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Volume 65, Issue 6
1 June 2016
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes May 2016, Vol.65, 1449-1450. doi:https://doi.org/10.2337/db16-ti06

Editor’s Note

A Special Thanks to the Reviewers of Diabetes
View articletitled, A Special Thanks to the Reviewers of <em>Diabetes</em>
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Diabetes May 2016, Vol.65, 1451. doi:https://doi.org/10.2337/db16-en06

Banting Lecture

The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
Philipp E. Scherer
View articletitled, The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
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Diabetes May 2016, Vol.65, 1452-1461. doi:https://doi.org/10.2337/db16-0339

Outstanding Scientific Achievement Award Lecture

Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture
George L. King; Kyoungmin Park; Qian Li
View articletitled, Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture
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Diabetes May 2016, Vol.65, 1462-1471. doi:https://doi.org/10.2337/db16-0152

Perspectives in Diabetes

A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
Terence P. Herbert; D. Ross Laybutt
View articletitled, A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
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Diabetes May 2016, Vol.65, 1472-1480. doi:https://doi.org/10.2337/db15-1633

Commentaries

Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain–Liver Connection
Heather A. Ferris; C. Ronald Kahn
View articletitled, Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain–Liver Connection
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Diabetes May 2016, Vol.65, 1481-1483. doi:https://doi.org/10.2337/dbi16-0010
A NEET Way to Impair Mitochondrial Function in α- and β-Cells
Changhong Li; Joseph A. Baur
View articletitled, A NEET Way to Impair Mitochondrial Function in α- and β-Cells
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Diabetes May 2016, Vol.65, 1484-1486. doi:https://doi.org/10.2337/dbi16-0011
Glucagon-Like Peptide 1 Receptor Activation and Platelet Function: Beyond Glycemic Control
Guanghong Jia; Annayya R. Aroor; James R. Sowers
View articletitled, Glucagon-Like Peptide 1 Receptor Activation and Platelet Function: Beyond Glycemic Control
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Diabetes May 2016, Vol.65, 1487-1489. doi:https://doi.org/10.2337/dbi16-0014
Linking MTNR1B Variants to Diabetes: The Role of Circadian Rhythms
Cheng Hu; Weiping Jia
View articletitled, Linking <em>MTNR1B</em> Variants to Diabetes: The Role of Circadian Rhythms
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Diabetes May 2016, Vol.65, 1490-1492. doi:https://doi.org/10.2337/dbi16-0012
Targeting AMP Kinase in Myeloid Cells to Reduce Atherosclerosis
Ajay Chaudhuri; Husam Ghanim; Paresh Dandona
View articletitled, Targeting AMP Kinase in Myeloid Cells to Reduce Atherosclerosis
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Diabetes May 2016, Vol.65, 1493-1495. doi:https://doi.org/10.2337/dbi16-0004
DYRK1A: A Promising Drug Target for Islet Transplant–Based Diabetes Therapies
Bengt-Frederik Belgardt; Eckhard Lammert
View articletitled, DYRK1A: A Promising Drug Target for Islet Transplant–Based Diabetes Therapies
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Diabetes May 2016, Vol.65, 1496-1498. doi:https://doi.org/10.2337/dbi16-0013

Metabolism

Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction
Desiree Wanders; Kirsten P. Stone; Laura A. Forney; Cory C. Cortez; Kelly N. Dille; Jacob Simon; Mark Xu; Elisabeth C. Hotard; Inna A. Nikonorova; Ashley P. Pettit; Tracy G. Anthony; Thomas W. Gettys
View articletitled, Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction
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Diabetes March 2016, Vol.65, 1499-1510. doi:https://doi.org/10.2337/db15-1324
Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Thomas Scherer; Claudia Lindtner; James O’Hare; Martina Hackl; Elizabeth Zielinski; Angelika Freudenthaler; Sabina Baumgartner-Parzer; Klaus Tödter; Joerg Heeren; Martin Krššák; Ludger Scheja; Clemens Fürnsinn; Christoph Buettner
View articletitled, Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Supplementary data
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Diabetes February 2016, Vol.65, 1511-1520. doi:https://doi.org/10.2337/db15-1552
Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver
Hyeyoung Nam; Deborah Jones; Robert C. Cooksey; Yan Gao; Sandy Sink; James Cox; Donald A. McClain
View articletitled, Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver
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Diabetes March 2016, Vol.65, 1521-1533. doi:https://doi.org/10.2337/db15-0580
MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk
Christine M. Kusminski; Shiuhwei Chen; Risheng Ye; Kai Sun; Qiong A. Wang; Stephen B. Spurgin; Phillip E. Sanders; Joseph T. Brozinick; Werner J. Geldenhuys; Wen-hong Li; Roger H. Unger; Philipp E. Scherer
View articletitled, MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk
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Diabetes March 2016, Vol.65, 1534-1555. doi:https://doi.org/10.2337/db15-1323
Hepatic and Extrahepatic Insulin Clearance Are Differentially Regulated: Results From a Novel Model-Based Analysis of Intravenous Glucose Tolerance Data
David C. Polidori; Richard N. Bergman; Stephanie T. Chung; Anne E. Sumner
View articletitled, Hepatic and Extrahepatic Insulin Clearance Are Differentially Regulated: Results From a Novel Model-Based Analysis of Intravenous Glucose Tolerance Data
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Diabetes March 2016, Vol.65, 1556-1564. doi:https://doi.org/10.2337/db15-1373
Myeloid Deletion of α1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice
Qiang Cao; Xin Cui; Rui Wu; Lin Zha; Xianfeng Wang; John S. Parks; Liqing Yu; Hang Shi; Bingzhong Xue
View articletitled, Myeloid Deletion of α1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice
Supplementary data
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Diabetes January 2016, Vol.65, 1565-1576. doi:https://doi.org/10.2337/db15-0917
Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
Reema P. Vazirani; Akanksha Verma; L. Amanda Sadacca; Melanie S. Buckman; Belen Picatoste; Muheeb Beg; Christopher Torsitano; Joanne H. Bruno; Rajesh T. Patel; Kotryna Simonyte; Joao P. Camporez; Gabriela Moreira; Domenick J. Falcone; Domenico Accili; Olivier Elemento; Gerald I. Shulman; Barbara B. Kahn; Timothy E. McGraw
View articletitled, Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
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Diabetes March 2016, Vol.65, 1577-1589. doi:https://doi.org/10.2337/db15-1128
Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice
Li Kang; Shilpa Mokshagundam; Bradley Reuter; Daniel S. Lark; Claire C. Sneddon; Chandani Hennayake; Ashley S. Williams; Deanna P. Bracy; Freyja D. James; Ambra Pozzi; Roy Zent; David H. Wasserman
View articletitled, Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice
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Diabetes April 2016, Vol.65, 1590-1600. doi:https://doi.org/10.2337/db15-1434
Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia
Evita C. Wiegers; Hanne M. Rooijackers; Cees J. Tack; Arend Heerschap; Bastiaan E. de Galan; Marinette van der Graaf
View articletitled, Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia
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Diabetes March 2016, Vol.65, 1601-1605. doi:https://doi.org/10.2337/db16-0068

Obesity Studies

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Marissa J. Schafer; Thomas A. White; Glenda Evans; Jason M. Tonne; Grace C. Verzosa; Michael B. Stout; Daniel L. Mazula; Allyson K. Palmer; Darren J. Baker; Michael D. Jensen; Michael S. Torbenson; Jordan D. Miller; Yasuhiro Ikeda; Tamara Tchkonia; Jan M. van Deursen; James L. Kirkland; Nathan K. LeBrasseur
View articletitled, Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
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Diabetes March 2016, Vol.65, 1606-1615. doi:https://doi.org/10.2337/db15-0291
IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity
Se-Hyung Park; Zun Liu; Yipeng Sui; Robert N. Helsley; Beibei Zhu; David K. Powell; Philip A. Kern; Changcheng Zhou
View articletitled, IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity
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Diabetes March 2016, Vol.65, 1616-1629. doi:https://doi.org/10.2337/db15-1156
The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway
Yang Sun; Yili Yang; Zhen Qin; Jinya Cai; Xiuming Guo; Yun Tang; Jingjing Wan; Ding-Feng Su; Xia Liu
View articletitled, The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway
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Diabetes March 2016, Vol.65, 1630-1641. doi:https://doi.org/10.2337/db15-1193
Differences in In Vivo Cellular Kinetics in Abdominal and Femoral Subcutaneous Adipose Tissue in Women
Ursula A. White; Mark D. Fitch; Robbie A. Beyl; Marc K. Hellerstein; Eric Ravussin
View articletitled, Differences in In Vivo Cellular Kinetics in Abdominal and Femoral Subcutaneous Adipose Tissue in Women
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Diabetes March 2016, Vol.65, 1642-1647. doi:https://doi.org/10.2337/db15-1617

Islet Studies

VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells
Kyota Aoyagi; Mica Ohara-Imaizumi; Makoto Itakura; Seiji Torii; Yoshihiro Akimoto; Chiyono Nishiwaki; Yoko Nakamichi; Takuma Kishimoto; Hayato Kawakami; Akihiro Harada; Masami Takahashi; Shinya Nagamatsu
View articletitled, VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells
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Diabetes March 2016, Vol.65, 1648-1659. doi:https://doi.org/10.2337/db15-1207
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
Ercument Dirice; Deepika Walpita; Amedeo Vetere; Bennett C. Meier; Sevim Kahraman; Jiang Hu; Vlado Dančík; Sean M. Burns; Tamara J. Gilbert; David E. Olson; Paul A. Clemons; Rohit N. Kulkarni; Bridget K. Wagner
View articletitled, Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
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Diabetes March 2016, Vol.65, 1660-1671. doi:https://doi.org/10.2337/db15-1127
The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
Anders Molven; Jennifer Hollister-Lock; Jiang Hu; Rachael Martinez; Pål R. Njølstad; Chong Wee Liew; Gordon Weir; Rohit N. Kulkarni
View articletitled, The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
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Diabetes March 2016, Vol.65, 1672-1678. doi:https://doi.org/10.2337/db15-1475

Immunology and Transplantation

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells
James A. Pearson; Terri C. Thayer; James E. McLaren; Kristin Ladell; Evy De Leenheer; Amy Phillips; Joanne Davies; Dimitri Kakabadse; Kelly Miners; Peter Morgan; Li Wen; David A. Price; F. Susan Wong
View articletitled, Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8<sup>+</sup> T Cells
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Diabetes March 2016, Vol.65, 1679-1689. doi:https://doi.org/10.2337/db15-1498
Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes
Kerry A. McLaughlin; Carolyn C. Richardson; Aarthi Ravishankar; Cristina Brigatti; Daniela Liberati; Vito Lampasona; Lorenzo Piemonti; Diana Morgan; Richard G. Feltbower; Michael R. Christie
View articletitled, Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes
Supplementary data
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Diabetes March 2016, Vol.65, 1690-1698. doi:https://doi.org/10.2337/db15-1058

Complications

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy
Branka Vulesevic; Brian McNeill; Ferdinando Giacco; Kay Maeda; Nick J.R. Blackburn; Michael Brownlee; Ross W. Milne; Erik J. Suuronen
View articletitled, Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy
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Diabetes March 2016, Vol.65, 1699-1713. doi:https://doi.org/10.2337/db15-0568
Glucagon-Like Peptide 1 Receptor Activation Attenuates Platelet Aggregation and Thrombosis
Alison Cameron-Vendrig; Adili Reheman; M. Ahsan Siraj; Xiaohong Ruby Xu; Yiming Wang; Xi Lei; Talat Afroze; Eric Shikatani; Omar El-Mounayri; Hossein Noyan; Ralph Weissleder; Heyu Ni; Mansoor Husain
View articletitled, Glucagon-Like Peptide 1 Receptor Activation Attenuates Platelet Aggregation and Thrombosis
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Diabetes March 2016, Vol.65, 1714-1723. doi:https://doi.org/10.2337/db15-1141

Pharmacology and Therapeutics

[11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency
Jonas B. Jensen; Elias I. Sundelin; Steen Jakobsen; Lars C. Gormsen; Ole L. Munk; Jørgen Frøkiær; Niels Jessen
View articletitled, [<sup>11</sup>C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency
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Diabetes March 2016, Vol.65, 1724-1730. doi:https://doi.org/10.2337/db16-0032

Genetics / Genomes / Proteomics / Metabolomics

Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis
Min Xu; Ya Huang; Lan Xie; Kui Peng; Lin Ding; Lin Lin; Po Wang; Mingli Hao; Yuhong Chen; Yimin Sun; Lu Qi; Weiqing Wang; Guang Ning; Yufang Bi
View articletitled, Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis
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Diabetes March 2016, Vol.65, 1731-1740. doi:https://doi.org/10.2337/db15-1533
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology
Jacqueline M. Lane; Anne-Marie Chang; Andrew C. Bjonnes; Daniel Aeschbach; Clare Anderson; Brian E. Cade; Sean W. Cain; Charles A. Czeisler; Sina A. Gharib; Joshua J. Gooley; Daniel J. Gottlieb; Struan F.A. Grant; Elizabeth B. Klerman; Diane S. Lauderdale; Steven W. Lockley; Miriam Munch; Sanjay Patel; Naresh M. Punjabi; Shanthakumar M.W. Rajaratnam; Melanie Rueger; Melissa A. St. Hilaire; Nayantara Santhi; Karin Scheuermaier; Eliza Van Reen; Phyllis C. Zee; Steven A. Shea; Jeanne F. Duffy; Orfeu M. Buxton; Susan Redline; Frank A.J.L. Scheer; Richa Saxena
View articletitled, Impact of Common Diabetes Risk Variant in <em>MTNR1B</em> on Sleep, Circadian, and Melatonin Physiology
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Diabetes February 2016, Vol.65, 1741-1751. doi:https://doi.org/10.2337/db15-0999

Erratum

Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585–597
Asger Lund; Jonatan I. Bagger; Nicolai J. Wewer Albrechtsen; Mikkel Christensen; Magnus Grøndahl; Bolette Hartmann; Elisabeth R. Mathiesen; Carsten P. Hansen; Jan H. Storkholm; Gerrit van Hall; Jens F. Rehfeld; Daniel Hornburg; Felix Meissner; Matthias Mann; Steen Larsen; Jens J. Holst; Tina Vilsbøll; Filip K. Knop
View articletitled, Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:<span class="related-article"><a href="XSLT_Related_Article_Replace_Href" data-vol="65" data-page="585">585–597</a></span>
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Diabetes May 2016, Vol.65, 1752. doi:https://doi.org/10.2337/db16-er06

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes May 2016, Vol.65, 1753. doi:https://doi.org/10.2337/db16-ie06

E-Letters: Comments and Responses

Comment on Goldsworthy et al. Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes. Diabetes 2016;65:1434–1446
Ion Cristóbal; Juan Madoz-Gúrpide; Federico Rojo; Jesús García-Foncillas
View articletitled, Comment on Goldsworthy et al. Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in <em>Ppp2r2a</em> Results in a Novel Digenic Mouse Model of Type 2 Diabetes. Diabetes 2016;65:1434–1446
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Diabetes May 2016, Vol.65, e22-e23. doi:https://doi.org/10.2337/db16-0249
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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