Issues

On the cover: Regulatory CD3+ (green) FoxP3+ (red) T cells in CXCL10-deficient intact pancreatic islet isografts on day 100 after engraftment. CXCL10 influences the autoimmune destruction of islet isografts in mice with type 1 diabetes. A markedly increased number of regulatory T cells was detected surrounding the islet isografts under the kidney capsule of nondiabetic mice. Image courtesy of Christine Bender, Institute for Pharmacology and Toxicology, Pharmazentrum Frankfurt/Center for Drug Research, Development, and Safety (ZAFES), Goethe University Hospital Frankfurt, Frankfurt am Main, Germany. Her article, “Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes,” appears in this issue of Diabetes (p. 113).


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