Issues

On the cover: Visualization of diabetogenic T cells undergoing tolerance induction in the spleen. Shown in this image are diabetogenic NOD.BDC2.5 TCR transgenic T cells, labeled in red, that have been transferred to a NOD.CD11c-YFP mouse. This recipient mouse has dendritic cells that express the yellow fluorescent protein under the control of the CD11c-specific promoter. Polyclonal NOD CD4⁺ T cells were labeled blue with cell trace violet. A time-lapse series was imaged for this region to determine the dynamic motility in vivo of activated diabetes inducing NOD.BDC2.5 CD4⁺ T cells (red) in a spleen interacting with yellow CD11c dendritic cells 18 h after transfer and blue polyclonal T cells. Image courtesy of Jason Mitchell, Justin A. Spanier, and Brian T. Fife from the University of Minnesota Department of Medicine, Center for Immunology, Minneapolis, MN. The article “Increased Effector Memory Insulin-Specific CD4⁺ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes,” appears in this issue of Diabetes (p. 3051).


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