Ozanne; Peter Voshol; Amanda N. Sferruzzi-Perri; Abigail L. Fowden
Topics:
glucose
,
insulin
,
insulin sensitivity
,
mice
,
pregnancy
Diabetes January 2016, Vol.65, 851-860. doi:https://doi.org/10.2337/db15-1531
PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B
Topics:
lipids
,
mice
,
vascular endothelial growth factor b
,
mitochondria
,
fatty acids
Diabetes January 2016, Vol.65, 861-873. doi:https://doi.org/10.2337/db15-1231
Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet–Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents
Gianluca Gortan Cappellari; Michela Zanetti; Annamaria Semolic; Pierandrea Vinci; Giulia Ruozi; Antonella Falcione; Nicoletta Filigheddu; Gianfranco Guarnieri; Andrea Graziani; Mauro Giacca; Rocco Barazzoni
Topics:
ghrelin
,
hyperglycemia
,
inflammation
,
insulin
,
insulin resistance
Diabetes January 2016, Vol.65, 874-886. doi:https://doi.org/10.2337/db15-1019
Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance
Ron T. Varghese; Ivan Viegas; Cristina Barosa; Catia Marques; Meera Shah; Robert A. Rizza; John G. Jones; Adrian Vella
Topics:
chief complaint
,
fasting
,
gluconeogenesis
,
glucose
,
insulin
Diabetes January 2016, Vol.65, 887-892. doi:https://doi.org/10.2337/db15-1593
Maternal Glucose and Fatty Acid Kinetics and Infant Birth Weight in Obese Women With Type 2 Diabetes
Topics:
birth weight
,
fatty acids
,
glucose
,
infant
,
kinetics
Diabetes February 2016, Vol.65, 893-901. doi:https://doi.org/10.2337/db15-1061
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
Asma Ejaz; Laura Martinez-Guino; Allison B. Goldfine; Francesc Ribas-Aulinas; Valeria De Nigris; Sílvia Ribó; Alba Gonzalez-Franquesa; Pablo M. Garcia-Roves; Elizabeth Li; Jonathan M. Dreyfuss; Walt Gall; Jason K. Kim; Teodoro Bottiglieri; Francesc Villarroya; Robert E. Gerszten; Mary-Elizabeth Patti; Carles Lerin
Diabetes February 2016, Vol.65, 902-912. doi:https://doi.org/10.2337/db15-1094
Signal Transduction
Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance
Yacir Benomar; Hamza Amine; Délphine Crépin; Sarah Al Rifai; Laure Riffault; Arieh Gertler; Mohammed Taouis
Topics:
adiponectin
,
infusion procedures
,
insulin
,
resistin
,
toll-like receptor 4
Diabetes January 2016, Vol.65, 913-926. doi:https://doi.org/10.2337/db15-1029
Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue
Cassie M. Tran; Sarmistha Mukherjee; Lan Ye; David W. Frederick; Megan Kissig; James G. Davis; Dudley W. Lamming; Patrick Seale; Joseph A. Baur
Topics:
rapamycin
,
common cold
,
adipocytes
,
gene expression
,
mice
Diabetes February 2016, Vol.65, 927-941. doi:https://doi.org/10.2337/db15-0502
Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats
Haobo Li; Weifeng Yao; Zipeng Liu; Aimin Xu; Yu Huang; Xin-liang Ma; Michael G. Irwin; Zhengyuan Xia
Topics:
cardiac myocytes
,
mice
,
myocardium
,
rats
,
stat3 protein
Diabetes December 2015, Vol.65, 942-955. doi:https://doi.org/10.2337/db15-0782
Obesity Studies
Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese Mice
Dionne E. Maessen; Olaf Brouwers; Katrien H. Gaens; Kristiaan Wouters; Jack P. Cleutjens; Ben J. Janssen; Toshio Miyata; Coen D. Stehouwer; Casper G. Schalkwijk
Topics:
adipose tissue
,
diet, high-fat
,
inflammation
,
insulin
,
insulin resistance
Diabetes December 2015, Vol.65, 956-966. doi:https://doi.org/10.2337/db15-1390
Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue
Topics:
autophagy
,
lipids
,
macrophages
,
mice
,
obesity
Diabetes February 2016, Vol.65, 967-980. doi:https://doi.org/10.2337/db15-1219
Islet Studies
Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor
Rachel E. Stamateris; Rohit B. Sharma; Yahui Kong; Pantea Ebrahimpour; Deepika Panday; Pavana Ranganath; Baobo Zou; Helena Levitt; Nisha Abraham Parambil; Christopher P. O’Donnell; Adolfo García-Ocaña; Laura C. Alonso
Topics:
cyclins
,
glucose
,
irs2 protein, human
,
mice
,
mtor serine-threonine kinases
Diabetes January 2016, Vol.65, 981-995. doi:https://doi.org/10.2337/db15-0529
Coxsackievirus B5 Infection Induces Dysregulation of microRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets
Ki Wook Kim; Andy Ho; Ammira Alshabee-Akil; Anandwardhan A. Hardikar; Thomas W.H. Kay; William D. Rawlinson; Maria E. Craig
Topics:
diabetes mellitus, type 1
,
genes
,
infections
,
micrornas
,
endocrine pancreas
Diabetes November 2015, Vol.65, 996-1003. doi:https://doi.org/10.2337/db15-0956
An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas
Topics:
endocrine pancreas
,
immunohistochemistry
,
lymphatic capillaries
,
pancreas
,
diabetes mellitus, type 2
Diabetes January 2016, Vol.65, 1004-1008. doi:https://doi.org/10.2337/db15-1285
Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores
Alice Marmugi; Julia Parnis; Xi Chen; LeAnne Carmichael; Julie Hardy; Naila Mannan; Piero Marchetti; Lorenzo Piemonti; Domenico Bosco; Paul Johnson; James A.M. Shapiro; Céline Cruciani-Guglielmacci; Christophe Magnan; Mark Ibberson; Bernard Thorens; Héctor H. Valdivia; Guy A. Rutter; Isabelle Leclerc
Topics:
calcium
,
emergency service, hospital
,
glucose
,
insulin
,
mice
Diabetes January 2016, Vol.65, 1009-1021. doi:https://doi.org/10.2337/db15-1334
Immunology and Transplantation
Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes
Massimo Porta; Iiro Toppila; Niina Sandholm; S. Mohsen Hosseini; Carol Forsblom; Kustaa Hietala; Lorenzo Borio; Valma Harjutsalo; Barbara E. Klein; Ronald Klein; Andrew D. Paterson; for the DCCT/EDIC Research Group; Per-Henrik Groop; on behalf of the FinnDiane Study Group
Topics:
dcct trial
,
diabetes mellitus, type 1
,
edic trial
,
kidney failure, chronic
,
phenotype
Diabetes December 2015, Vol.65, 1022-1030. doi:https://doi.org/10.2337/db15-1247
A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes
Anne M. Pesenacker; Adele Y. Wang; Amrit Singh; Jana Gillies; Youngwoong Kim; Ciriaco A. Piccirillo; Duc Nguyen; W. Nicholas Haining; Scott J. Tebbutt; Constadina Panagiotopoulos; Megan K. Levings
Topics:
biological markers
,
gene expression profiling
,
genes
,
regulatory t-lymphocytes
,
diabetes mellitus, type 1
Diabetes January 2016, Vol.65, 1031-1039. doi:https://doi.org/10.2337/db15-0572
Pathophysiology
Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release
Topics:
blood glucose normal
,
leptin
,
mice
,
stat3 protein
,
streptozocin
Diabetes January 2016, Vol.65, 1040-1049. doi:https://doi.org/10.2337/db15-1160
Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum
Topics:
disulfides
,
proinsulin
,
insulin
Diabetes January 2016, Vol.65, 1050-1060. doi:https://doi.org/10.2337/db15-1345
Complications
NETosis Delays Diabetic Wound Healing in Mice and Humans
Gian Paolo Fadini; Lisa Menegazzo; Mauro Rigato; Valentina Scattolini; Nicol Poncina; Andrea Bruttocao; Stefano Ciciliot; Fabio Mammano; Catalin Dacian Ciubotaru; Enrico Brocco; Maria Cristina Marescotti; Roberta Cappellari; Giorgio Arrigoni; Renato Millioni; Saula Vigili de Kreutzenberg; Mattia Albiero; Angelo Avogaro
Topics:
biological markers
,
diabetic foot ulcer
,
dna, double-stranded
,
elastases
,
histones
Diabetes January 2016, Vol.65, 1061-1071. doi:https://doi.org/10.2337/db15-0863
Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet–Induced Diabetic Retinopathy
Topics:
diet
,
mice
,
retina
,
diabetes mellitus, type 2
,
diabetic retinopathy
Diabetes January 2016, Vol.65, 1072-1084. doi:https://doi.org/10.2337/db15-1255
Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis
Melinda T. Coughlan; Gavin C. Higgins; Tuong-Vi Nguyen; Sally A. Penfold; Vicki Thallas-Bonke; Sih Min Tan; Georg Ramm; Nicole J. Van Bergen; Darren C. Henstridge; Karly C. Sourris; Brooke E. Harcourt; Ian A. Trounce; Portia M. Robb; Adrienne Laskowski; Sean L. McGee; Amanda J. Genders; Ken Walder; Brian G. Drew; Paul Gregorevic; Hongwei Qian; Merlin C. Thomas; George Jerums; Richard J. Macisaac; Alison Skene; David A. Power; Elif I. Ekinci; Xiaonan W. Wijeyeratne; Linda A. Gallo; Michal Herman-Edelstein; Michael T. Ryan; Mark E. Cooper; David R. Thorburn; Josephine M. Forbes
Topics:
kidney
,
kidney failure, chronic
,
mice
,
mitochondria
Diabetes January 2016, Vol.65, 1085-1098. doi:https://doi.org/10.2337/db15-0864
Genetics / Genomes / Proteomics / Metabolomics
Plasma Metabonomic Profiling of Diabetic Retinopathy
Liyan Chen; Ching-Yu Cheng; Hyungwon Choi; Mohammad Kamran Ikram; Charumathi Sabanayagam; Gavin S.W. Tan; Dechao Tian; Liang Zhang; Gopalakrishnan Venkatesan; E Shyong Tai; Jie Jin Wang; Paul Mitchell; Chiu Ming Gemmy Cheung; Roger Wilmer Beuerman; Lei Zhou; Eric Chun Yong Chan; Tien Yin Wong
Topics:
metabolites
,
plasma
Diabetes January 2016, Vol.65, 1099-1108. doi:https://doi.org/10.2337/db15-0661
HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression
Alberto Pugliese; David Boulware; Liping Yu; Sunanda Babu; Andrea K. Steck; Dorothy Becker; Henry Rodriguez; Linda DiMeglio; Carmella Evans-Molina; Leonard C. Harrison; Desmond Schatz; Jerry P. Palmer; Carla Greenbaum; George S. Eisenbarth; Jay M. Sosenko; the Type 1 Diabetes TrialNet Study Group
Topics:
autoantibodies
,
haplotypes
,
human leukocyte antigens
,
diabetes mellitus, type 1
,
disease progression
Diabetes January 2016, Vol.65, 1109-1119. doi:https://doi.org/10.2337/db15-1105
Erratum
Erratum. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat–Fed Mice. Diabetes 2015;64:2996—3009
Topics:
glucagon-like peptide 1
,
glucose
,
mice
,
peptides
,
satiation
Diabetes March 2016, Vol.65, 1120. doi:https://doi.org/10.2337/db16-er04
Expressions of Concern
Expression of Concern. Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei. Diabetes 2013;62:137–148. DOI: 10.2337/db11-1388
Patrícia O. Prada; Paula G.F. Quaresma; Andrea M. Caricilli; Andressa C. Santos; Dioze Guadagnini; Joseane Morari; Laís Weissmann; Eduardo R. Ropelle; José Barreto C. Carvalheira; Lício A. Velloso; Mario J.A. Saad
Topics:
hypothalamic nucleus
,
insulin
,
leptin
,
signal transduction
Diabetes March 2016, Vol.65, 1121-1122. doi:https://doi.org/10.2337/db16-ec04
Expression of Concern. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss. Diabetes 2008;57:594–605. DOI: 10.2337/db07-0573
Eduardo R. Ropelle; José R. Pauli; Maria Fernanda A. Fernandes; Silvana A. Rocco; Rodrigo M. Marin; Joseane Morari; Kellen K. Souza; Marília M. Dias; Maria C. Gomes-Marcondes; José A.R. Gontijo; Kleber G. Franchini; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
Topics:
ampk
,
high-protein diet
,
mammals
,
mtor serine-threonine kinases
,
protein kinase
Diabetes March 2016, Vol.65, 1122-1123. doi:https://doi.org/10.2337/db16-ec04a
Statements of Retraction
Statement of Retraction. Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats. Diabetes 2011;60:784–796. DOI: 10.2337/db09-1907
Alexandre G. Oliveira; Bruno M. Carvalho; Natália Tobar; Eduardo R. Ropelle; José R. Pauli; Renata A. Bagarolli; Dioze Guadagnini; José B.C. Carvalheira; Mario J.A. Saad
Topics:
insulin
,
lipopolysaccharides
,
rats
,
signal transduction
,
toll-like receptor 4
Diabetes March 2016, Vol.65, 1124-1125. doi:https://doi.org/10.2337/db16-rt04
Statement of Retraction. Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance. Diabetes 2007;56:1986–1998. DOI: 10.2337/db06-1595
Daniela M.L. Tsukumo; Marco A. Carvalho-Filho; José B.C. Carvalheira; Patrícia O. Prada; Sandro M. Hirabara; André A. Schenka; Eliana P. Araújo; José Vassallo; Rui Curi; Lício A. Velloso; Mario J.A. Saad
Topics:
diet
,
insulin resistance
,
loss of function mutation
,
obesity
,
toll-like receptor 4
Diabetes March 2016, Vol.65, 1126-1127. doi:https://doi.org/10.2337/db16-rt04a
Statement of Retraction. Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats. Diabetes 2006;55:2554–2561. DOI: 10.2337/db05-1622
Marcelo B.S. Flores; Maria Fernanda A. Fernandes; Eduardo R. Ropelle; Marcel C. Faria; Mirian Ueno; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
Topics:
hypothalamus
,
insulin
,
leptin
,
rats, wistar
Diabetes March 2016, Vol.65, 1127-1128. doi:https://doi.org/10.2337/db16-rt04b
Statement of Retraction. Effect of Captopril, Losartan, and Bradykinin on Early Steps of Insulin Action. Diabetes 1997;46:1950–1957. DOI: 10.2337/diab.46.12.1950
Topics:
bradykinin
,
captopril
,
insulin
,
losartan
Diabetes March 2016, Vol.65, 1128. doi:https://doi.org/10.2337/db16-rt04c
Issues and Events
Issues and Events
Topics:
chronic limb-threatening ischemia
,
mobile applications
,
podcasts
,
standard of care
,
health personnel
Diabetes March 2016, Vol.65, 1129. doi:https://doi.org/10.2337/db16-ie04
E-Letters: Comments and Responses
Comment on Kolwicz et al. Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress. Diabetes 2015;64:2817–2827
Topics:
ischemia
,
stress
,
triglyceride metabolism
,
intravenous fat emulsions
,
reperfusion therapy
Diabetes March 2016, Vol.65, e18. doi:https://doi.org/10.2337/db15-1640
Response to Comment on Kolwicz et al. Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress. Diabetes 2015;64:2817–2827
Topics:
ischemia
,
stress
,
triglyceride metabolism
,
intravenous fat emulsions
Diabetes March 2016, Vol.65, e19-e20. doi:https://doi.org/10.2337/dbi15-0043
