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1 May 2016
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes April 2016, Vol.65, 1131-1132. doi:https://doi.org/10.2337/db16-ti05
Perspectives in Diabetes
Accurate Measurement of Postprandial Glucose Turnover: Why Is It Difficult and How Can It Be Done (Relatively) Simply?
Diabetes April 2016, Vol.65, 1133-1145. doi:https://doi.org/10.2337/db15-1166
Commentaries
Prostaglandin I2 Receptor Agonism for Proteinuria and Diabetes: Good for the Goose and Good for the Gander?
Diabetes April 2016, Vol.65, 1149-1151. doi:https://doi.org/10.2337/dbi16-0009
Targeting miR-200c to Ameliorate Diabetes-Induced Endothelial Dysfunction
Diabetes April 2016, Vol.65, 1152-1154. doi:https://doi.org/10.2337/dbi16-0006
A Role for the Host in the Roadmap to Diabetes Stem Cell Therapy
Diabetes April 2016, Vol.65, 1155-1157. doi:https://doi.org/10.2337/dbi16-0003
Metabolism
Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells
Kosuke Takeda; Sandhya Sriram; Xin Hui Derryn Chan; Wee Kiat Ong; Chia Rou Yeo; Betty Tan; Seung-Ah Lee; Kien Voon Kong; Shawn Hoon; Hongfeng Jiang; Jason J. Yuen; Jayakumar Perumal; Madhur Agrawal; Candida Vaz; Jimmy So; Asim Shabbir; William S. Blaner; Malini Olivo; Weiping Han; Vivek Tanavde; Sue-Anne Toh; Shigeki Sugii
Diabetes March 2016, Vol.65, 1164-1178. doi:https://doi.org/10.2337/db15-1315
Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
Mark J.W. Hanssen; Anouk A.J.J. van der Lans; Boudewijn Brans; Joris Hoeks; Kelly M.C. Jardon; Gert Schaart; Felix M. Mottaghy; Patrick Schrauwen; Wouter D. van Marken Lichtenbelt
Diabetes December 2015, Vol.65, 1179-1189. doi:https://doi.org/10.2337/db15-1372
Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
Ele Ferrannini; Simona Baldi; Silvia Frascerra; Brenno Astiarraga; Tim Heise; Roberto Bizzotto; Andrea Mari; Thomas R. Pieber; Elza Muscelli
Diabetes February 2016, Vol.65, 1190-1195. doi:https://doi.org/10.2337/db15-1356
Signal Transduction
Inhibition of miR-200c Restores Endothelial Function in Diabetic Mice Through Suppression of COX-2
Huina Zhang; Jian Liu; Dan Qu; Li Wang; Jiang-Yun Luo; Chi Wai Lau; Pingsheng Liu; Zhen Gao; George L. Tipoe; Hung Kay Lee; Chi Fai Ng; Ronald Ching Wan Ma; Xiaoqiang Yao; Yu Huang
Diabetes January 2016, Vol.65, 1196-1207. doi:https://doi.org/10.2337/db15-1067
Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication
Diabetes March 2016, Vol.65, 1208-1218. doi:https://doi.org/10.2337/db15-1331
Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise
Rasmus Kjøbsted; Andreas J.T. Pedersen; Janne R. Hingst; Rugivan Sabaratnam; Jesper B. Birk; Jonas M. Kristensen; Kurt Højlund; Jørgen F.P. Wojtaszewski
Diabetes January 2016, Vol.65, 1219-1230. doi:https://doi.org/10.2337/db15-1034
Obesity Studies
DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework
Rebecca C. Richmond; Gemma C. Sharp; Mary E. Ward; Abigail Fraser; Oliver Lyttleton; Wendy L. McArdle; Susan M. Ring; Tom R. Gaunt; Debbie A. Lawlor; George Davey Smith; Caroline L. Relton
Diabetes February 2016, Vol.65, 1231-1244. doi:https://doi.org/10.2337/db15-0996
Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans
Tracey McLaughlin; Colleen Craig; Li-Fen Liu; Dalia Perelman; Candice Allister; Daniel Spielman; Samuel W. Cushman
Diabetes February 2016, Vol.65, 1245-1254. doi:https://doi.org/10.2337/db15-1213
Antiobesity Action of ACAM by Modulating the Dynamics of Cell Adhesion and Actin Polymerization in Adipocytes
Kazutoshi Murakami; Jun Eguchi; Kazuyuki Hida; Atsuko Nakatsuka; Akihiro Katayama; Miwa Sakurai; Haruki Choshi; Masumi Furutani; Daisuke Ogawa; Kohji Takei; Fumio Otsuka; Jun Wada
Diabetes March 2016, Vol.65, 1255-1267. doi:https://doi.org/10.2337/db15-1304
Islet Studies
Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion
Aida Martinez-Sanchez; Timothy J. Pullen; Pauline Chabosseau; Qifeng Zhang; Elizabeth Haythorne; Matthew C. Cane; Marie-Sophie Nguyen-Tu; Sophie R. Sayers; Guy A. Rutter
Diabetes February 2016, Vol.65, 1268-1282. doi:https://doi.org/10.2337/db15-1240
PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2
Jayalakshmi Lakshmipathi; Juan Carlos Alvarez-Perez; Carolina Rosselot; Gabriella P. Casinelli; Rachel E. Stamateris; Francisco Rausell-Palamos; Christopher P. O’Donnell; Rupangi C. Vasavada; Donald K. Scott; Laura C. Alonso; Adolfo Garcia-Ocaña
Diabetes February 2016, Vol.65, 1283-1296. doi:https://doi.org/10.2337/db15-1398
Hypothyroidism Impairs Human Stem Cell–Derived Pancreatic Progenitor Cell Maturation in Mice
Jennifer E. Bruin; Nelly Saber; Shannon O’Dwyer; Jessica K. Fox; Majid Mojibian; Payal Arora; Alireza Rezania; Timothy J. Kieffer
Diabetes January 2016, Vol.65, 1297-1309. doi:https://doi.org/10.2337/db15-1439
Immunology and Transplantation
A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice
Ronald G. Gill; Philippe P. Pagni; Tinalyn Kupfer; Clive H. Wasserfall; Songyan Deng; Amanda Posgai; Yulia Manenkova; Amira Bel Hani; Laura Straub; Philip Bernstein; Mark A. Atkinson; Kevan C. Herold; Matthias von Herrath; Teodora Staeva; Mario R. Ehlers; Gerald T. Nepom
Diabetes December 2015, Vol.65, 1310-1316. doi:https://doi.org/10.2337/db15-0492
Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance
Pedro M. Moraes-Vieira; Angela Castoldi; Pratik Aryal; Kerry Wellenstein; Odile D. Peroni; Barbara B. Kahn
Diabetes March 2016, Vol.65, 1317-1327. doi:https://doi.org/10.2337/db15-1696
Antigen-Encoding Bone Marrow Terminates Islet-Directed Memory CD8+ T-Cell Responses to Alleviate Islet Transplant Rejection
Miranda A. Coleman; Claire F. Jessup; Jennifer A. Bridge; Nana H. Overgaard; Daniella Penko; Stacey Walters; Danielle J. Borg; Ryan Galea; Josephine M. Forbes; Ranjeny Thomas; Patrick T.C. Coates; Shane T. Grey; James W. Wells; Raymond J. Steptoe
Diabetes March 2016, Vol.65, 1328-1340. doi:https://doi.org/10.2337/db15-1418
Expression-Based Genome-Wide Association Study Links Vitamin D–Binding Protein With Autoantigenicity in Type 1 Diabetes
Keiichi Kodama; Zhiyuan Zhao; Kyoko Toda; Linda Yip; Rebecca Fuhlbrigge; Dongmei Miao; C. Garrison Fathman; Satoru Yamada; Atul J. Butte; Liping Yu
Diabetes March 2016, Vol.65, 1341-1349. doi:https://doi.org/10.2337/db15-1308
Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold
Dora M. Berman; R. Damaris Molano; Carmen Fotino; Ulisse Ulissi; Jennifer Gimeno; Armando J. Mendez; Norman M. Kenyon; Norma S. Kenyon; David M. Andrews; Camillo Ricordi; Antonello Pileggi
Diabetes February 2016, Vol.65, 1350-1361. doi:https://doi.org/10.2337/db15-1525
Pathophysiology
Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes
Pia Leete; Abby Willcox; Lars Krogvold; Knut Dahl-Jørgensen; Alan K. Foulis; Sarah J. Richardson; Noel G. Morgan
Diabetes February 2016, Vol.65, 1362-1369. doi:https://doi.org/10.2337/db15-1615
Risk Factors for Cardiovascular Disease in Type 1 Diabetes
Diabetes February 2016, Vol.65, 1370-1379. doi:https://doi.org/10.2337/db15-1517
Combined Insulin Deficiency and Endotoxin Exposure Stimulate Lipid Mobilization and Alter Adipose Tissue Signaling in an Experimental Model of Ketoacidosis in Subjects With Type 1 Diabetes: A Randomized Controlled Crossover Trial
Mads Svart; Ulla Kampmann; Thomas Voss; Steen B. Pedersen; Mogens Johannsen; Nikolaj Rittig; Per L. Poulsen; Thomas S. Nielsen; Niels Jessen; Niels Møller
Diabetes February 2016, Vol.65, 1380-1386. doi:https://doi.org/10.2337/db15-1645
Complications
HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice
Bijaya K. Nayak; Karthigayan Shanmugasundaram; William E. Friedrichs; Rita C. Cavaglierii; Mandakini Patel; Jeffrey Barnes; Karen Block
Diabetes February 2016, Vol.65, 1387-1397. doi:https://doi.org/10.2337/db15-0519
Prostaglandin I2 Receptor Agonism Preserves β-Cell Function and Attenuates Albuminuria Through Nephrin-Dependent Mechanisms
Sri N. Batchu; Syamantak Majumder; Bridgit B. Bowskill; Kathryn E. White; Suzanne L. Advani; Angela S. Brijmohan; Youan Liu; Kerri Thai; Paymon M. Azizi; Warren L. Lee; Andrew Advani
Diabetes February 2016, Vol.65, 1398-1409. doi:https://doi.org/10.2337/db15-0783
Pharmacology and Therapeutics
A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis
Diabetes March 2016, Vol.65, 1410-1423. doi:https://doi.org/10.2337/db15-0662
Genetics / Genomes / Proteomics / Metabolomics
Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
Geoffrey A. Walford; Yong Ma; Clary Clish; Jose C. Florez; Thomas J. Wang; Robert E. Gerszten; for the Diabetes Prevention Program Research Group
Diabetes February 2016, Vol.65, 1424-1433. doi:https://doi.org/10.2337/db15-1063
Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes
Michelle Goldsworthy; Ying Bai; Chi-Ming Li; Huanying Ge; Edwin Lamas; Helen Hilton; Christopher T. Esapa; Dan Baker; Will Baron; Todd Juan; Murielle M. Véniant; David J. Lloyd; Roger D. Cox
Diabetes February 2016, Vol.65, 1434-1446. doi:https://doi.org/10.2337/db15-1276
Statement of Retraction
Statement of Retraction. Replication of Obesity and Associated Signaling Pathways Through Transfer of Microbiota From Obese-Prone Rats. Diabetes 2014;63:1624–1636. DOI: 10.2337/db13-1526
Frank A. Duca; Yassine Sakar; Patricia Lepage; Fabienne Devime; Bénédicte Langelier; Joël Doré; Mihai Covasa
Diabetes April 2016, Vol.65, 1447. doi:https://doi.org/10.2337/db16-rt05
