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1 January 2017
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Cover Image
Cover Image
On the cover: Regulatory CD3+ (green) FoxP3+ (red) T cells in CXCL10-deficient intact pancreatic islet isografts on day 100 after engraftment. CXCL10 influences the autoimmune destruction of islet isografts in mice with type 1 diabetes. A markedly increased number of regulatory T cells was detected surrounding the islet isografts under the kidney capsule of nondiabetic mice. Image courtesy of Christine Bender, Institute for Pharmacology and Toxicology, Pharmazentrum Frankfurt/Center for Drug Research, Development, and Safety (ZAFES), Goethe University Hospital Frankfurt, Frankfurt am Main, Germany. Her article, “Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes,” appears in this issue of Diabetes (p. 113).
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ISSN 0012-1797
EISSN 1939-327X
In this Issue
In This Issue
In This Issue of Diabetes
Diabetes December 2016, Vol.66, 1-2. doi:https://doi.org/10.2337/db17-ti01
Editor's Commentaries
Perspectives in Diabetes
Platelet Hyperreactivity in Diabetes: Focus on GPVI Signaling—Are Useful Drugs Already Available?
Diabetes December 2016, Vol.66, 7-13. doi:https://doi.org/10.2337/db16-1098
Commentaries
Getting a “GRiP” on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity
Diabetes December 2016, Vol.66, 17-19. doi:https://doi.org/10.2337/dbi16-0057
Exocrine and Endocrine Interactions in Cystic Fibrosis: A Potential Key to Understanding Insulin Secretion in Health and Disease?
Diabetes December 2016, Vol.66, 20-22. doi:https://doi.org/10.2337/dbi16-0049
Metabolism
Hepatic DPP4 DNA Methylation Associates With Fatty Liver
Christian Baumeier; Sophie Saussenthaler; Anne Kammel; Markus Jähnert; Luisa Schlüter; Deike Hesse; Mickaël Canouil; Stephane Lobbens; Robert Caiazzo; Violeta Raverdy; François Pattou; Emma Nilsson; Jussi Pihlajamäki; Charlotte Ling; Philippe Froguel; Annette Schürmann; Robert W. Schwenk
Diabetes October 2016, Vol.66, 25-35. doi:https://doi.org/10.2337/db15-1716
Effects of 13-Hour Hyperglucagonemia on Energy Expenditure and Hepatic Glucose Production in Humans
Manu Chakravarthy; Stephanie Parsons; Michael E. Lassman; Kristin Butterfield; Anita Y.H. Lee; Ying Chen; Stephen Previs; Jeffrey Spond; Shan Yang; Christopher Bock; Fanchao Yi; Jon Moon; Erica Wohlers-Kariesch; Steven R. Smith; Christian Meyer
Diabetes October 2016, Vol.66, 36-44. doi:https://doi.org/10.2337/db16-0746
Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes
Dahai Zhang; Fulong Wang; Nathaniel Lal; Amy Pei-Ling Chiu; Andrea Wan; Jocelyn Jia; Denise Bierende; Stephane Flibotte; Sunita Sinha; Ali Asadi; Xiaoke Hu; Farnaz Taghizadeh; Thomas Pulinilkunnil; Corey Nislow; Israel Vlodavsky; James D. Johnson; Timothy J. Kieffer; Bahira Hussein; Brian Rodrigues
Diabetes October 2016, Vol.66, 45-57. doi:https://doi.org/10.2337/db16-0761
Hepatocytes Are the Principal Source of Circulating RBP4 in Mice
Spencer J. Thompson; Ashot Sargsyan; Seung-Ah Lee; Jason J. Yuen; Jinjin Cai; Rana Smalling; Norbert Ghyselinck; Manuel Mark; William S. Blaner; Timothy E. Graham
Diabetes October 2016, Vol.66, 58-63. doi:https://doi.org/10.2337/db16-0286
Signal Transduction
Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I
Ana M. Fernandez; Edwin Hernandez-Garzón; Paloma Perez-Domper; Alberto Perez-Alvarez; Sara Mederos; Takashi Matsui; Andrea Santi; Angel Trueba-Saiz; Lucía García-Guerra; Julia Pose-Utrilla; Jens Fielitz; Eric N. Olson; Ruben Fernandez de la Rosa; Luis Garcia Garcia; Miguel Angel Pozo; Teresa Iglesias; Alfonso Araque; Hideaki Soya; Gertrudis Perea; Eduardo D. Martin; Ignacio Torres Aleman
Diabetes October 2016, Vol.66, 64-74. doi:https://doi.org/10.2337/db16-0861
Obesity Studies
Renal and Systemic Effects of Calorie Restriction in Patients With Type 2 Diabetes With Abdominal Obesity: A Randomized Controlled Trial
Piero Ruggenenti; Manuela Abbate; Barbara Ruggiero; Stefano Rota; Matias Trillini; Carolina Aparicio; Aneliya Parvanova; Ilian Petrov Iliev; Giovanna Pisanu; Annalisa Perna; Angela Russo; Olimpia Diadei; Davide Martinetti; Antonio Cannata; Fabiola Carrara; Silvia Ferrari; Nadia Stucchi; Giuseppe Remuzzi; Luigi Fontana; on behalf of the C.RE.S.O. Study Group
Diabetes September 2016, Vol.66, 75-86. doi:https://doi.org/10.2337/db16-0607
Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity
Cristina Contreras; Ismael González-García; Patricia Seoane-Collazo; Noelia Martínez-Sánchez; Laura Liñares-Pose; Eva Rial-Pensado; Johan Fernø; Manuel Tena-Sempere; Núria Casals; Carlos Diéguez; Rubén Nogueiras; Miguel López
Diabetes September 2016, Vol.66, 87-99. doi:https://doi.org/10.2337/db15-1547
Islet Studies
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
Fabio Arturo Grieco; Guido Sebastiani; Jonas Juan-Mateu; Olatz Villate; Laura Marroqui; Laurence Ladrière; Ksenya Tugay; Romano Regazzi; Marco Bugliani; Piero Marchetti; Francesco Dotta; Décio L. Eizirik
Diabetes October 2016, Vol.66, 100-112. doi:https://doi.org/10.2337/db16-0592
Immunology and Transplantation
Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes
Christine Bender; Selina Christen; Klaus Scholich; Monika Bayer; Josef M. Pfeilschifter; Edith Hintermann; Urs Christen
Diabetes October 2016, Vol.66, 113-126. doi:https://doi.org/10.2337/db16-0547
Hematopoietic Stem Cell Mobilization Is Necessary but Not Sufficient for Tolerance in Islet Transplantation
Blair T. Stocks; Analise B. Thomas; Sydney K. Elizer; Yuantee Zhu; Andrew F. Marshall; Christopher S. Wilson; Daniel J. Moore
Diabetes October 2016, Vol.66, 127-133. doi:https://doi.org/10.2337/db16-0444
Pathophysiology
Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance
Saba Sheikh; Lalitha Gudipaty; Diva D. De Leon; Denis Hadjiliadis; Christina Kubrak; Nora K. Rosenfeld; Sarah C. Nyirjesy; Amy J. Peleckis; Saloni Malik; Darko Stefanovski; Marina Cuchel; Ronald C. Rubenstein; Andrea Kelly; Michael R. Rickels
Diabetes August 2016, Vol.66, 134-144. doi:https://doi.org/10.2337/db16-0394
A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats
Natasha Qaisar; Suvana Lin; Glennice Ryan; Chaoxing Yang; Sarah R. Oikemus; Michael H. Brodsky; Rita Bortell; John P. Mordes; Jennifer P. Wang
Diabetes October 2016, Vol.66, 145-157. doi:https://doi.org/10.2337/db16-0462
Subclinical Disease Burden as Assessed by Whole-Body MRI in Subjects With Prediabetes, Subjects With Diabetes, and Normal Control Subjects From the General Population: The KORA-MRI Study
Fabian Bamberg; Holger Hetterich; Susanne Rospleszcz; Roberto Lorbeer; Sigrid D. Auweter; Christopher L. Schlett; Anina Schafnitzel; Christian Bayerl; Andreas Schindler; Tobias Saam; Katharina Müller-Peltzer; Wieland Sommer; Tanja Zitzelsberger; Jürgen Machann; Michael Ingrisch; Sonja Selder; Wolfgang Rathmann; Margit Heier; Birgit Linkohr; Christa Meisinger; Christian Weber; Birgit Ertl-Wagner; Steffen Massberg; Maximilian F. Reiser; Annette Peters
Diabetes October 2016, Vol.66, 158-169. doi:https://doi.org/10.2337/db16-0630
Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging
Elisa Fabbri; Chee W. Chia; Richard G. Spencer; Kenneth W. Fishbein; David A. Reiter; Donnie Cameron; Ariel C. Zane; Zenobia A. Moore; Marta Gonzalez-Freire; Marco Zoli; Stephanie A. Studenski; Rita R. Kalyani; Josephine M. Egan; Luigi Ferrucci
Diabetes October 2016, Vol.66, 170-176. doi:https://doi.org/10.2337/db16-0754
Complications
Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs
Diabetes September 2016, Vol.66, 177-192. doi:https://doi.org/10.2337/db16-0052
Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
Diabetes October 2016, Vol.66, 193-205. doi:https://doi.org/10.2337/db16-0915
Pharmacology and Therapeutics
Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance
Anne M. Cieniewicz; Thomas Kirchner; Simon A. Hinke; Rupesh Nanjunda; Katharine D’Aquino; Ken Boayke; Philip R. Cooper; Robert Perkinson; Mark L. Chiu; Stephen Jarantow; Dana L. Johnson; Jean M. Whaley; Eilyn R. Lacy; Russell B. Lingham; Yin Liang; Anthony J. Kihm
Diabetes October 2016, Vol.66, 206-217. doi:https://doi.org/10.2337/db16-0633
Genetics / Genomes / Proteomics / Metabolomics
Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution
Anna Ehrlund; Niklas Mejhert; Christel Björk; Robin Andersson; Agné Kulyté; Gaby Åström; Masayoshi Itoh; Hideya Kawaji; Timo Lassmann; Carsten O. Daub; Piero Carninci; Alistair R.R. Forrest; Yoshihide Hayashizaki; Albin Sandelin; Erik Ingelsson; FANTOM Consortium; Mikael Rydén; Jurga Laurencikiene; Peter Arner; Erik Arner
Diabetes November 2016, Vol.66, 218-230. doi:https://doi.org/10.2337/db16-0631
Erratum
Erratum. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes 2016;65:3289–3300
Laura K. Cole; Edgard M. Mejia; Marilyne Vandel; Genevieve C. Sparagna; Steven M. Claypool; Laura Dyck-Chan; Julianne Klein; Grant M. Hatch
Diabetes November 2016, Vol.66, 231. doi:https://doi.org/10.2337/db17-er01a
