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1 March 2017
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Cover Image
Cover Image
On the cover: Scanning electron micrograph of a glomerulus from a 3-week diabetic mouse depicting glomerular open capillaries and podocytes. Images were taken by Dr. Kerstin Ebefors, Department of Molecular and Clinical Medicine/Nephrology, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. See the article, “Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility,” by Qi et al., which appears in this issue of Diabetes (p. 763).
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ISSN 0012-1797
EISSN 1939-327X
In This Issue
In This Issue of Diabetes
Diabetes February 2017, Vol.66, 563-564. doi:https://doi.org/10.2337/db17-ti03
Commentaries
Circulating MicroRNAs to Predict the Risk for Metabolic Diseases in the General Population?
Diabetes February 2017, Vol.66, 565-567. doi:https://doi.org/10.2337/dbi16-0072
Targeting the Gut Microbiota–FXR Signaling Axis for Glycemic Control: Does a Dietary Supplement Work Magic?
Diabetes February 2017, Vol.66, 571-573. doi:https://doi.org/10.2337/dbi16-0066
Preserving Cognition in Children With Diabetes: Do Alterations in Functional Network Connectivity Play a Role?
Diabetes February 2017, Vol.66, 574-576. doi:https://doi.org/10.2337/dbi16-0060
Metabolism
Associations of Steroid Sex Hormones and Sex Hormone–Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis
Taulant Muka; Jana Nano; Loes Jaspers; Cindy Meun; Wichor M. Bramer; Albert Hofman; Abbas Dehghan; Maryam Kavousi; Joop S.E. Laven; Oscar H. Franco
Diabetes October 2016, Vol.66, 577-586. doi:https://doi.org/10.2337/db16-0473
Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation
Candace M. Reno; Erwin C. Puente; Zhenyu Sheng; Dorit Daphna-Iken; Adam J. Bree; Vanessa H. Routh; Barbara B. Kahn; Simon J. Fisher
Diabetes October 2016, Vol.66, 587-597. doi:https://doi.org/10.2337/db16-0917
Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK
Rasmus Kjøbsted; Nanna Munk-Hansen; Jesper B. Birk; Marc Foretz; Benoit Viollet; Marie Björnholm; Juleen R. Zierath; Jonas T. Treebak; Jørgen F.P. Wojtaszewski
Diabetes October 2016, Vol.66, 598-612. doi:https://doi.org/10.2337/db16-0530
An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice
Cen Xie; Changtao Jiang; Jingmin Shi; Xiaoxia Gao; Dongxue Sun; Lulu Sun; Ting Wang; Shogo Takahashi; Mallappa Anitha; Kristopher W. Krausz; Andrew D. Patterson; Frank J. Gonzalez
Diabetes November 2016, Vol.66, 613-626. doi:https://doi.org/10.2337/db16-0663
Age-Dependent Control of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to Maternal Diet–Induced Fetal Programming
Olivier Dumortier; Estelle Roger; Didier F. Pisani; Virginie Casamento; Nadine Gautier; Patricia Lebrun; Hereroa Johnston; Pascal Lopez; Ez-Zoubir Amri; Céline Jousse; Pierre Fafournoux; Marc Prentki; Charlotte Hinault; Emmanuel Van Obberghen
Diabetes December 2016, Vol.66, 627-639. doi:https://doi.org/10.2337/db16-0956
Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure
Jiali Deng; Feixiang Yuan; Yajie Guo; Yuzhong Xiao; Yuguo Niu; Yalan Deng; Xiao Han; Youfei Guan; Shanghai Chen; Feifan Guo
Diabetes December 2016, Vol.66, 640-650. doi:https://doi.org/10.2337/db16-0954
Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle
Jonathan M. Mudry; David G. Lassiter; Carolina Nylén; Sonia García-Calzón; Erik Näslund; Anna Krook; Juleen R. Zierath
Diabetes December 2016, Vol.66, 651-662. doi:https://doi.org/10.2337/db16-0882
Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia
Ting Yao; Zhuo Deng; Yong Gao; Jia Sun; Xingxing Kong; Yiru Huang; Zhenyan He; Yanchao Xu; Yongsheng Chang; Kai-jiang Yu; Brianna G. Findley; Eric D. Berglund; Rui-tao Wang; Hongbo Guo; Hong Chen; Xu Li; Randal J. Kaufman; Jianqun Yan; Tiemin Liu; Kevin W. Williams
Diabetes December 2016, Vol.66, 663-673. doi:https://doi.org/10.2337/db16-0533
Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release
Lee D. Roberts; Tom Ashmore; Ben D. McNally; Steven A. Murfitt; Bernadette O. Fernandez; Martin Feelisch; Ross Lindsay; Mario Siervo; Elizabeth A. Williams; Andrew J. Murray; Julian L. Griffin
Diabetes December 2016, Vol.66, 674-688. doi:https://doi.org/10.2337/db16-0843
Obesity Studies
Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice
Diabetes December 2016, Vol.66, 689-698. doi:https://doi.org/10.2337/db16-1104
Islet Studies
Endogenous α2A-Adrenoceptor–Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling
Kiyonori Ito; Katsuya Dezaki; Masashi Yoshida; Hodaka Yamada; Rina Miura; Rauza Sukma Rita; Susumu Ookawara; Kaoru Tabei; Masanobu Kawakami; Kazuo Hara; Yoshiyuki Morishita; Toshihiko Yada; Masafumi Kakei
Diabetes December 2016, Vol.66, 699-709. doi:https://doi.org/10.2337/db16-1166
Immunology and Transplantation
Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes
John P. Driver; Jeremy J. Racine; Cheng Ye; Deanna J. Lamont; Brittney N. Newby; Caroline M. Leeth; Harold D. Chapman; Todd M. Brusko; Yi-Guang Chen; Clayton E. Mathews; David V. Serreze
Diabetes December 2016, Vol.66, 710-721. doi:https://doi.org/10.2337/db16-0846
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
Aaron W. Michels; Laurie G. Landry; Kristen A. McDaniel; Liping Yu; Martha Campbell-Thompson; William W. Kwok; Kenneth L. Jones; Peter A. Gottlieb; John W. Kappler; Qizhi Tang; Bart O. Roep; Mark A. Atkinson; Clayton E. Mathews; Maki Nakayama
Diabetes December 2016, Vol.66, 722-734. doi:https://doi.org/10.2337/db16-1025
An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8
Axel Wester; Hanna Skärstrand; Alexander Lind; Anita Ramelius; Annelie Carlsson; Elisabeth Cedervall; Björn Jönsson; Sten A. Ivarsson; Helena Elding Larsson; Karin Larsson; Bengt Lindberg; Jan Neiderud; Malin Fex; Carina Törn; Åke Lernmark
Diabetes December 2016, Vol.66, 735-740. doi:https://doi.org/10.2337/db16-0891
Pathophysiology
Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion
Corey N. Cunningham; Kaiyu He; Anoop Arunagiri; Adrienne W. Paton; James C. Paton; Peter Arvan; Billy Tsai
Diabetes December 2016, Vol.66, 741-753. doi:https://doi.org/10.2337/db16-1338
Complications
Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
Manish Saggar; Eva Tsalikian; Nelly Mauras; Paul Mazaika; Neil H. White; Stuart Weinzimer; Bruce Buckingham; Tamara Hershey; Allan L. Reiss; for the Diabetes Research in Children Network (DirecNet)
Diabetes October 2016, Vol.66, 754-762. doi:https://doi.org/10.2337/db16-0414
Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility
Haiying Qi; Gabriella Casalena; Shaolin Shi; Liping Yu; Kerstin Ebefors; Yezhou Sun; Weijia Zhang; Vivette D’Agati; Detlef Schlondorff; Börje Haraldsson; Erwin Böttinger; Ilse Daehn
Diabetes November 2016, Vol.66, 763-778. doi:https://doi.org/10.2337/db16-0695
Genetics / Genomes / Proteomics / Metabolomics
Placental and Cord Blood Methylation of Genes Involved in Energy Homeostasis: Association With Fetal Growth and Neonatal Body Composition
Marta Díaz; Cristina García; Giorgia Sebastiani; Francis de Zegher; Abel López-Bermejo; Lourdes Ibáñez
Diabetes December 2016, Vol.66, 779-784. doi:https://doi.org/10.2337/db16-0776
Statements of Retraction
Statement of Retraction. Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei. Diabetes 2013;62:137–148. DOI: 10.2337/db11-1388
Patrícia O. Prada; Paula G.F. Quaresma; Andrea M. Caricilli; Andressa C. Santos; Dioze Guadagnini; Joseane Morari; Laís Weissmann; Eduardo R. Ropelle; José Barreto C. Carvalheira; Lício A. Velloso; Mario J.A. Saad
Diabetes February 2017, Vol.66, 785-786. doi:https://doi.org/10.2337/db17-rt03a
Statement of Retraction. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss. Diabetes 2008;57:594–605. DOI: 10.2337/db07-0573
Eduardo R. Ropelle; José R. Pauli; Maria Fernanda A. Fernandes; Silvana A. Rocco; Rodrigo M. Marin; Joseane Morari; Kellen K. Souza; Marília M. Dias; Maria C. Gomes-Marcondes; José A.R. Gontijo; Kleber G. Franchini; Lício A. Velloso; Mario J.A. Saad; José B.C. Carvalheira
Diabetes February 2017, Vol.66, 786-787. doi:https://doi.org/10.2337/db17-rt03b
