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Volume 65, Issue 9
1 September 2016
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ISSN 0012-1797
EISSN 1939-327X
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In This Issue

In This Issue of Diabetes
View articletitled, In This Issue of <em>Diabetes</em>
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Diabetes August 2016, Vol.65, 2465-2466. doi:https://doi.org/10.2337/db16-ti09

Commentaries

Central Regulation of Glucose Metabolism in Humans: Fact or Fiction?
Sofiya Gancheva; Michael Roden
View articletitled, Central Regulation of Glucose Metabolism in Humans: Fact or Fiction?
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Diabetes August 2016, Vol.65, 2467-2469. doi:https://doi.org/10.2337/dbi16-0032
Islets Transplanted Into the Eye: Do They Improve Our Insight Into Islet Adaptation to Insulin Resistance?
Leslie S. Satin; Joon Ha; Arthur S. Sherman
View articletitled, Islets Transplanted Into the Eye: Do They Improve Our Insight Into Islet Adaptation to Insulin Resistance?
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Diabetes August 2016, Vol.65, 2470-2472. doi:https://doi.org/10.2337/dbi16-0025
Orphaned No More? Glucose-Sensing Hypothalamic Neurons Control Insulin Secretion
Charles V. Mobbs
View articletitled, Orphaned No More? Glucose-Sensing Hypothalamic Neurons Control Insulin Secretion
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Diabetes August 2016, Vol.65, 2473-2475. doi:https://doi.org/10.2337/dbi16-0027
The Muscle Race After Bariatric Surgery: Ribosomal Proteins Come First
María Isabel Hernández-Alvarez; Antonio Zorzano
View articletitled, The Muscle Race After Bariatric Surgery: Ribosomal Proteins Come First
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Diabetes August 2016, Vol.65, 2476-2478. doi:https://doi.org/10.2337/dbi16-0035
Is There Enhanced Risk of Cerebral Ischemic Stroke by Sulfonylureas in Type 2 Diabetes?
Fiona E. Parkinson; Grant M. Hatch
View articletitled, Is There Enhanced Risk of Cerebral Ischemic Stroke by Sulfonylureas in Type 2 Diabetes?
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Diabetes August 2016, Vol.65, 2479-2481. doi:https://doi.org/10.2337/dbi16-0037

Technological Advances

Positron Emission Tomography to Assess the Outcome of Intraportal Islet Transplantation
Olof Eriksson; Ramkumar Selvaraju; Torsten Eich; Mariam Willny; Torkel B. Brismar; Lina Carlbom; Håkan Ahlström; Gunnar Tufvesson; Torbjörn Lundgren; Olle Korsgren
View articletitled, Positron Emission Tomography to Assess the Outcome of Intraportal Islet Transplantation
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Diabetes June 2016, Vol.65, 2482-2489. doi:https://doi.org/10.2337/db16-0222

Metabolism

β-Lapachone Prevents Diet-Induced Obesity by Increasing Energy Expenditure and Stimulating the Browning of White Adipose Tissue via Downregulation of miR-382 Expression
Won Hee Choi; Jiyun Ahn; Chang Hwa Jung; Young Jin Jang; Tae Youl Ha
View articletitled, β-Lapachone Prevents Diet-Induced Obesity by Increasing Energy Expenditure and Stimulating the Browning of White Adipose Tissue via Downregulation of miR-382 Expression
Supplementary data
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Diabetes May 2016, Vol.65, 2490-2501. doi:https://doi.org/10.2337/db15-1423
NOV/CCN3: A New Adipocytokine Involved in Obesity-Associated Insulin Resistance
Cécile Martinerie; Marie Garcia; Thi Thu Huong Do; Bénédicte Antoine; Marthe Moldes; Guillaume Dorothee; Chantal Kazazian; Martine Auclair; Marion Buyse; Tatiana Ledent; Pierre-Olivier Marchal; Maria Fesatidou; Adrien Beisseiche; Haruhiko Koseki; Shuichi Hiraoka; Christos Evangelos Chadjichristos; Bertrand Blondeau; Raphael Georges Denis; Serge Luquet; Bruno Fève
View articletitled, NOV/CCN3: A New Adipocytokine Involved in Obesity-Associated Insulin Resistance
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Diabetes June 2016, Vol.65, 2502-2515. doi:https://doi.org/10.2337/db15-0617
Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis
Jung Eun Jang; Myoung Seok Ko; Ji-Young Yun; Mi-Ok Kim; Jin Hee Kim; Hye Sun Park; Ah-Ram Kim; Hyuk-Joong Kim; Bum Joong Kim; Young Eun Ahn; Jin Sun Oh; Woo Je Lee; Robert A. Harris; Eun Hee Koh; Ki-Up Lee
View articletitled, Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis
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Diabetes May 2016, Vol.65, 2516-2528. doi:https://doi.org/10.2337/db15-1624
A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes
Amina Allalou; Amarnadh Nalla; Kacey J. Prentice; Ying Liu; Ming Zhang; Feihan F. Dai; Xian Ning; Lucy R. Osborne; Brian J. Cox; Erica P. Gunderson; Michael B. Wheeler
View articletitled, A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes
Supplementary data
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Diabetes June 2016, Vol.65, 2529-2539. doi:https://doi.org/10.2337/db15-1720
Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice
Andras Franko; Peter Huypens; Susanne Neschen; Martin Irmler; Jan Rozman; Birgit Rathkolb; Frauke Neff; Cornelia Prehn; Guillaume Dubois; Martina Baumann; Rebecca Massinger; Daniel Gradinger; Gerhard K.H. Przemeck; Birgit Repp; Michaela Aichler; Annette Feuchtinger; Philipp Schommers; Oliver Stöhr; Carmen Sanchez-Lasheras; Jerzy Adamski; Andreas Peter; Holger Prokisch; Johannes Beckers; Axel K. Walch; Helmut Fuchs; Eckhard Wolf; Markus Schubert; Rudolf J. Wiesner; Martin Hrabě de Angelis
View articletitled, Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice
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Diabetes June 2016, Vol.65, 2540-2552. doi:https://doi.org/10.2337/db15-1670
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet–Fed Mice
Terence E. Ryan; Cameron A. Schmidt; Thomas D. Green; Espen E. Spangenburg; P. Darrell Neufer; Joseph M. McClung
View articletitled, Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet–Fed Mice
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Diabetes June 2016, Vol.65, 2553-2568. doi:https://doi.org/10.2337/db16-0387
Central Regulation of Glucose Production May Be Impaired in Type 2 Diabetes
Yonah B. Esterson; Michelle Carey; Laura Boucai; Akankasha Goyal; Pooja Raghavan; Kehao Zhang; Deeksha Mehta; Daorong Feng; Licheng Wu; Sylvia Kehlenbrink; Sudha Koppaka; Preeti Kishore; Meredith Hawkins
View articletitled, Central Regulation of Glucose Production May Be Impaired in Type 2 Diabetes
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Diabetes May 2016, Vol.65, 2569-2579. doi:https://doi.org/10.2337/db15-1465
Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
Ondrej Kuda; Marie Brezinova; Martina Rombaldova; Barbora Slavikova; Martin Posta; Petr Beier; Petra Janovska; Jiri Veleba; Jan Kopecky, Jr.; Eva Kudova; Terezie Pelikanova; Jan Kopecky
View articletitled, Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
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Diabetes June 2016, Vol.65, 2580-2590. doi:https://doi.org/10.2337/db16-0385
A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity
Marc J. Tol; Roelof Ottenhoff; Marco van Eijk; Noam Zelcer; Jan Aten; Sander M. Houten; Dirk Geerts; Cindy van Roomen; Marlou C. Bierlaagh; Saskia Scheij; Marten A. Hoeksema; Johannes M. Aerts; Jonathan S. Bogan; Gerald W. Dorn, 2nd; Carmen A. Argmann; Arthur J. Verhoeven
View articletitled, A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity
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Diabetes June 2016, Vol.65, 2591-2605. doi:https://doi.org/10.2337/db16-0243

Signal Transduction

Protein Phosphatase 1-α Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle
Pragya Sharma; Edward B. Arias; Gregory D. Cartee
View articletitled, Protein Phosphatase 1-α Regulates AS160 Ser<sup>588</sup> and Thr<sup>642</sup> Dephosphorylation in Skeletal Muscle
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Diabetes May 2016, Vol.65, 2606-2617. doi:https://doi.org/10.2337/db15-0867

Obesity Studies

Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D2 Receptor Binding and Age in Obesity
Marta Y. Pepino; Sarah A. Eisenstein; Allison N. Bischoff; Samuel Klein; Stephen M. Moerlein; Joel S. Perlmutter; Kevin J. Black; Tamara Hershey
View articletitled, Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D<sub>2</sub> Receptor Binding and Age in Obesity
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Diabetes June 2016, Vol.65, 2618-2623. doi:https://doi.org/10.2337/db16-0407
Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity
Mira Ham; Sung Sik Choe; Kyung Cheul Shin; Goun Choi; Ji-Won Kim; Jung-Ran Noh; Yong-Hoon Kim; Je-won Ryu; Kun-Ho Yoon; Chul-Ho Lee; Jae Bum Kim
View articletitled, Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity
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Diabetes June 2016, Vol.65, 2624-2638. doi:https://doi.org/10.2337/db16-0060
Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis
Yong Hwan Han; Márcio Buffolo; Karla Maria Pires; Shaobo Pei; Philipp E. Scherer; Sihem Boudina
View articletitled, Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis
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Diabetes June 2016, Vol.65, 2639-2651. doi:https://doi.org/10.2337/db16-0283
Nck2 Deficiency in Mice Results in Increased Adiposity Associated With Adipocyte Hypertrophy and Enhanced Adipogenesis
Julie Dusseault; Bing Li; Nida Haider; Marie-Anne Goyette; Jean-François Côté; Louise Larose
View articletitled, Nck2 Deficiency in Mice Results in Increased Adiposity Associated With Adipocyte Hypertrophy and Enhanced Adipogenesis
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Diabetes June 2016, Vol.65, 2652-2666. doi:https://doi.org/10.2337/db15-1559
Gastric Bypass Reduces Symptoms and Hormonal Responses in Hypoglycemia
Niclas Abrahamsson; Joey Lau Börjesson; Magnus Sundbom; Urban Wiklund; F. Anders Karlsson; Jan W. Eriksson
View articletitled, Gastric Bypass Reduces Symptoms and Hormonal Responses in Hypoglycemia
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Diabetes June 2016, Vol.65, 2667-2675. doi:https://doi.org/10.2337/db16-0341

Islet Studies

Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset
Chunguang Chen; Helena Chmelova; Christian M. Cohrs; Julie A. Chouinard; Stephan R. Jahn; Julia Stertmann; Ingo Uphues; Stephan Speier
View articletitled, Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset
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Diabetes April 2016, Vol.65, 2676-2685. doi:https://doi.org/10.2337/db15-1718
Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity
Edward A. Phelps; Chiara Cianciaruso; Iacovos P. Michael; Miriella Pasquier; Jamil Kanaani; Rita Nano; Vanessa Lavallard; Nils Billestrup; Jeffrey A. Hubbell; Steinunn Baekkeskov
View articletitled, Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity
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Diabetes June 2016, Vol.65, 2686-2699. doi:https://doi.org/10.2337/db16-0180
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity
Trillian Gregg; Chetan Poudel; Brian A. Schmidt; Rashpal S. Dhillon; Sophia M. Sdao; Nathan A. Truchan; Emma L. Baar; Luis A. Fernandez; John M. Denu; Kevin W. Eliceiri; Jeremy D. Rogers; Michelle E. Kimple; Dudley W. Lamming; Matthew J. Merrins
View articletitled, Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced K<sub>ATP</sub> Channel Activity
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Diabetes June 2016, Vol.65, 2700-2710. doi:https://doi.org/10.2337/db16-0432
The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
Wilfredo Rosario; Inderroop Singh; Arnaud Wautlet; Christa Patterson; Jonathan Flak; Thomas C. Becker; Almas Ali; Natalia Tamarina; Louis H. Philipson; Lynn W. Enquist; Martin G. Myers, Jr.; Christopher J. Rhodes
View articletitled, The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
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Diabetes April 2016, Vol.65, 2711-2723. doi:https://doi.org/10.2337/db15-0629

Pathophysiology

Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery
Latoya E. Campbell; Paul R. Langlais; Samantha E. Day; Richard L. Coletta; Tonya R. Benjamin; Elena Anna De Filippis; James A. Madura, II; Lawrence J. Mandarino; Lori R. Roust; Dawn K. Coletta
View articletitled, Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery
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Diabetes May 2016, Vol.65, 2724-2731. doi:https://doi.org/10.2337/db16-0004
Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight
Stephanie R. Sisley; Deanna M. Arble; Adam P. Chambers; Ruth Gutierrez-Aguilar; Yanlin He; Yong Xu; David Gardner; David D. Moore; Randy J. Seeley; Darleen A. Sandoval
View articletitled, Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight
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Diabetes May 2016, Vol.65, 2732-2741. doi:https://doi.org/10.2337/db16-0309
Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes
Sophie Dogné; Géraldine Rath; François Jouret; Nathalie Caron; Chantal Dessy; Bruno Flamion
View articletitled, Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes
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Diabetes May 2016, Vol.65, 2742-2753. doi:https://doi.org/10.2337/db15-1662

Complications

Effects of γ-Aminobutyric Acid A Receptor Activation on Counterregulatory Responses to Subsequent Exercise in Individuals With Type 1 Diabetes
Maka S. Hedrington; Maia Mikeladze; Donna B. Tate; Lisa M. Younk; Ian Davis; Stephen N. Davis
View articletitled, Effects of γ-Aminobutyric Acid A Receptor Activation on Counterregulatory Responses to Subsequent Exercise in Individuals With Type 1 Diabetes
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Diabetes May 2016, Vol.65, 2754-2759. doi:https://doi.org/10.2337/db16-0207
Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance
Sayaka Katagiri; Kyoungmin Park; Yasutaka Maeda; Tata Nageswara Rao; Mogher Khamaisi; Qian Li; Hisashi Yokomizo; Akira Mima; Luca Lancerotto; Amy Wagers; Dennis P. Orgill; George L. King
View articletitled, Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance
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Diabetes May 2016, Vol.65, 2760-2771. doi:https://doi.org/10.2337/db15-1721
Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury
Miao Liu; Nirmal Verma; Xiaoli Peng; Sarah Srodulski; Andrew Morris; Martin Chow; Louis B. Hersh; Jing Chen; Haining Zhu; Mihai G. Netea; Kenneth B. Margulies; Sanda Despa; Florin Despa
View articletitled, Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury
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Diabetes June 2016, Vol.65, 2772-2783. doi:https://doi.org/10.2337/db16-0044

Pharmacology and Therapeutics

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
Simon A. Hawley; Rebecca J. Ford; Brennan K. Smith; Graeme J. Gowans; Sarah J. Mancini; Ryan D. Pitt; Emily A. Day; Ian P. Salt; Gregory R. Steinberg; D. Grahame Hardie
View articletitled, The Na<sup>+</sup>/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
Supplementary data
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Diabetes July 2016, Vol.65, 2784-2794. doi:https://doi.org/10.2337/db16-0058
Cerebrovascular Safety of Sulfonylureas: The Role of KATP Channels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes
Rui Liu; Haitao Wang; Baofeng Xu; Wenliang Chen; Ekaterina Turlova; Nan Dong; Christopher L.F. Sun; Yangqingqin Lu; Hanhui Fu; Ranran Shi; Andrew Barszczyk; Dongzi Yang; Tianru Jin; Edoardo Mannucci; Zhong-Ping Feng; Hong-Shuo Sun
View articletitled, Cerebrovascular Safety of Sulfonylureas: The Role of K<sub>ATP</sub> Channels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes
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Diabetes May 2016, Vol.65, 2795-2809. doi:https://doi.org/10.2337/db15-1737

Genetics / Genomes / Proteomics / Metabolomics

Isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation
Jayne A.L. Houghton; Galvin H. Swift; Charles Shaw-Smith; Sarah E. Flanagan; Elisa de Franco; Richard Caswell; Khalid Hussain; Sarar Mohamed; Majedah Abdulrasoul; Andrew T. Hattersley; Raymond J. MacDonald; Sian Ellard
View articletitled, Isolated Pancreatic Aplasia Due to a Hypomorphic <em>PTF1A</em> Mutation
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Diabetes June 2016, Vol.65, 2810-2815. doi:https://doi.org/10.2337/db15-1666

Erratum

Erratum. Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells. Diabetes 2016;65:1164–1178
Kosuke Takeda; Sandhya Sriram; Xin Hui Derryn Chan; Wee Kiat Ong; Chia Rou Yeo; Betty Tan; Seung-Ah Lee; Kien Voon Kong; Shawn Hoon; Hongfeng Jiang; Jason J. Yuen; Jayakumar Perumal; Madhur Agrawal; Candida Vaz; Jimmy So; Asim Shabbir; William S. Blaner; Malini Olivo; Weiping Han; Vivek Tanavde; Sue-Anne Toh; Shigeki Sugii
View articletitled, Erratum. Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells. Diabetes 2016;65:<span class="related-article"><a href="XSLT_Related_Article_Replace_Href" data-vol="65" data-page="1164">1164–1178</a></span>
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Diabetes August 2016, Vol.65, 2816. doi:https://doi.org/10.2337/db16-er09

Issues and Events

Issues and Events
View articletitled, Issues and Events
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Diabetes August 2016, Vol.65, 2817. doi:https://doi.org/10.2337/db16-ie09

E-Letters: Comments and Responses

Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302
Haiyu Tang; Chuanyu Gao
View articletitled, Comment on The Look AHEAD Research Group. Prospective Association of <em>GLUL</em> rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302
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Diabetes August 2016, Vol.65, e29. doi:https://doi.org/10.2337/db16-0410
Response to Comment on The Look AHEAD Research Group. Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302
Jeanne M. McCaffery; Gordon S. Huggins
View articletitled, Response to Comment on The Look AHEAD Research Group. Prospective Association of <em>GLUL</em> rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study. Diabetes 2016;65:297–302
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Diabetes August 2016, Vol.65, e30. doi:https://doi.org/10.2337/dbi16-0029
Comment on Menke et al. Metals in Urine and Diabetes in U.S. Adults. Diabetes 2016;65:164–171
Winifred P. Wong; Amisha Wallia; Joshua R. Edwards; Malek El Muayed
View articletitled, Comment on Menke et al. Metals in Urine and Diabetes in U.S. Adults. Diabetes 2016;65:164–171
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Diabetes August 2016, Vol.65, e31. doi:https://doi.org/10.2337/db16-0555
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
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