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August 2016
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Topics:
atrasentan
,
diabetes mellitus, type 1
,
diabetes mellitus, type 2
,
dipeptidyl-peptidase iv
,
glucagon-like peptide 1
Diabetes July 2016, Vol.65, 2103-2104. doi:https://doi.org/10.2337/db16-ti08
Perspectives in Diabetes
Thinking Outside the Cell: A Key Role for Hyaluronan in the Pathogenesis of Human Type 1 Diabetes
Topics:
diabetes mellitus, type 1
,
inflammation
Diabetes July 2016, Vol.65, 2105-2114. doi:https://doi.org/10.2337/db15-1750
Commentaries
Endothelium-Derived Hyperpolarizing Factors: A Potential Therapeutic Target for Vascular Dysfunction in Obesity and Insulin Resistance
Topics:
endothelium
,
insulin resistance
,
obesity
,
endothelium-dependent hyperpolarization factor
,
insulin
Diabetes July 2016, Vol.65, 2118-2120. doi:https://doi.org/10.2337/dbi16-0026
Defective Invariant Natural Killer T-Cell Suppression in Patients With Type 1 Diabetes
Topics:
diabetes mellitus, type 1
,
natural killer t-cells
,
psychological suppression
,
interleukin-13
,
t-lymphocytes
Diabetes July 2016, Vol.65, 2121-2123. doi:https://doi.org/10.2337/dbi16-0021
DPP-4 Inhibition and the Known Unknown
Topics:
dipeptidyl-peptidase iv
,
glucose
,
glucagon-like peptide 1
,
diabetes mellitus, type 2
,
dipeptidyl-peptidase iv inhibitors
Diabetes July 2016, Vol.65, 2124-2126. doi:https://doi.org/10.2337/dbi16-0023
Uncovering a Mineralocorticoid Receptor–Dependent Adipose–Vascular Axis: Implications for Vascular Dysfunction in Obesity?
Topics:
mineralocorticoid receptor
,
obesity
Diabetes July 2016, Vol.65, 2127-2129. doi:https://doi.org/10.2337/dbi16-0028
The Immune Pathogenesis of Type 1 Diabetes: Not Only Thinking Outside the Cell but Also Outside the Islet and Out of the Box
Topics:
diabetes mellitus, type 1
,
cells
,
mice, inbred nod
Diabetes July 2016, Vol.65, 2130-2133. doi:https://doi.org/10.2337/dbi16-0030
Technological Advances
CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes
Xiaotian Lin; Stephane Pelletier; Sebastien Gingras; Stephanie Rigaud; Christian J. Maine; Kristi Marquardt; Yang D. Dai; Karsten Sauer; Alberto R. Rodriguez; Greg Martin; Sergey Kupriyanov; Ling Jiang; Liping Yu; Douglas R. Green; Linda A. Sherman
Topics:
crispr-cas9
,
genome
,
mice
,
mice, inbred nod
,
mutation
Diabetes April 2016, Vol.65, 2134-2138. doi:https://doi.org/10.2337/db16-0061
Metabolism
ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance
Ivet Elias; Tura Ferré; Laia Vilà; Sergio Muñoz; Alba Casellas; Miquel Garcia; Maria Molas; Judith Agudo; Carles Roca; Jesús Ruberte; Fatima Bosch; Sylvie Franckhauser
Topics:
adipose tissue
,
diet
,
glucose
,
insulin
,
insulin resistance
Diabetes May 2016, Vol.65, 2139-2150. doi:https://doi.org/10.2337/db16-0040
A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARα
Yajie Guo; Junjie Yu; Jiali Deng; Bin Liu; Yuzhong Xiao; Kai Li; Fei Xiao; Feixiang Yuan; Yong Liu; Shanghai Chen; Feifan Guo
Topics:
fat metabolism
,
insulin
,
insulin sensitivity
,
mice
,
ppar alpha
Diabetes May 2016, Vol.65, 2151-2163. doi:https://doi.org/10.2337/db15-1565
Renal Denervation for Resistant Hypertension Fails to Improve Insulin Resistance as Assessed by Hyperinsulinemic-Euglycemic Step Clamp
Atena K. Miroslawska; Petter F. Gjessing; Marit D. Solbu; Ole M. Fuskevåg; Trond G. Jenssen; Terje K. Steigen
Topics:
c-peptide
,
fasting
,
glucose
,
hypertension, refractory
,
infusion procedures
Diabetes May 2016, Vol.65, 2164-2168. doi:https://doi.org/10.2337/db16-0205
Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity
Jong Han Lee; Ligen Lin; Pingwen Xu; Kenji Saito; Qiong Wei; Adelina G. Meadows; Odelia Y.N. Bongmba; Geetali Pradhan; Hui Zheng; Yong Xu; Yuxiang Sun
Diabetes May 2016, Vol.65, 2169-2178. doi:https://doi.org/10.2337/db15-1587
Leptin Substitution in Patients With Lipodystrophy: Neural Correlates for Long-term Success in the Normalization of Eating Behavior
Haiko Schlögl; Karsten Müller; Annette Horstmann; Konstanze Miehle; Janett Püschel; Arno Villringer; Burkhard Pleger; Michael Stumvoll; Mathias Fasshauer
Topics:
brain
,
feeding behaviors
,
functional magnetic resonance imaging
,
leptin
,
lipodystrophy
Diabetes May 2016, Vol.65, 2179-2186. doi:https://doi.org/10.2337/db15-1550
Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD
Samir Softic; Jeremie Boucher; Marie H. Solheim; Shiho Fujisaka; Max-Felix Haering; Erica P. Homan; Jonathon Winnay; Antonio R. Perez-Atayde; C. Ronald Kahn
Topics:
liver
,
mice
,
non-alcoholic fatty liver disease
,
blood glucose
,
fibrosis
Diabetes May 2016, Vol.65, 2187-2200. doi:https://doi.org/10.2337/db16-0213
Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function
Jeremie Boucher; Samir Softic; Abdelfattah El Ouaamari; Megan T. Krumpoch; Andre Kleinridders; Rohit N. Kulkarni; Brian T. O’Neill; C. Ronald Kahn
Topics:
insulin
,
insulin-like-growth factor i receptor
,
leptin
,
lipids
,
mice
Diabetes May 2016, Vol.65, 2201-2213. doi:https://doi.org/10.2337/db16-0212
Connections Between the Gut Microbiome and Metabolic Hormones in Early Pregnancy in Overweight and Obese Women
Luisa F. Gomez-Arango; Helen L. Barrett; H. David McIntyre; Leonie K. Callaway; Mark Morrison; Marloes Dekker Nitert; for the SPRING Trial Group
Topics:
hormones
,
microbiome
,
obesity
,
overweight
,
pregnancy
Diabetes May 2016, Vol.65, 2214-2223. doi:https://doi.org/10.2337/db16-0278
Signal Transduction
Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes
Zhiyong Zhang; Louis F. Amorosa; Susette M. Coyle; Marie A. Macor; Morris J. Birnbaum; Leonard Y. Lee; Beatrice Haimovich
Topics:
diabetes mellitus, type 2
,
insulin
,
leukocytes
,
proto-oncogene proteins c-akt
,
signal transduction
Diabetes May 2016, Vol.65, 2224-2234. doi:https://doi.org/10.2337/db16-0027
4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass
Manuel Blandino-Rosano; Joshua O. Scheys; Margarita Jimenez-Palomares; Rebecca Barbaresso; Aaron S. Bender; Akiko Yanagiya; Ming Liu; Liangyou Rui; Nahum Sonenberg; Ernesto Bernal-Mizrachi
Topics:
irs2 protein, human
,
mice
Diabetes May 2016, Vol.65, 2235-2248. doi:https://doi.org/10.2337/db15-1443
Obesity Studies
Temporal Changes in Skeletal Muscle Capillary Responses and Endothelial-Derived Vasodilators in Obesity-Related Insulin Resistance
Scott M. Chadderdon; J. Todd Belcik; Lindsay Bader; Dawn M. Peters; Paul Kievit; Nabil J. Alkayed; Sanjiv Kaul; Kevin L. Grove; Jonathan R. Lindner
Topics:
blood capillaries
,
eicosanoids
,
endothelium
,
glucose
,
insulin
Diabetes April 2016, Vol.65, 2249-2257. doi:https://doi.org/10.2337/db15-1574
DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the Offspring
Topics:
histones
,
obesity
,
pro-opiomelanocortin
,
dna
,
methylation
Diabetes May 2016, Vol.65, 2258-2267. doi:https://doi.org/10.2337/db15-1608
CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity
Jason Hellmann; Brian E. Sansbury; Candice R. Holden; Yunan Tang; Blenda Wong; Marcin Wysoczynski; Jorge Rodriguez; Aruni Bhatnagar; Bradford G. Hill; Matthew Spite
Topics:
mice
,
obesity
,
inflammation
,
adipose tissue
,
macrophages
Diabetes May 2016, Vol.65, 2268-2281. doi:https://doi.org/10.2337/db15-1689
Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation
Mingzhan Xue; Martin O. Weickert; Sheharyar Qureshi; Ngianga-Bakwin Kandala; Attia Anwar; Molly Waldron; Alaa Shafie; David Messenger; Mark Fowler; Gail Jenkins; Naila Rabbani; Paul J. Thornalley
Topics:
obesity
,
overweight
,
screening
,
lactoylglutathione lyase
,
glycemic control
Diabetes May 2016, Vol.65, 2282-2294. doi:https://doi.org/10.2337/db16-0153
AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity
Ting Luo; Allison Nocon; Jessica Fry; Alex Sherban; Xianliang Rui; Bingbing Jiang; X. Julia Xu; Jingyan Han; Yun Yan; Qin Yang; Qifu Li; Mengwei Zang
Diabetes May 2016, Vol.65, 2295-2310. doi:https://doi.org/10.2337/db15-1122
Islet Studies
A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes
Richard Yan-Do; Eric Duong; Jocelyn E. Manning Fox; Xiaoqing Dai; Kunimasa Suzuki; Shara Khan; Austin Bautista; Mourad Ferdaoussi; James Lyon; Xichen Wu; Stephen Cheley; Patrick E. MacDonald; Matthias Braun
Topics:
diabetes mellitus, type 2
,
glycine
,
insulin
,
donors
,
insulin secretion
Diabetes May 2016, Vol.65, 2311-2321. doi:https://doi.org/10.2337/db15-1272
Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells
Ronadip R. Banerjee; Holly A. Cyphert; Emily M. Walker; Harini Chakravarthy; Heshan Peiris; Xueying Gu; Yinghua Liu; Elizabeth Conrad; Lisa Goodrich; Roland W. Stein; Seung K. Kim
Topics:
mice
,
pregnancy
,
signal transduction
,
gestational diabetes
,
serotonin
Diabetes May 2016, Vol.65, 2331-2341. doi:https://doi.org/10.2337/db15-1527
Immunology and Transplantation
Adrenomedullin 2 Improves Early Obesity-Induced Adipose Insulin Resistance by Inhibiting the Class II MHC in Adipocytes
Song-Yang Zhang; Ying Lv; Heng Zhang; Song Gao; Ting Wang; Juan Feng; Yuhui Wang; George Liu; Ming-Jiang Xu; Xian Wang; Changtao Jiang
Topics:
adipocytes
,
inflammation
,
insulin resistance
,
mice
,
obesity
Diabetes May 2016, Vol.65, 2342-2355. doi:https://doi.org/10.2337/db15-1626
Interleukin-13 Pathway Alterations Impair Invariant Natural Killer T-Cell–Mediated Regulation of Effector T Cells in Type 1 Diabetes
Lorena Usero; Ana Sánchez; Eduarda Pizarro; Cristina Xufré; Mercè Martí; Dolores Jaraquemada; Carme Roura-Mir
Topics:
interleukin-13
,
psychological suppression
,
bodily secretions
,
cytokine
Diabetes April 2016, Vol.65, 2356-2366. doi:https://doi.org/10.2337/db15-1350
Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice
Parameswaran Ramakrishnan; Mary A. Yui; Jeffrey A. Tomalka; Devdoot Majumdar; Reshmi Parameswaran; David Baltimore
Topics:
mice, inbred nod
,
regulatory t-lymphocytes
,
t-lymphocytes
,
autoimmunity
,
mice
Diabetes May 2016, Vol.65, 2367-2379. doi:https://doi.org/10.2337/db15-1607
Pathophysiology
Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance
Wei Zhang; Mengrui Wu; Teayoun Kim; Ravi H. Jariwala; W. John Garvey; Nanlan Luo; Minsung Kang; Elizabeth Ma; Ling Tian; Dennis Steverson; Qinglin Yang; Yuchang Fu; W. Timothy Garvey
Topics:
glucose
,
insulin
,
insulin resistance
,
mice
,
skeletal muscles
Diabetes May 2016, Vol.65, 2380-2391. doi:https://doi.org/10.2337/db16-0154
Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase
Aurelie Nguyen Dinh Cat; Tayze T. Antunes; Glaucia E. Callera; Ana Sanchez; Sofia Tsiropoulou; Maria G. Dulak-Lis; Aikaterini Anagnostopoulou; Ying He; Augusto C. Montezano; Frederic Jaisser; Rhian M. Touyz
Topics:
adipocytes
,
mice
,
phosphotransferases
,
hydrogen peroxide
,
mesenteric arteries
Diabetes April 2016, Vol.65, 2392-2403. doi:https://doi.org/10.2337/db15-1627
Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study
Frank C.G. van Bussel; Walter H. Backes; Tamar M. van Veenendaal; Paul A.M. Hofman; Martin P.J. van Boxtel; Miranda T. Schram; Simone J.S. Sep; Pieter C. Dagnelie; Nicolaas Schaper; Coen D.A. Stehouwer; Joachim E. Wildberger; Jacobus F.A. Jansen
Topics:
brain
,
diabetes mellitus, type 2
,
prediabetes
,
graphical displays
Diabetes May 2016, Vol.65, 2404-2413. doi:https://doi.org/10.2337/db16-0128
Complications
Essential Role of Transglutaminase 2 in Vascular Endothelial Growth Factor–Induced Vascular Leakage in the Retina of Diabetic Mice
Yeon-Ju Lee; Se-Hui Jung; Su-Hyeon Kim; Min-Soo Kim; Sungeun Lee; JongYun Hwang; Soo-Youl Kim; Young-Myeong Kim; Kwon-Soo Ha
Topics:
cadherins
,
intravitreal injections
,
mice
,
retina
,
rna, small interfering
Diabetes April 2016, Vol.65, 2414-2428. doi:https://doi.org/10.2337/db15-1594
Pharmacology and Therapeutics
Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy
Margien G.S. Boels; M. Cristina Avramut; Angela Koudijs; Martijn J.C. Dane; Dae Hyun Lee; Johan van der Vlag; Abraham J. Koster; Anton Jan van Zonneveld; Ernst van Faassen; Hermann-Josef Gröne; Bernard M. van den Berg; Ton J. Rabelink
Topics:
apolipoprotein e
,
atrasentan
,
endothelium
,
glycocalyx
,
kidney glomerulus
Diabetes March 2016, Vol.65, 2429-2439. doi:https://doi.org/10.2337/db15-1413
Quantification of the Contribution of GLP-1 to Mediating Insulinotropic Effects of DPP-4 Inhibition With Vildagliptin in Healthy Subjects and Patients With Type 2 Diabetes Using Exendin [9-39] as a GLP-1 Receptor Antagonist
Michael A. Nauck; Joachim Kind; Lars D. Köthe; Jens J. Holst; Carolyn F. Deacon; Matthias Broschag; Yan Ling He; Lise Kjems; James Foley
Topics:
diabetes mellitus, type 2
,
dipeptidyl-peptidase iv
,
glucagon-like peptide 1
,
glucose
,
insulin
Diabetes April 2016, Vol.65, 2440-2447. doi:https://doi.org/10.2337/db16-0107
Genetics / Genomes / Proteomics / Metabolomics
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
Hanieh Yaghootkar; Luca A. Lotta; Jessica Tyrrell; Roelof A.J. Smit; Sam E. Jones; Louise Donnelly; Robin Beaumont; Archie Campbell; Marcus A. Tuke; Caroline Hayward; Katherine S. Ruth; Sandosh Padmanabhan; J. Wouter Jukema; Colin C. Palmer; Andrew Hattersley; Rachel M. Freathy; Claudia Langenberg; Nicholas J. Wareham; Andrew R. Wood; Anna Murray; Michael N. Weedon; Naveed Sattar; Ewan Pearson; Robert A. Scott; Timothy M. Frayling
Topics:
genetics
,
obesity
,
biobanks
,
risk reduction
,
diabetes mellitus, type 2
Diabetes April 2016, Vol.65, 2448-2460. doi:https://doi.org/10.2337/db15-1671
Expressions of Concern
Expression of Concern. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014;63:3974. DOI: 10.2337/db14-er11
Luan Shu; Nadine S. Sauter; Fabienne T. Schulthess; Aleksey V. Matveyenko; José Oberholzer; Kathrin Maedler
Topics:
endocrine pancreas
,
tcf7l2 gene
Diabetes July 2016, Vol.65, 2461. doi:https://doi.org/10.2337/db16-ec08
Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430
Kathrin Maedler; Desiree M. Schumann; Nadine Sauter; Helga Ellingsgaard; Domenico Bosco; Reto Baertschiger; Yoichiro Iwakura; José Oberholzer; Claes B. Wollheim; Benoit R. Gauthier; Marc Y. Donath
Diabetes July 2016, Vol.65, 2462. doi:https://doi.org/10.2337/db16-ec08a
Statement of Retraction
Statement of Retraction. Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver. Diabetes 2011;60:2720–2729. DOI: 10.2337/db11-0455
Eric D. Berglund; Daniel G. Lustig; Richard A. Baheza; Clinton M. Hasenour; Robert S. Lee-Young; E. Patrick Donahue; Sara E. Lynes; Larry L. Swift; Maureen J. Charron; Bruce M. Damon; David H. Wasserman
Topics:
fatty liver
,
glucagon
,
mice
Diabetes July 2016, Vol.65, 2463. doi:https://doi.org/10.2337/db16-rt08
Issues and Events
Issues and Events
Topics:
databases
,
podcasts
,
standard of care
,
health personnel
Diabetes July 2016, Vol.65, 2464. doi:https://doi.org/10.2337/db16-ie08
E-Letters: Comments and Responses
Comment on Alarcon et al. Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function. Diabetes 2016;65:438–450
Topics:
insulin
,
obesity
,
pancreas
,
diabetes mellitus, type 2
Diabetes July 2016, Vol.65, e28. doi:https://doi.org/10.2337/db16-0492