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1 February 2017
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Cover Image
Cover Image
On the cover: Primary rat islet cells immunostained for insulin (green), the exosome marker CD81 (red), trans Golgi marker TGN38 (magenta), and nuclei (blue) reveal colocalization of insulin and CD81 in a subgroup of insulin-positive vesicles budding off from the trans Golgi membranes. Image courtesy of Chiara Cianciaruso, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Her article, “Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity,” appears in this issue of Diabetes (p. 460).
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes January 2017, Vol.66, 233-234. doi:https://doi.org/10.2337/db17-ti02
Perspectives in Diabetes
Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver–α-Cell Axis
Diabetes January 2017, Vol.66, 235-240. doi:https://doi.org/10.2337/db16-0994
Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
Jay S. Skyler; George L. Bakris; Ezio Bonifacio; Tamara Darsow; Robert H. Eckel; Leif Groop; Per-Henrik Groop; Yehuda Handelsman; Richard A. Insel; Chantal Mathieu; Allison T. McElvaine; Jerry P. Palmer; Alberto Pugliese; Desmond A. Schatz; Jay M. Sosenko; John P.H. Wilding; Robert E. Ratner
Diabetes December 2016, Vol.66, 241-255. doi:https://doi.org/10.2337/db16-0806
Commentaries
Bonding With β-Cells—A Role for Oxytocin in Glucose Handling
Diabetes January 2017, Vol.66, 256-257. doi:https://doi.org/10.2337/dbi16-0053
Follicular T Helper Cells: A New Marker of Type 1 Diabetes Risk?
Diabetes January 2017, Vol.66, 258-260. doi:https://doi.org/10.2337/dbi16-0062
Müller Cell–Microglia Cross Talk Drives Neuroinflammation in Diabetic Retinopathy
Diabetes January 2017, Vol.66, 261-263. doi:https://doi.org/10.2337/dbi16-0047
Metabolism
Oxytocin Improves β-Cell Responsivity and Glucose Tolerance in Healthy Men
Johanna Klement; Volker Ott; Kristina Rapp; Swantje Brede; Francesca Piccinini; Claudio Cobelli; Hendrik Lehnert; Manfred Hallschmid
Diabetes August 2016, Vol.66, 264-271. doi:https://doi.org/10.2337/db16-0569
Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition
Kristina M. Mueller; Kerstin Hartmann; Doris Kaltenecker; Sabine Vettorazzi; Mandy Bauer; Lea Mauser; Sabine Amann; Sigrid Jall; Katrin Fischer; Harald Esterbauer; Timo D. Müller; Matthias H. Tschöp; Christoph Magnes; Johannes Haybaeck; Thomas Scherer; Natalie Bordag; Jan P. Tuckermann; Richard Moriggl
Diabetes September 2016, Vol.66, 272-286. doi:https://doi.org/10.2337/db16-0381
Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain
Natalie J. Haywood; Paul A. Cordell; Kar Yeun Tang; Natallia Makova; Nadira Y. Yuldasheva; Helen Imrie; Hema Viswambharan; Alexander F. Bruns; Richard M. Cubbon; Mark T. Kearney; Stephen B. Wheatcroft
Diabetes November 2016, Vol.66, 287-299. doi:https://doi.org/10.2337/db16-0997
Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity
Peishan Li; Yu Song; Wenying Zan; Liping Qin; Shuang Han; Baichun Jiang; Hao Dou; Changshun Shao; Yaoqin Gong
Diabetes November 2016, Vol.66, 300-313. doi:https://doi.org/10.2337/db16-0743
Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis
Chloé Chrétien; Claire Fenech; Fabienne Liénard; Sylvie Grall; Charlène Chevalier; Sylvie Chaudy; Xavier Brenachot; Raymond Berges; Katie Louche; Romana Stark; Emmanuelle Nédélec; Amélie Laderrière; Zane B. Andrews; Alexandre Benani; Veit Flockerzi; Jean Gascuel; Jana Hartmann; Cédric Moro; Lutz Birnbaumer; Corinne Leloup; Luc Pénicaud; Xavier Fioramonti
Diabetes November 2016, Vol.66, 314-324. doi:https://doi.org/10.2337/db16-1114
Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance
Ashley S. Williams; Elijah Trefts; Louise Lantier; Carrie A. Grueter; Deanna P. Bracy; Freyja D. James; Ambra Pozzi; Roy Zent; David H. Wasserman
Diabetes November 2016, Vol.66, 325-334. doi:https://doi.org/10.2337/db16-0484
Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population
Laeya Abdoli Najmi; Ingvild Aukrust; Jason Flannick; Janne Molnes; Noel Burtt; Anders Molven; Leif Groop; David Altshuler; Stefan Johansson; Lise Bjørkhaug; Pål Rasmus Njølstad
Diabetes November 2016, Vol.66, 335-346. doi:https://doi.org/10.2337/db16-0460
Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes
Peter Willeit; Philipp Skroblin; Alexander R. Moschen; Xiaoke Yin; Dorothee Kaudewitz; Anna Zampetaki; Temo Barwari; Meredith Whitehead; Cristina M. Ramírez; Leigh Goedeke; Noemi Rotllan; Enzo Bonora; Alun D. Hughes; Peter Santer; Carlos Fernández-Hernando; Herbert Tilg; Johann Willeit; Stefan Kiechl; Manuel Mayr
Diabetes November 2016, Vol.66, 347-357. doi:https://doi.org/10.2337/db16-0731
Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation
Diabetes November 2016, Vol.66, 358-371. doi:https://doi.org/10.2337/db16-0876
The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice
Melissa A. Burmeister; Jennifer E. Ayala; Hannah Smouse; Adriana Landivar-Rocha; Jacob D. Brown; Daniel J. Drucker; Doris A. Stoffers; Darleen A. Sandoval; Randy J. Seeley; Julio E. Ayala
Diabetes December 2016, Vol.66, 372-384. doi:https://doi.org/10.2337/db16-1102
Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy
Cheol Ryong Ku; Narae Lee; Jae Won Hong; In Gyu Kwon; Woo Jin Hyung; Sung Hoon Noh; Eun Jig Lee; Mijin Yun; Arthur Cho
Diabetes November 2016, Vol.66, 385-391. doi:https://doi.org/10.2337/db16-1000
Obesity Studies
Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice
Brian F. Zamarron; Taleen A. Mergian; Kae Won Cho; Gabriel Martinez-Santibanez; Danny Luan; Kanakadurga Singer; Jennifer L. DelProposto; Lynn M. Geletka; Lindsey A. Muir; Carey N. Lumeng
Diabetes November 2016, Vol.66, 392-406. doi:https://doi.org/10.2337/db16-0500
Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model
Liufeng Mao; Baoming Nie; Tao Nie; Xiaoyan Hui; Xuefei Gao; Xiaoliang Lin; Xin Liu; Yong Xu; Xiaofeng Tang; Ran Yuan; Kuai Li; Peng Li; Ke Ding; Yu Wang; Aimin Xu; Jian Fei; Weiping Han; Pentao Liu; Lise Madsen; Karsten Kristiansen; Zhiguang Zhou; Sheng Ding; Donghai Wu
Diabetes November 2016, Vol.66, 407-417. doi:https://doi.org/10.2337/db16-0343
Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome
Miranda M. Sung; Ty T. Kim; Emmanuel Denou; Carrie-Lynn M. Soltys; Shereen M. Hamza; Nikole J. Byrne; Grant Masson; Heekuk Park; David S. Wishart; Karen L. Madsen; Jonathan D. Schertzer; Jason R.B. Dyck
Diabetes November 2016, Vol.66, 418-425. doi:https://doi.org/10.2337/db16-0680
Islet Studies
Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
Tehila Dahan; Oren Ziv; Elad Horwitz; Hai Zemmour; Judith Lavi; Avital Swisa; Gil Leibowitz; Frances M. Ashcroft; Peter In’t Veld; Benjamin Glaser; Yuval Dor
Diabetes November 2016, Vol.66, 426-436. doi:https://doi.org/10.2337/db16-0641
Immunology and Transplantation
Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies
Tyyne Viisanen; Emmi-Leena Ihantola; Kirsti Näntö-Salonen; Heikki Hyöty; Noora Nurminen; Jenni Selvenius; Auni Juutilainen; Leena Moilanen; Jussi Pihlajamäki; Riitta Veijola; Jorma Toppari; Mikael Knip; Jorma Ilonen; Tuure Kinnunen
Diabetes October 2016, Vol.66, 437-447. doi:https://doi.org/10.2337/db16-0714
Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells
Tatiana Takiishi; Dana Paulina Cook; Hannelie Korf; Guido Sebastiani; Francesca Mancarella; João Paulo Monteiro Carvalho Mori Cunha; Clive Wasserfall; Noelia Casares; Juan José Lasarte; Lothar Steidler; Pieter Rottiers; Francesco Dotta; Conny Gysemans; Chantal Mathieu
Diabetes November 2016, Vol.66, 448-459. doi:https://doi.org/10.2337/db15-1625
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity
Chiara Cianciaruso; Edward A. Phelps; Miriella Pasquier; Romain Hamelin; Davide Demurtas; Mohamed Alibashe Ahmed; Lorenzo Piemonti; Sachiko Hirosue; Melody A. Swartz; Michele De Palma; Jeffrey A. Hubbell; Steinunn Baekkeskov
Diabetes November 2016, Vol.66, 460-473. doi:https://doi.org/10.2337/db16-0671
Pathophysiology
Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistance
Yamilee Hurtado-Roca; Hector Bueno; Antonio Fernandez-Ortiz; Jose Maria Ordovas; Borja Ibañez; Valentin Fuster; Fernando Rodriguez-Artalejo; Martin Laclaustra
Diabetes December 2016, Vol.66, 474-482. doi:https://doi.org/10.2337/db16-0933
Complications
CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
Jose-Andres C. Portillo; Yalitza Lopez Corcino; Yanling Miao; Jie Tang; Nader Sheibani; Timothy S. Kern; George R. Dubyak; Carlos S. Subauste
Diabetes July 2016, Vol.66, 483-493. doi:https://doi.org/10.2337/db16-0051
Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy
Xin Wang; Bing Yao; Yinqiu Wang; Xiaofeng Fan; Suwan Wang; Aolei Niu; Haichun Yang; Agnes Fogo; Ming-Zhi Zhang; Raymond C. Harris
Diabetes November 2016, Vol.66, 494-504. doi:https://doi.org/10.2337/db16-0773
Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes
Goutham Vasam; Shrinidh Joshi; Sean E. Thatcher; Stephen H. Bartelmez; Lisa A. Cassis; Yagna P.R. Jarajapu
Diabetes November 2016, Vol.66, 505-518. doi:https://doi.org/10.2337/db16-1039
PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice
Wai San Cheang; Wing Tak Wong; Lei Zhao; Jian Xu; Li Wang; Chi Wai Lau; Zhen Yu Chen; Ronald Ching Wan Ma; Aimin Xu; Nanping Wang; Xiao Yu Tian; Yu Huang
Diabetes November 2016, Vol.66, 519-528. doi:https://doi.org/10.2337/db15-1657
Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy
Junlian Gu; Yanli Cheng; Hao Wu; Lili Kong; Shudong Wang; Zheng Xu; Zhiguo Zhang; Yi Tan; Bradley B. Keller; Honglan Zhou; Yuehui Wang; Zhonggao Xu; Lu Cai
Diabetes November 2016, Vol.66, 529-542. doi:https://doi.org/10.2337/db15-1274
Genetics / Genomes / Proteomics / Metabolomics
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Rachael C. Aikens; Wei Zhao; Danish Saleheen; Muredach P. Reilly; Stephen E. Epstein; Emmi Tikkanen; Veikko Salomaa; Benjamin F. Voight
Diabetes October 2016, Vol.66, 543-550. doi:https://doi.org/10.2337/db16-0868
hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn2+ and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins
Diabetes November 2016, Vol.66, 551-559. doi:https://doi.org/10.2337/db16-0323
Errata
Erratum. Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study. Diabetes 2016;65:2404–2413
Frank C.G. van Bussel; Walter H. Backes; Tamar M. van Veenendaal; Paul A.M. Hofman; Martin P.J. van Boxtel; Miranda T. Schram; Simone J.S. Sep; Pieter C. Dagnelie; Nicolaas Schaper; Coen D.A. Stehouwer; Joachim E. Wildberger; Jacobus F.A. Jansen
Diabetes December 2016, Vol.66, 560. doi:https://doi.org/10.2337/db17-er02a
Erratum. Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism. Diabetes 2016;65:3610–3620
Blake J. Cochran; Liming Hou; Anil Paul Chirackal Manavalan; Benjamin M. Moore; Fatiha Tabet; Afroza Sultana; Luisa Cuesta Torres; Shudi Tang; Sudichhya Shrestha; Praween Senanayake; Mili Patel; William J. Ryder; Andre Bongers; Marie Maraninchi; Valerie C. Wasinger; Marit Westerterp; Alan R. Tall; Philip J. Barter; Kerry-Anne Rye
Diabetes December 2016, Vol.66, 560. doi:https://doi.org/10.2337/db17-er02b
